-
Abdominal CT metrics in 17,646 patients reveal associations between myopenia, myosteatosis, and medical phenotypes: a phenome-wide association study EBioMedicine (IF 11.1) Pub Date : 2024-04-17 Juan M. Zambrano Chaves, Leon Lenchik, Isabel O. Gallegos, Louis Blankemeier, Tie Liang, Daniel L. Rubin, Marc H. Willis, Akshay S. Chaudhari, Robert D. Boutin
Deep learning facilitates large-scale automated imaging evaluation of body composition. However, associations of body composition biomarkers with medical phenotypes have been underexplored. Phenome-wide association study (PheWAS) techniques search for medical phenotypes associated with biomarkers. A PheWAS integrating large-scale analysis of imaging biomarkers and electronic health record (EHR) data
-
The increasing use of T-cell stimulation for successful dengue vaccination EBioMedicine (IF 11.1) Pub Date : 2024-04-10 eBioMedicine
-
Using generative AI to investigate medical imagery models and datasets EBioMedicine (IF 11.1) Pub Date : 2024-04-01 Oran Lang, Doron Yaya-Stupp, Ilana Traynis, Heather Cole-Lewis, Chloe R. Bennett, Courtney R. Lyles, Charles Lau, Michal Irani, Christopher Semturs, Dale R. Webster, Greg S. Corrado, Avinatan Hassidim, Yossi Matias, Yun Liu, Naama Hammel, Boris Babenko
-
A single-cell characterised signature integrating heterogeneity and microenvironment of lung adenocarcinoma for prognostic stratification EBioMedicine (IF 11.1) Pub Date : 2024-03-28 Jiachen Xu, Yundi Zhang, Man Li, Zhuo Shao, Yiting Dong, Qingqing Li, Hua Bai, Jianchun Duan, Jia Zhong, Rui Wan, Jing Bai, Xin Yi, Fuchou Tang, Jie Wang, Zhijie Wang
The high heterogeneity of tumour and the complexity of tumour microenvironment (TME) greatly impacted the tumour development and the prognosis of cancer in the era of immunotherapy. In this study, we aimed to portray the single cell-characterised landscape of lung adenocarcinoma (LUAD), and develop an integrated signature incorporating both tumour heterogeneity and TME for prognosis stratification
-
Acute and two-week effects of neotame, stevia rebaudioside M and sucrose-sweetened biscuits on postprandial appetite and endocrine response in adults with overweight/obesity—a randomised crossover trial from the SWEET consortium EBioMedicine (IF 11.1) Pub Date : 2024-03-28 Catherine Gibbons, Kristine Beaulieu, Eva Almiron-Roig, Santiago Navas-Carretero, J. Alfredo Martínez, Beverley O’Hara, Dominic O’Connor, Julie-Anne Nazare, Alain Le Bail, Cécile Rannou, Charlotte Hardman, Moon Wilton, Louise Kjølbæk, Corey Scott, Hariklia Moshoyiannis, Anne Raben, Joanne A. Harrold, Jason C.G. Halford, Graham Finlayson
Sweeteners and sweetness enhancers (S&SE) are used to replace energy yielding sugars and maintain sweet taste in a wide range of products, but controversy exists about their effects on appetite and endocrine responses in reduced or no added sugar solid foods. The aim of the current study was to evaluate the acute (1 day) and repeated (two-week daily) ingestive effects of 2 S&SE vs. sucrose formulations
-
A personalized medicine approach identifies enasidenib as an efficient treatment for IDH2 mutant chondrosarcoma EBioMedicine (IF 11.1) Pub Date : 2024-03-27 Verónica Rey, Juan Tornín, Juan Jose Alba-Linares, Cristina Robledo, Dzohara Murillo, Aida Rodríguez, Borja Gallego, Carmen Huergo, Cristina Viera, Alejandro Braña, Aurora Astudillo, Dominique Heymann, Karoly Szuhai, Judith V.M.G. Bovée, Agustín F. Fernández, Mario F. Fraga, Javier Alonso, René Rodríguez
Sarcomas represent an extensive group of malignant diseases affecting mesodermal tissues. Among sarcomas, the clinical management of chondrosarcomas remains a complex challenge, as high-grade tumours do not respond to current therapies. Mutations in the () 1 and 2 genes are among the most common mutations detected in chondrosarcomas and may represent a therapeutic opportunity. The presence of mutated
-
A growth chart of brain function from infancy to adolescence based on EEG EBioMedicine (IF 11.1) Pub Date : 2024-03-27 Kartik K. Iyer, James A. Roberts, Michaela Waak, Simon J. Vogrin, Ajay Kevat, Jasneek Chawla, Leena M. Haataja, Leena Lauronen, Sampsa Vanhatalo, Nathan J. Stevenson
In children, objective, quantitative tools that determine functional neurodevelopment are scarce and rarely scalable for clinical use. Direct recordings of cortical activity using routinely acquired electroencephalography (EEG) offer reliable measures of brain function. We developed and validated a measure of functional brain age (FBA) using a residual neural network-based interpretation of the paediatric
-
Emerging role of ferroptosis in metabolic dysfunction-associated steatotic liver disease: revisiting hepatic lipid peroxidation EBioMedicine (IF 11.1) Pub Date : 2024-03-26 Cédric Peleman, Sven Francque, Tom Vanden Berghe
Metabolic dysfunction-associated steatohepatitis (MASH) is characterised by cell death of parenchymal liver cells which interact with their microenvironment to drive disease activity and liver fibrosis. The identification of the major death type could pave the way towards pharmacotherapy for MASH. To date, increasing evidence suggest a type of regulated cell death, named ferroptosis, which occurs through
-
Identifying local foci of tuberculosis transmission in Moldova using a spatial multinomial logistic regression model EBioMedicine (IF 11.1) Pub Date : 2024-03-26 Yu Lan, Valeriu Crudu, Nelly Ciobanu, Alexandru Codreanu, Melanie H. Chitwood, Benjamin Sobkowiak, Joshua L. Warren, Ted Cohen
