Effectively prolonging the residence time of nanoprobes in the tumor region and reducing the accumulation of nanoprobes in the vital organs (for example, lung, liver and spleen) is crucial for high-efficiency photodynamic therapy (PDT) of cancer. Herein, we systematically report an ultra-small and highly stable nanoplatform with diameters of 4, 8 and 13 nm that exhibited excellent photodynamic therapeutic efficacy using Fe₃O₄@polymer-NPO/PEG-Glc@Ce6 nanoprobes. Based on the small size effect, the nanoprobes displayed lower cytotoxicity and excellent biocompatibility. Owing to the synergistic virtues of markedly active targeting and intrinsic small size effect, the Fe₃O₄@P-NPO/PEG-Glc@Ce6 nanoprobes can effectively prolong their residence time in the tumor region and reduce accumulation in the normal organs. Benefitting from the small size effect, the synthesized Fe₃O₄@P-NPO/PEG-Glc@Ce6 nanoprobes exhibited excellent tumor-targeting capability and photodynamic therapeutic efficacy by inhibiting the growth of tumors in mice under visible red light irradiation with a relatively lower power. The successful application of the small size effect in Fe₃O₄@P-NPO/PEG-Glc@Ce6 nanoprobes to significantly improve the PDT efficiency in our strategy suggests new building blocks for PDT of tumors and paves a new way for clinical therapies and translation in the near future.

有效延长纳米探针在肿瘤区域的停留时间并减少纳米探针在重要器官（例如肺，肝和脾脏）中的积累对于癌症的高效光动力疗法（PDT）至关重要。在本文中，我们系统地报道了直径为4、8和13 nm的超小型且高度稳定的纳米平台，该平台使用Fe ₃ O ₄ @ polymer-NPO / PEG-Glc @ Ce6纳米探针表现出出色的光动力治疗功效。基于小尺寸效应，纳米探针显示出较低的细胞毒性和优异的生物相容性。由于具有明显的主动靶向作用和固有的小尺寸效应，Fe ₃ O ₄具有协同作用。@ P-NPO / PEG-Glc @ Ce6纳米探针可以有效地延长其在肿瘤区域的停留时间，并减少在正常器官中的积累。得益于小尺寸效应，合成的Fe ₃ O ₄ @ P-NPO / PEG-Glc @ Ce6纳米探针通过相对可见的红光照射抑制小鼠肿瘤的生长，表现出优异的肿瘤靶向能力和光动力治疗功效。较低的功率。Fe ₃ O ₄ @ P-NPO / PEG-Glc @ Ce6纳米探针中成功实现了小尺寸效应以显着提高PDT效率，这在我们的策略中表明了肿瘤PDT的新组成部分，并为临床治疗和治疗铺平了道路。翻译在不久的将来。