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  • Coherent wavepackets in the Fenna–Matthews–Olson complex are robust to excitonic-structure perturbations caused by mutagenesis
    Nat. Chem. (IF 25.87) Pub Date : 2018-01-15
    Margherita Maiuri, Evgeny E. Ostroumov, Rafael G. Saer, Robert E. Blankenship, Gregory D. Scholes

    Femtosecond pulsed excitation of light-harvesting complexes creates oscillatory features in their response. This phenomenon has inspired a large body of work aimed at uncovering the origin of the coherent beatings and possible implications for function. Here we exploit site-directed mutagenesis to change the excitonic level structure in Fenna–Matthews–Olson (FMO) complexes and compare the coherences using broadband pump–probe spectroscopy. Our experiments detect two oscillation frequencies with dephasing on a picosecond timescale—both at 77 K and at room temperature. By studying these coherences with selective excitation pump–probe experiments, where pump excitation is in resonance only with the lowest excitonic state, we show that the key contributions to these oscillations stem from ground-state vibrational wavepackets. These experiments explicitly show that the coherences—although in the ground electronic state—can be probed at the absorption resonances of other bacteriochlorophyll molecules because of delocalization of the electronic excitation over several chromophores.

    更新日期:2018-01-15
  • Transferring the entatic-state principle to copper photochemistry
    Nat. Chem. (IF 25.87) Pub Date : 2018-01-15
    B. Dicke, A. Hoffmann, J. Stanek, M. S. Rampp, B. Grimm-Lebsanft, F. Biebl, D. Rukser, B. Maerz, D. Göries, M. Naumova, M. Biednov, G. Neuber, A. Wetzel, S. M. Hofmann, P. Roedig, A. Meents, J. Bielecki, J. Andreasson, K. R. Beyerlein, H. N. Chapman, C. Bressler, W. Zinth, M. Rübhausen, S. Herres-Pawlis

    The entatic state denotes a distorted coordination geometry of a complex from its typical arrangement that generates an improvement to its function. The entatic-state principle has been observed to apply to copper electron-transfer proteins and it results in a lowering of the reorganization energy of the electron-transfer process. It is thus crucial for a multitude of biochemical processes, but its importance to photoactive complexes is unexplored. Here we study a copper complex—with a specifically designed constraining ligand geometry—that exhibits metal-to-ligand charge-transfer state lifetimes that are very short. The guanidine–quinoline ligand used here acts on the bis(chelated) copper(I) centre, allowing only small structural changes after photoexcitation that result in very fast structural dynamics. The data were collected using a multimethod approach that featured time-resolved ultraviolet–visible, infrared and X-ray absorption and optical emission spectroscopy. Through supporting density functional calculations, we deliver a detailed picture of the structural dynamics in the picosecond-to-nanosecond time range.

    更新日期:2018-01-15
  • Evaluating differences in the active-site electronics of supported Au nanoparticle catalysts using Hammett and DFT studies
    Nat. Chem. (IF 25.87) Pub Date : 2018-01-15
    Gaurav Kumar, Luke Tibbitts, Jaclyn Newell, Basu Panthi, Ahana Mukhopadhyay, Robert M. Rioux, Christopher J. Pursell, Michael Janik, Bert D. Chandler

    Supported metal catalysts, which are composed of metal nanoparticles dispersed on metal oxides or other high-surface-area materials, are ubiquitous in industrially catalysed reactions. Identifying and characterizing the catalytic active sites on these materials still remains a substantial challenge, even though it is required to guide rational design of practical heterogeneous catalysts. Metal–support interactions have an enormous impact on the chemistry of the catalytic active site and can determine the optimum support for a reaction; however, few direct probes of these interactions are available. Here we show how benzyl alcohol oxidation Hammett studies can be used to characterize differences in the catalytic activity of Au nanoparticles hosted on various metal-oxide supports. We combine reactivity analysis with density functional theory calculations to demonstrate that the slope of experimental Hammett plots is affected by electron donation from the underlying oxide support to the Au particles.

    更新日期:2018-01-15
  • Engineered modular biomaterial logic gates for environmentally triggered therapeutic delivery
    Nat. Chem. (IF 25.87) Pub Date : 2018-01-15
    Barry A. Badeau, Michael P. Comerford, Christopher K. Arakawa, Jared A. Shadish, Cole A. DeForest

    The successful transport of drug- and cell-based therapeutics to diseased sites represents a major barrier in the development of clinical therapies. Targeted delivery can be mediated through degradable biomaterial vehicles that utilize disease biomarkers to trigger payload release. Here, we report a modular chemical framework for imparting hydrogels with precise degradative responsiveness by using multiple environmental cues to trigger reactions that operate user-programmable Boolean logic. By specifying the molecular architecture and connectivity of orthogonal stimuli-labile moieties within material cross-linkers, we show selective control over gel dissolution and therapeutic delivery. To illustrate the versatility of this methodology, we synthesized 17 distinct stimuli-responsive materials that collectively yielded all possible YES/OR/AND logic outputs from input combinations involving enzyme, reductant and light. Using these hydrogels we demonstrate the first sequential and environmentally stimulated release of multiple cell lines in well-defined combinations from a material. We expect these platforms will find utility in several diverse fields including drug delivery, diagnostics and regenerative medicine.

    更新日期:2018-01-15
  • Ultrafast dynamics of low-energy electron attachment via a non-valence correlation-bound state
    Nat. Chem. (IF 25.87) Pub Date : 2018-01-08
    Joshua P. Rogers, Cate S. Anstöter, Jan R. R. Verlet

    The primary electron-attachment process in electron-driven chemistry represents one of the most fundamental chemical transformations with wide-ranging importance in science and technology. However, the mechanistic detail of the seemingly simple reaction of an electron and a neutral molecule to form an anion remains poorly understood, particularly at very low electron energies. Here, time-resolved photoelectron imaging was used to probe the electron-attachment process to a non-polar molecule using time-resolved methods. An initially populated diffuse non-valence state of the anion that is bound by correlation forces evolves coherently in ∼30 fs into a valence state of the anion. The extreme efficiency with which the correlation-bound state serves as a doorway state for low-energy electron attachment explains a number of electron-driven processes, such as anion formation in the interstellar medium and electron attachment to fullerenes.

