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  • Ultrasound-triggered release of sinoporphyrin sodium from liposome-microbubble complexes and its enhanced sonodynamic toxicity in breast cancer
    Nano Res. (IF 7.354) Pub Date : 2017-08-23
    Yixiang Li, Huanxiao An, Xiaobing Wang, Pan Wang, Fei Qu, Yan Jiao, Kun Zhang, Quanhong Liu

    Applying ultrasound (US) to drug delivery and disease therapy is important work. Sonodynamic therapy (SDT)—a comprehensive therapy using US and a sonosensitizer—exhibits antineoplastic activity in many tumors. In this study, we investigated the feasibility of using a new sonosensitizer (sinoporphyrin sodium, DVDMS) loaded into liposome–microbubble complexes (DLMBs) as a possible candidate to enhance SDT against breast cancer. DLMBs were synthesized via the biotin–avidin linkage and confirmed to have good US response. US-induced cavitation played a key role to trigger a boosted payload release from DLMBs and improve the cellular uptake and intratumoral diffusion of DVDMS to realize better SDT effect. The combination of DLMBs and US treatment resulted in significant changes to cell morphology, mitochondria damage, and cell apoptosis in vitro. In vivo, the combined treatment markedly inhibited tumor growth, which appeared to result from increased apoptosis and reduced proliferation activity. The significant increase in the antitumor effect of DLMBs plus US suggests their potential use as a new approach to promote the killing activity of SDT against breast cancer.

    更新日期:2018-01-18
  • Erratum to: Epitaxial growth of hyperbranched Cu/Cu 2 O/CuO core–shell nanowire heterostructures for lithium-ion batteries
    Nano Res. (IF 7.354) Pub Date : 2017-09-15
    Yuxin Zhao, Ying Zhang, Hu Zhao, Xuejin Li, Yanpeng Li, Ling Wen, Zifeng Yan, Ziyang Huo

    The authors note that there is an extra incorrect citation for Fig. S5 appeared on page 2770. It has also come to our attention that Figs. 5 and 6 appeared incorrectly. The correct figures and their legend appear below. These errors don’t affect the conclusions of the article. Figure 5 (a) Typical SEM image (scale bar: 1 μm), inset shows the close magnification of two overlapping branched NWs (NS-NWs), scale bar is 100 nm. (b) TEM observation of prepared samples (scale bar: 1 μm) and (c) a single NS-NW (scale bar: 100 nm), where the inset of panel (c) is the corresponding selected area electron diffraction (SAED) pattern. (d) EDS point scanning data from the three regions of the NS-NW. Scale bar: 100 nm. Al signals generated from the Al substrate. (e) Cu and (f) O elemental distribution across the axis of the heterostructures. Figure 6 Typical galvanostatic charge–discharge curves of (a) Cu/Cu2O/CuO NS-NW and (b) Cu/Cu2O/CuO NW cells at a current density of 100 mA·g−1 in the range 0.005–3 V vs. Li. (c) Cyclic voltammograms of the Cu/Cu2O/CuO NS-NW cell cycled between 0.02–3 V vs. Li at a scan rate of 2 mV·s−1. (d) Cycling performances of Cu/Cu2O/CuO NS-NW (black) and Cu/Cu2O/CuO NW cells (red). Inset: corresponding TEM images of triplex components NS-NW (black framed) and NW (red framed). (e) Representative charge and discharge voltage profiles of Cu/Cu2O/CuO NS-NW cell at various current densities. (f) Capacity retention of Cu/Cu2O/CuO NS-NW (black) and Cu/Cu2O/CuO NW (red) cells at different current rates.

    更新日期:2018-01-12
  • Erratum to: Mitochondria-targeting self-assembled nanoparticles derived from triphenylphosphonium-conjugated cyanostilbene enable site-specific imaging and anticancer drug delivery
    Nano Res. (IF 7.354) Pub Date : 2017-09-12
    Ka Young Kim, Hanyong Jin, Jaehyeon Park, Sung Ho Jung, Ji Ha Lee, Hyesong Park, Sung Kuk Kim, Jeehyeon Bae, Jong Hwa Jung

    One of the correspondence authors, Jeehyeon Bae, in the original version of this article was unfortunately not marked on page 1082 and the first page of the ESM. Instead of Ka Young Kim1,§, Hanyong Jin2,§, Jaehyeon Park1, Sung Ho Jung1, Ji Ha Lee1, Hyesong Park1, Sung Kuk Kim1, Jeehyeon Bae2, and Jong Hwa Jung1 (✉) It should be Ka Young Kim1,§, Hanyong Jin2,§, Jaehyeon Park1, Sung Ho Jung1, Ji Ha Lee1, Hyesong Park1, Sung Kuk Kim1, Jeehyeon Bae2 (✉), and Jong Hwa Jung1 (✉) One of the correspondence authors, Jeehyeon Bae, and his email address in the original version of this article were unfortunately not written on page 1082 and the first page of the ESM. Instead of Address correspondence to jonghwa@gnu.ac.kr It should be Address correspondence to Jong Hwa Jung, jonghwa@gnu.ac.kr; Jeehyeon Bae, jeehyeon@cau.ac.kr

    更新日期:2018-01-12
  • Construction of Pd-M (M = Ni, Ag, Cu) alloy surfaces for catalytic applications
    Nano Res. (IF 7.354) Pub Date : 2017-08-19
    Xiang Li, Xixi Wang, Maochang Liu, Hongyang Liu, Qiang Chen, Yadong Yin, Mingshang Jin

    The fabrication of ultrathin alloy shells as heterogeneous catalysts to increase the utilization efficiency and enhance the catalytic activity of metal atoms has been recognized as an effective method for the construction of efficient metal nanocatalysts, particularly noble-metal nanocatalysts. In this study, we demonstrate the successful formation of Pd-M (M = Ni, Ag, Cu) alloy shells with a tunable thickness on preformed nanoscale Pd seeds. The success of this synthesis mainly relies on the combination of the slow reduction of “M” ions and the subsequent diffusion of M ad-atoms into the surface lattice of Pd seeds. The composition of the Pd-M alloy shell is easily tuned by changing the type and amount of the added precursor, and the shell thickness is manipulated according to the reaction time. More significantly, the surface structure of these alloy shells is maintained after the reaction, implying that any desired surface structure of Pd-M alloy shells can be prepared by using the appropriate starting materials. Further catalytic evaluation of the hydrogenation of chloronitrobenzenes shows that these alloy surfaces exhibit significantly improved selectivity compared to the Pd seeds. The Pd-Ni alloy surfaces exhibit much better catalytic selectivity (as high as > 99%) than Pd catalysts.

    更新日期:2018-01-12
  • Enhanced stabilization of inorganic cesium lead triiodide (CsPbI 3 ) perovskite quantum dots with tri-octylphosphine
    Nano Res. (IF 7.354) Pub Date : 2017-07-12
    Chang Lu, Hui Li, Kathy Kolodziejski, Chaochao Dun, Wenxiao Huang, David Carroll, Scott M. Geyer

    In recent years, significant attention has been paid to perovskite materials. In particular, lead triiodide-based perovskites have exhibited superb optoelectronic properties. Enhancing the stability of these materials is an essential step towards large-scale applications. In this study, by simply adding trioctylphosphine (TOP) as part of the post-synthesis treatment, we significantly enhance the stability of CsPbI3 quantum dots (QDs) in the solution phase, which otherwise decay rapidly in hours. For CsPbI3 QDs treated with TOP, the absorption and photoluminescence emission properties are unchanged over the course of weeks, and the quantum yield remains almost constant at 30% even after 1 month. The morphologies of both treated and untreated QDs are initially cubic; however, the treated QDs largely maintain their initial size and shape, while the untreated ones lose size uniformity, which is a sign of degradation. Infrared spectroscopy and X-ray photoelectron spectroscopy confirm the presence of P in the TOP-treated QDs. We insights that help to resolve the intrinsic instability issue of triiodide perovskite materials and devices.