Multidrug resistant tuberculosis (MDR-TB) represents a major public health concern in the Republic of Moldova, with an estimated 31% of new and 56% of previously treated TB cases having MDR disease in 2022. A recent genomic epidemiology study of incident TB occurring in 2018 and 2019 found that 92% of MDR-TB was the result of transmission. The MDR phenotype was concentrated among two () lineages: L2
-
Quality assurance for focused ultrasound-induced blood-brain barrier opening procedure using passive acoustic detection EBioMedicine (IF 11.1) Pub Date : 2024-03-26 Chih-Yen Chien, Lu Xu, Jinyun Yuan, Siaka Fadera, Andrew H. Stark, Umeshkumar Athiraman, Eric C. Leuthardt, Hong Chen
Focused ultrasound (FUS) combined with microbubbles is a promising technique for noninvasive, reversible, and spatially targeted blood-brain barrier opening, with clinical trials currently ongoing. Despite the fast development of this technology, there is a lack of established quality assurance (QA) strategies to ensure procedure consistency and safety. To address this challenge, this study presents
-
Effect of increasing cognitive activity participation on default mode network in older adults with subjective cognitive decline: a randomised controlled trial EBioMedicine (IF 11.1) Pub Date : 2024-03-25 Allen Ting Chun Lee, Yishan Luo, Zhaohua Huo, Lin Shi, Winnie Chiu Wing Chu, Linda Chiu Wa Lam
Having more cognitive activities may prevent dementia, but its evidence of modulating the functional brain network is limited. This randomised controlled trial (RCT) investigated the effect of increased cognitive activity participation on the default mode network (DMN) in older adults who had already been having regular cognitive activity participation and experiencing subjective cognitive decline
-
High-throughput screening of small-molecules libraries identified antibacterials against clinically relevant multidrug-resistant A. baumannii and K. pneumoniae EBioMedicine (IF 11.1) Pub Date : 2024-03-22 Benjamin Blasco, Soojin Jang, Hiroki Terauchi, Naoki Kobayashi, Shuichi Suzuki, Yuichiro Akao, Atsuko Ochida, Nao Morishita, Terufumi Takagi, Hiroyuki Nagamiya, Yamato Suzuki, Toshiaki Watanabe, Hyunjung Lee, Sol Lee, David Shum, Ahreum Cho, Dahae Koh, Soonju Park, Honggun Lee, Kideok Kim, Henni-Karoliina Ropponen, Renata Maria Augusto da Costa, Steven Dunn, Sunil Ghosh, Peter Sjö, Laura J.V. Piddock
-
Dynamics and prognostic value of serum neurofilament light chain in Guillain-Barré syndrome EBioMedicine (IF 11.1) Pub Date : 2024-03-22 Sander J. van Tilburg, Charlotte E. Teunissen, Carolien C.H.M. Maas, Robin C.M. Thomma, Christa Walgaard, Hans Heijst, Ruth Huizinga, Pieter A. van Doorn, Bart C. Jacobs
Neurofilament light chain (NfL) is a biomarker for axonal damage in several neurological disorders. We studied the longitudinal changes in serum NfL in patients with Guillain-Barré syndrome (GBS) in relation to disease severity, electrophysiological subtype, treatment response, and prognosis. We included patients with GBS who participated in a double-blind, randomised, placebo-controlled trial that
-
Potential of PSMA-targeting radioligand therapy for malignant primary and secondary brain tumours using super-selective intra-arterial administration: a single centre, open label, non-randomised prospective imaging study EBioMedicine (IF 11.1) Pub Date : 2024-03-22 Ilanah J. Pruis, Pieter Jan van Doormaal, Rutger K. Balvers, Martin J. van den Bent, Anita A. Harteveld, Linda C. de Jong, Mark W. Konijnenberg, Marcel Segbers, Roelf Valkema, Frederik A. Verburg, Marion Smits, Sophie E.M. Veldhuijzen van Zanten
The aim of this study was to provide quantitative evidence for the potential of PSMA-targeting radioligand therapy (RLT) as treatment approach for malignant brain tumours, and to explore whether tumour uptake could be enhanced by super-selective intra-arterial (ssIA)-administration. Ten patients (n = 5 high-grade glioma, n = 5 brain metastasis) received 1.5 MBq/kg [Ga]Ga-PSMA-11 intravenously and,
-
Corrigendum for “LncRNA EPB41L4A-AS1 regulates glycolysis and glutaminolysis by mediating nucleolar translocation of HDAC2” [eBioMedicine 41 (2019) 200–213] EBioMedicine (IF 11.1) Pub Date : 2024-03-21 Meijian Liao, Weijie Liao, Naihan Xu, Bing Li, Fuhai Liu, Shikuan Zhang, Yanzhi Wang, Songmao Wang, Yuanchang Zhu, Deheng Chen, Weidong Xie, Yuyang Jiang, Liu Cao, Burton B. Yang, Yaou Zhang
-
Multimorbidity analysis with low condition counts: a robust Bayesian approach for small but important subgroups EBioMedicine (IF 11.1) Pub Date : 2024-03-21 Guillermo Romero Moreno, Valerio Restocchi, Jacques D. Fleuriot, Atul Anand, Stewart W. Mercer, Bruce Guthrie
Robustly examining associations between long-term conditions may be important in identifying opportunities for intervention in multimorbidity but is challenging when evidence is limited. We have developed a Bayesian inference framework that is robust to sparse data and used it to quantify morbidity associations in the oldest old, a population with limited available data. We conducted a retrospective
-
Predictors of liver disease progression in people living with HIV-HBV co-infection on antiretroviral therapy EBioMedicine (IF 11.1) Pub Date : 2024-03-21 Kasha P. Singh, Anchalee Avihingsanon, Jennifer M. Zerbato, Wei Zhao, Sabine Braat, Surekha Tennakoon, Ajantha Rhodes, Gail V. Matthews, Christopher K. Fairley, Joe Sasadeusz, Megan Crane, Jennifer Audsley, Sharon R. Lewin