    更新日期:2018-01-08
  • Asymmetric transfer hydrogenation by synthetic catalysts in cancer cells
    Nat. Chem. (IF 25.87) Pub Date : 2018-01-08
    James P. C. Coverdale, Isolda Romero-Canelón, Carlos Sanchez-Cano, Guy J. Clarkson, Abraha Habtemariam, Martin Wills, Peter J. Sadler

    Catalytic anticancer metallodrugs active at low doses could minimize side-effects, introduce novel mechanisms of action that combat resistance and widen the spectrum of anticancer-drug activity. Here we use highly stable chiral half-sandwich organometallic Os(II) arene sulfonyl diamine complexes, [Os(arene)(TsDPEN)] (TsDPEN, N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine), to achieve a highly enantioselective reduction of pyruvate, a key intermediate in metabolic pathways. Reduction is shown both in aqueous model systems and in human cancer cells, with non-toxic concentrations of sodium formate used as a hydride source. The catalytic mechanism generates selectivity towards ovarian cancer cells versus non-cancerous fibroblasts (both ovarian and lung), which are commonly used as models of healthy proliferating cells. The formate precursor N-formylmethionine was explored as an alternative to formate in PC3 prostate cancer cells, which are known to overexpress a deformylase enzyme. Transfer-hydrogenation catalysts that generate reductive stress in cancer cells offer a new approach to cancer therapy.

    更新日期:2018-01-08
  • Pt/Cu single-atom alloys as coke-resistant catalysts for efficient C–H activation
    Nat. Chem. (IF 25.87) Pub Date : 
    Matthew D. Marcinkowski, Matthew T. Darby, Jilei Liu, Joshua M. Wimble, Felicia R. Lucci, Sungsik Lee, Angelos Michaelides, Maria Flytzani-Stephanopoulos, Michail Stamatakis, E. Charles H. Sykes

    The recent availability of shale gas has led to a renewed interest in C–H bond activation as the first step towards the synthesis of fuels and fine chemicals. Heterogeneous catalysts based on Ni and Pt can perform this chemistry, but deactivate easily due to coke formation. Cu-based catalysts are not practical due to high C–H activation barriers, but their weaker binding to adsorbates offers resilience to coking. Using Pt/Cu single-atom alloys (SAAs), we examine C–H activation in a number of systems including methyl groups, methane and butane using a combination of simulations, surface science and catalysis studies. We find that Pt/Cu SAAs activate C–H bonds more efficiently than Cu, are stable for days under realistic operating conditions, and avoid the problem of coking typically encountered with Pt. Pt/Cu SAAs therefore offer a new approach to coke-resistant C–H activation chemistry, with the added economic benefit that the precious metal is diluted at the atomic limit.

    更新日期:2018-01-08
  • Direct observation of the influence of cardiolipin and antibiotics on lipid II binding to MurJ
    Nat. Chem. (IF 25.87) Pub Date : 
    Jani Reddy Bolla, Joshua B. Sauer, Di Wu, Shahid Mehmood, Timothy M. Allison, Carol V. Robinson

    Translocation of lipid II across the cytoplasmic membrane is essential in peptidoglycan biogenesis. Although most steps are understood, identifying the lipid II flippase has yielded conflicting results, and the lipid II binding properties of two candidate flippases—MurJ and FtsW—remain largely unknown. Here we apply native mass spectrometry to both proteins and characterize lipid II binding. We observed lower levels of lipid II binding to FtsW compared to MurJ, consistent with MurJ having a higher affinity. Site-directed mutagenesis of MurJ suggests that mutations at A29 and D269 attenuate lipid II binding to MurJ, whereas chemical modification of A29 eliminates binding. The antibiotic ramoplanin dissociates lipid II from MurJ, whereas vancomycin binds to form a stable complex with MurJ:lipid II. Furthermore, we reveal cardiolipins associate with MurJ but not FtsW, and exogenous cardiolipins reduce lipid II binding to MurJ. These observations provide insights into determinants of lipid II binding to MurJ and suggest roles for endogenous lipids in regulating substrate binding.

    更新日期:2018-01-08
  • Palladium-catalysed anti-Markovnikov selective oxidative amination
    Nat. Chem. (IF 25.87) Pub Date : 2018-01-01
    Daniel G. Kohler, Samuel N. Gockel, Jennifer L. Kennemur, Peter J. Waller, Kami L. Hull

    In recent years, the synthesis of amines and other nitrogen-containing motifs has been a major area of research in organic chemistry because they are widely represented in biologically active molecules. Current strategies rely on a multistep approach and require one reactant to be activated prior to the carbon–nitrogen bond formation. This leads to a reaction inefficiency and functional group intolerance. As such, a general approach to the synthesis of nitrogen-containing compounds from readily available and benign starting materials is highly desirable. Here we present a palladium-catalysed oxidative amination reaction in which the addition of the nitrogen occurs at the less-substituted carbon of a double bond, in what is known as anti-Markovnikov selectivity. Alkenes are shown to react with imides in the presence of a palladate catalyst to generate the terminal imide through trans-aminopalladation. Subsequently, olefin isomerization occurs to afford the thermodynamically favoured products. Both the scope of the transformation and mechanistic investigations are reported.

    更新日期:2018-01-01
  • An integrated native mass spectrometry and top-down proteomics method that connects sequence to structure and function of macromolecular complexes
    Nat. Chem. (IF 25.87) Pub Date : 2018-01-01
    Huilin Li, Hong Hanh Nguyen, Rachel R. Ogorzalek Loo, Iain D. G. Campuzano, Joseph A. Loo

    Mass spectrometry (MS) has become a crucial technique for the analysis of protein complexes. Native MS has traditionally examined protein subunit arrangements, while proteomics MS has focused on sequence identification. These two techniques are usually performed separately without taking advantage of the synergies between them. Here we describe the development of an integrated native MS and top-down proteomics method using Fourier-transform ion cyclotron resonance (FTICR) to analyse macromolecular protein complexes in a single experiment. We address previous concerns of employing FTICR MS to measure large macromolecular complexes by demonstrating the detection of complexes up to 1.8 MDa, and we demonstrate the efficacy of this technique for direct acquirement of sequence to higher-order structural information with several large complexes. We then summarize the unique functionalities of different activation/dissociation techniques. The platform expands the ability of MS to integrate proteomics and structural biology to provide insights into protein structure, function and regulation.