    更新日期:2018-01-12
  • Mesoporous H-ZSM-5 nanocrystals with programmable number of acid sites as “solid ligands” to activate Pd nanoparticles for C–C coupling reactions
    Nano Res. (IF 7.354) Pub Date : 2017-07-12
    Wenyu Ke, Tianlu Cui, Qiuying Yu, Mengying Wang, Libing Lv, Honghui Wang, Zhidong Jiang, XinhHao Li, Jiesheng Chen

    In this work, we described a proof-of-concept method to promote the activity and selectivity of Pd nanoparticles for heterogeneous catalysis (exemplified by C–C coupling reactions) by using acid sites within a zeolite framework. The Pd nanoparticles were encapsulated inside the crystalline walls of mesoporous H-ZSM-5 leading to hybrid samples (denoted as Pd@mZ-x-H) with controlled number of acid sites. A linear relationship between the number of acid sites of the zeolite nanocrystals and the catalytic activities of the Pd nanoparticles in organic reactions was established. Moreover, the shape-dependent selectivity of Pd@mZ-x-H was not sacrificed when the final activity was enhanced.

    更新日期:2018-01-12
  • Chemically doped macroscopic graphene fibers with significantly enhanced thermoelectric properties
    Nano Res. (IF 7.354) Pub Date : 2017-08-19
    Weigang Ma, Yingjun Liu, Shen Yan, Tingting Miao, Shaoyi Shi, Zhen Xu, Xing Zhang, Chao Gao

    Flexible wearable electronics, when combined with outstanding thermoelectric properties, are promising candidates for future energy harvesting systems. Graphene and its macroscopic assemblies (e.g., graphene-based fibers and films) have thus been the subject of numerous studies because of their extraordinary electrical and mechanical properties. However, these assemblies have not been considered suitable for thermoelectric applications owing to their high intrinsic thermal conductivity. In this study, bromine doping is demonstrated to be an effective method for significantly enhancing the thermoelectric properties of graphene fibers. Doping enhances phonon scattering due to the increased defects and thus decreases the thermal conductivity, while the electrical conductivity and Seebeck coefficient are increased by the Fermi level downshift. As a result, the maximum figure of merit is 2.76 × 10–3, which is approximately four orders of magnitude larger than that of the undoped fibers throughout the temperature range. Moreover, the room temperature power factor is shown to increase up to 624 μW·m–1·K–2, which is higher than that of any other material solely composed of carbon nanotubes and graphene. The enhanced thermoelectric properties indicate the promising potential for graphene fibers in wearable energy harvesting systems.

    更新日期:2018-01-12
  • Mitochondria-targeting self-assembled nanoparticles derived from triphenylphosphonium-conjugated cyanostilbene enable site-specific imaging and anticancer drug delivery
    Nano Res. (IF 7.354) Pub Date : 2017-08-29
    Ka Young Kim, Hanyong Jin, Jaehyeon Park, Sung Ho Jung, Ji Ha Lee, Hyesong Park, Sung Kuk Kim, Jeehyeon Bae, Jong Hwa Jung

    Subcellular organelle-specific nanoparticles for simultaneous tumor targeting, imaging, and drug delivery are of enormous interest in cancer therapy. Herein, we report a selective mitochondria-targeting probe 1, which was synthesized by incorporating a triphenyl phosphine with a cyanostilbene and a long alkyl chain moiety. Probe 1 was found to display fluorescence via aggregation-induced emission (AIE). The low molecular-weight cyanostilbene-based probe 1, with and without an anticancer drug, formed a narrow homogeneous nanorod with ca. 110 nm of length or nanoparticles with ca. 20 nm diameter in aqueous media. The self-assembled cyanostilbene nanoparticles (N1) selectively accumulated in the mitochondria of cancer cells and emitted fluorescence. N1 was also able to deliver an anticancer drug, doxorubicin (DOX), to the mitochondria with high efficiency. More importantly, N1 exhibited highly selective cytotoxicity for cancer cells over normal cells. The great potential applications of this self-assembled nanoparticle to biological systems result from its ability to aggregate in the mitochondria. This aggregation led to a significant increase in the generation of intracellular reactive oxygen species and to a decrease in the mitochondrial membrane potential in cancer cells. Furthermore, tumor tissue uptake experiments in mice proposed that the self-assembled N1 had the ability to internalize and deliver the anticancer drug into tumor tissues effectively. Moreover, both N1 and N1-encapsulated doxorubicin (N1-DOX) effectively suppressed tumor growth in a xenograft model in vivo. Taken together, our findings indicate that applications of N1 as a mitochondrial targeting probe, drug delivery platform, and chemotherapeutic agent provide a unique strategy for potential image-guided therapy as well as a site-specific delivery system to cancer cells.

    更新日期:2018-01-12
  • Photocatalytic H 2 evolution improvement for H free-radical stabilization by electrostatic interaction of a Cu-BTC MOF with ZnO/GO
    Nano Res. (IF 7.354) Pub Date : 2017-07-29
    Xifeng Shi, Jiahui Zhang, Guanwei Cui, Ning Deng, Wen Wang, Qian Wang, Bo Tang

    Metal-organic frameworks (MOFs) are self-assembled molecular containers that can encapsulate and stabilize short-lived reaction intermediates. In this study, the Cu-benzene-1,3,5-tricarboxylate (BTC) MOF was incorporated in a ZnO/graphene oxide (GO) photocatalytic system by electrostatic interaction, and the obtained assembly showed improved hydrogen evolution activity. Electron spin resonance analysis was used to detect and monitor free radicals in the photocatalytic system, and demonstrated that Cu-BTC MOF could stabilize and extend the lifetime of free radicals, increasing the chance of H· radical recombination to form H2. This work provides a new strategy for designing highly efficient photocatalysts.

    更新日期:2018-01-12
  • Copper nanowire/multi-walled carbon nanotube composites as all-nanowire flexible electrode for fast-charging/discharging lithium-ion battery
    Nano Res. (IF 7.354) Pub Date : 2017-08-22
    Zhenxing Yin, Sanghun Cho, Duck-Jae You, Yong-keon Ahn, Jeeyoung Yoo, Youn Sang Kim

    A novel lightweight three-dimensional (3D) composite anode for a fast-charging/discharging Li-ion battery (LIB) was fabricated entirely using one-dimensional (1D) nanomaterials, i.e., Cu nanowires (CuNWs) and multi-walled C nanotubes (MWCNTs). Because of the excellent electrical conductivity, high-aspect ratio structures, and large surface areas of these nanomaterials, the CuNW-MWCNT composite (CNMC) with 3D structure provides significant advantages regarding the transport pathways for both electrons and ions. As an advanced binder-free anode, a CuNW-MWCNT composite film with a controllable thickness (∼600 μm) exhibited a considerably low sheet resistance, and internal cell resistance. Furthermore, the random CuNW network with 3D structure acting as a rigid framework not only prevented MWCNT shrinkage and expansion due to aggregation and swelling but also minimized the effect of the volume change during the charge/discharge process. Both a half cell and a full cell of LIBs with the CNMC anode exhibited high specific capacities and Coulombic efficiencies, even at a high current. More importantly, we for the first time overcame the limitation of MWCNTs as anode materials for fast-charging/discharging LIBs (both half cells and full cells) by employing CuNWs, and the resulting anode can be applied to flexible LIBs. This innovative anode structure can lead to the development of ultrafast chargeable LIBs for electric vehicles.