In people living with HIV-HBV, liver fibrosis progression can occur even with suppressive antiretroviral therapy (ART). We investigated the relationship between liver fibrosis and biomarkers of inflammation, apoptosis, and microbial translocation. In this observational cohort study adults living with HIV-HBV already on effective ART were recruited in Australia and Thailand and followed for 3 years
-
The genetic landscape and phenotypic spectrum of GAA-FGF14 ataxia in China: a large cohort study EBioMedicine (IF 11.1) Pub Date : 2024-03-20 Riwei Ouyang, Linlin Wan, David Pellerin, Zhe Long, Jian Hu, Qian Jiang, Chunrong Wang, Linliu Peng, Huirong Peng, Lang He, Rong Qiu, Junling Wang, Jifeng Guo, Lu Shen, Bernard Brais, Matt C. Danzi, Stephan Zuchner, Beisha Tang, Zhao Chen, Hong Jiang
An intronic GAA repeat expansion in was recently identified as a cause of GAA- ataxia. We aimed to characterise the frequency and phenotypic profile of GAA ataxia in a large Chinese ataxia cohort. A total of 1216 patients that included 399 typical late-onset cerebellar ataxia (LOCA), 290 early-onset cerebellar ataxia (EOCA), and 527 multiple system atrophy with predominant cerebellar ataxia (MSA-c)
-
Detection of endometrial cancer in cervico-vaginal fluid and blood plasma: leveraging proteomics and machine learning for biomarker discovery EBioMedicine (IF 11.1) Pub Date : 2024-03-20 Kelechi Njoku, Andrew Pierce, Davide Chiasserini, Bethany Geary, Amy E. Campbell, Janet Kelsall, Rachel Reed, Nophar Geifman, Anthony D. Whetton, Emma J. Crosbie
The anatomical continuity between the uterine cavity and the lower genital tract allows for the exploitation of uterine-derived biomaterial in cervico-vaginal fluid for endometrial cancer detection based on non-invasive sampling methodologies. Plasma is an attractive biofluid for cancer detection due to its simplicity and ease of collection. In this biomarker discovery study, we aimed to identify proteomic
-
GAA-FGF14 disease: defining its frequency, molecular basis, and 4-aminopyridine response in a large downbeat nystagmus cohort EBioMedicine (IF 11.1) Pub Date : 2024-03-19 David Pellerin, Felix Heindl, Carlo Wilke, Matt C. Danzi, Andreas Traschütz, Catherine Ashton, Marie-Josée Dicaire, Alexanne Cuillerier, Giulia Del Gobbo, Kym M. Boycott, Jens Claassen, Dan Rujescu, Annette M. Hartmann, Stephan Zuchner, Bernard Brais, Michael Strupp, Matthis Synofzik
GAA- disease/spinocerebellar ataxia 27B is a recently described neurodegenerative disease caused by (GAA) expansions in the fibroblast growth factor 14 () gene, but its phenotypic spectrum, pathogenic threshold, and evidence-based treatability remain to be established. We report on the frequency of (GAA) and (GAA) expansions in a large cohort of patients with idiopathic downbeat nystagmus (DBN) and
-
Hepatotoxicity in patients with non-small cell lung cancer treated with sotorasib after prior immunotherapy: a comprehensive clinical and pharmacokinetic analysis EBioMedicine (IF 11.1) Pub Date : 2024-03-19 Sophie M. Ernst, Maaike M. Hofman, Tessa E. van der Horst, Marthe S. Paats, Frank W.J. Heijboer, Joachim G.J.V. Aerts, Daphne W. Dumoulin, Robin Cornelissen, Jan H. von der Thüsen, Peter de Bruijn, Esther Oomen-de Hoop, Ron H.J. Mathijssen, Stijn L.W. Koolen, Anne-Marie C. Dingemans
Sotorasib given after immunotherapy could put patients at increased risk of hepatotoxicity. Therefore, there is a need to gain insight into the potential correlation between anti-PD-(L)1 treatment, anti-PD-(L)1 concentrations, sotorasib concentrations, and the incidence of hepatotoxicity during sotorasib. Patients with -mutated NSCLC treated with sotorasib were prospectively enrolled in our biomarker
-
Peripheral amyloid-β clearance mediates cognitive impairment in non-alcoholic fatty liver disease EBioMedicine (IF 11.1) Pub Date : 2024-03-19 Xiaobo Peng, Xing Zhang, Zihui Xu, Linyan Li, Xiaoxing Mo, Zhao Peng, Zhilei Shan, Hong Yan, Jian Xu, Liegang Liu
Non-alcoholic fatty liver disease (NAFLD) is a prevalent risk factor for cognitive impairment. Cerebral amyloid-β (Aβ) accumulation, as an important pathology of cognitive impairment, can be caused by impaired Aβ clearance in the periphery. The liver is the primary organ for peripheral Aβ clearance, but the role of peripheral Aβ clearance in NAFLD-induced cognitive impairment remains unclear. We examined
-
An integrative pan-cancer analysis of the molecular characteristics of dietary restriction in tumour microenvironment EBioMedicine (IF 11.1) Pub Date : 2024-03-19 Xiaoyi Song, Jiaxing Wei, Yang Li, Wen Zhu, Zhiyuan Cai, Kunwei Li, Jingyue Wei, Jieyu Lu, Wanping Pan, Man Li
Dietary restriction (DR), a general term for dieting, has been demonstrated as an effective intervention in reducing the occurrence of cancers. Molecular activities associated with DR are crucial in mediating its anti-cancer effects, yet a comprehensive exploration of the landscape of these activities at the pan-cancer level is still lacking. We proposed a computational approach for quantifying DR-related
-