    更新日期:2018-01-01
  • Labelling and determination of the energy in reactive intermediates in solution enabled by energy-dependent reaction selectivity
    Nat. Chem. (IF 25.87) Pub Date : 2018-01-01
    Hiroaki Kurouchi, Daniel A. Singleton

    Any long-lived chemical structure in solution is subject to statistical energy equilibration, so the history of any specific structure does not affect its subsequent reactions. This is not true for very short-lived intermediates because energy equilibration takes time. Here, this idea is applied to achieve the ‘energy labelling’ of a reactive intermediate. The selectivity of the ring-opening α-cleavage reaction of the 1-methylcyclobutoxy radical is found here to vary broadly depending on how the radical was formed. Reactions that provide little excess energy to the intermediate lead to a high selectivity in the subsequent cleavage (measured as a kinetic isotope effect), whereas reactions that provide more excess energy to the intermediate exhibit a lower selectivity. Accounting for the expected excess energy allows the prediction of the observed product ratios and, in turn, the product ratios can be used to determine the energy present in an intermediate.

    更新日期:2018-01-01
  • Acceleration of a ground-state reaction by selective femtosecond-infrared-laser-pulse excitation
    Nat. Chem. (IF 25.87) Pub Date : 2018-01-01
    Till Stensitzki, Yang Yang, Valeri Kozich, Ashour A. Ahmed, Florian Kössl, Oliver Kühn, Karsten Heyne

    Infrared (IR) excitation of vibrations that participate in the reaction coordinate of an otherwise thermally driven chemical reaction are believed to lead to its acceleration. Attempts at the practical realization of this concept have been hampered so far by competing processes leading to sample heating. Here we demonstrate, using femtosecond IR-pump IR-probe experiments, the acceleration of urethane and polyurethane formation due to vibrational excitation of the reactants for 1:1 mixtures of phenylisocyanate and cyclohexanol, and toluene-2,4-diisocyanate and 2,2,2-trichloroethane-1,1-diol, respectively. We measured reaction rate changes upon selective vibrational excitation with negligible heating of the sample and observed an increase of the reaction rate up to 24%. The observation is rationalized using reactant and transition-state structures obtained from quantum chemical calculations. We subsequently used IR-driven reaction acceleration to write a polyurethane square on sample windows using a femtosecond IR pulse.

    更新日期:2018-01-01
  • Terbium glows green
    Nat. Chem. (IF 25.87) Pub Date : 2017-12-19
    Geng Deng

    Terbium glows green Terbium glows green, Published online: 19 December 2017; doi:10.1038/nchem.2914 Geng Deng relates how terbium, a garden-variety lanthanide, has found its way into our daily lives owing to its green fluorescence.

    更新日期:2017-12-19
  • Making molecular monsters
    Nat. Chem. (IF 25.87) Pub Date : 2017-12-19
    Michelle Francl

    Making molecular monsters Making molecular monsters, Published online: 19 December 2017; doi:10.1038/nchem.2920 Michelle Francl muses on fantastic beasts of chemistry and why we try to find them.

    更新日期:2017-12-19
  • Collaborative routes to clarifying the murky waters of aqueous supramolecular chemistry
    Nat. Chem. (IF 25.87) Pub Date : 2017-12-19
    Paul S. Cremer, Amar H. Flood, Bruce C. Gibb, David L. Mobley

    On planet Earth, water is everywhere: the majority of the surface is covered with it; it is a key component of all life; its vapour and droplets fill the lower atmosphere; and even rocks contain it and undergo geomorphological changes because of it. A community of physical scientists largely drives studies of the chemistry of water and aqueous solutions, with expertise in biochemistry, spectroscopy and computer modelling. More recently, however, supramolecular chemists — with their expertise in macrocyclic synthesis and measuring supramolecular interactions — have renewed their interest in water-mediated non-covalent interactions. These two groups offer complementary expertise that, if harnessed, offer to accelerate our understanding of aqueous supramolecular chemistry and water writ large. This Review summarizes the state-of-the-art of the two fields, and highlights where there is latent chemical space for collaborative exploration by the two groups.

    更新日期:2017-12-19
  • Erratum: Glucose-responsive insulin by molecular and physical design
    Nat. Chem. (IF 25.87) Pub Date : 2017-12-19
    Naveed A. Bakh, Abel B. Cortinas, Michael A. Weiss, Robert S. Langer, Daniel G. Anderson, Zhen Gu, Sanjoy Dutta, Michael S. Strano

    Erratum: Glucose-responsive insulin by molecular and physical design Erratum: Glucose-responsive insulin by molecular and physical design, Published online: 19 December 2017; doi:10.1038/nchem.2898 Erratum: Glucose-responsive insulin by molecular and physical design

    更新日期:2017-12-19
  • Flexible molecular materials: Stressed out crystals
    Nat. Chem. (IF 25.87) Pub Date : 2017-12-19
    Bart Kahr, Michael D. Ward

    Flexible molecular materials: Stressed out crystals Flexible molecular materials: Stressed out crystals, Published online: 19 December 2017; doi:10.1038/nchem.2913 Molecular crystals have recently started to shake their inflexible reputation. Now, copper(II) acetylacetonate needles have been shown to be very flexible, and their mechanical deformation has been assessed through materials constants using methods customarily reserved for non-molecular materials.

    更新日期:2017-12-19
  • Water splitting: Passing the acid test
    Nat. Chem. (IF 25.87) Pub Date : 2017-12-19
    Qiushi Yin, Craig L. Hill

    Water splitting: Passing the acid test Water splitting: Passing the acid test, Published online: 19 December 2017; doi:10.1038/nchem.2921 Water-oxidation catalysts that are fast and efficient in strong acid are rare even though there are several benefits for systems working at low pH. Such catalysts usually feature expensive noble metals such as ruthenium and iridum; however, an electrocatalytic system that is exceptionally efficient and based on cobalt has now been developed.

