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Overcoming BRAF and CDK4/6 inhibitor resistance by inhibiting MAP3K3-dependent protection against YAP lysosomal degradation Exp. Mol. Med. (IF 12.8) Pub Date : 2024-04-16 Sanghyun Park, Won-Ji Ryu, Tae Yeong Kim, Yumi Hwang, Hyun Ju Han, Jeong Dong Lee, Gun Min Kim, Joohyuk Sohn, Sang Kyum Kim, Min Hwan Kim, Joon Kim
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Loss of SREBP-1c ameliorates iron-induced liver fibrosis by decreasing lipocalin-2 Exp. Mol. Med. (IF 12.8) Pub Date : 2024-04-16 Eun-Ho Lee, Jae-Ho Lee, Do-Young Kim, Young-Seung Lee, Yunju Jo, Tam Dao, Kyung Eun Kim, Dae-Kyu Song, Ji Hae Seo, Young-Kyo Seo, Je Kyung Seong, Changjong Moon, Eugene Han, Mi Kyung Kim, Seungwan Ryu, Minsang Shin, Gu Seob Roh, Hye Ra Jung, Timothy F. Osborne, Dongryeol Ryu, Tae-Il Jeon, Seung-Soon Im
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Central neurocytoma exhibits radial glial cell signatures with FGFR3 hypomethylation and overexpression Exp. Mol. Med. (IF 12.8) Pub Date : 2024-04-12 Yeajina Lee, Tamrin Chowdhury, Sojin Kim, Hyeon Jong Yu, Kyung-Min Kim, Ho Kang, Min-Sung Kim, Jin Wook Kim, Yong-Hwy Kim, So Young Ji, Kihwan Hwang, Jung Ho Han, Jinha Hwang, Seong-Keun Yoo, Kyu Sang Lee, Gheeyoung Choe, Jae-Kyung Won, Sung-Hye Park, Yong Kyu Lee, Joo Heon Shin, Chul-Kee Park, Chae-Yong Kim, Jong-Il Kim
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Regulation of cargo selection in exosome biogenesis and its biomedical applications in cancer Exp. Mol. Med. (IF 12.8) Pub Date : 2024-04-05 Yu Jin Lee, Kyeong Jin Shin, Young Chan Chae
Extracellular vesicles (EVs), including exosomes, are increasingly recognized as potent mediators of intercellular communication due to their capacity to transport a diverse array of bioactive molecules. They assume vital roles in a wide range of physiological and pathological processes and hold significant promise as emerging disease biomarkers, therapeutic agents, and carriers for drug delivery.
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Entosis: the core mechanism and crosstalk with other cell death programs Exp. Mol. Med. (IF 12.8) Pub Date : 2024-04-02 Sunghoon Kim, Donghyuk Lee, Sung Eun Kim, Michael Overholtzer
Cell death pathways play critical roles in organism development and homeostasis as well as in the pathogenesis of various diseases. While studies over the last decade have elucidated numerous different forms of cell death that can eliminate cells in various contexts, how certain mechanisms impact physiology is still not well understood. Moreover, recent studies have shown that multiple forms cell death
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Transmembrane proteins with unknown function (TMEMs) as ion channels: electrophysiological properties, structure, and pathophysiological roles Exp. Mol. Med. (IF 12.8) Pub Date : 2024-04-01 Hyunji Kang, C. Justin Lee
A transmembrane (TMEM) protein with an unknown function is a type of membrane-spanning protein expressed in the plasma membrane or the membranes of intracellular organelles. Recently, several TMEM proteins have been identified as functional ion channels. The structures and functions of these proteins have been extensively studied over the last two decades, starting with TMEM16A (ANO1). In this review
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Methyl-CpG binding domain protein 2 (Mbd2) drives breast cancer progression through the modulation of epithelial-to-mesenchymal transition Exp. Mol. Med. (IF 12.8) Pub Date : 2024-04-01 Niaz Mahmood, Ani Arakelian, Moshe Szyf, Shafaat A. Rabbani
Methyl-CpG-binding domain protein 2 (Mbd2), a reader of DNA methylation, has been implicated in different types of malignancies, including breast cancer. However, the exact role of Mbd2 in various stages of breast cancer growth and progression in vivo has not been determined. To test whether Mbd2 plays a causal role in mammary tumor growth and metastasis, we performed genetic knockout (KO) of Mbd2
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Recent advances in CRISPR-based functional genomics for the study of disease-associated genetic variants Exp. Mol. Med. (IF 12.8) Pub Date : 2024-04-01 Heon Seok Kim, Jiyeon Kweon, Yongsub Kim