Mitochondrial DNA deletions in the cerebrospinal fluid of patients with idiopathic REM sleep behaviour disorder EBioMedicine (IF 11.1) Pub Date : 2024-03-18 Margalida Puigròs, Anna Calderon, Daniel Martín-Ruiz, Mònica Serradell, Manel Fernández, Amaia Muñoz-Lopetegi, Gerard Mayà, Joan Santamaria, Carles Gaig, Anna Colell, Eduard Tolosa, Alex Iranzo, Ramon Trullas
Idiopathic rapid eye movement (REM) sleep behaviour disorder (IRBD) represents the prodromal stage of Lewy body disorders (Parkinson's disease (PD) and dementia with Lewy bodies (DLB)) which are linked to variations in circulating cell-free mitochondrial DNA (cf-mtDNA). Here, we assessed whether altered cf-mtDNA release and integrity are already present in IRBD. We used multiplex digital PCR (dPCR)
-
Takotsubo syndrome outcomes predicted by thyroid hormone signature: insights from cluster analysis of a multicentre registry EBioMedicine (IF 11.1) Pub Date : 2024-03-18 Assem Aweimer, Johannes W. Dietrich, Francesco Santoro, Mireia Camins Fàbregas, Andreas Mügge, Iván J. Núñez-Gil, Ravi Vazirani, Oscar Vedia, Toni Pätz, Ilaria Ragnatela, Luca Arcari, Massimo Volpe, Miguel Corbì-Pascual, Manuel Martinez-Selles, Manuel Almendro-Delia, Alessandro Sionis, Aitor Uribarri, Holger Thiele, Natale Daniele Brunetti, Ingo Eitel, Thomas Stiermaier, Nazha Hamdani, Mohammad Abumayyaleh
Recently, abnormal thyroid function was shown to be common in patients with Takotsubo syndrome (TTS), being classified into “endocrine-type” and “stress-type” responses. The aim of this study was to investigate the association between thyroid homeostasis and TTS in a larger international registry. In total 288 patients with TTS were enrolled through the GEIST multicentre registry from Germany, Italy
-
The HHIP gene: from a candidate to an established participant in COPD susceptibility EBioMedicine (IF 11.1) Pub Date : 2024-03-16 Zakaria Lahmar, Anne Bergougnoux, Arnaud Bourdin
-
Advancing cancer immunotherapy: the promise of self-photoconversion reporters for immune cell migration tracking EBioMedicine (IF 11.1) Pub Date : 2024-03-15 Maochao Zheng, Shasha He, Huayu Tian
-
Comprehensive analysis of transcription factor-based molecular subtypes and their correlation to clinical outcomes in small-cell lung cancer EBioMedicine (IF 11.1) Pub Date : 2024-03-15 Sehhoon Park, Tae Hee Hong, Soohyun Hwang, Simon Heeke, Carl M. Gay, Jiyeon Kim, Hyun-Ae Jung, Jong-Mu Sun, Jin Seok Ahn, Myung-Ju Ahn, Jong Ho Cho, Yong Soo Choi, Jhingook Kim, Young Mog Shim, Hong Kwan Kim, Lauren Averett Byers, John V. Heymach, Yoon-La Choi, Se-Hoon Lee, Keunchil Park
Recent studies have reported the predictive and prognostic value of novel transcriptional factor-based molecular subtypes in small-cell lung cancer (SCLC). We conducted an in-depth analysis pairing multi-omics data with immunohistochemistry (IHC) to elucidate the underlying characteristics associated with differences in clinical outcomes between subtypes. IHC (n = 252), target exome sequencing (n = 422)
-
Implantation of a double allogeneic human engineered tissue graft on damaged heart: insights from the PERISCOPE phase I clinical trial EBioMedicine (IF 11.1) Pub Date : 2024-03-14 Antoni Bayes-Genis, Paloma Gastelurrutia, Marta Monguió-Tortajada, Maria Luisa Cámara, Cristina Prat-Vidal, German Cediel, Luciano Rodríguez-Gómez, Albert Teis, Elena Revuelta-López, Gemma Ferrer-Curriu, Santiago Roura, Carolina Gálvez-Montón, Felipe Bisbal, Joaquim Vives, Anna Vilarrodona, Christian Muñoz-Guijosa, Sergi Querol
In preclinical studies, the use of double allogeneic grafts has shown promising results in promoting tissue revascularization, reducing infarct size, preventing adverse remodelling and fibrosis, and ultimately enhancing cardiac function. Building upon these findings, the safety of PeriCord, an engineered tissue graft consisting of a decellularised pericardial matrix and umbilical cord Wharton's jelly
-
Female mice display sex-specific differences in cerebrovascular function and subarachnoid haemorrhage-induced injury EBioMedicine (IF 11.1) Pub Date : 2024-03-14 Danny D. Dinh, Hoyee Wan, Darcy Lidington, Steffen-Sebastian Bolz
In male mice, a circadian rhythm in myogenic reactivity influences the extent of brain injury following subarachnoid haemorrhage (SAH). We hypothesized that female mice have a different cerebrovascular phenotype and consequently, a distinct SAH-induced injury phenotype. SAH was modelled by pre-chiasmatic blood injection. Olfactory cerebral resistance arteries were functionally assessed by pressure
-
Enhancer infestation drives tumorigenic activation of inactive B compartment in Epstein-Barr virus-positive nasopharyngeal carcinoma EBioMedicine (IF 11.1) Pub Date : 2024-03-14 Harue Mizokami, Atsushi Okabe, Ruchi Choudhary, Masato Mima, Kenta Saeda, Masaki Fukuyo, Bahityar Rahmutulla, Motoaki Seki, Boon-Cher Goh, Satoru Kondo, Hirotomo Dochi, Makiko Moriyama-Kita, Kiyoshi Misawa, Toyoyuki Hanazawa, Patrick Tan, Tomokazu Yoshizaki, Melissa Jane Fullwood, Atsushi Kaneda
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated malignant epithelial tumor endemic to Southern China and Southeast Asia. While previous studies have revealed a low frequency of gene mutations in NPC, its epigenomic aberrations are not fully elucidated apart from DNA hypermethylation. Epigenomic rewiring and enhancer dysregulation, such as enhancer hijacking due to genomic structural
-