    更新日期:2017-12-19
  • Correction
    Nat. Chem. (IF 25.87) Pub Date : 2017-12-19

    Correction Correction, Published online: 19 December 2017; doi:10.1038/nchem.2925 Correction

    更新日期:2017-12-19
  • Thermally activated delayed photoluminescence from pyrenyl-functionalized CdSe quantum dots
    Nat. Chem. (IF 25.87) Pub Date : 2017-12-18
    Cédric Mongin, Pavel Moroz, Mikhail Zamkov, Felix N. Castellano

    Thermally activated delayed photoluminescence from pyrenyl-functionalized CdSe quantum dots Thermally activated delayed photoluminescence from pyrenyl-functionalized CdSe quantum dots, Published online: 18 December 2017; doi:10.1038/nchem.2906 The ability to merge the photophysical properties of semiconductor quantum dots with those of well-understood and inexpensive molecular chromophores is important for the development of various emerging photonic and optoelectronic technologies. Now, 1-pyrenecarboxylic acid-functionalized CdSe quantum dots have been shown to undergo thermally activated delayed photoluminescence and display tunable photophysical properties.

    更新日期:2017-12-18
  • Substrate-driven chemotactic assembly in an enzyme cascade
    Nat. Chem. (IF 25.87) Pub Date : 2017-12-18
    Xi Zhao, Henri Palacci, Vinita Yadav, Michelle M. Spiering, Michael K. Gilson, Peter J. Butler, Henry Hess, Stephen J. Benkovic, Ayusman Sen

    Substrate-driven chemotactic assembly in an enzyme cascade Substrate-driven chemotactic assembly in an enzyme cascade, Published online: 18 December 2017; doi:10.1038/nchem.2905 Enzymes that form a metabolic pathway in which the product of one enzyme is the substrate for the next have now been shown to associate through a process of sequential, directed chemotactic movement. The extent of enzyme migration is proportional to the exposure time to the substrate gradient.

    更新日期:2017-12-18
  • Iridium-catalysed arylation of C–H bonds enabled by oxidatively induced reductive elimination
    Nat. Chem. (IF 25.87) Pub Date : 2017-12-11
    Kwangmin Shin, Yoonsu Park, Mu-Hyun Baik, Sukbok Chang

    Iridium-catalysed arylation of C–H bonds enabled by oxidatively induced reductive elimination Iridium-catalysed arylation of C–H bonds enabled by oxidatively induced reductive elimination, Published online: 11 December 2017; doi:10.1038/nchem.2900 The direct arylation of C–H bonds is an attractive synthetic step, but the reductive elimination of an organometallic catalyst carrying the desired C–H and aryl functionalities has remained challenging. Now, this step has been achieved by first oxidizing the iridium centre of the catalyst, which facilitates the arylation of arene C–H bonds of a range of substrates.

    更新日期:2017-12-11
  • The role of uranium–arene bonding in H2O reduction catalysis
    Nat. Chem. (IF 25.87) Pub Date : 2017-12-11
    Dominik P. Halter, Frank W. Heinemann, Laurent Maron, Karsten Meyer

    The role of uranium–arene bonding in H2O reduction catalysis The role of uranium–arene bonding in H2O reduction catalysis, Published online: 11 December 2017; doi:10.1038/nchem.2899 An arene-anchored uranium(III) complex that facilitates the electrocatalytic formation of H2 from H2O has now been shown to involve redox-cooperativity between the uranium centre and its covalently bound mesitylene ligand. The oxidative addition of H2O to the uranium catalyst is a concerted two-electron reaction — atypical for f-block metals.

    更新日期:2017-12-11
  • De novo design and engineering of non-ribosomal peptide synthetases
    Nat. Chem. (IF 25.87) Pub Date : 2017-12-11
    Kenan A. J. Bozhüyük, Florian Fleischhacker, Annabell Linck, Frank Wesche, Andreas Tietze, Claus-Peter Niesert, Helge B. Bode

    De novo design and engineering of non-ribosomal peptide synthetases De novo design and engineering of non-ribosomal peptide synthetases, Published online: 11 December 2017; doi:10.1038/nchem.2890 Peptides derived from non-ribosomal peptide synthetases (NRPS) are an important class of pharmaceutically relevant drugs. However, no general rules for the modification of NRPS or the generation of artificial NRPS are known. Now, a new strategy for the modification of NRPS has been developed that uses defined exchange units that are fused at specific positions connecting the condensation and adenylation domains.

    更新日期:2017-12-11
  • A general approach to intermolecular carbonylation of arene C–H bonds to ketones through catalytic aroyl triflate formation
    Nat. Chem. (IF 25.87) Pub Date : 2017-12-11
    R. Garrison Kinney, Jevgenijs Tjutrins, Gerardo M. Torres, Nina Jiabao Liu, Omkar Kulkarni, Bruce A. Arndtsen

    A general approach to intermolecular carbonylation of arene C–H bonds to ketones through catalytic aroyl triflate formation A general approach to intermolecular carbonylation of arene C–H bonds to ketones through catalytic aroyl triflate formation, Published online: 11 December 2017; doi:10.1038/nchem.2903 Catalytic transformations that incorporate carbonyl functional groups in arene C–H bonds have remained limited, despite being attractive synthetic steps. Now, the intermolecular carbonylative coupling of a broad range of simple arenes into ketones has been developed. The reaction occurs through the palladium-catalysed generation of high-energy aroyl triflate electrophiles.

    更新日期:2017-12-11
  • Decarboxylative alkylation for site-selective bioconjugation of native proteins via oxidation potentials
    Nat. Chem. (IF 25.87) Pub Date : 2017-12-04
    Steven Bloom, Chun Liu, Dominik K. Kölmel, Jennifer X. Qiao, Yong Zhang, Michael A. Poss, William R. Ewing, David W. C. MacMillan

    Decarboxylative alkylation for site-selective bioconjugation of native proteins via oxidation potentials Decarboxylative alkylation for site-selective bioconjugation of native proteins via oxidation potentials, Published online: 04 December 2017; doi:10.1038/nchem.2888 Selectively targeting native amino acids for late-stage protein modification is a significant challenge, but now it has been shown that photoredox catalysis can be used to specifically target protein C-termini toward decarboxylative-alkylation with Michael acceptors. This technology harnesses innate differences in side-chain oxidation potentials to select between the various functional groups typical among proteins in order to form a single modified product.