Advances in sequencing technology have greatly increased our ability to gather genomic data, yet understanding the impact of genetic mutations, particularly variants of uncertain significance (VUSs), remains a challenge in precision medicine. The CRISPR‒Cas system has emerged as a pivotal tool for genome engineering, enabling the precise incorporation of specific genetic variations, including VUSs
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Cargo specificity, regulation, and therapeutic potential of cytoplasmic dynein Exp. Mol. Med. (IF 12.8) Pub Date : 2024-04-01 Jin-Gyeong Park, Hanul Jeon, Kwang Yeon Hwang, Sun-Shin Cha, Rafael T. Han, Hyesung Cho, In-Gyun Lee
Intracellular retrograde transport in eukaryotic cells relies exclusively on the molecular motor cytoplasmic dynein 1. Unlike its counterpart, kinesin, dynein has a single isoform, which raises questions about its cargo specificity and regulatory mechanisms. The precision of dynein-mediated cargo transport is governed by a multitude of factors, including temperature, phosphorylation, the microtubule
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Transcriptome-based deep learning analysis identifies drug candidates targeting protein synthesis and autophagy for the treatment of muscle wasting disorder Exp. Mol. Med. (IF 12.8) Pub Date : 2024-04-01 Min Hak Lee, Bada Lee, Se Eun Park, Ga Eul Yang, Seungwoo Cheon, Dae Hoon Lee, Sukyeong Kang, Ye Ji Sun, Yongjin Kim, Dong-sub Jung, Wonwoo Kim, Jihoon Kang, Yi Rang Kim, Jin Woo Choi
Sarcopenia, the progressive decline in skeletal muscle mass and function, is observed in various conditions, including cancer and aging. The complex molecular biology of sarcopenia has posed challenges for the development of FDA-approved medications, which have mainly focused on dietary supplementation. Targeting a single gene may not be sufficient to address the broad range of processes involved in
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Ceramide kinase-mediated C1P metabolism attenuates acute liver injury by inhibiting the interaction between KEAP1 and NRF2 Exp. Mol. Med. (IF 12.8) Pub Date : 2024-04-01 Wei Dong, Qing Li, Xing Lu, Jianfeng Lan, Zhidong Qiu, Xuehong Wang, Junnan Wang, Xiaojiao Zheng, Sifan Chen, Chong Zhang, Junfei Jin
Acute liver injury is the basis of the pathogenesis of diverse liver diseases. However, the mechanism underlying liver injury is complex and not completely understood. In our study, we revealed that CERK, which phosphorylates ceramide to produce ceramide-1-phosphate (C1P), was the sphingolipid pathway-related protein that had the most significantly upregulated expression during acute liver injury.
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Age-dependent loss of Crls1 causes myopathy and skeletal muscle regeneration failure Exp. Mol. Med. (IF 12.8) Pub Date : 2024-04-01 Youngbum Yoo, MyeongHoon Yeon, Won-Kyung Kim, Hyeon-Bin Shin, Seung-Min Lee, Mee-Sup Yoon, Hyunju Ro, Young-Kyo Seo
Skeletal muscle aging results in the gradual suppression of myogenesis, leading to muscle mass loss. However, the specific role of cardiolipin in myogenesis has not been determined. This study investigated the crucial role of mitochondrial cardiolipin and cardiolipin synthase 1 (Crls1) in age-related muscle deterioration and myogenesis. Our findings demonstrated that cardiolipin and Crls1 are downregulated
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Recent advances in extracellular vesicles for therapeutic cargo delivery Exp. Mol. Med. (IF 12.8) Pub Date : 2024-04-01 Hyo In Kim, Jinbong Park, Yin Zhu, Xiaoyun Wang, Yohan Han, Duo Zhang
Exosomes, which are nanosized vesicles secreted by cells, are attracting increasing interest in the field of biomedical research due to their unique properties, including biocompatibility, cargo loading capacity, and deep tissue penetration. They serve as natural signaling agents in intercellular communication, and their inherent ability to carry proteins, lipids, and nucleic acids endows them with
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The acute phase reactant orosomucoid-2 directly promotes rheumatoid inflammation Exp. Mol. Med. (IF 12.8) Pub Date : 2024-04-01 Ki-Myo Kim, Kang-Gu Lee, Saseong Lee, Bong-Ki Hong, Heejae Yun, Yune-Jung Park, Seung-Ah Yoo, Wan-Uk Kim