Post-hoc standardisation of parametric T1 maps in cardiovascular magnetic resonance imaging: a proof-of-concept EBioMedicine (IF 11.1) Pub Date : 2024-03-14 Darian Viezzer, Thomas Hadler, Jan Gröschel, Clemens Ammann, Edyta Blaszczyk, Christoph Kolbitsch, Simone Hufnagel, Riccardo Kranzusch-Groß, Steffen Lange, Jeanette Schulz-Menger
In cardiovascular magnetic resonance imaging parametric T1 mapping lacks universally valid reference values. This limits its extensive use in the clinical routine. The aim of this work was the introduction of our self-developed Magnetic Resonance Imaging Software for Standardization (MARISSA) as a post-hoc standardisation approach. Our standardisation approach minimises the bias of confounding parameters
-
Phototruncation cell tracking with near-infrared photoimmunotherapy using heptamethine cyanine dye to visualise migratory dynamics of immune cells EBioMedicine (IF 11.1) Pub Date : 2024-03-14 Hiroshi Fukushima, Aki Furusawa, Seiichiro Takao, Siddharth S. Matikonda, Makoto Kano, Shuhei Okuyama, Hiroshi Yamamoto, Peter L. Choyke, Martin J. Schnermann, Hisataka Kobayashi
Noninvasive cell tracking is valuable in understanding the mechanisms that enhance anti-cancer immunity. We have recently developed a new method called phototruncation-assisted cell tracking (PACT), that uses photoconvertible cell tracking technology to detect cell migration. This method has the advantages of not requiring genetic engineering of cells and employing tissue-penetrant near-infrared light
-
Temporary increase in circulating replication-competent latent HIV-infected resting CD4+ T cells after switch to an integrase inhibitor based antiretroviral regimen EBioMedicine (IF 11.1) Pub Date : 2024-03-13 Roux-Cil Ferreira, Steven J. Reynolds, Adam A. Capoferri, Owen R. Baker, Erin E. Brown, Ethan Klock, Jernelle Miller, Jun Lai, Sharada Saraf, Charles Kirby, Briana Lynch, Jada Hackman, Sarah N. Gowanlock, Stephen Tomusange, Samiri Jamiru, Aggrey Anok, Taddeo Kityamuweesi, Paul Buule, Daniel Bruno, Craig Martens, Rebecca Rose, Susanna L. Lamers, Ronald M. Galiwango, Art F.Y. Poon, Thomas C. Quinn, Jessica
The principal barrier to an HIV cure is the presence of the latent viral reservoir (LVR), which has been understudied in African populations. From 2018 to 2019, Uganda instituted a nationwide rollout of ART consisting of Dolutegravir (DTG) with two NRTI, which replaced the previous regimen of one NNRTI and the same two NRTI. Changes in the inducible replication-competent LVR (RC-LVR) of ART-suppressed
-
Whole exome sequencing and machine learning germline analysis of individuals presenting with extreme phenotypes of high and low risk of developing tobacco-associated lung adenocarcinoma EBioMedicine (IF 11.1) Pub Date : 2024-03-13 Ana Patiño-García, Elizabeth Guruceaga, Maria Pilar Andueza, Marimar Ocón, Jafait Junior Fodop Sokoudjou, Nicolás de Villalonga Zornoza, Gorka Alkorta-Aranburu, Ibon Tamayo Uria, Alfonso Gurpide, Carlos Camps, Eloísa Jantus-Lewintre, Maria Navamuel-Andueza, Miguel F. Sanmamed, Ignacio Melero, Mohamed Elgendy, Juan Pablo Fusco, Javier J. Zulueta, Juan P. de-Torres, Gorka Bastarrika, Luis Seijo, Ruben
Tobacco is the main risk factor for developing lung cancer. Yet, while some heavy smokers develop lung cancer at a young age, other heavy smokers never develop it, even at an advanced age, suggesting a remarkable variability in the individual susceptibility to the carcinogenic effects of tobacco. We characterized the germline profile of subjects presenting these extreme phenotypes with Whole Exome
-
Desulfovibrio desulfuricans and its derived metabolites confer resistance to FOLFOX through METTL3 EBioMedicine (IF 11.1) Pub Date : 2024-03-13 Guifang Li, Huan Liu, Yangmeng Yu, Qian Wang, Chen Yang, Yang Yan, Fang Wang, Yong Mao
Chemoresistance is a critical factor contributing to poor prognosis in clinical patients with cancer undergoing postoperative adjuvant chemotherapy. The role of gut microbiota in mediating resistance to tumour chemotherapy remains to be investigated. Patients with CRC were categorised into clinical benefit responders (CBR) and no clinical benefit responders (NCB) based on chemotherapy efficacy. Differential
-
High lymphocyte signature genes expression in parathyroid endocrine cells and its downregulation linked to tumorigenesis EBioMedicine (IF 11.1) Pub Date : 2024-03-11 Chong Geng, Junjun Liu, Bingzhou Guo, Kailin Liu, Pengfei Gong, Bao Wang, Qiang Wan, Liang Sun, Jiajun Zhao, Yongfeng Song
To date, because of the difficulty in obtaining normal parathyroid gland samples in human or in animal models, our understanding of this last-discovered organ remains limited. In the present study, we performed a single-cell transcriptome analysis of six normal parathyroid and eight parathyroid adenoma samples using 10 × Genomics platform. We have provided a detailed expression atlas of parathyroid
-
Drop the shortcuts: image augmentation improves fairness and decreases AI detection of race and other demographics from medical images EBioMedicine (IF 11.1) Pub Date : 2024-03-11 Ryan Wang, Po-Chih Kuo, Li-Ching Chen, Kenneth Patrick Seastedt, Judy Wawira Gichoya, Leo Anthony Celi
-
Mitoquinone mesylate as post-exposure prophylaxis against SARS-CoV-2 infection in humans: an exploratory single center pragmatic open label non-randomized pilot clinical trial with matched controls EBioMedicine (IF 11.1) Pub Date : 2024-03-11 Keren Chen, Nicholas J. Jackson, Theodoros Kelesidis
