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Lkb1 orchestrates γδ T-cell metabolic and functional fitness to control IL-17-mediated autoimmune hepatitis Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-04-19 Zhiqiang Xiao, Shanshan Wang, Liang Luo, Wenkai Lv, Peiran Feng, Yadong Sun, Quanli Yang, Jun He, Guangchao Cao, Zhinan Yin, Meixiang Yang
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Targeting macrophage metabolism to enhance tumor immunotherapy Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-04-17 Jing Liu, Zhibo Ma, Wenlong Jia, Peixiang Lan
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Bypassing PELO-mediated ATPase activation of the NLR is a common pathogenic cause of NLR-associated autoinflammatory diseases Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-04-17 Xiurong Wu, Zhang-Hua Yang, Yue Zheng, Jianfeng Wu, Jiahuai Han
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Neuropilin-1high monocytes protect against neonatal inflammation Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-04-17 Xiaoqing Zheng, Wen Lei, Yongmei Zhang, Han Jin, Cha Han, Fan Wu, Chonghong Jia, Ruihong Zeng, Zhanghua Chen, Yuxia Zhang, Haitao Wang, Qiang Liu, Zhi Yao, Ying Yu, Jie Zhou
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Synthetic biology approaches for improving the specificity and efficacy of cancer immunotherapy Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-04-11 Bo Zhu, Hang Yin, Di Zhang, Meiling Zhang, Xiaojuan Chao, Luca Scimeca, Ming-Ru Wu
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GSNOR negatively regulates the NLRP3 inflammasome via S-nitrosation of MAPK14 Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-04-03 Qianjin Liu, Lijin Jiao, Mao-Sen Ye, Zhiyu Ma, Jinsong Yu, Ling-Yan Su, Wei-Yin Zou, Lu-Xiu Yang, Chang Chen, Yong-Gang Yao
Hyperactivation of the NLRP3 inflammasome has been implicated in the pathogenesis of numerous diseases. However, the precise molecular mechanisms that modulate the transcriptional regulation of NLRP3 remain largely unknown. In this study, we demonstrated that S-nitrosoglutathione reductase (GSNOR) deficiency in macrophages leads to significant increases in the Nlrp3 and Il-1β expression levels and
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Cellular metabolism regulates the differentiation and function of T-cell subsets Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-04-02 Sicong Ma, Yanan Ming, Jingxia Wu, Guoliang Cui
T cells are an important component of adaptive immunity and protect the host from infectious diseases and cancers. However, uncontrolled T cell immunity may cause autoimmune disorders. In both situations, antigen-specific T cells undergo clonal expansion upon the engagement and activation of antigens. Cellular metabolism is reprogrammed to meet the increase in bioenergetic and biosynthetic demands
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Defining two subpopulations of marginal zone B cells Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-03-27 Xiaojing Liu, Fei-Long Meng
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Novel insights into regulation of butyrophilin molecules: critical components of cancer immunosurveillance by γδ T cells Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-03-26 Dieter Kabelitz
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The chemerin-CMKLR1 axis in keratinocytes impairs innate host defense against cutaneous Staphylococcus aureus infection Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-03-26 Yu Chen, Yan Song, Zhe Wang, Yangfan Lai, Wei Yin, Qian Cai, Miaomiao Han, Yiheng Cai, Yushan Xue, Zhengrong Chen, Xi Li, Jing Chen, Min Li, Huabin Li, Rui He
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Aerobic glycolysis enables the effector differentiation potential of stem-like CD4+ T cells to combat cancer Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-03-21 Dawei Zou, Xiaolong Zhang, Shuang Li, Xiang Xiao, Nancy M. Gonzalez, Laurie J. Minze, Xian C. Li, Wenhao Chen