    更新日期:2018-01-12
  • Oxidation layering mechanism of graphene-like MoS 2 prepared by the intercalation-detonation method
    Nano Res. (IF 7.354) Pub Date : 2017-07-29
    Fan Yang, Kuaishe Wang, Ping Hu, Zhenyu Chen, Jie Deng, Boliang Hu, Weicheng Cao, Dongxin Liu, Geng An, Alex A. Volinsky

    Graphene-like MoS2 has attracted significant interest because of its unique electronic, optical, and catalytic properties with two-dimensional lamellar structure. Three kinds of intercalated MoS2 samples were prepared using different oxidation layering methods, which are the first steps of intercalation-detonation. The oxidation layering mechanism of graphene-like MoS2 was systematically characterized using Fourier transform infrared, X-ray photoelectron, and Raman spectroscopy techniques. The bulk MoS2 sample was gradually oxidized from the edge to the interlayer in the presence of concentrated H2SO4 and KMnO4. A large number of hydroxyl groups were bonded to the sulfur atom layer, forming S–OH bonds in the basal planes of the MoS2 structure. The addition of deionized water to concentrated H2SO4 generated a large amount of heat, promoting the generation of more S–OH bonds, destroying residual Van der Waals forces between the layers, and finally stripping off parts of the flakes. The continuous addition of deionized water in the high temperature stage resulted in the largest oxidative intercalation effect. Additionally, the η factor was determined to compare the intensities of B1u and A1g peaks in the Raman spectra and quantify the effect of oxidative intercalation. The highest value of η was obtained when deionized water was added continuously during the preparation of intercalated MoS2.

    更新日期:2018-01-12
  • Inhibition of osteosarcoma growth and metastasis using a polysaccharide derivative of Amy-g-PLLD for the delivery of AEG-1 siRNA
    Nano Res. (IF 7.354) Pub Date : 2018-01-05
    Fen Wang, Jiadong Pang, Leilei Huang, Ran Wang, Qing Jiang, Liming Zhang, Kang Sun

    None

    更新日期:2018-01-06
  • MoS 2 embedded in 3D interconnected carbon nanofiber film as a free-standing anode for sodium-ion batteries
    Nano Res. (IF 7.354) Pub Date : 2018-01-05
    Hai Yang, Min Wang, Xiaowu Liu, Yu Jiang, Yan Yu

    None

    更新日期:2018-01-05
  • Metallized siligraphene nanosheets (SiC 7 ) as high capacity hydrogen storage materials
    Nano Res. (IF 7.354) Pub Date : 2018-01-04
    Syeda R. Naqvi, Tanveer Hussain, Wei Luo, Rajeev Ahuja

    A planar honeycomb monolayer of siligraphene (SiC7) could be a prospective medium for clean energy storage due to its light weight, and its remarkable mechanical and unique electronic properties. By employing van der Waals-induced first principles calculations based on density functional theory (DFT), wehave explored the structural, electronic, and hydrogen (H2) storage characteristicsof SiC7 sheets decorated with various light metals. The binding energies oflithium (Li), sodium (Na), potassium (K), magnesium (Mg), calcium (Ca),scandium (Sc), and titanium (Ti) dopants on a SiC7monolayer were studied at various doping concentrations, and found to be strong enough to counteract the metal clustering effect. We further verified the stabilities of the metallized SiC7sheets at room temperature using ab initio molecular dynamics (MD) simulations.Bader charge analysis revealed that upon adsorption, due to the difference in electronegativity, all the metal adatoms donated a fraction of their electroniccharges to the SiC7 sheet. Each partially charged metal center on the SiC7sheets could bind a maximum of 4 to 5 H2 molecules. A high H2 gravimetric density was achieved for several dopants at a doping concentration of 12.50%. The H2binding energies were found to fall within the ideal range of 0.2–0.6 eV. Based on these findings, we propose that metal-doped SiC7 sheets can operate as efficient H2 storage media under ambient conditions.

    更新日期:2018-01-05
  • Synthesis of ultrathin semicircle-shaped copper nanowires in ethanol solution for low haze flexible transparent conductors
    Nano Res. (IF 7.354) Pub Date : 2018-01-04
    Ye Zhang, Jiangna Guo, Dan Xu, Yi Sun, Feng Yan

    Copper nanowires (CuNWs) are becoming an indispensable item for next-generation transparent optical devices due to their excellent conductivity and transparency. In this work, ultrathin semicircle-shaped copper nanowires(SCuNWs) with a diameter of ∼ 15 nm and a length of ∼ 30 μm (aspect ratio of ∼2,000) were synthesized in ethanol solution. The mechanism and factors that affect the morphology and dispersity of the SCuNWs were investigated. The prepared SCuNWs were coated on polyethylene terephthalate (PET) or polydimethylsiloxane (PDMS) substrate to fabricate flexible transparent conductors (FTCs). The fabricated FTCs exhibited excellent optoelectrical performance and low haze. In addition, the fabricated FTCs showed high mechanical stability during stretching and bending, indicating their great potential in flexible optical devices.

    更新日期:2018-01-05
  • Piezo-phototronic and pyro-phototronic effects to enhance Cu(In, Ga)Se 2 thin film solar cells
    Nano Res. (IF 7.354) Pub Date : 2018-01-04
    Laipan Zhu, Pei Lin, Baodong Chen, Longfei Wang, Libo Chen, Ding Li, Zhong Lin Wang

    Cu(In, Ga)Se2 (CIGS)-based materials have gained remarkable attention for thin-film photovoltaic applications due to their high absorption coefficient, tunable bandgap, compositional tolerance, outstanding stabilities, and high efficiency. A small increase in the efficiency of CIGS solar cells has huge economic impact and practical importance. As such, we fabricated a flexible CIGS solar cell on amica substrate and demonstrated the enhanced device performance through the piezo- and pyro-phototronic effects based on a ZnO thin film. The device showed enhanced energy conversion efficiency from 13.48% to 14.23% by decreasing the temperature from 31 to 2 °C at a rate of ∼ 0.6 °C·s−1 via the pyro-phototronic effect, and further enhanced from 14.23% to 14.37% via the piezo-phototronic effect by further applying a static compressive strain. A pyro-electric nanogenerator effect was also found to promote the performance of the CIGS solar cell at the beginning of the cooling process. The manipulated energy band of the CIGS/CdS/ZnO heterojunction under the influence of the inner pyroelectric and piezoelectric potentials is believed to contribute to the sephenomena. Applying the piezo- and pyro-phototronic effects simultaneously offers a new opportunity for enhancing the output performance of commercialthin film solar cells.

    更新日期:2018-01-05
  • Osiers-sprout-like heteroatom-doped carbon nanofibers as ultrastable anodes for lithium/sodium ion storage
    Nano Res. (IF 7.354) Pub Date : 2018-01-04
    Hang Zhang, Guanhua Zhang, Zhiqin Li, Ke Qu, Huimin Shi, Qingfeng Zhang, Huigao Duan, Jianhui Jiang

    None

    更新日期:2018-01-05
  • Cross-linked self-assembling peptide scaffolds
    Nano Res. (IF 7.354) Pub Date : 2017-10-18
    Raffaele Pugliese, Amanda Marchini, Gloria Anna Ada Saracino, Ronald N. Zuckermann, Fabrizio Gelain

    Self-assembling peptides (SAPs) are synthetic bioinspired biomaterials that can be feasibly multi-functionalized for cell transplantation and/or drug delivery therapies. Despite their superior biocompatibility and ease of scaling-up for production, they are unfortunately hampered by weak mechanical properties due to transient non-covalent interactions among and within the self-assembled peptide chains, thus limiting their potential applications as fillers, hemostat solutions, and fragile scaffolds for soft tissues. Here, we have developed and characterized a cross-linking strategy that increases both the stiffness and the tailorability of SAP hydrogels, enabling the preparation of transparent flexible threads, discs, channels, and hemispherical constructs. Empirical and computational results, in close agreement with each other, confirmed that the cross-linking reaction does not affect the previously self-assembled secondary structures. In vitro tests also provided a first hint of satisfactory biocompatibility by favoring viability and differentiation of human neural stem cells. This work could bring self-assembling peptide technology to many applications that have been precluded so far, especially in regenerative medicine.