    更新日期:2017-12-05
  • Artificial muscle-like function from hierarchical supramolecular assembly of photoresponsive molecular motors
    Nat. Chem. (IF 25.87) Pub Date : 2017-12-04
    Jiawen Chen, Franco King-Chi Leung, Marc C. A. Stuart, Takashi Kajitani, Takanori Fukushima, Erik van der Giessen, Ben L. Feringa

    Artificial muscle-like function from hierarchical supramolecular assembly of photoresponsive molecular motors Artificial muscle-like function from hierarchical supramolecular assembly of photoresponsive molecular motors, Published online: 04 December 2017; doi:10.1038/nchem.2887 A centimetre-long string formed by the hierarchical self-assembly of a photoresponsive amphiphilic molecular motor — composed of 95 wt% of water — undergoes muscle-like contraction. Under irradiation, rotary motion at the molecular level is amplified through non-covalent interactions to sustain a fast macroscopic mechanical motion of large amplitude.

    更新日期:2017-12-05
  • DNA-imprinted polymer nanoparticles with monodispersity and prescribed DNA-strand patterns
    Nat. Chem. (IF 25.87) Pub Date : 2017-12-04
    Tuan Trinh, Chenyi Liao, Violeta Toader, Maciej Barłóg, Hassan S. Bazzi, Jianing Li, Hanadi F. Sleiman

    DNA-imprinted polymer nanoparticles with monodispersity and prescribed DNA-strand patterns DNA-imprinted polymer nanoparticles with monodispersity and prescribed DNA-strand patterns, Published online: 04 December 2017; doi:10.1038/nchem.2893 DNA–polymer conjugates are attractive materials that combine the programmability of nucleic acid assembly with polymer functionality. Now, through a DNA cube template, monodisperse polymer particles have been imprinted with several DNA strands in pre-designed orientations — each independently set and addressable. The resulting hybrid particles can further assemble into well-defined, non-centrosymmetric structures.

    更新日期:2017-12-05
  • Direct observation of sequential oxidations of a titania-bound molecular proxy catalyst generated through illumination of molecular sensitizers
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-27
    Hsiang-Yun Chen, Shane Ardo

    Direct observation of sequential oxidations of a titania-bound molecular proxy catalyst generated through illumination of molecular sensitizers Direct observation of sequential oxidations of a titania-bound molecular proxy catalyst generated through illumination of molecular sensitizers, Published online: 27 November 2017; doi:10.1038/nchem.2892 Photosynthesis uses sunlight to oxidize or reduce reaction centres multiple times and prepare them for multiple-electron-transfer reactions. Now, it has been shown that a molecular proxy for a multiple-electron-transfer electrocatalyst can be oxidized twice by dye molecules when both are anchored to a mesoporous TiO2 thin film and excited with low-intensity visible light.

    更新日期:2017-11-28
  • Multi-electron transfer photochemistry: Caught in the act
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-27
    Anna M. Beiler, Gary F. Moore

    Multi-electron transfer photochemistry: Caught in the act Multi-electron transfer photochemistry: Caught in the act, Published online: 27 November 2017; doi:10.1038/nchem.2896 The accumulation of multiple redox equivalents is essential in photo-driven catalytic reactions such as solar water splitting. However, direct spectroscopic observation of a twice-oxidized species under diffuse illumination has proved elusive until now.

    更新日期:2017-11-28
  • Direct observation of sequential oxidations of a titania-bound molecular proxy catalyst generated through illumination of molecular sensitizers
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-27
    Hsiang-Yun Chen, Shane Ardo

    Direct observation of sequential oxidations of a titania-bound molecular proxy catalyst generated through illumination of molecular sensitizers Direct observation of sequential oxidations of a titania-bound molecular proxy catalyst generated through illumination of molecular sensitizers, Published online: 27 November 2017; doi:10.1038/nchem.2892 Photosynthesis uses sunlight to oxidize or reduce reaction centres multiple times and prepare them for multiple-electron-transfer reactions. Now, it has been shown that a molecular proxy for a multiple-electron-transfer electrocatalyst can be oxidized twice by dye molecules when both are anchored to a mesoporous TiO2 thin film and excited with low-intensity visible light.

    更新日期:2017-11-28
  • Multi-electron transfer photochemistry: Caught in the act
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-27
    Anna M. Beiler, Gary F. Moore

    Multi-electron transfer photochemistry: Caught in the act Multi-electron transfer photochemistry: Caught in the act, Published online: 27 November 2017; doi:10.1038/nchem.2896 The accumulation of multiple redox equivalents is essential in photo-driven catalytic reactions such as solar water splitting. However, direct spectroscopic observation of a twice-oxidized species under diffuse illumination has proved elusive until now.

    更新日期:2017-11-28
  • Retraction: Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-23
    Tony Z. Jia, Albert C. Fahrenbach, Neha P. Kamat, Katarzyna P. Adamala, Jack W. Szostak

    Retraction: Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication Retraction: Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication, Published online: 23 November 2017; doi:10.1038/nchem.2885 Retraction: Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication

    更新日期:2017-11-23
  • Superatomic solids: Intercalation without altercation
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-23
    Shiv N. Khanna, Arthur C. Reber

    Superatomic solids: Intercalation without altercation Superatomic solids: Intercalation without altercation, Published online: 23 November 2017; doi:10.1038/nchem.2895 Building materials with clusters instead of atoms promises unconventional properties, but those 'superatomic solids' are often too fragile to manipulate. Now, intercalating a guest within an ionic layered solid made of fullerenes and metal chalcogenide clusters greatly alters its conductivity and optical properties without disrupting its crystalline structure.