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Insm1: orchestrating cellular mimicry in the thymus medulla Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-03-19 K. D. James, J. E. Cowan
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Neutrophil ALDH2 is a new therapeutic target for the effective treatment of sepsis-induced ARDS Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-03-12 Changchang Xu, Lin Zhang, Shaoyu Xu, Zichen Wang, Qi Han, Ying Lv, Xingfang Wang, Xiangxin Zhang, Qingju Zhang, Ying Zhang, Simeng He, Qiuhuan Yuan, Yuan Bian, Chuanbao Li, Jiali Wang, Feng Xu, Yihai Cao, Jiaojiao Pang, Yuguo Chen
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Neutrophils in the tumor microenvironment – when a company becomes a crowd Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-03-08 Zvi G. Fridlender, Zvi Granot
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Mucosal T-cell responses to chronic viral infections: Implications for vaccine design Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-03-08 Mohammed Al-Talib, Sandra Dimonte, Ian R. Humphreys
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Engagement of sialylated glycans with Siglec receptors on suppressive myeloid cells inhibits anticancer immunity via CCL2 Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-03-06 Ronja Wieboldt, Michael Sandholzer, Emanuele Carlini, Chia-wei Lin, Anastasiya Börsch, Andreas Zingg, Didier Lardinois, Petra Herzig, Leyla Don, Alfred Zippelius, Heinz Läubli, Natalia Rodrigues Mantuano
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gp120-derived amyloidogenic peptides form amyloid fibrils that increase HIV-1 infectivity Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-03-05 Suiyi Tan, Wenjuan Li, Chan Yang, Qingping Zhan, Kunyu Lu, Jun Liu, Yong-Mei Jin, Jin-Song Bai, Lin Wang, Jinqing Li, Zhaofeng Li, Fei Yu, Yu-Ye Li, Yue-Xun Duan, Lu Lu, Tong Zhang, Jiaqi Wei, Lin Li, Yong-Tang Zheng, Shibo Jiang, Shuwen Liu
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Development of NK cell-based cancer immunotherapies through receptor engineering Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-03-05 Audrey Page, Nicolas Chuvin, Jenny Valladeau-Guilemond, Stéphane Depil
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Two distinct subpopulations of marginal zone B cells exhibit differential antibody-producing capacities and radioresistance Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-03-01 Sujin Lee, Yeunjung Ko, Hyun Woo Lee, Won Joon Oh, Hun Gi Hong, Dinuka Ariyaratne, Se Jin Im, Tae Jin Kim
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Targeting PHGDH reverses the immunosuppressive phenotype of tumor-associated macrophages through α-ketoglutarate and mTORC1 signaling Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-02-27 Zhengnan Cai, Wan Li, Sonja Hager, Jayne Louise Wilson, Leila Afjehi-Sadat, Elke H. Heiss, Thomas Weichhart, Petra Heffeter, Wolfram Weckwerth
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Inactivation of TGF-β signaling in CAR-T cells Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-02-26 Zaopeng Yang, Yang-Xin Fu
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Coming of age: the formation and function of age-associated B cells Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-02-26 Ke Rui, Nan Che, Kongyang Ma, Hejian Zou, Fan Xiao, Liwei Lu
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NLRP3 inflammasome activation and NETosis positively regulate each other and exacerbate proinflammatory responses: implications of NETosis inhibition for acne skin inflammation treatment Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-02-26 Hyo Jeong Kim, Yun Sang Lee, Bok-Soon Lee, Chang-Hak Han, Sang Gyu Kim, Chul-Ho Kim
