The discovery and identification of targets is of far-reaching significance for developing novel pesticide candidates and increasing the probability of success. To explore and identify highly effective tobacco mosaic virus (TMV) helicase-targeted lead structures, a series of novel phosphonate derivatives containing a 1,2,3-triazole motif were rationally engineered and their antiviral activity was assessed.

中文翻译：

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发现含有不同取代的 1,2,3-三唑基序的膦酸酯衍生物作为有前景的烟草花叶病毒 (TMV) 解旋酶抑制剂，用于控制植物病毒病

靶标的发现和识别对于开发新型候选农药和提高成功概率具有深远的意义。为了探索和鉴定高效的烟草花叶病毒（TMV）解旋酶靶向先导结构，合理设计了一系列含有1,2,3-三唑基序的新型膦酸酯衍生物，并评估了它们的抗病毒活性。