    更新日期:2017-11-23
  • Thoroughly enthralling thulium
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-23
    Polly Arnold

    Thoroughly enthralling thulium Thoroughly enthralling thulium, Published online: 23 November 2017; doi:10.1038/nchem.2897 Named after a mysterious place, thulium — one of the rarest rare earths — has some exotic chemistry in store for us, says Polly Arnold.

    更新日期:2017-11-23
  • Polymer mechanochemistry: Up another rung
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-23
    Stephen L. Craig

    Polymer mechanochemistry: Up another rung Polymer mechanochemistry: Up another rung, Published online: 23 November 2017; doi:10.1038/nchem.2902 The use of mechanical force to break and build chemical bonds in polymers can enable transformations that cannot be conducted using stimuli such as light and heat. Now, an insulating polymer has been mechanically unzipped to create a semiconducting polymer with extended regions of conjugation.

    更新日期:2017-11-23
  • Molecular organic networks: A step beyond flatland
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-23
    Manfred Buck

    Molecular organic networks: A step beyond flatland Molecular organic networks: A step beyond flatland, Published online: 23 November 2017; doi:10.1038/nchem.2901 Non-covalent interactions can organize planar molecules into two-dimensional arrays. It has now been shown that such arrays can be combined at the solid–liquid interface into bilayered heterostructures.

    更新日期:2017-11-23
  • Retraction: Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-23
    Tony Z. Jia, Albert C. Fahrenbach, Neha P. Kamat, Katarzyna P. Adamala, Jack W. Szostak

    Retraction: Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication Retraction: Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication, Published online: 23 November 2017; doi:10.1038/nchem.2885 Retraction: Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication

    更新日期:2017-11-23
  • Superatomic solids: Intercalation without altercation
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-23
    Shiv N. Khanna, Arthur C. Reber

    Superatomic solids: Intercalation without altercation Superatomic solids: Intercalation without altercation, Published online: 23 November 2017; doi:10.1038/nchem.2895 Building materials with clusters instead of atoms promises unconventional properties, but those 'superatomic solids' are often too fragile to manipulate. Now, intercalating a guest within an ionic layered solid made of fullerenes and metal chalcogenide clusters greatly alters its conductivity and optical properties without disrupting its crystalline structure.

    更新日期:2017-11-23
  • Thoroughly enthralling thulium
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-23
    Polly Arnold

    Thoroughly enthralling thulium Thoroughly enthralling thulium, Published online: 23 November 2017; doi:10.1038/nchem.2897 Named after a mysterious place, thulium — one of the rarest rare earths — has some exotic chemistry in store for us, says Polly Arnold.

    更新日期:2017-11-23
  • Polymer mechanochemistry: Up another rung
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-23
    Stephen L. Craig

    Polymer mechanochemistry: Up another rung Polymer mechanochemistry: Up another rung, Published online: 23 November 2017; doi:10.1038/nchem.2902 The use of mechanical force to break and build chemical bonds in polymers can enable transformations that cannot be conducted using stimuli such as light and heat. Now, an insulating polymer has been mechanically unzipped to create a semiconducting polymer with extended regions of conjugation.

    更新日期:2017-11-23
  • Molecular organic networks: A step beyond flatland
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-23
    Manfred Buck

    Molecular organic networks: A step beyond flatland Molecular organic networks: A step beyond flatland, Published online: 23 November 2017; doi:10.1038/nchem.2901 Non-covalent interactions can organize planar molecules into two-dimensional arrays. It has now been shown that such arrays can be combined at the solid–liquid interface into bilayered heterostructures.

    更新日期:2017-11-23
  • A dual role for a polyketide synthase in dynemicin enediyne and anthraquinone biosynthesis
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-20
    Douglas R. Cohen, Craig A. Townsend

    A dual role for a polyketide synthase in dynemicin enediyne and anthraquinone biosynthesis A dual role for a polyketide synthase in dynemicin enediyne and anthraquinone biosynthesis, Published online: 20 November 2017; doi:10.1038/nchem.2876 The anthraquinone and enediyne halves of the antitumor antibiotic dynemicin A were previously thought to be assembled by two separate polyketide synthases (PKS). Now, a single polyketide synthase has been proposed to be responsible for their production, and a working model for their biosynthesis from a common octaketide intermediate has been suggested.

    更新日期:2017-11-21
  • Theory-driven design of high-valence metal sites for water oxidation confirmed using in situ soft X-ray absorption
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-20
    Xueli Zheng, Bo Zhang, Phil De Luna, Yufeng Liang, Riccardo Comin, Oleksandr Voznyy, Lili Han, F. Pelayo García de Arquer, Min Liu, Cao Thang Dinh, Tom Regier, James J. Dynes, Sisi He, Huolin L. Xin, Huisheng Peng, David Prendergast, Xiwen Du, Edward H. Sargent

    Theory-driven design of high-valence metal sites for water oxidation confirmed using in situ soft X-ray absorption Theory-driven design of high-valence metal sites for water oxidation confirmed using in situ soft X-ray absorption, Published online: 20 November 2017; doi:10.1038/nchem.2886 Water oxidation is key to the production of chemical fuels from electricity. Now, guided by theory, NiCoFeP oxyhydroxide catalysts have been developed that require an overpotential lower than that required by IrO2. In situ soft X-ray absorption studies of neutral-pH NiCoFeP catalysts indicate formation of Ni4+, which is favourable for water oxidation.

    更新日期:2017-11-21
  • Nonribosomal biosynthesis of backbone-modified peptides
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-20
    David L. Niquille, Douglas A. Hansen, Takahiro Mori, David Fercher, Hajo Kries, Donald Hilvert

    Nonribosomal biosynthesis of backbone-modified peptides Nonribosomal biosynthesis of backbone-modified peptides, Published online: 20 November 2017; doi:10.1038/nchem.2891 Nonribosomal peptide synthetases (NRPSs) produce vital natural products but have proven recalcitrant to biosynthetic engineering. Now, a combination of yeast surface display and fluorescence activated cell sorting (FACS) has been used to reprogram an L-Phe-incorporating module for β-Phe. The resulting module is highly selective and functions efficiently in NRPS pathways.

