Objective

A large body of literature has noted detrimental effects of childhood adversity on young adult behavioral health, yet few studies have assessed how early childhood adversity influences the development of alcohol and cannabis co-use.

Method

In the present study we use data from an ongoing longitudinal cohort (N = 2507) to understand how early childhood adversity influences transitions into alcohol and cannabis co-use trajectories. We also explore how sex, depression, and anxiety are associated with transition probabilities. We used latent transition analysis to examine transitions from emergent childhood adversity classes to classes of parallel alcohol and cannabis co-use from ages 17 to 24 years.

Results

Those who reported high levels of childhood adversity were more likely to transition into classes with relatively chronic and rapidly increasing alcohol and cannabis co-use during young adulthood. Young adults who both experienced high levels of childhood adversity and transitioned into increasing alcohol and cannabis co- use trajectories were more likely to be male and meet clinical cutoff for depression.

Conclusion

Our results indicate an incrementally more nuanced set of risk profiles, with differential risk of alcohol and cannabis co-use trajectories, dependent on one's experience of childhood adversity.

Public health significance

Results of the present study note important heterogeneity in alcohol and cannabis co-use throughout young adulthood, with general trends showing increases in co-use. The present study also shows differential risk of alcohol and cannabis co-use dependent on prior experience of childhood adversity.

中文翻译：

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童年逆境以及酒精和大麻共同使用的发展轨迹

客观的

大量文献指出童年时期的逆境对年轻人行为健康的不利影响，但很少有研究评估童年时期的逆境如何影响酒精和大麻共同使用的发展。

方法

在本研究中，我们使用来自正在进行的纵向队列（N  = 2507）的数据来了解幼儿期逆境如何影响向酒精和大麻共同使用轨迹的转变。我们还探讨了性、抑郁和焦虑与转变概率的关系。我们使用潜在转变分析来研究 17 至 24 岁从紧急童年逆境类别到平行酒精和大麻共同使用类别的转变。

结果

那些自称童年时期经历过严重逆境的人更有可能进入在成年早期酒精和大麻混合使用相对长期且迅速增加的班级。经历过严重童年逆境并逐渐酗酒和吸食大麻的年轻人更有可能是男性，并且符合抑郁症的临床临界值。

结论

我们的研究结果表明，风险状况逐渐变得更加细致，酒精和大麻共同使用的风险轨迹有所不同，具体取决于一个人童年逆境的经历。

公共卫生意义

本研究的结果指出，整个青年期酒精和大麻的共同使用存在重要的异质性，总体趋势显示共同使用有所增加。本研究还表明，酒精和大麻共同使用的风险存在差异，具体取决于先前的童年逆境经历。