    更新日期:2017-12-31
  • Facile growth of homogeneous Ni(OH) 2 coating on carbon nanosheets for high-performance asymmetric supercapacitor applications
    Nano Res. (IF 7.354) Pub Date : 2017-07-25
    Mingjiang Xie, Zhicheng Xu, Shuyi Duan, Zhengfang Tian, Yu Zhang, Kun Xiang, Ming Lin, Xuefeng Guo, Weiping Ding

    The growth of a Ni(OH)2 coating on conductive carbon substrates is an efficient way to address issues related to their poor conductivity in electrochemical capacitor applications. However, the direct growth of nickel hydroxide coatings on a carbon substrate is challenging, because the surfaces of these systems are not compatible and a preoxidation treatment of the conductive carbon substrate is usually required. Herein, we present a facile preoxidation-free approach to fabricate a uniform Ni(OH)2 coating on carbon nanosheets (CNs) by an ion-exchange reaction to achieve the in situ transformation of a MgO/C composite to a Ni(OH)2/C one. The obtained Ni(OH)2/CNs hybrids possess nanosheet morphology, a large surface area (278 m2/g), and homogeneous elemental distributions. When employed as supercapacitors in a three-electrode configuration, the Ni(OH)2/CNs hybrid achieves a large capacitance of 2,218 F/g at a current density of 1.0 A/g. Moreover, asymmetric supercapacitors fabricated with the Ni(OH)2/CNs hybrid exhibit superior supercapacitive performances, with a large capacity of 198 F/g, and high energy density of 56.7 Wh/kg at a power density of 4.0 kW/kg. They show excellent cycling stability with 93% capacity retention after 10,000 cycles, making the Ni(OH)2/CNs hybrid a promising candidate for practical applications in supercapacitor devices.

    更新日期:2017-12-31
  • Site-specific determination of TTR-related functional peptides by using scanning tunneling microscopy
    Nano Res. (IF 7.354) Pub Date : 2017-09-21
    Lanlan Yu, Yongfang Zheng, Jing Xu, Fuyang Qu, Yuchen Lin, Yimin Zou, Yanlian Yang, Sally L. Gras, Chen Wang

    For the design and optimization of functional peptides, unravelling the structures of individual building blocks as well as the properties of the ensemble is paramount. TTR1, derived from human transthyretin, is a fibril-forming peptide implicated in diseases such as familial amyloid polyneuropathy and senile systemic amyloidosis. The functional peptide TTR1-RGD, based on a TTR1 scaffold, was designed to specifically interact with cells. Here, we used scanning tunneling microscopy (STM) to analyze the assembly structures of TTR1-related peptides with both the reverse sequence and the modified forward sequence. The sitespecific analyses show the following: i) The TTR1 peptide is involved in assembly, nearly covering the entire length within the ordered β-sheet structures. ii) For TTR1-RGD peptide assemblies, the TTR1 motif forms the ordered β-sheet while the RGDS motif adopts a flexible conformation allowing it to promote cell adhesion. The key site is clearly identified as the linker residue Gly13. iii) Close inspection of the forward and reverse peptide assemblies show that in spite of the difference in chemistry, they display similar assembling characteristics, illustrating the robust nature of these peptides. iv) Glycine linker residues are included in the β-strands, which strongly suggests that the sequence could be optimized by adding more linker residues. These garnered insights into the assembled structures of these peptides help unravel the mechanism driving peptide assemblies and instruct the rational design and optimization of sequenceprogrammed peptide architectures.

    更新日期:2017-12-31
  • Egg-like magnetically immobilized nanospheres: A long-lived catalyst model for the hydrogen transfer reaction in a continuous-flow reactor
    Nano Res. (IF 7.354) Pub Date : 2017-08-19
    Yongjian Ai, Zenan Hu, Zixing Shao, Li Qi, Lei Liu, Junjie Zhou, Hongbin Sun, Qionglin Liang

    A novel egg-like nanosphere was designed as a long-lived catalyst and is described as Fe3O4@nSiO2-NH2-Fe2O3•xBi2O3@mSiO2. The catalyst was prepared using a modified Stöber method with template-free surface-protected etching. The catalyst particle consists of a magnetic Fe3O4 core as the “yolk”, an inner silica shell bearing active Fe2O3•xBi2O3 species as the “egg white”, and outer mesoporous silica as the “egg shell”. It exhibits an excellent performance in the catalytic reduction of nitro aromatics to corresponding anilines in a fixed-bed continuous-flow reactor. The reaction could be performed at 80 °C and could reach complete conversion in less than 1 min with only a 7% excess of hydrazine hydrate. The catalyst bed could be easily shifted between different substrates without cross-contamination because of the uniformity of the catalyst particles. This catalyst exhibited very good stability in the continuous-flow protocol. In the long-term reduction of p-nitrophenol with 0.5 mmol·min−1 productivity, it worked for more than 1,500 cycles without any catalytic activity loss.

    更新日期:2017-12-31
  • Metal-organic framework-derived, Zn-doped porous carbon polyhedra with enhanced activity as bifunctional catalysts for rechargeable zinc-air batteries
    Nano Res. (IF 7.354) Pub Date : 2017-07-07
    Xuan Wu, Ge Meng, Wenxian Liu, Tian Li, Qiu Yang, Xiaoming Sun, Junfeng Liu

    Zinc-air batteries have recently attracted considerable interest owing to the larger storage capacity and lower cost compared to their lithium-ion counterparts. Electrode catalysts for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) play a critical role in the operation of rechargeable zinc-air batteries. Herein, we report a simple and scalable strategy to fabricate porous carbon polyhedra using Zn-doped Co-based zeolitic imidazolate frameworks (ZnCo-ZIFs) as precursors. Strikingly, Zn doping leads to smaller Co nanoparticles and higher nitrogen content, which in turn enhances the ORR and OER activities of the obtained porous carbon polyhedra. The synergistic effect of the N-doped carbon and cobalt nanoparticles in the composite, the improved conductivity resulting from the high graphitization of carbon, and the large surface area of the porous polyhedral structure resulted in porous carbon polyhedra with excellent ORR and OER electrocatalytic activity in alkaline media. More importantly, air cathodes based on the optimal porous carbon polyhedra further exhibited superior performance to Pt/C catalysts in primary and rechargeable zinc-air batteries.

    更新日期:2017-12-31
  • Electrosynthesis of Co 3 O 4 and Co(OH) 2 ultrathin nanosheet arrays for efficient electrocatalytic water splitting in alkaline and neutral media
    Nano Res. (IF 7.354) Pub Date : 2017-07-17
    Lin Zhang, Bingrui Liu, Ning Zhang, Mingming Ma

    The dimensional confinement endows ultrathin nanosheets with unique physical and chemical properties, which have been widely studied for the purpose of developing active electrocatalysts for water splitting. Ultrathin nanosheets are generally synthesized by chemical vapor deposition, exfoliation, or surfactant-assisted synthesis, which either require special equipment and reaction conditions, or is limited by the low yields and the difficulty in controlling the lateral size and structure of the nanosheets. In addition, achieving a high loading of ultrathin nanosheets on the electrodes without compromising their catalytic activity still remains a challenge. Herein, we report a simple electrodeposition method for preparing Co3O4 and Co(OH)2 ultrathin nanosheet arrays (UNA) without using templates or surfactants. The obtained arrays exhibit high activity for oxygen and hydrogen evolution reactions, in both alkaline and neutral media. The electrolyzer based on Co3O4 and Co(OH)2 UNA shows superior activity and stability than that based on IrO2 and Pt/C, which demonstrates the potential of the present electrodeposition method for developing active and stable electrocatalysts for water splitting.