    更新日期:2017-11-21
  • Structure-based inhibitors of tau aggregation
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-20
    P. M. Seidler, D. R. Boyer, J. A. Rodriguez, M. R. Sawaya, D. Cascio, K. Murray, T. Gonen, D. S. Eisenberg

    Structure-based inhibitors of tau aggregation Structure-based inhibitors of tau aggregation, Published online: 20 November 2017; doi:10.1038/nchem.2889 Tau aggregation is associated with Alzheimer's disease and dozens of related dementias. Now atomic structures of the aggregation-prone segment VQIINK in repeat 2 of tau have been reported. Inhibitors designed using these structures block seeding by full-length tau better than inhibitors that target the VQIVYK aggregation segment in repeat 3.

    更新日期:2017-11-21
  • A dual role for a polyketide synthase in dynemicin enediyne and anthraquinone biosynthesis
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-20
    Douglas R. Cohen, Craig A. Townsend

    A dual role for a polyketide synthase in dynemicin enediyne and anthraquinone biosynthesis A dual role for a polyketide synthase in dynemicin enediyne and anthraquinone biosynthesis, Published online: 20 November 2017; doi:10.1038/nchem.2876 The anthraquinone and enediyne halves of the antitumor antibiotic dynemicin A were previously thought to be assembled by two separate polyketide synthases (PKS). Now, a single polyketide synthase has been proposed to be responsible for their production, and a working model for their biosynthesis from a common octaketide intermediate has been suggested.

    更新日期:2017-11-21
  • Theory-driven design of high-valence metal sites for water oxidation confirmed using in situ soft X-ray absorption
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-20
    Xueli Zheng, Bo Zhang, Phil De Luna, Yufeng Liang, Riccardo Comin, Oleksandr Voznyy, Lili Han, F. Pelayo García de Arquer, Min Liu, Cao Thang Dinh, Tom Regier, James J. Dynes, Sisi He, Huolin L. Xin, Huisheng Peng, David Prendergast, Xiwen Du, Edward H. Sargent

    Theory-driven design of high-valence metal sites for water oxidation confirmed using in situ soft X-ray absorption Theory-driven design of high-valence metal sites for water oxidation confirmed using in situ soft X-ray absorption, Published online: 20 November 2017; doi:10.1038/nchem.2886 Water oxidation is key to the production of chemical fuels from electricity. Now, guided by theory, NiCoFeP oxyhydroxide catalysts have been developed that require an overpotential lower than that required by IrO2. In situ soft X-ray absorption studies of neutral-pH NiCoFeP catalysts indicate formation of Ni4+, which is favourable for water oxidation.

    更新日期:2017-11-21
  • Nonribosomal biosynthesis of backbone-modified peptides
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-20
    David L. Niquille, Douglas A. Hansen, Takahiro Mori, David Fercher, Hajo Kries, Donald Hilvert

    Nonribosomal biosynthesis of backbone-modified peptides Nonribosomal biosynthesis of backbone-modified peptides, Published online: 20 November 2017; doi:10.1038/nchem.2891 Nonribosomal peptide synthetases (NRPSs) produce vital natural products but have proven recalcitrant to biosynthetic engineering. Now, a combination of yeast surface display and fluorescence activated cell sorting (FACS) has been used to reprogram an L-Phe-incorporating module for β-Phe. The resulting module is highly selective and functions efficiently in NRPS pathways.

    更新日期:2017-11-21
  • Structure-based inhibitors of tau aggregation
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-20
    P. M. Seidler, D. R. Boyer, J. A. Rodriguez, M. R. Sawaya, D. Cascio, K. Murray, T. Gonen, D. S. Eisenberg

    Structure-based inhibitors of tau aggregation Structure-based inhibitors of tau aggregation, Published online: 20 November 2017; doi:10.1038/nchem.2889 Tau aggregation is associated with Alzheimer's disease and dozens of related dementias. Now atomic structures of the aggregation-prone segment VQIINK in repeat 2 of tau have been reported. Inhibitors designed using these structures block seeding by full-length tau better than inhibitors that target the VQIVYK aggregation segment in repeat 3.

    更新日期:2017-11-21
  • Biocatalytic site- and enantioselective oxidative dearomatization of phenols
    Nat. Chem. (IF 25.87) Pub Date : 
    Summer A. Baker Dockrey, April L. Lukowski, Marc R. Becker, Alison R. H. Narayan

    Biocatalytic site- and enantioselective oxidative dearomatization of phenols Biocatalytic site- and enantioselective oxidative dearomatization of phenols, Published online: 13 November 2017; doi:10.1038/nchem.2879 NatureArticleSnippet(type=short-summary, markup= Within natural product biosynthetic pathways, nature has evolved highly selective catalysts capable of complexity generating reactions. Leveraging these tools, a suite of catalysts with complementary site- and stereoselectivity have been applied to the oxidative dearomatization of phenolic compounds, enabling one-pot transformations of phenols into various natural products. , isJats=true)

    更新日期:2017-11-13
  • Biocatalytic site- and enantioselective oxidative dearomatization of phenols
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-13
    Summer A. Baker Dockrey, April L. Lukowski, Marc R. Becker, Alison R. H. Narayan

    Biocatalytic site- and enantioselective oxidative dearomatization of phenols Biocatalytic site- and enantioselective oxidative dearomatization of phenols, Published online: 13 November 2017; doi:10.1038/nchem.2879 NatureArticleSnippet(type=short-summary, markup= Within natural product biosynthetic pathways, nature has evolved highly selective catalysts capable of complexity generating reactions. Leveraging these tools, a suite of catalysts with complementary site- and stereoselectivity have been applied to the oxidative dearomatization of phenolic compounds, enabling one-pot transformations of phenols into various natural products. , isJats=true)

    更新日期:2017-11-13
  • Programmable autonomous synthesis of single-stranded DNA
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-06
    Jocelyn Y. Kishi, Thomas E. Schaus, Nikhil Gopalkrishnan, Feng Xuan, Peng Yin