Acute phase proteins involved in chronic inflammatory diseases have not been systematically analyzed. Here, global proteome profiling of serum and urine revealed that orosomucoid-2 (ORM2), an acute phase reactant, was differentially expressed in rheumatoid arthritis (RA) patients and showed the highest fold change. Therefore, we questioned the extent to which ORM2, which is produced mainly in the liver
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Experimental capture of miRNA targetomes: disease-specific 3′UTR library-based miRNA targetomics for Parkinson’s disease Exp. Mol. Med. (IF 12.8) Pub Date : 2024-04-01 Martin Hart, Fabian Kern, Claudia Fecher-Trost, Lena Krammes, Ernesto Aparicio, Annika Engel, Pascal Hirsch, Viktoria Wagner, Verena Keller, Georges Pierre Schmartz, Stefanie Rheinheimer, Caroline Diener, Ulrike Fischer, Jens Mayer, Markus R. Meyer, Veit Flockerzi, Andreas Keller, Eckart Meese
The identification of targetomes remains a challenge given the pleiotropic effect of miRNAs, the limited effects of miRNAs on individual targets, and the sheer number of estimated miRNA–target gene interactions (MTIs), which is around 44,571,700. Currently, targetome identification for single miRNAs relies on computational evidence and functional studies covering smaller numbers of targets. To ensure
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Extracellular vesicle-mediated transfer of miRNA-1 from primary tumors represses the growth of distant metastases Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-27 Chae-Yi Kim, Kang-Hoon Lee, Keun Hong Son, Tae-Jin Shin, Je-Yoel Cho
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Involvement of DJ-1 in the pathogenesis of intervertebral disc degeneration via hexokinase 2-mediated mitophagy Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-27 Jialiang Lin, Longjie Wang, Yuhao Wu, Qian Xiang, Yongzhao Zhao, Xuanqi Zheng, Shuai Jiang, Zhuoran Sun, Dongwei Fan, Weishi Li
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Acetyl-CoA synthetase 2 contributes to a better prognosis for liver cancer by switching acetate-glucose metabolism Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-25 Kyung Hee Jung, Sujin Lee, Han Sun Kim, Jin-Mo Kim, Yun Ji Lee, Min Seok Park, Myeong-Seong Seo, Misu Lee, Mijin Yun, Sunghyouk Park, Soon-Sun Hong
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Cancer-derived exosomal Alu RNA promotes colorectal cancer progression Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-14 Sara Magliacane Trotta, Antonio Adinolfi, Luca D’Orsi, Sonia Panico, Grazia Mercadante, Patrick Mehlen, Jayakrishna Ambati, Sandro De Falco, Valeria Tarallo
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Prmt7 regulates the JAK/STAT/Socs3 signaling pathway in postmenopausal cardiomyopathy Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-14 Byeong-Yun Ahn, Yan Zhang, Shibo Wei, Yideul Jeong, Dong-Hyun Park, Sang-Jin Lee, Young-Eun Leem, Jong-Sun Kang
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Dysregulated CREB3 cleavage at the nuclear membrane induces karyoptosis-mediated cell death Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-13 Ga-Eun Lee, Geul Bang, Jiin Byun, Cheol-Jung Lee, Weidong Chen, Dohyun Jeung, Hyun-Jung An, Han Chang Kang, Joo Young Lee, Hye Suk Lee, Young-Soo Hong, Dae Joon Kim, Megan Keniry, Jin Young Kim, Jin-Sung Choi, Manolis Fanto, Sung-Jun Cho, Kwang-Dong Kim, Yong-Yeon Cho
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Immunopathology of and potential therapeutics for secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome: a translational perspective Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-06 Tram T. T. Nguyen, Yoon Tae Kim, Geunyeol Jeong, Mirim Jin
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The Mst1/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-05 Dae Jin Jeong, Jee-Hyun Um, Young Yeon Kim, Dong Jin Shin, Sangwoo Im, Kang-Min Lee, Yun-Hee Lee, Dae-sik Lim, Donghoon Kim, Jeanho Yun
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Rebuilding the microenvironment of primary tumors in humans: a focus on stroma Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-05 Siwon Mun, Hyun Jin Lee, Pilnam Kim