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CD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-02-21 Xin Lei, Daniël C. de Groot, Marij J. P. Welters, Tom de Wit, Ellen Schrama, Hans van Eenennaam, Saskia J. Santegoets, Timo Oosenbrug, Annemarthe van der Veen, Joris L. Vos, Charlotte L. Zuur, Noel F. C. C. de Miranda, Heinz Jacobs, Sjoerd H. van der Burg, Jannie Borst, Yanling Xiao
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Unsynchronized butyrophilin molecules dictate cancer cell evasion of Vγ9Vδ2 T-cell killing Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-02-20 Zeguang Wu, Qiezhong Lamao, Meichao Gu, Xuanxuan Jin, Ying Liu, Feng Tian, Ying Yu, Pengfei Yuan, Shuaixin Gao, Thomas S. Fulford, Adam P. Uldrich, Catherine CL Wong, Wensheng Wei
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CD200Rhigh neutrophils with dysfunctional autophagy establish systemic immunosuppression by increasing regulatory T cells Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-02-05 Ye Seon Kim, Yu Sun Jeong, Geon Ho Bae, Ji Hyeon Kang, Mingyu Lee, Brian A. Zabel, Yoe-Sik Bae
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Activation of leukotriene B4 receptor 1 is a prerequisite for complement receptor 3-mediated antifungal responses of neutrophils Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-01-31 Yan Xin, Sihan Xiong, Linghong Zhou, Xin Lin
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Id2 epigenetically controls CD8+ T-cell exhaustion by disrupting the assembly of the Tcf3-LSD1 complex Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-01-29 Yiming Li, Mingwei Han, Haolin Wei, Wan Huang, Zhinan Chen, Tianjiao Zhang, Meirui Qian, Lin Jing, Gang Nan, Xiuxuan Sun, Shuhui Dai, Kun Wang, Jianli Jiang, Ping Zhu, Liang Chen
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COVID-19 vaccines and beyond Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-01-26 Yiyuan Liu, Danying Li, Jiahuai Han
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Disulfiram ameliorates STING/MITA-dependent inflammation and autoimmunity by targeting RNF115 Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-01-24 Zhi-Dong Zhang, Chang-Rui Shi, Fang-Xu Li, Hu Gan, Yanhong Wei, Qianhui Zhang, Xin Shuai, Min Chen, Yu-Lin Lin, Tian-Chen Xiong, Xiaoqi Chen, Bo Zhong, Dandan Lin
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CD8+ T cell metabolic flexibility elicited by CD28-ARS2 axis-driven alternative splicing of PKM supports antitumor immunity Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-01-18 G. Aaron Holling, Colin A. Chavel, Anand P. Sharda, Mackenzie M. Lieberman, Caitlin M. James, Shivana M. Lightman, Jason H. Tong, Guanxi Qiao, Tiffany R. Emmons, Thejaswini Giridharan, Shengqi Hou, Andrew M. Intlekofer, Richard M. Higashi, Teresa W. M. Fan, Andrew N. Lane, Kevin H. Eng, Brahm H. Segal, Elizabeth A. Repasky, Kelvin P. Lee, Scott H. Olejniczak
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SARS-CoV-2 immunity in animal models Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-01-18 Zhao Chen, Yaochang Yuan, Qingtao Hu, Airu Zhu, Fenghua Chen, Shu Li, Xin Guan, Chao Lv, Tian Tang, Yiyun He, Jinling Cheng, Jie Zheng, Xiaoyu Hu, Jingxian Zhao, Jincun Zhao, Jing Sun
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Tissue-resident macrophages exacerbate lung injury after remote sterile damage Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-01-17 Hanhui Zhong, Jingjing Ji, Jinling Zhuang, Ziying Xiong, Pengyun Xie, Xiaolei Liu, Jundi Zheng, Wangli Tian, Xiaoyang Hong, Jing Tang
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Not to be and how not to be: the questions of Tregs controlled by RIPK1 Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-01-15 Zhengcai Peng, Huiyuan Zhang, Hongbo Hu
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Silent battles: immune responses in asymptomatic SARS-CoV-2 infection Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-01-15 Nina Le Bert, Taraz Samandari
