We developed a rapid and accurate biosensor to detect SARS-CoV-2 and distinguish its mutations. Benefitting from a DNA framework-modified ordered interface and a dual signal amplification strategy, our biosensor could detect SARS-CoV-2 with a detection limit down to 10 fM. It performed well on pseudo virus and SARS-CoV-2 RNA standard materials, revealing the potential application in disease diagnosis and spread, in combination with a home-made smartphone.

中文翻译：

---

基于 DNA 框架的双信号放大生物传感器，用于便携式检测 SARS-CoV-2 及其突变

我们开发了一种快速准确的生物传感器来检测 SARS-CoV-2 并区分其突变。受益于 DNA 框架修饰的有序接口和双信号放大策略，我们的生物传感器可以检测 SARS-CoV-2，检测限低至 10 fM。它在假病毒和 SARS-CoV-2 RNA 标准材料上表现良好，揭示了与自制智能手机结合在疾病诊断和传播方面的潜在应用。