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SIRT1 ISGylation accelerates tumor progression by unleashing SIRT1 from the inactive state to promote its deacetylase activity Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-05 Ji An Kang, Yoon Jung Kim, Kyu Yun Jang, Hye Won Moon, Haeseung Lee, Seonjeong Lee, Hyun Kyu Song, Sang Woo Cho, Yoon Sun Yoo, Hye Gyeong Han, Min-Ju Kim, Myoung Ja Chung, Cheol Yong Choi, Cheolju Lee, Chaeuk Chung, Gang Min Hur, You-Sun Kim, Young Joo Jeon
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Extramedullary hematopoiesis in cancer Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-05 Derek A. G. Barisas, Kyunghee Choi
Hematopoiesis can occur outside of the bone marrow during inflammatory stress to increase the production of primarily myeloid cells at extramedullary sites; this process is known as extramedullary hematopoiesis (EMH). As observed in a broad range of hematologic and nonhematologic diseases, EMH is now recognized for its important contributions to solid tumor pathology and prognosis. To initiate EMH
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Advances in single-cell omics and multiomics for high-resolution molecular profiling Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-05 Jongsu Lim, Chanho Park, Minjae Kim, Hyukhee Kim, Junil Kim, Dong-Sung Lee
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Advances in cancer DNA methylation analysis with methPLIER: use of non-negative matrix factorization and knowledge-based constraints to enhance biological interpretability Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-04 Ken Takasawa, Ken Asada, Syuzo Kaneko, Kouya Shiraishi, Hidenori Machino, Satoshi Takahashi, Norio Shinkai, Nobuji Kouno, Kazuma Kobayashi, Masaaki Komatsu, Takaaki Mizuno, Yu Okubo, Masami Mukai, Tatsuya Yoshida, Yukihiro Yoshida, Hidehito Horinouchi, Shun-Ichi Watanabe, Yuichiro Ohe, Yasushi Yatabe, Takashi Kohno, Ryuji Hamamoto
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Intestinal stem cells: guardians of homeostasis in health and aging amid environmental challenges Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-01 Jiahn Choi, Leonard H. Augenlicht
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RNA m5C modification upregulates E2F1 expression in a manner dependent on YBX1 phase separation and promotes tumor progression in ovarian cancer Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-01 Xiaoyi Liu, Qinglv Wei, Chenyue Yang, Hongyan Zhao, Jie Xu, Youchaou Mobet, Qingya Luo, Dan Yang, Xinzhao Zuo, Ningxuan Chen, Yu Yang, Li Li, Wei Wang, Jianhua Yu, Jing Xu, Tao Liu, Ping Yi
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Synergistic toxicity with copper contributes to NAT2-associated isoniazid toxicity Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-01 Jihoon G. Yoon, Dong Geon Jang, Sung-Gyu Cho, Chaeyoung Lee, Shin Hye Noh, Soo Kyung Seo, Jung Woo Yu, Hyeon Woo Chung, KyeoRe Han, Soon Sung Kwon, Dai Hoon Han, Jaeseong Oh, In-Jin Jang, Sang-Hoon Kim, Young-Koo Jee, Hyun Lee, Dong Won Park, Jang Won Sohn, Ho Joo Yoon, Chul Hoon Kim, Jae Myun Lee, Sang-Heon Kim, Min Goo Lee
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IL-27-induced PD-L1highSca-1+ innate lymphoid cells suppress contact hypersensitivity in an IL-10-dependent manner Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-01 Keun Young Min, Do-Kyun Kim, Min Geun Jo, min Yeong Choi, Dajeong Lee, Jeong Won Park, Young-Jun Park, Yeonseok Chung, Young Mi Kim, Yeong-Min Park, Hyuk Soon Kim, Wahn Soo Choi
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Hypoxia, oxidative stress, and the interplay of HIFs and NRF2 signaling in cancer Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-01 Taegeun Bae, Steffanus Pranoto Hallis, Mi-Kyoung Kwak
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Mechanical overload-induced release of extracellular mitochondrial particles from tendon cells leads to inflammation in tendinopathy Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-01 Ziming Chen, Mengyuan Li, Peilin Chen, Andrew Tai, Jiayue Li, Euphemie Landao Bassonga, Junjie Gao, Delin Liu, David Wood, Brendan F. Kennedy, Qiujian Zheng, Ming H. Zheng
