Secondary organic aerosols (SOAs) have emerged recently as a major component of fine particulate matter. Cell culture studies revealed a role for SOAs in cell oxidative stress, toxicity and inflammation and only a few studies investigated short-term SOA exposure in animal models. Here, mice were chronically exposed to naphthalene-derived SOAs for one and two months. Weight monitoring indicated a marked mass loss, especially in females, following chronic exposure to SOAs. Significantly, a cytokine antibody microarray approach revealed SOA-induced abnormal lung inflammation similar to that seen in cigarette smoke-induced chronic obstructive pulmonary disease (COPD). This in vivo study testifies to the pathogenic role of sub-chronic SOA exposure on human health.

中文翻译：

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长期暴露于二次有机气溶胶的小鼠体重减轻和肺部异常炎症

二次有机气溶胶 (SOA) 最近已成为细颗粒物的主要成分。细胞培养研究揭示了 SOA 在细胞氧化应激、毒性和炎症中的作用，只有少数研究调查了动物模型中的短期 SOA 暴露。在这里，老鼠长期暴露在萘衍生的 SOA 中一两个月。体重监测表明，在长期接触 SOA 后体重明显下降，尤其是女性。值得注意的是，细胞因子抗体微阵列方法揭示了 SOA 诱导的异常肺部炎症，类似于香烟烟雾诱导的慢性阻塞性肺病 (COPD)。这项体内研究证明了亚慢性 SOA 暴露对人类健康的致病作用。