An ongoing important need exists to rapidly develop novel therapeutics for COVID-19 that will retain antiviral efficacy in the setting of rapidly evolving SARS-CoV-2 variants and potential future development of resistance of SARS-COV-2 to remdesivir and protease inhibitors. To date, there is no FDA-approved treatment for post-exposure prophylaxis against SAR-CoV-2. We have shown that the mitochondrial
-
Tryptophan degradation as a systems phenomenon in inflammation – an analysis across 13 chronic inflammatory diseases EBioMedicine (IF 11.1) Pub Date : 2024-03-11 Danielle M.M. Harris, Silke Szymczak, Sven Schuchardt, Johannes Labrenz, Florian Tran, Lina Welz, Hanna Graßhoff, Henner Zirpel, Melike Sümbül, Mhmd Oumari, Nils Engelbogen, Ralf Junker, Claudio Conrad, Diamant Thaçi, Norbert Frey, Andre Franke, Stephan Weidinger, Bimba Hoyer, Philip Rosenstiel, Silvio Waschina, Stefan Schreiber, Konrad Aden
Chronic inflammatory diseases (CIDs) are systems disorders that affect diverse organs including the intestine, joints and skin. The essential amino acid tryptophan (Trp) can be broken down to various bioactive derivatives important for immune regulation. Increased Trp catabolism has been observed in some CIDs, so we aimed to characterise the specificity and extent of Trp degradation as a systems phenomenon
-
Comparison of two plasma p-tau217 assays to detect and monitor Alzheimer’s pathology EBioMedicine (IF 11.1) Pub Date : 2024-03-11 Joseph Therriault, Nicholas James Ashton, Ilaria Pola, Gallen Triana-Baltzer, Wagner Scheeren Brum, Guglielmo Di Molfetta, Burak Arslan, Nesrine Rahmouni, Cecile Tissot, Stijn Servaes, Jenna Stevenson, Arthur Cassa Macedo, Tharick Ali Pascoal, Hartmuth Christian Kolb, Andreas Jeromin, Kaj Blennow, Henrik Zetterberg, Pedro Rosa-Neto, Andrea Lessa Benedet
Blood-based biomarkers of Alzheimer’s disease (AD) have become increasingly important as scalable tools for diagnosis and determining clinical trial eligibility. P-tau217 is the most promising due to its excellent sensitivity and specificity for AD-related pathological changes. We compared the performance of two commercially available plasma p-tau217 assays (ALZpath p-tau217 and Janssen p-tau217+)
-
Differential depletion of GluN2A induces heterogeneous schizophrenia-related phenotypes in mice EBioMedicine (IF 11.1) Pub Date : 2024-03-11 Yi Lu, Longyu Mu, Justin Elstrott, Chaoying Fu, Cailu Sun, Tonghui Su, Xiaofan Ma, Jia Yan, Hong Jiang, Jesse E. Hanson, Yang Geng, Yelin Chen
Schizophrenia, a debilitating psychiatric disorder, displays considerable interindividual variation in clinical presentations. The ongoing debate revolves around whether this heterogeneity signifies a continuum of severity linked to a singular causative factor or a collection of distinct subtypes with unique origins. Within the realm of schizophrenia, the functional impairment of GluN2A, a subtype
-
The performance of 11 fingertip pulse oximeters during hypoxemia in healthy human participants with varied, quantified skin pigment EBioMedicine (IF 11.1) Pub Date : 2024-03-08 Gregory Leeb, Isabella Auchus, Tyler Law, Philip Bickler, John Feiner, Shamsudini Hashi, Ellis Monk, Elizabeth Igaga, Michael Bernstein, Yu Celine Chou, Caroline Hughes, Deleree Schornack, Jenna Lester, Kelvin Moore Jr., Olubunmi Okunlola, Jana Fernandez, Leonid Shmuylovich, Michael Lipnick
Fingertip pulse oximeters are widely available, inexpensive, and commonly used to make clinical decisions in many settings. Device performance is largely unregulated and poorly characterised, especially in people with dark skin pigmentation. Eleven popular fingertip pulse oximeters were evaluated using the US Food and Drug Administration (FDA) Guidance (2013) and International Organization for Standardization
-
Metabolite signatures associated with microRNA miR-143-3p serve as drivers of poor lung function trajectories in childhood asthma EBioMedicine (IF 11.1) Pub Date : 2024-03-07 Kevin M. Mendez, Sofina Begum, Anshul Tiwari, Rinku Sharma, Qingwen Chen, Rachel S. Kelly, Nicole Prince, Mengna Huang, Priyadarshini Kachroo, Su H. Chu, Yulu Chen, Kathleen Lee-Sarwar, David I. Broadhurst, Stacey N. Reinke, Robert Gerszten, Clary Clish, Lydiana Avila, Juan C. Celedón, Craig E. Wheelock, Scott T. Weiss, Michael McGeachie, Jessica A. Lasky-Su
Lung function trajectories (LFTs) have been shown to be an important measure of long-term health in asthma. While there is a growing body of metabolomic studies on asthma status and other phenotypes, there are no prospective studies of the relationship between metabolomics and LFTs or their genomic determinants. We utilized ordinal logistic regression to identify plasma metabolite principal components
-
Differential anti-viral response to respiratory syncytial virus A in preterm and term infants EBioMedicine (IF 11.1) Pub Date : 2024-03-06 Jeremy Anderson, Samira Imran, Yan Yung Ng, Tongtong Wang, Sarah Ashley, Cao Minh Thang, Le Quang Thanh, Vo Thi Trang Dai, Phan Van Thanh, Bui Thi Hong Nhu, Do Ngoc Xuan Trang, Phan Thi Phuong Trinh, Le Thanh Binh, Nguyen Thuong Vu, Nguyen Trong Toan, Boris Novakovic, Mimi L.K. Tang, Danielle Wurzel, Kim Mulholland, Daniel G. Pellicci, Lien Anh Ha Do, Paul V. Licciardi
Preterm infants are more likely to experience severe respiratory syncytial virus (RSV) disease compared to term infants. The reasons for this are multi-factorial, however their immature immune system is believed to be a major contributing factor. We collected cord blood from 25 preterm (gestational age 30.4–34.1 weeks) and 25 term infants (gestation age 37–40 weeks) and compared the response of cord