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Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-01 Sheng Yang, JiaJun Xie, ZhiJie Pan, HongMei Guan, YueSheng Tu, YuanJian Ye, ShouBin Huang, ShiQiang Fu, KangXian Li, ZhiWei Huang, XiaoQi Li, ZhanJun Shi, Le Li, Yang Zhang
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Role of lung ornithine aminotransferase in idiopathic pulmonary fibrosis: regulation of mitochondrial ROS generation and TGF-β1 activity Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-28 Jong-Uk Lee, Ki Sung Song, Jisu Hong, Hyesun Shin, Eunji Park, Junyeong Baek, Shinhee Park, Ae-Rin Baek, Junehyuk Lee, An Soo Jang, Do Jin Kim, Su Sie Chin, U-Jin Kim, Sung Hwan Jeong, Sung-Woo Park
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Cost and time-efficient construction of a 3′-end mRNA library from unpurified bulk RNA in a single tube Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-27 Jungwon Choi, Jungheun Hyun, Jieun Hyun, Jae-Hee Kim, Ji Hyun Lee, Duhee Bang
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NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-27 Hye Yeon Choi, Yicheng Zhu, Xuyao Zhao, Simran Mehta, Juan Carlos Hernandez, Jae-Jin Lee, Yi Kou, Risa Machida, Mauro Giacca, Giannino Del Sal, Ratna Ray, Hyungjin Eoh, Stanley M. Tahara, Lin Chen, Hidekazu Tsukamoto, Keigo Machida
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Baf-mediated transcriptional regulation of teashirt is essential for the development of neural progenitor cell lineages Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-19 Byung Su Ko, Myeong Hoon Han, Min Jee Kwon, Dong Gon Cha, Yuri Ji, Eun Seo Park, Min Jae Jeon, Somi Kim, Kyeongho Lee, Yoon Ha Choi, Jusung Lee, Monica Torras-Llort, Ki-Jun Yoon, Hyosang Lee, Jong Kyoung Kim, Sung Bae Lee
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Helicobacter pylori CagA-mediated ether lipid biosynthesis promotes ferroptosis susceptibility in gastric cancer Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-21 Yanmei Peng, Xuetao Lei, Qingbin Yang, Guofan Zhang, Sixiao He, Minghao Wang, Ruoyu Ling, Boyang Zheng, Jiayong He, Xinhua Chen, Fengping Li, Qiming Zhou, Liying Zhao, Gengtai Ye, Guoxin Li
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Distinct characteristics of the DNA damage response in mammalian oocytes Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-14 Jiyeon Leem, Crystal Lee, Da Yi Choi, Jeong Su Oh
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Emerging roles of MITF as a crucial regulator of immunity Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-13 Aram Lee, Jihyun Lim, Jong-Seok Lim
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Acid sphingomyelinase as a pathological and therapeutic target in neurological disorders: focus on Alzheimer’s disease Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-09 Byung Jo Choi, Min Hee Park, Hee Kyung Jin, Jae-sung Bae
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Nucleus pulposus cells regulate macrophages in degenerated intervertebral discs via the integrated stress response-mediated CCL2/7-CCR2 signaling pathway Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-05 Shuo Tian, Xuanzuo Chen, Wei Wu, Hui Lin, Xiangcheng Qing, Sheng Liu, BaiChuan Wang, Yan Xiao, Zengwu Shao, Yizhong Peng
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The deubiquitinase USP40 preserves endothelial integrity by targeting the heat shock protein HSP90β Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-02 Jiaxing Miao, Lian Li, Nargis Shaheen, Jianxin Wei, Anastasia M. Jacko, Prithu Sundd, Sarah J. Taleb, Rama K. Mallampalli, Yutong Zhao, Jing Zhao
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Regulation of autophagy by perilysosomal calcium: a new player in β-cell lipotoxicity Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-01 Ha Thu Nguyen, Andreas Wiederkehr, Claes B. Wollheim, Kyu-Sang Park
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Role of UPF1 in lncRNA-HEIH regulation for hepatocellular carcinoma therapy Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-01 Hyunho Cha, Minwoo Kim, Narae Ahn, Seong Dong Jeong, Elizaveta Ignatova, Sung Wook Chi, Hyeon Ho Kim, Jungwook Hwang
