Proliferative cells require excess cholesterol to support rapid membrane biogenesis. Using a mutant KRAS mouse model of non-small cell lung cancer, Guilbaud et al. show that lung cancers accumulate cholesterol by locally and distally reprogramming lipid trafficking and that cholesterol-removing interventions may hold promise as a therapeutic strategy.

中文翻译：

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我们需要谈谈肺癌的胆固醇囤积问题

增殖细胞需要过量的胆固醇来支持快速的膜生物发生。Guilbaud 等人使用非小细胞肺癌的突变 KRAS 小鼠模型。表明肺癌通过局部和远端重新编程脂质运输来积累胆固醇，并且去除胆固醇的干预措施可能有望成为一种治疗策略。