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Total Synthesis of Thiamyxins A–C and Thiamyxin E, a Potent Class of RNA-Virus-Inhibiting (Cyclo)depsipeptides
Angewandte Chemie International Edition ( IF 16.6 ) Pub Date : 2023-05-31 , DOI: 10.1002/anie.202305445 Kevin Bauer 1 , Uli Kazmaier 1
Angewandte Chemie International Edition ( IF 16.6 ) Pub Date : 2023-05-31 , DOI: 10.1002/anie.202305445 Kevin Bauer 1 , Uli Kazmaier 1
Affiliation
A first total synthesis of thiamyxins A–C and E, an interesting group of natural products with antiviral activity and an acid-labile C2 exomethine position, is described. Overcoming the problem of inseparable diastereomers of the open-chain variants, thiamyxin C and E were obtained by opening the cyclic thiamyxins A and B.
中文翻译:
硫霉素 A–C 和硫霉素 E(一类有效的 RNA 病毒抑制(环)缩酚肽)的全合成
描述了硫霉素 A-C 和 E 的首次全合成,这是一组有趣的天然产物,具有抗病毒活性和酸不稳定的 C2 外甲氨酸位置。克服了开链变体不可分离的非对映异构体的问题,通过打开环状硫霉素A和B获得了硫霉素C和E。
更新日期:2023-05-31
中文翻译:
硫霉素 A–C 和硫霉素 E(一类有效的 RNA 病毒抑制(环)缩酚肽)的全合成
描述了硫霉素 A-C 和 E 的首次全合成,这是一组有趣的天然产物,具有抗病毒活性和酸不稳定的 C2 外甲氨酸位置。克服了开链变体不可分离的非对映异构体的问题,通过打开环状硫霉素A和B获得了硫霉素C和E。