-
A 14-gene B-cell immune signature in early-stage triple-negative breast cancer (TNBC): a pooled analysis of seven studies EBioMedicine (IF 11.1) Pub Date : 2024-03-05 Benedetta Conte, Fara Brasó-Maristany, Adela Rodríguez Hernández, Tomás Pascual, Guillermo Villacampa, Francesco Schettini, Maria J. Vidal Losada, Elia Seguí, Laura Angelats, Isabel Garcia-Fructuoso, Raquel Gómez-Bravo, Natàlia Lorman-Carbó, Laia Paré, Mercedes Marín-Aguilera, Olga Martínez-Sáez, Barbara Adamo, Esther Sanfeliu, Beatrice Fratini, Claudette Falato, Núria Chic, Ana Vivancos, Patricia
Early-stage triple-negative breast cancer (TNBC) displays clinical and biological diversity. From a biological standpoint, immune infiltration plays a crucial role in TNBC prognosis. Currently, there is a lack of genomic tools aiding in treatment decisions for TNBC. This study aims to assess the effectiveness of a B-cell/immunoglobulin signature (IGG) alone, or in combination with tumor burden, in
-
May continuous positive airway pressure (CPAP) treatment be detrimental in obstructive sleep apnea? EBioMedicine (IF 11.1) Pub Date : 2024-03-02 Alessandra Castrogiovanni, Maria R. Bonsignore
-
Upper limb movements as digital biomarkers in people with ALS EBioMedicine (IF 11.1) Pub Date : 2024-03-02 Marcin Straczkiewicz, Marta Karas, Stephen A. Johnson, Katherine M. Burke, Zoe Scheier, Tim B. Royse, Narghes Calcagno, Alison Clark, Amrita Iyer, James D. Berry, Jukka-Pekka Onnela
Objective evaluation of people with amyotrophic lateral sclerosis (PALS) in free-living settings is challenging. The introduction of portable digital devices, such as wearables and smartphones, may improve quantifying disease progression and hasten therapeutic development. However, there is a need for tools to characterize upper limb movements in neurologic disease and disability. Twenty PALS wore
-
Pharmacokinetics of single dose doxycycline in the rectum, vagina, and urethra: implications for prevention of bacterial sexually transmitted infections EBioMedicine (IF 11.1) Pub Date : 2024-02-29 Richard E. Haaland, Jeffrey Fountain, Tiancheng E. Edwards, Chuong Dinh, Amy Martin, Deborah Omoyege, Christopher Conway-Washington, Colleen F. Kelley, Walid Heneine
Clinical trials showed a single oral dose of doxycycline taken after sex protects against STIs among men who have sex with men (MSM) but not women. Pharmacokinetic data at vaginal, rectal and penile sites of STI exposure are lacking. We examined vaginal, rectal and urethral doxycycline concentrations in men and women to better inform STI prevention. Doxycycline pharmacokinetics in male and female participants
-
Dynamic establishment of recipient resident memory T cell repertoire after human intestinal transplantation EBioMedicine (IF 11.1) Pub Date : 2024-02-28 Wenyu Jiao, Mercedes Martinez, Constanza Bay Muntnich, Julien Zuber, Christopher Parks, Aleksandar Obradovic, Guangyao Tian, Zicheng Wang, Katherine D. Long, Elizabeth Waffarn, Kristjana Frangaj, Rebecca Jones, Alaka Gorur, Brittany Shonts, Kortney Rogers, Guoyue Lv, Monica Velasco, Shilpa Ravella, Joshua Weiner, Tomoaki Kato, Yufeng Shen, Jianing Fu, Megan Sykes
Understanding formation of the human tissue resident memory T cell (TRM) repertoire requires longitudinal access to human non-lymphoid tissues. By applying flow cytometry and next generation sequencing to serial blood, lymphoid tissue, and gut samples from 16 intestinal transplantation (ITx) patients, we assessed the origin, distribution, and specificity of human TRMs at phenotypic and clonal levels
-
Genome-wide enhancer-associated tandem repeats are expanded in cardiomyopathy EBioMedicine (IF 11.1) Pub Date : 2024-02-27 Aleksandra Mitina, Mahreen Khan, Robert Lesurf, Yue Yin, Worrawat Engchuan, Omar Hamdan, Giovanna Pellecchia, Brett Trost, Ian Backstrom, Keyi Guo, Linda M. Pallotto, Phoenix Hoi Lam Doong, Zhuozhi Wang, Thomas Nalpathamkalam, Bhooma Thiruvahindrapuram, Tanya Papaz, Christopher E. Pearson, Jiannis Ragoussis, Padmaja Subbarao, Meghan B. Azad, Stuart E. Turvey, Piushkumar Mandhane, Theo J. Moraes, Elinor
Cardiomyopathy is a clinically and genetically heterogeneous heart condition that can lead to heart failure and sudden cardiac death in childhood. While it has a strong genetic basis, the genetic aetiology for over 50% of cardiomyopathy cases remains unknown. In this study, we analyse the characteristics of tandem repeats from genome sequence data of unrelated individuals diagnosed with cardiomyopathy
-
Identification of a distal enhancer regulating hedgehog interacting protein gene in human lung epithelial cells EBioMedicine (IF 11.1) Pub Date : 2024-02-27 Feng Guo, Li Zhang, Yuzhen Yu, Lu Gong, Shiyue Tao, Rhiannon B. Werder, Shreya Mishra, Yihan Zhou, Wardatul Jannat Anamika, Taotao Lao, Hiroyuki Inuzuka, Yihan Zhang, Betty Pham, Tao Liu, Tiffany S. Tufenkjian, Bradley W. Richmond, Wenyi Wei, Hongmei Mou, Andrew A. Wilson, Ming Hu, Wei Chen, Xiaobo Zhou
An intergenic region at chromosome 4q31 is one of the most significant regions associated with COPD susceptibility and lung function in GWAS. In this region, the implicated causal gene has a unique epithelial expression pattern in adult human lungs, in contrast to dominant expression in fibroblasts in murine lungs. However, the mechanism underlying the species-dependent cell type-specific regulation