    Programmable autonomous synthesis of single-stranded DNA Programmable autonomous synthesis of single-stranded DNA, Published online: 06 November 2017; doi:10.1038/nchem.2872 NatureArticleSnippet(type=short-summary, markup= Primer exchange reaction (PER) cascades have now been used to grow nascent single-stranded DNA with user-specified sequences following prescribed reaction pathways. PER synthesis occurs in a programmable, autonomous, in situ and environmentally responsive fashion, providing a platform for engineering molecular circuits and devices with a wide range of sensing, monitoring, recording, signal processing and actuation capabilities. , isJats=true)

    更新日期:2017-11-06
  • Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-06
    Clémentine Gibard, Subhendu Bhowmik, Megha Karki, Eun-Kyong Kim, Ramanarayanan Krishnamurthy

    Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions, Published online: 06 November 2017; doi:10.1038/nchem.2878 NatureArticleSnippet(type=short-summary, markup= Phosphorylation of (pre)biological molecules in water has been a long-sought goal in prebiotic chemistry. Now, it has been demonstrated that diamidophosphate phosphorylates nucleosides, amino acids and glycerol/fatty acids in aqueous medium, while simultaneously leading to higher-order structures such as oligonucleotides, peptides and liposomes in the same reaction mixture. , isJats=true)

    更新日期:2017-11-06
  • Direct α-C–H bond functionalization of unprotected cyclic amines
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-06
    Weijie Chen, Longle Ma, Anirudra Paul, Daniel Seidel

    Direct α-C–H bond functionalization of unprotected cyclic amines Direct α-C–H bond functionalization of unprotected cyclic amines, Published online: 06 November 2017; doi:10.1038/nchem.2871 NatureArticleSnippet(type=short-summary, markup= Cyclic amines bearing α-substituents are valuable building blocks for drug discovery and natural product synthesis. Introduction of α-substituents via site-selective replacement of C–H bonds is highly attractive but typically limited to protected amine substrates. Now, an operationally simple hydride-transfer-based approach enables the introduction of α-substituents on unprotected amines. , isJats=true)

    更新日期:2017-11-06
  • Predicting DNA hybridization kinetics from sequence
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-06
    Jinny X. Zhang, John Z. Fang, Wei Duan, Lucia R. Wu, Angela W. Zhang, Neil Dalchau, Boyan Yordanov, Rasmus Petersen, Andrew Phillips, David Yu Zhang

    Predicting DNA hybridization kinetics from sequence Predicting DNA hybridization kinetics from sequence, Published online: 06 November 2017; doi:10.1038/nchem.2877 NatureArticleSnippet(type=short-summary, markup= The rate constant of DNA hybridization varies over several orders of magnitude and is affected by temperature and DNA sequence. A machine-learning algorithm that is capable of accurately predicting hybridization rate constants has now been developed. Tests with this algorithm showed that over 90% of predictions were correct to within a factor of three. , isJats=true)

    更新日期:2017-11-06
  • Programmable autonomous synthesis of single-stranded DNA
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-06
    Jocelyn Y. Kishi, Thomas E. Schaus, Nikhil Gopalkrishnan, Feng Xuan, Peng Yin

    Programmable autonomous synthesis of single-stranded DNA Programmable autonomous synthesis of single-stranded DNA, Published online: 06 November 2017; doi:10.1038/nchem.2872 NatureArticleSnippet(type=short-summary, markup= Primer exchange reaction (PER) cascades have now been used to grow nascent single-stranded DNA with user-specified sequences following prescribed reaction pathways. PER synthesis occurs in a programmable, autonomous, in situ and environmentally responsive fashion, providing a platform for engineering molecular circuits and devices with a wide range of sensing, monitoring, recording, signal processing and actuation capabilities. , isJats=true)

    更新日期:2017-11-06
  • Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-06
    Clémentine Gibard, Subhendu Bhowmik, Megha Karki, Eun-Kyong Kim, Ramanarayanan Krishnamurthy

    Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions, Published online: 06 November 2017; doi:10.1038/nchem.2878 NatureArticleSnippet(type=short-summary, markup= Phosphorylation of (pre)biological molecules in water has been a long-sought goal in prebiotic chemistry. Now, it has been demonstrated that diamidophosphate phosphorylates nucleosides, amino acids and glycerol/fatty acids in aqueous medium, while simultaneously leading to higher-order structures such as oligonucleotides, peptides and liposomes in the same reaction mixture. , isJats=true)

    更新日期:2017-11-06
  • Direct α-C–H bond functionalization of unprotected cyclic amines
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-06
    Weijie Chen, Longle Ma, Anirudra Paul, Daniel Seidel

    Direct α-C–H bond functionalization of unprotected cyclic amines Direct α-C–H bond functionalization of unprotected cyclic amines, Published online: 06 November 2017; doi:10.1038/nchem.2871 NatureArticleSnippet(type=short-summary, markup= Cyclic amines bearing α-substituents are valuable building blocks for drug discovery and natural product synthesis. Introduction of α-substituents via site-selective replacement of C–H bonds is highly attractive but typically limited to protected amine substrates. Now, an operationally simple hydride-transfer-based approach enables the introduction of α-substituents on unprotected amines. , isJats=true)

    更新日期:2017-11-06
  • Predicting DNA hybridization kinetics from sequence
    Nat. Chem. (IF 25.87) Pub Date : 2017-11-06
    Jinny X. Zhang, John Z. Fang, Wei Duan, Lucia R. Wu, Angela W. Zhang, Neil Dalchau, Boyan Yordanov, Rasmus Petersen, Andrew Phillips, David Yu Zhang

    Predicting DNA hybridization kinetics from sequence Predicting DNA hybridization kinetics from sequence, Published online: 06 November 2017; doi:10.1038/nchem.2877 NatureArticleSnippet(type=short-summary, markup= The rate constant of DNA hybridization varies over several orders of magnitude and is affected by temperature and DNA sequence. A machine-learning algorithm that is capable of accurately predicting hybridization rate constants has now been developed. Tests with this algorithm showed that over 90% of predictions were correct to within a factor of three. , isJats=true)

    更新日期:2017-11-06
Some contents have been Reproduced with permission of the American Chemical Society.
Some contents have been Reproduced by permission of The Royal Society of Chemistry.
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