    更新日期:2017-12-31
  • Intracellular in situ labeling of TiO 2 nanoparticles for fluorescence microscopy detection
    Nano Res. (IF 7.354) Pub Date : 2017-07-19
    Koshonna Brown, Ted Thurn, Lun Xin, William Liu, Remon Bazak, Si Chen, Barry Lai, Stefan Vogt, Chris Jacobsen, Tatjana Paunesku, Gayle E. Woloschak

    Titanium dioxide (TiO2) nanoparticles are produced for many different purposes, including development of therapeutic and diagnostic nanoparticles for cancer detection and treatment, drug delivery, induction of DNA double-strand breaks, and imaging of specific cells and subcellular structures. Currently, the use of optical microscopy, an imaging technique most accessible to biology and medical pathology, to detect TiO2 nanoparticles in cells and tissues ex vivo is limited with low detection limits, while more sensitive imaging methods (transmission electron microscopy, X-ray fluorescence microscopy, etc.) have low throughput and technical and operational complications. Herein, we describe two in situ posttreatment labeling approaches to stain TiO2 nanoparticles taken up by the cells. The first approach utilizes fluorescent biotin and fluorescent streptavidin to label the nanoparticles before and after cellular uptake; the second approach is based on the copper-catalyzed azide-alkyne cycloaddition, the so-called Click chemistry, for labeling and detection of azide-conjugated TiO2 nanoparticles with alkyneconjugated fluorescent dyes such as Alexa Fluor 488. To confirm that optical fluorescence signals of these nanoparticles match the distribution of the Ti element, we used synchrotron X-ray fluorescence microscopy (XFM) at the Advanced Photon Source at Argonne National Laboratory. Titanium-specific XFM showed excellent overlap with the location of optical fluorescence detected by confocal microscopy. Therefore, future experiments with TiO2 nanoparticles may safely rely on confocal microscopy after in situ nanoparticle labeling using approaches described here.

    更新日期:2017-12-31
  • Highly uniform ultrasound-sensitive nanospheres produced by a pH-induced micelle-to-vesicle transition for tumor-targeted drug delivery
    Nano Res. (IF 7.354) Pub Date : 2017-12-26
    Yiru Wang, Tinghui Yin, Zhenwei Su, Chen Qiu, Yong Wang, Rongqin Zheng, Meiwan Chen, Xintao Shuai

    None

    更新日期:2017-12-27
  • Large capacitance and fast polarization response of thin electrolyte dielectrics by spin coating for two-dimensional MoS 2 devices
    Nano Res. (IF 7.354) Pub Date : 2017-12-26
    Wu Zan, Qiaochu Zhang, Hu Xu, Fuyou Liao, Zhongxun Guo, Jianan Deng, Jing Wan, Hao Zhu, Lin Chen, Qingqing Sun, Shijin Ding, Peng Zhou, Wenzhong Bao, David Wei Zhang

    None

    更新日期:2017-12-27
  • Recovery of edge states of graphene nanoislands onan iridium substrate by silicon intercalation
    Nano Res. (IF 7.354) Pub Date : 2017-12-26
    Hui Chen, Yande Que, Lei Tao, Yu-Yang Zhang, Xiao Lin, Wende Xiao, Dongfei Wang, Shixuan Du, Sokrates T. Pantelides, Hong-Jun Gao

    None

    更新日期:2017-12-27
  • Stability and protection of nanowire devices in air
    Nano Res. (IF 7.354) Pub Date : 2017-12-23
    Zhen He, Muhammad Hassan, Huan-Xin Ju, Rui Wang, Jin-Long Wang, Jia-Fu Chen, Jun-Fa Zhu, Jian-Wei Liu, Shu-Hong Yu

    Nanowire devices have attracted considerable attention because of their unique structure and novel properties, and have opened up significant developmentopportunities. However, not many studies have focused on their stability anddurability under practical conditions, which limits the rapid development of real applications. Herein, we systematically investigate three different treatments,polymer coating, inert atmosphere protection, and thickness-induced self-protection, to protect the tellurium nanowire devices from oxidation whenexposed to open air. The degree of oxidation was monitored by examiningchanges in the valence states of tellurium elementand in the morphology of the nanowires. After the protective treatments, the tellurium nanowire devicesshowed improved stability and remained stable even after 800 days of storage. This work highlights the importance of investigating the stability of nanowiredevices, especially for their practical applications.

    更新日期:2017-12-23
  • Mesoporous Mn-Sn bimetallic oxide nanocubes as long cycle life anodes for Li-ion half/full cells and sulfur hosts for Li-S batteries
    Nano Res. (IF 7.354) Pub Date : 2017-12-23
    Yanyan He, Liqiang Xu, Chuanchuan Li, Xiaoxia Chen, Gang Xu, Xiaoyun Jiao

    Mesoporous Mn-Sn bimetallic oxide (BO) nanocubes with sizes of 15–30 nm show outstanding stable and reversible capacities in lithium ion batteries (LIBs), reaching 856.8 mAh·g–1 after 400 cycles at 500 mA·g–1 and 506 mAh·g–1 after 850 cycles at 1,000 mA·g–1. The preliminary investigation of the reaction mechanism, based on X-ray diffraction measurements, indicates the occurrence of both conversion and alloying–dealloying reactions in the Mn-Sn bimetallic oxide electrode. Moreover, Mn-Sn BO//LiCoO2 Li-ion full cells were successfully assembled for the first time, and found to deliver a relatively high energy density of 176.25 Wh·kg–1 at 16.35 W·kg–1 (based on the total weight of anode and cathode materials). The superior long-term stability of these materials might be attributed to their nanoscale size and unique mesoporous nanocubic structure, which provide short Li+ diffusion pathways and a high contact area between electrolyte and active material. In addition, the Mn-Sn BOs could be used as advanced sulfur hosts for lithium-sulfur batteries, owing to their adequate mesoporous structure and relatively strong chemisorption of lithium polysulfide. The present results thus highlight the promising potential of mesoporous Mn-Sn bimetallic oxides for application in Li-ion and Li-S batteries.

    更新日期:2017-12-23
  • Development of fluorinated polyplex nanoemulsions for improved small interfering RNA delivery and cancer therapy
    Nano Res. (IF 7.354) Pub Date : 2017-12-22
    Gang Chen, Kaikai Wang, Pengkai Wu, Yixin Wang, Zhanwei Zhou, Lifang Yin, Minjie Sun, David Oupický

    None

    更新日期:2017-12-22
  • Self-powered nanofiber-based screen-print triboelectric sensors for respiratory monitoring
    Nano Res. (IF 7.354) Pub Date : 2017-12-20
    Ran Cao, Jiaona Wang, Shuyu Zhao, Wei Yang, Zuqing Yuan, Yingying Yin, Xinyu Du, Nian-Wu Li, Xiuling Zhang, Xiuyan Li, Zhong Lin Wang, Congju Li

    Scientific and commercial advances have set high requirements for wearable electronics. However, the power supply, breathability, and mass production of wearable electronics still have many challenges that need to be overcome. In this study, a self-powered nanofiber-based triboelectric sensor (SNTS) was fabricatedby batch-scale fabrication technologies using electrospinning and screen-printing for health monitoring via respiratory monitoring. Typically, an arch structural SNTS is assembled by a nanofiber membrane and a Ag nanoparticle electrode. The pile of nanofibers and the conductive network of Ag nanoparticles ensure agas channel across the whole device. The gas permeability of the SNTS was as high as 6.16 mm/s, which has overwhelming advantages when compared with commonly used wearable devices composed of air-tight cast films. Due to the softness of the nanofiber membrane, the SNTS showed excellent electronic output performance irrespective of whether it was bent, twisted, or folded. The superior properties, such as breathability, skin-friendliness, self-power, and batch fabrication of SNTS offer huge potential for their application in healthcare monitoring and multifunctional intelligent systems.