-
Variant to gene mapping for carpal tunnel syndrome risk loci implicates skeletal muscle regulatory elements EBioMedicine (IF 11.1) Pub Date : 2024-02-27 Matthew C. Pahl, Lin Liu, James A. Pippin, Yadav Wagley, Keith Boehm, Kurt D. Hankenson, Andrew D. Wells, Wenli Yang, Struan F.A. Grant
Carpal tunnel syndrome (CTS) is a common disorder caused by compression of the median nerve in the wrist, resulting in pain and numbness throughout the hand and forearm. While multiple behavioural and physiological factors influence CTS risk, a growing body of evidence supports a strong genetic contribution. Recent genome-wide association study (GWAS) efforts have reported 53 independent signals associated
-
Taking a step beyond serology: progress in the search for a biomarker predicting the risk of maternal-fetal transmission of cytomegalovirus (CMV) EBioMedicine (IF 11.1) Pub Date : 2024-02-26 M, a, r, k, , R, ., , S, c, h, l, e, i, s, s
-
Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) EBioMedicine (IF 11.1) Pub Date : 2024-02-26 Rhea Harewood, Joseph A. Rothwell, Jelena Bešević, Vivian Viallon, David Achaintre, Audrey Gicquiau, Sabina Rinaldi, Roland Wedekind, Cornelia Prehn, Jerzy Adamski, Julie A. Schmidt, Inarie Jacobs, Anne Tjønneland, Anja Olsen, Gianluca Severi, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Marcela Prada, Giovanna Masala, Claudia Agnoli, Salvatore Panico, Carlotta Sacerdote, Paula Gabriela Jakszyn
Altered lipid metabolism is a hallmark of cancer development. However, the role of specific lipid metabolites in colorectal cancer development is uncertain. In a case–control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), we examined associations between pre-diagnostic circulating concentrations of 97 lipid metabolites (acylcarnitines, glycerophospholipids
-
Characterization of a human H3N8 influenza virus EBioMedicine (IF 11.1) Pub Date : 2024-02-25 Chunyang Gu, Shufang Fan, Randall Dahn, Lavanya Babujee, Shiho Chiba, Lizheng Guan, Tadashi Maemura, David Pattinson, Gabriele Neumann, Yoshihiro Kawaoka
In 2022 and 2023, novel reassortant H3N8 influenza viruses infected three people, marking the first human infections with viruses of this subtype. Here, we generated one of these viruses (A/Henan/4-10CNIC/2022; hereafter called A/Henan/2022 virus) by using reverse genetics and characterized it. In intranasally infected mice, reverse genetics-generated A/Henan/2022 virus caused weight loss in all five
-
CPAP may promote an endothelial inflammatory milieu in sleep apnoea after coronary revascularization EBioMedicine (IF 11.1) Pub Date : 2024-02-24 Yuksel Peker, Yeliz Celik, Afrouz Behboudi, Susan Redline, Jing Lyu, Ying Wei, Daniel J. Gottlieb, Sanja Jelic
Continuous positive airway pressure (CPAP) has failed to reduce cardiovascular risk in obstructive sleep apnoea (OSA) in randomized trials. CPAP increases angiopoietin-2, a lung distension-responsive endothelial proinflammatory marker associated with increased cardiovascular risk. We investigated whether CPAP has unanticipated proinflammatory effects in patients with OSA and cardiovascular disease
-
STING signalling compensates for low tumour mutation burden to drive anti-tumour immunity EBioMedicine (IF 11.1) Pub Date : 2024-02-23 Jiayi Tan, Colt A. Egelston, Weihua Guo, Jeremy M. Stark, Peter P. Lee
While mutation-derived neoantigens are well recognized in generating anti-tumour T cell response, increasing evidences highlight the complex association between tumour mutation burden (TMB) and tumour infiltrating lymphocytes (TILs). The exploration of non-TMB determinants of active immune response could improve the prognosis prediction and provide guidance for current immunotherapy. The transcriptomic
-
Regulatory T cell: a double-edged sword from metabolic-dysfunction-associated steatohepatitis to hepatocellular carcinoma EBioMedicine (IF 11.1) Pub Date : 2024-02-23 Han Wang, Allan Tsung, Lopa Mishra, Hai Huang
Metabolic-dysfunction-associated steatotic liver disease (MASLD) is becoming a leading cause of end-stage liver disease globally. Metabolic-dysfunction-associated steatohepatitis (MASH) represents a progressive inflammatory manifestation of MASLD. MASH underlies a versatile and dynamic inflammatory microenvironment, accompanied by aberrant metabolism and ongoing liver regeneration, establishing itself
-
Ventilatory capacity in CLAD is driven by dysfunctional airway structure EBioMedicine (IF 11.1) Pub Date : 2024-02-22 Pieterjan Kerckhof, Gene P.L. Ambrocio, Hanne Beeckmans, Janne Kaes, Vincent Geudens, Saskia Bos, Lynn Willems, Astrid Vermaut, Marie Vermant, Tinne Goos, Charlotte De Fays, Lucia Aversa, Yousry Mohamady, Arno Vanstapel, Michaela Orlitová, Jan Van Slambrouck, Xin Jin, Vimi Varghese, Iván Josipovic, Matthieu N. Boone, Lieven J. Dupont, Birgit Weynand, Adriana Dubbeldam, Dirk E. Van Raemdonck, Laurens
Chronic lung allograft dysfunction (CLAD) encompasses three main phenotypes: bronchiolitis obliterans syndrome (BOS), restrictive allograft syndrome (RAS) and a Mixed phenotype combining both pathologies. How the airway structure in its entirety is affected in these phenotypes is still poorly understood. A detailed analysis of airway morphometry was applied to gain insights on the effects of airway