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Nuclear receptor coactivator 6 is a critical regulator of NLRP3 inflammasome activation and gouty arthritis Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-01-10 Kang-Gu Lee, Bong-Ki Hong, Saseong Lee, Naeun Lee, Seung-Whan Kim, Donghyun Kim, Wan-Uk Kim
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ROS-induced metabolic reprogramming to one-carbon metabolism and S-adenosylmethionine-mediated epigenetic modification in IL-10-producing B cells for the resolution of pneumonia Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-01-04 Sujin Lee, Tae Jin Kim
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SMAD7 expression in CAR-T cells improves persistence and safety for solid tumors Cell. Mol. Immunol. (IF 24.1) Pub Date : 2024-01-04 Sixin Liang, Rui Zheng, Baile Zuo, Jia Li, Yiyi Wang, Yujie Han, Hao Dong, Xiaojuan Zhao, Yiting Zhang, Pengju Wang, Ruotong Meng, Lintao Jia, Angang Yang, Bo Yan
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In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms Cell. Mol. Immunol. (IF 24.1) Pub Date : 2023-12-26 S. Cankat, M. U. Demael, L. Swadling
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Olfactory immune response to SARS-CoV-2 Cell. Mol. Immunol. (IF 24.1) Pub Date : 2023-12-25 Sebastian A. Wellford, E. Ashley Moseman
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The RNA m6A demethylase ALKBH5 drives emergency granulopoiesis and neutrophil mobilization by upregulating G-CSFR expression Cell. Mol. Immunol. (IF 24.1) Pub Date : 2023-12-20 Yang Liu, Renjie Song, Zhike Lu, Lu Zhao, Xinyi Zhan, Yini Li, Xuetao Cao
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Thirteen years to get from b to a: one of the neglected isoforms of IL-37 enters the stage Cell. Mol. Immunol. (IF 24.1) Pub Date : 2023-12-18 Steven X. Cho, Ina Rudloff, Andrew M. Ellisdon, Claudia A. Nold-Petry, Marcel F. Nold
Interleukin (IL)-37 is one of the few anti-inflammatory members of the predominantly pro-inflammatory IL-1 cytokine family. IL-37 possesses alarmin-like properties [1] and exerts its activities via intracellular [2] as well as cell surface receptor-dependent mechanisms, and the latter involves IL-1R8 and IL-18Rα [3]. Because of its powerful and broad-spectrum “peacemaking” [4] functions, considerable
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Metabolic reprogramming by Syntenin-1 directs RA FLS and endothelial cell-mediated inflammation and angiogenesis Cell. Mol. Immunol. (IF 24.1) Pub Date : 2023-12-18 Anja Meyer, Stephanie R. Zack, Wes Nijim, Adel Burgos, Vishwa Patel, Brian Zanotti, Michael V. Volin, M. Asif Amin, Myles J. Lewis, Costantino Pitzalis, Shiva Arami, Joseph A. Karam, Nadera J. Sweiss, Shiva Shahrara
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The E3 ubiquitin ligase TRAF6 controls CTLA-4 turnover and promotes T-cell-mediated antitumor immunity Cell. Mol. Immunol. (IF 24.1) Pub Date : 2023-12-11 Xiao-Liang Jie, Hua Guo, Guang-Biao Zhou
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RIPK1 plays a crucial role in maintaining regulatory T-Cell homeostasis by inhibiting both RIPK3- and FADD-mediated cell death Cell. Mol. Immunol. (IF 24.1) Pub Date : 2023-12-11 Xiaoxue Deng, Lingxia Wang, Yunze Zhai, Qiuyue Liu, Fengxue Du, Yu Zhang, Wenxing Zhao, Tingtao Wu, Yiwen Tao, Jie Deng, Yongbing Cao, Pei Hao, Jiazi Ren, Yunli Shen, Zuoren Yu, Yuejuan Zheng, Haibing Zhang, Haikun Wang
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Oxidative stress-initiated one-carbon metabolism drives the generation of interleukin-10-producing B cells to resolve pneumonia Cell. Mol. Immunol. (IF 24.1) Pub Date : 2023-12-11 Ying Fu, Baichao Yu, Qi Wang, Zhou Lu, Hushan Zhang, Dan Zhang, Feifei Luo, Ronghua Liu, Luman Wang, Yiwei Chu
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The BCL-2 inhibitor APG-2575 resets tumor-associated macrophages toward the M1 phenotype, promoting a favorable response to anti-PD-1 therapy via NLRP3 activation Cell. Mol. Immunol. (IF 24.1) Pub Date : 2023-12-07 Fan Luo, Han Li, Wenjuan Ma, Jiaxin Cao, Qun Chen, Feiteng Lu, Miaozhen Qiu, Penghui Zhou, Zengfei Xia, Kangmei Zeng, Jianhua Zhan, Ting Zhou, Qiuyun Luo, Wentao Pan, Lin Zhang, Chaozhuo Lin, Yan Huang, Li Zhang, Dajun Yang, Hongyun Zhao