    更新日期:2017-12-20
  • Phytochemical-encapsulated nanoplatform for “on-demand” synergistic treatment of multidrug-resistant bacteria
    Nano Res. (IF 7.354) Pub Date : 2017-12-20
    Panpan Sun, Yan Zhang, Xiang Ran, Chaoying Liu, Zhenzhen Wang, Jinsong Ren, Xiaogang Qu

    None

    更新日期:2017-12-20
  • An additive dripping technique using diphenyl ether fortuning perovskite crystallization for high-efficiency solar cells
    Nano Res. (IF 7.354) Pub Date : 2017-12-20
    Di Huang, Tenghooi Goh, Yifan Zheng, Zilun Qin, Jiao Zhao, Suling Zhao, Zheng Xu, André D. Taylor

    Controlling the morphology of the MAPbI3−xClx active layer has remained a challenge towards advancing perovskite solar cells (PvSCs). Here, we demonstrate that a low temperature additive dripping (AD) treatment step, using diphenyl ether (DPE), can significantly improve the power conversion efficiency (PCE), compared to the control device using chlorobenzene (CB), by 15% up to 16.64%, with a high current density (JSC) of 22.67 mA/cm2. We chose DPE for its small and appropriate dipole moment to adjust the solubility of the MAPbI3−xClx precursor during the formation of the intermediate phase and the MAPbI3−xClx phase. The low DPE vapor pressure provides a longer processing window for the removal of residual dimethylformamide (DMF), during the annealing process, for improved perovskite formation. Imaging and X-ray analysis both reveal that the MAPbI3−xClx film exhibits enlarged grains with increased crystallinity. Together, these improvements result in reduced carrier recombination and hole trap-state density in the MAPbI3−xClx film, while minimizing the hysteresis problem typical of PvSCs. These results show thatthe AD approach is a promising technique for improving PvSCs.

    更新日期:2017-12-20
  • Wafer-scale synthesis of monolayer WS 2 for high-performance flexible photodetectors by enhanced chemical vapor deposition
    Nano Res. (IF 7.354) Pub Date : 2017-12-16
    Changyong Lan, Ziyao Zhou, Zhifei Zhou, Chun Li, Lei Shu, Lifan Shen, Dapan Li, Ruoting Dong, SenPo Yip, Johnny C. Ho

    None

    更新日期:2017-12-18
  • Synthesis, mechanical investigation, and application of nitrogen and phosphorus co-doped carbon dots with a high photoluminescent quantum yield
    Nano Res. (IF 7.354) Pub Date : 2017-12-16
    Quan Xu, Bofan Li, Yingchun Ye, Wei Cai, Weijun Li, Chuanyao Yang, Yusheng Chen, Meng Xu, Neng Li, Xusheng Zheng, Jason Street, Yan Luo, Lulu Cai

    None

    更新日期:2017-12-18
  • Photocatalytic hydrogenation of nitroarenes using Cu 1.94 S-Zn 0.23 Cd 0.77 S heteronanorods
    Nano Res. (IF 7.354) Pub Date : 2017-12-16
    Zhanjun Yu, Zheng Chen, Yueguang Chen, Qing Peng, Rui Lin, Yu Wang, Rongan Shen, Xing Cao, Zhongbin Zhuang, Yadong Li

    None

    更新日期:2017-12-18
  • Facile synthesis of porous germanium-iron bimetal oxide nanowires as anode materials for lithium-ion batteries
    Nano Res. (IF 7.354) Pub Date : 2017-12-16
    Xiongwu Zhong, Huijuan Huan, Xiaowu Liu, Yan Yu

    None

    更新日期:2017-12-18
  • Erratum to: Generation of graphene-based aerogel microspheres for broadband and tunable high-performance microwave absorption by electrospinning-freeze drying process
    Nano Res. (IF 7.354) Pub Date : 2017-12-16
    Fanbin Meng, Huagao Wang, Wei Wei, Zijian Chen, Tian Li, Chunyuan Li, Yu Xuan, Zuowan Zhou

    The name of the third author in the original version of this article was unfortunately wrongly written on the first pages of the main text and the ESM. Instead of Wei It should read Wei Wei

    更新日期:2017-12-16
  • Erratum to: High-purity helical carbon nanotubes by trace-waterassisted chemical vapor deposition: Large-scale synthesis and growth mechanism
    Nano Res. (IF 7.354) Pub Date : 2017-12-16
    Fanbin Meng, Ying Wang, Qiang Wang, Xiaoling Xu, Man Jiang, Xuesong zhou, Ping He, Zuowan Zhou

    The first author, Fanbin Meng, and the second author, Ying Wang, contributed equally to this work was unfortunately forgotten to write on the first pages of the main text and the ESM of the original version of this article. Instead of Fanbin Meng1, Ying Wang1, Qiang Wang1, Xiaoling Xu1, Man Jiang1, Xuesong zhou2, Ping He2, and Zuowan Zhou1 (✉) 1 Key Laboratory of Advanced Technologies of Materials (Ministry of Education), School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China 2 Zhonghao Heiyuan Research Institute of Chemical Industry, Zigong 643201, China It should read Fanbin Meng1,§, Ying Wang1,§, Qiang Wang1, Xiaoling Xu1, Man Jiang1, Xuesong zhou2, Ping He2, and Zuowan Zhou1 (✉) 1 Key Laboratory of Advanced Technologies of Materials (Ministry of Education), School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China 2 Zhonghao Heiyuan Research Institute of Chemical Industry, Zigong 643201, China § Fanbin Meng and Ying Wang contributed equally to this work.

    更新日期:2017-12-16
  • Functional interlayer of PVDF-HFP and carbon nanofiberfor long-life lithium-sulfur batteries
    Nano Res. (IF 7.354) Pub Date : 2017-12-16
    Anyi Zhang, Xin Fang, Chenfei Shen, Yihang Liu, In Gi Seo, Yuqiang Ma, Liang Chen, Patrick Cottingham, Chongwu Zhou

    None

    更新日期:2017-12-16
  • Ultra-small Cu nanoparticles embedded in N-doped carbon arrays for electrocatalytic CO 2 reduction reaction in dimethylformamide
    Nano Res. (IF 7.354) Pub Date : 2017-12-16
    Xiaolong Zhang, Ying Zhang, Fengwang Li, Christopher D. Easton, Alan M. Bond, Jie Zhang

    None

    更新日期:2017-12-16
  • Ni-doped ZnCo 2 O 4 atomic layers to boost the selectivity in solar-driven reduction of CO 2
    Nano Res. (IF 7.354) Pub Date : 2017-12-16
    Katong Liu, Xiaodong Li, Liang Liang, Ju Wu, Xingchen Jiao, Jiaqi Xu, Yongfu Sun, Yi Xie

    None

    更新日期:2017-12-16
  • A sustainable aqueous Zn-I 2 battery
    Nano Res. (IF 7.354) Pub Date : 2017-12-15
    Chong Bai, Fengshi Cai, Lingchang Wang, Shengqi Guo, Xizheng Liu, Zhihao Yuan

    Rechargeable metal-iodine batteries are an emerging attractive electrochemical energy storage technology that combines metallic anodes with halogen cathodes. Such batteries using aqueous electrolytes represent a viable solution for the safety and cost issues associated with organic electrolytes. A hybrid-electrolyte battery architecture has been adopted in a lithium-iodine battery using a solid ceramic membrane that protects the metallic anode from contacting the aqueous electrolyte. Here we demonstrate an eco-friendly, low-cost zinc-iodine battery with an aqueous electrolyte, wherein active I2 is confined in a nanoporous carbon cloth substrate. The electrochemical reaction is confined in the nanopores as a single conversion reaction, thus avoiding the production of I3− intermediates. The cathode architecture fully utilizes the active I2, showing a capacity of 255 mAh·g−1 and low capacity cycling fading. The battery provides an energy density of ∼ 151 Wh·kg−1 and exhibits an ultrastable cycle life of more than 1,500 cycles.

