Western diet is thought to increase susceptibility to inflammatory bowel disease (IBD), and probiotics are a potential therapeutic agent for IBD. This study revealed the effects of Lactobacillus plantarum AR113 and L. plantarum AR113Δbsh1 on a dextran sulfate sodium (DSS)-induced colitis mouse model under the Western diet (WD). After four weeks of WD and low-sugar and low-fat diet (LD) intervention, induction with 3% DSS, and intragastric administration of probiotics, we found that L. plantarum AR113 could regulate blood glucose and lipid levels and have a certain protective effect on hepatocytes. Our results suggested that the L. plantarum AR113 alleviated DSS-induced colitis under the Western diet by improving dyslipidemia, repairing intestinal barrier dysfunction, and inhibiting the TLR4/Myd88/TRAF-6/NF-κB inflammatory pathway. However, these changes were not demonstrated in the L. plantarum AR113Δbsh1, and therefore, we reasoned that the presence of bsh1 may play a crucial role in the L. plantarum AR113 exerting its anti-inflammatory function. The relationship between bile salt hydrolase (BSH) and colitis was worthy of further exploration.

中文翻译：

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植物乳杆菌AR113的bsh1基因在改善西方饮食加重的结肠炎中发挥重要作用

西方饮食被认为会增加炎症性肠病 (IBD) 的易感性，而益生菌是 IBD 的潜在治疗剂。本研究揭示了植物乳杆菌AR113 和植物乳杆菌AR113Δ bsh 1 对西方饮食 (WD) 下葡聚糖硫酸钠 (DSS) 诱导的结肠炎小鼠模型的影响。经过4周的WD和低糖低脂饮食（LD）干预、3% DSS诱导以及益生菌灌胃后，我们发现植物乳杆菌AR113可以调节血糖和血脂水平，并具有一定的保护作用。对肝细胞的作用。我们的结果表明，植物乳杆菌AR113通过改善血脂异常、修复肠道屏障功能障碍和抑制TLR4/Myd88/TRAF-6/NF-κB炎症通路来缓解西方饮食下DSS诱导的结肠炎。然而，这些变化在植物乳杆菌AR113Δ bsh 1中并未得到证实，因此，我们推断bsh 1的存在可能在植物乳杆菌AR113发挥其抗炎功能中发挥着至关重要的作用。胆盐水解酶（BSH）与结肠炎之间的关系值得进一步探讨。