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Exploring the potential of Toxoplasma gondii in drug development and as a delivery system Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-01 Chanjin Yoon, Yu Seong Ham, Woo Jin Gil, Chul-Su Yang
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Synaptotagmin-4 induces anhedonic responses to chronic stress via BDNF signaling in the medial prefrontal cortex Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-01 Jeongseop Kim, Sihwan Seol, Tae-Eun Kim, Joonhee Lee, Ja Wook Koo, Hyo Jung Kang
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Cathepsin D promotes polarization of tumor-associated macrophages and metastasis through TGFBI-CCL20 signaling Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-01 Seul Gi Lee, Seon Min Woo, Seung Un Seo, Chan-Hyeong Lee, Moon-Chang Baek, Se Hwan Jang, Zee Yong Park, Simmyung Yook, Ju-Ock Nam, Taeg Kyu Kwon
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Targeting the m6A RNA methyltransferase METTL3 attenuates the development of kidney fibrosis Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-01 Hae Rim Jung, Jeonghwan Lee, Seung-Pyo Hong, Nayeon Shin, Ara Cho, Dong-Jin Shin, Jin Woo Choi, Jong-Il Kim, Jung Pyo Lee, Sung-Yup Cho
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Unraveling the intricacies of osteoclast differentiation and maturation: insight into novel therapeutic strategies for bone-destructive diseases Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-01 Noriko Takegahara, Hyunsoo Kim, Yongwon Choi
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HIRA vs. DAXX: the two axes shaping the histone H3.3 landscape Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-01 Jinmi Choi, Taewan Kim, Eun-Jung Cho
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Deficiency of circadian clock gene Bmal1 exacerbates noncanonical inflammasome-mediated pyroptosis and lethality via Rev-erbα-C/EBPβ-SAA1 axis Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-01 Do-Wan Shim, Jun-Cheol Eo, Saeyoung Kim, Inhwa Hwang, BoYoung Nam, Jae-Eun Shin, Seung Hyeok Han, Je-Wook Yu
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CYB5R3 functions as a tumor suppressor by inducing ER stress-mediated apoptosis in lung cancer cells via the PERK-ATF4 and IRE1α-JNK pathways Exp. Mol. Med. (IF 12.8) Pub Date : 2024-01-22 Joo-Young Im, Soo Jin Kim, Jong-Lyul Park, Tae-Hee Han, Woo-il Kim, Inhyub Kim, Bomin Ko, So-Young Chun, Mi-Jung Kang, Bo-Kyung Kim, Sol A. Jeon, Seon-Kyu Kim, Incheol Ryu, Seon-Young Kim, Ki-Hoan Nam, Inah Hwang, Hyun Seung Ban, Misun Won
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PRKCSH contributes to TNFSF resistance by extending IGF1R half-life and activation in lung cancer Exp. Mol. Med. (IF 12.8) Pub Date : 2024-01-10 Gu-Choul Shin, Hyeong Min Lee, Nayeon Kim, Sang-Uk Seo, Kwang Pyo Kim, Kyun-Hwan Kim
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The multifaceted functions of β-arrestins and their therapeutic potential in neurodegenerative diseases Exp. Mol. Med. (IF 12.8) Pub Date : 2024-01-11 Teresa R. Kee, Sophia A. Khan, Maya B. Neidhart, Brianna M. Masters, Victoria K. Zhao, Yenna K. Kim, Kyle C. McGill Percy, Jung-A A. Woo
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Maintaining Drosha expression with Cdk5 inhibitors as a potential therapeutic strategy for early intervention after TBI Exp. Mol. Med. (IF 12.8) Pub Date : 2024-01-10 Lu Huang, Li Xia, Tiejian Nie, Bozhou Cui, Jianjun Lu, Fangfang Lu, Feiyan Fan, Dongni Ren, Yuan Lu, Guodong Gao, Qian Yang
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The polyol pathway and nuclear ketohexokinase A signaling drive hyperglycemia-induced metastasis of gastric cancer Exp. Mol. Med. (IF 12.8) Pub Date : 2024-01-10 Ye-Lim Kang, Jiyoung Kim, Su-Bin Kwak, Yi-Sook Kim, June Huh, Jong-Wan Park
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Effects of fine particulate matter on bone marrow-conserved hematopoietic and mesenchymal stem cells: a systematic review Exp. Mol. Med. (IF 12.8) Pub Date : 2024-01-10 Govinda Bhattarai, Saroj Kumar Shrestha, Hyun-Jaung Sim, Jeong-Chae Lee, Sung-Ho Kook