    更新日期:2017-12-15
  • Highly efficient catalytic scavenging of oxygen freeradicals with graphene-encapsulated metal nanoshields
    Nano Res. (IF 7.354) Pub Date : 2017-12-12
    Junying Wang, Xiaoju Cui, Haobo Li, Jianping Xiao, Jiang Yang, Xiaoyu Mu, Haixia Liu, Yuan-Ming Sun, Xuhui Xue, Changlong Liu, Xiao-Dong Zhang, Dehui Deng, Xinhe Bao

    None

    更新日期:2017-12-15
  • Diphosphine-induced chiral propeller arrangement of gold nanoclusters for singlet oxygen photogeneration
    Nano Res. (IF 7.354) Pub Date : 2017-12-13
    Jiangwei Zhang, Yang Zhou, Kai Zheng, Hadi Abroshan, Douglas R. Kauffman, Junliang Sun, Gao Li

    In this study, 1,2-bis(diphenylphosphino)ethane (dppe) ligands are used to synthesize gold nanoclusters with an icosahedral Au13 core. The nanoclusters are characterized and formulated as [Au13(dppe)5Cl2]Cl3 using synchrotron radiation X-ray diffraction, UV/Vis absorption spectroscopy, electrospray ionization mass spectrometry, and density functional theory (DFT) calculations. The bidentate feature of dppe ligands and the positions of coordinating surface gold atoms induce a helical arrangement that forms a propeller-like structure, which reduces the symmetry of the gold nanocluster to C1. Therefore, dppe ligands perform as a directing agent to create chiral an ansa metallamacrocycle [Au13(dppe)5Cl2]3+ nanocluster, as confirmed by simulated electronic circular dichroism spectrum. The highest occupied molecular orbital (HOMO)–lowest unoccupied molecular orbital (LUMO) gap of the [Au13(dppe)5Cl2]3+ cluster is determined as approx. 1.9 eV, and further confirmed by ultraviolet photoemission spectroscopy analysis and DFT simulation. Furthermore, the photoactivity of [Au13(dppe)5Cl2]3+ is investigated, with the nanocluster shown to possess near-infrared photoluminescence properties, which can be employed for 1O2 photogeneration. The quantum yield of 1O2 photogeneration using the [Au13(dppe)5Cl2]3+ nanocluster is up to 0.71, which is considerably higher than those of anthracene (an organic dye), and Au25 and Au38 nanoclusters.

    更新日期:2017-12-13
  • Promoting osteogenic differentiation in pre-osteoblasts and reducing tibial fracture healing time using functional nanofibers
    Nano Res. (IF 7.354) Pub Date : 2017-12-13
    Gu Cheng, Jiajia Chen, Qun Wang, Xuewen Yang, Yuet Cheng, Zhi Li, Hu Tu, Hongbing Deng, Zubing Li

    Various composite materials are now used as artificial tissue substitutes, and are defining new frontiers in tissue engineering. In the present study, composite membranes based on silk fibroin (SF) were fabricated to form a synthetic periosteum. The fabricated membranes were physicochemically characterized by their morphology, porosity, biocompatibility, biodegradability, chemical structure, and mechanical properties. Following the addition of polycaprolactone (PCL) to the silk fibers, there was a 3–5-fold increase in the elongation at break compared with the pure silk membranes, and surface wettability was retained. The degradation time of the SF within the membranes was also prolonged by adding PCL. Compared with pure PCL membranes or plastic culture plates, the SF-based membranes significantly enhanced the cellular viability and osteogenic differentiation capability of MC3T3-E1 cells. Higher expression levels of osteogenic differentiation markers (runt-related transcription factor 2 (RUNX2), alkaline phosphatase (ALP), and osteopontin (OP)) further supported the use of the SF component in bone-related applications. A non-rigid internal fixation (non-RIF) fracture model that healed via endochondral bone formation was created, and fracture callus samples were collected to perform micro-computed tomography, histology, and immunohistochemistry analyses at 8 weeks after surgery. A smaller bone volume accompanied by a mineralized bony callus was observed in SF/PCL membrane-treated rats. Immunohistochemistry also indicated that the SF/PCL membrane-treated rats exhibited increased osteocalcin expression but reduced collagen type X expression. These findings could lead to an alternative strategy for treating comminuted fractures with enhanced intramembranous ossification and reduced endochondral ossification.

    更新日期:2017-12-13
  • Porous hollow palladium nanoplatform for imaging-guided trimodal chemo-, photothermal-, and radiotherapy
    Nano Res. (IF 7.354) Pub Date : 2017-12-12
    Menglin Song, Nian Liu, Le He, Gang Liu, Daishun Ling, Xinhui Su, Xiaolian Sun

    None

    更新日期:2017-12-13
  • Efficiency against multidrug resistance by co-delivery of doxorubicin and curcumin with a legumain-sensitive nanocarrier
    Nano Res. (IF 7.354) Pub Date : 2017-12-12
    Sen Lin, Peiling Xie, Mengmeng Luo, Qing Li, Ling Li, Jinzhao Zhang, Qinxiang Zheng, Hao Chen, Kaihui Nan

    None

    更新日期:2017-12-12
  • Nanoscale inhibition of polymorphic and ambidextrous IAPP amyloid aggregation with small molecules
    Nano Res. (IF 7.354) Pub Date : 2017-12-12
    Aleksandr Kakinen, Jozef Adamcik, Bo Wang, Xinwei Ge, Raffaele Mezzenga, Thomas P. Davis, Feng Ding, Pu Chun Ke

    None

    更新日期:2017-12-12
  • Consequence of shape elongation on emission asymmetry for colloidal CdSe/CdS nanoplatelets
    Nano Res. (IF 7.354) Pub Date : 2017-12-12
    Fu Feng, Loan Thu NGuyen, Michel Nasilowski, Brice Nadal, Benoît Dubertret, Laurent Coolen, Agnès Maître

    None

    更新日期:2017-12-12
  • Flavonoid moiety-incorporated carbon dots for ultrasensitive and highly selective fluorescence detection and removal of Pb 2+
    Nano Res. (IF 7.354) Pub Date : 2017-12-12
    Jing Xu, Xu Jie, Fengfeng Xie, Haimei Yang, Weili Wei, Zhining Xia

    None

    更新日期:2017-12-12
  • 更新日期:2017-12-12
  • Surface-adsorbed ions on TiO 2 nanosheets for selective photocatalytic CO 2 reduction
    Nano Res. (IF 7.354) Pub Date : 2017-12-11
    Xiaogang Li, Wentuan Bi, Zhe Wang, Wenguang Zhu, Wangsheng Chu, Changzheng Wu, Yi Xie

    None

    更新日期:2017-12-11
  • In situ atomic-scale observation of monolayer graphene growth from SiC
    Nano Res. (IF 7.354) Pub Date : 2017-12-08
    Kaihao Yu, Wen Zhao, Xing Wu, Jianing Zhuang, Xiaohui Hu, Qiubo Zhang, Jun Sun, Tao Xu, Yang Chai, Feng Ding, Litao Sun