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Glioma-derived ANXA1 suppresses the immune response to TLR3 ligands by promoting an anti-inflammatory tumor microenvironment Cell. Mol. Immunol. (IF 24.1) Pub Date : 2023-12-04 Yu Zheng, Haihui Jiang, Naixue Yang, Shaoping Shen, Daosheng Huang, Lemei Jia, Jing Ling, Longchen Xu, Mingxiao Li, Kefu Yu, Xiaohui Ren, Yong Cui, Xun Lan, Song Lin, Xin Lin
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Microglia out of place—mapping macrophages across the developing human body Cell. Mol. Immunol. (IF 24.1) Pub Date : 2023-11-28 Roman Sankowski, Marco Prinz
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Integrated NLRP3, AIM2, NLRC4, Pyrin inflammasome activation and assembly drive PANoptosis Cell. Mol. Immunol. (IF 24.1) Pub Date : 2023-11-27 SuHyeon Oh, Jihye Lee, Jueun Oh, Gyoengju Yu, Haesun Ryu, Daesik Kim, SangJoon Lee
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Interleukin-10 multitasking in allergic airway inflammation Cell. Mol. Immunol. (IF 24.1) Pub Date : 2023-11-22 Rudi W. Hendriks
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Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24 Cell. Mol. Immunol. (IF 24.1) Pub Date : 2023-11-22 Zhengzhou Ying, Swanand Hardikar, Joshua B. Plummer, Tewfik Hamidi, Bin Liu, Yueping Chen, Jianjun Shen, Yunxiang Mu, Kevin M. McBride, Taiping Chen
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A tumor-associated heparan sulfate-related glycosaminoglycan promotes the generation of functional regulatory T cells Cell. Mol. Immunol. (IF 24.1) Pub Date : 2023-11-22 Leticia Martín-Cruz, Marcos Viñuela, Ioanna Kalograiaki, Alba Angelina, Paola Oquist-Phillips, Irene Real-Arévalo, Francisco Javier Cañada, José Ignacio Tudela, Luis Moltó, Jesús Moreno-Sierra, José Luis Subiza, Oscar Palomares
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Insm1 regulates mTEC development and immune tolerance Cell. Mol. Immunol. (IF 24.1) Pub Date : 2023-11-21 Weihua Tao, Zhihuan Ye, Yiqiu Wei, Jianxue Wang, Weixin Yang, Guoxing Yu, Jieyi Xiong, Shiqi Jia
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SARS-CoV-2 and innate immunity: the good, the bad, and the “goldilocks” Cell. Mol. Immunol. (IF 24.1) Pub Date : 2023-11-20 Benjamin L. Sievers, Mark T. K. Cheng, Kata Csiba, Bo Meng, Ravindra K. Gupta
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CD97 negatively regulates the innate immune response against RNA viruses by promoting RNF125-mediated RIG-I degradation Cell. Mol. Immunol. (IF 24.1) Pub Date : 2023-11-17 Huasong Chang, Peili Hou, Xuefeng Wang, Aibiao Xiang, Hao Wu, Wenjing Qi, Rukun Yang, Xue Wang, Xingyu Li, Wenqi He, Guimin Zhao, Weiyang Sun, Tiecheng Wang, Daniel Chang He, Hongmei Wang, Yuwei Gao, Hongbin He
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The interplay of drug therapeutics and immune responses to SARS-CoV-2 Cell. Mol. Immunol. (IF 24.1) Pub Date : 2023-11-14 Valeria Fumagalli, Matteo Iannacone
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New insights into the role of the immune inhibitory receptor VSTM1 in autoimmune disease Cell. Mol. Immunol. (IF 24.1) Pub Date : 2023-11-07 Naijun Miao, Jing Wang
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The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8+ T-cell immunity Cell. Mol. Immunol. (IF 24.1) Pub Date : 2023-11-07 Jizhang Yu, Jikai Cui, Xi Zhang, Heng Xu, Zhang Chen, Yuan Li, Yuqing Niu, Song Wang, Shuan Ran, Yanqiang Zou, Weicong Ye, Dan Zhang, Cheng Zhou, Jiahong Xia, Jie Wu
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B-cell and antibody responses to SARS-CoV-2: infection, vaccination, and hybrid immunity Cell. Mol. Immunol. (IF 24.1) Pub Date : 2023-11-10 Dennis Lapuente, Thomas H. Winkler, Matthias Tenbusch