    Because of its high compatibility with conventional microfabrication processing technology, epitaxial graphene (EG) grown on SiC shows exceptional promise for graphene-based electronics. However, to date, a detailed understanding of the transformation from three-layer SiC to monolayer graphene is still lacking. Here, we demonstrate the direct atomic-scale observation of EG growth on a SiC (11̅00) surface at 1,000 °C by in situ transmission electron microscopy in combination with ab initio molecular dynamics (AIMD) simulations. Our detailed analysis of the growth dynamics of monolayer graphene reveals that three SiC (11̅00) layers decompose successively to form one graphene layer. Sublimation of the first layer causes the formation of carbon clusters containing short chains and hexagonal rings, which can be considered as the nuclei for graphene growth. Decomposition of the second layer results in the appearance of new chains connecting to the as-formed clusters and the formation of a network with large pores. Finally, the carbon atoms released from the third layer lead to the disappearance of the chains and large pores in the network, resulting in a whole graphene layer. Our study presents a clear picture of the epitaxial growth of the monolayer graphene from SiC and provides valuable information forfuture developments in SiC-derived EG technology.

    更新日期:2017-12-10
  • Observation of unconventionalanomalous Hall effect in epitaxial CrTe thin films
    Nano Res. (IF 7.354) Pub Date : 2017-12-07
    Dapeng Zhao, Liguo Zhang, Iftikhar Ahmed Malik, Menghan Liao, Wenqiang Cui, Xinqiang Cai, Cheng Zheng, Luxin Li, Xiaopeng Hu, Ding Zhang, Jinxing Zhang, Xi Chen, Wanjun Jiang, Qikun Xue

    None

    更新日期:2017-12-07
  • Stability of the Fe 12 O 12 cluster
    Nano Res. (IF 7.354) Pub Date : 2017-12-07
    Xiaohu Yu, Xuemei Zhang, Xun-Wang Yan

    None

    更新日期:2017-12-07
  • Metamaterial-based graphene thermal emitter
    Nano Res. (IF 7.354) Pub Date : 2017-12-06
    Cheng Shi, Nathan H. Mahlmeister, Isaac J. Luxmoore, Geoffrey R. Nash

    A thermal emitter composed of a frequency-selective surface metamaterial layer and a hexagonal boron nitride-encapsulated graphene filament is demonstrated. The broadband thermal emission of the metamaterial (consisting of ring resonators) was tailored into two discrete bands, and the measured reflection and emission spectra agreed well with the simulation results. The high modulation frequencies that can be obtained in these devices, coupled with their operation in air, confirm their feasibility for use in applications such as gas sensing.

    更新日期:2017-12-06
  • Surface charge tunable nanoparticles for TNF-α siRNA oral delivery for treating ulcerative colitis
    Nano Res. (IF 7.354) Pub Date : 2017-12-06
    Shoaib Iqbal, Xiaojiao Du, Jilong Wang, Hongjun Li, Youyong Yuan, Jun Wang

    Nanoparticle (NP) drug delivery systems have been successfully designed and implemented to orally deliver siRNAs for inflammatory disorders. However, the influence of surface charge on orally administered siRNA nanocarriers has not been investigated. In this study, we prepared structurally related poly(ethylene glycol)-block-poly(lactic-co-glycolic acid) (PEG5K-b-PLGA10K) NPs with the assistance of a synthesized lipid featuring surface amine groups for subsequent charge tuning. NPs were prepared by a double emulsion method, and their surface charge could be tuned and controlled by a succinylation reaction to yield NPs with different surface charges, while maintaining their size and composition. The prepared NPs were termed as aminated NPs (ANPs), plain NPs (PNPs), or carboxylated NPs (CNPs) based on their surface charge. All NPs exhibited the desired structural stability and siRNA integrity after enzymatic degradation. In vivo studies showed that ANPs significantly accumulated in inflamed colons, and they were successful in decreasing TNF-α secretion and mRNA expression levels while maintaining colonic histology in a murine model of acute ulcerative colitis (UC). This study described a methodology to modify the surface charge of siRNA-encapsulating polymeric NPs and highlighted the influence of surface charge on oral delivery of siRNA for localized inflammatory disorders.

    更新日期:2017-12-06
  • Acidity-triggered TAT-presenting nanocarriers augment tumor retention and nuclear translocation of drugs
    Nano Res. (IF 7.354) Pub Date : 2017-12-06
    Wei Jiang, Jilong Wang, Jinbin Yang, Zhiwei He, Zhenhui Hou, Yingli Luo, Li Wang, Jing Liu, Houbing Zhang, Yangyang Zhao, Guoqing Zhang, Fang Huang, Xuechang Zhou, Lifeng Yan, Xianzhu Yang, Yucai Wang, Jun Wang

    Hierarchical targeting strategy can combat the sequential drug delivery barriers by changing their properties with response to tumor stimuli. Among these strategies, much less attention has been paid to address the issues of rapid tumor clearance and insufficient cellular translocation. In this work, we demonstrate that a transactivator of transcription (TAT)-presenting nanomedicine (DATAT-NP/Pt), apart from improving tumor accumulation and cellular uptake, can simultaneously enhance tumor retention and promote nuclear translocation of encapsulated platinum prodrugs, and thus improve therapeutic efficacy. Specifically, a protecting 2,3-dimethylmaleic anhydride (DA) corona on the nanomedicine prevented the TAT peptide from serum. DATAT-NP/Pt efficiently accumulated at the tumor site through the enhanced permeability and retention (EPR) effect, followed by acid-triggered TAT presenting within the tumor acidic microenvironment (pH ~ 6.8). The exposed TAT peptide augmented tumor retention and nuclear translocation of DATAT-NP/Pt. We used a tumor-on-a-chip microfluidic system to real-time mimic and analyze tumor accumulation and retention at physiological flow conditions and revealed that surface absorption of nanomedicines on tumors was critical in determining their tumor retention and clearance. Furthermore, the TAT peptide rapidly translocated the DATAT-NP/Pt into the perinuclear region, allowing for higher nuclear platinum concentrations and increased Pt-DNA adduct formation in nuclei, which consequently reversed cisplatin resistance. Our work presents a new strategy to overcome pathophysiological barriers of tumor clearance and insufficient cellular translocation and provides new insights for the design of cancer nanomedicines.

    更新日期:2017-12-06
  • Design and applications of lattice plasmon resonances
    Nano Res. (IF 7.354) Pub Date : 2017-12-06
    Bharath Bangalore Rajeeva, Linhan Lin, Yuebing Zheng

    With their unique optical properties associated with the excitation of surface plasmons, metal nanoparticles (NPs) have been used in optical sensors and devices. The organization of these NPs into arrays can induce coupling effects to engineer new optical responses. In particular, lattice plasmon resonances (LPRs), which arise from coherent interactions and coupling among NPs in periodic arrays, have shown great promise for realizing narrow linewidths, angle-dependent dispersions, and high wavelength tunability of optical spectra. By engineering the materials, shapes, sizes, and spatial arrangements of NPs within arrays, one can tune the LPR-based spectral responses and electromagnetic field distributions to deliver a multitude of improvements, including a high figure-of-merit, superior light–matter interaction, and multiband operation. In this review, we discuss recent progress in designing and applying new metal nanostructures for LPR-based applications. We conclude this review with our perspective on the future opportunities and challenges of LPR-based devices.

    更新日期:2017-12-06
Some contents have been Reproduced with permission of the American Chemical Society.
Some contents have been Reproduced by permission of The Royal Society of Chemistry.
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