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Statement of Retraction: Contribution of nano-copper particles to in vivo liver dysfunction and cellular damage: Role of IκBα/NF-κB, MAPKs and mitochondrial signal Nanotoxicology (IF 5.0) Pub Date : 2024-03-20
Published in Nanotoxicology (Ahead of Print, 2024)
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Application of carbon nanostructures in biomedicine: realities, difficulties, prospects Nanotoxicology (IF 5.0) Pub Date : 2024-03-15 Konstantin N. Semenov, Sergei V. Ageev, Olegi N. Kukaliia, Igor V. Murin, Andrey V. Petrov, Gleb O. Iurev, Pavel A. Andoskin, Gaiane G. Panova, Oleg E. Molchanov, Dmitrii N. Maistrenko, Vladimir V. Sharoyko
The review systematizes data on the wide possibilities of practical application of carbon nanostructures. Much attention is paid to the use of carbon nanomaterials in medicine for the visualization...
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Nano-graphene oxide particles induce inheritable anomalies through altered gene expressions involved in oocyte maturation Nanotoxicology (IF 5.0) Pub Date : 2024-03-07 Sreelakshmi Krishnakumar, Raghunath Nair Malavika, Shantikumar V. Nair, Deepthy Menon, Bindhu Paul-Prasanth
The inheritable impact of exposure to graphene oxide nanoparticles (GO NPs) on vertebrate germline during critical windows of gamete development remain undetermined to date. Here, we analyzed the t...
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Genoprotective role of pembrolizumab liposome in isolated lymphocytes from head and neck squamous cell carcinoma patients compared to those from healthy individuals in vitro Nanotoxicology (IF 5.0) Pub Date : 2024-03-07 Nagah Bobtina, Maysa Alhawamdeh, Khaled Habas, Mohamed Isreb, Bayan Aburas, Andrew T. Harris, Mojgan Najafzadeh, Diana Anderson
Pembrolizumab has shown significant anticancer effects against various human cancers. The present study investigated the effects of pembrolizumab liposome and nano (naked) forms in treated lymphocy...
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Investigation of sex-based differences in the immunotoxicity of silver nanoparticles Nanotoxicology (IF 5.0) Pub Date : 2024-03-05 Brandon Canup, Paul Rogers, Angel Paredes, Wimolnut Manheng, Beverly Lyn-Cook, Tariq Fahmi
The growing application of silver nanoparticles (AgNPs) in consumer, healthcare, and industrial products has raised concern over potential health implications due to increasing exposure. The evalua...
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Food-grade titanium dioxide (E171) and zinc oxide nanoparticles induce mitochondrial permeability and cardiac damage after oral exposure in rats Nanotoxicology (IF 5.0) Pub Date : 2024-03-04 Francisco Correa Segura, Fernanda Isabel Macías Macías, Kimberly Abigaíl Velázquez Delgado, María del Pilar Ramos-Godinez, Angélica Ruiz-Ramírez, Pedro Flores, Elizabeth Huerta-García, Rebeca López-Marure
Food-grade titanium dioxide (E171) and zinc oxide nanoparticles (ZnO NPs) are found in diverse products for human use. E171 is used as whitening agent in food and cosmetics, and ZnO NPs in food pac...
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Biomarkers of exposure and effect in human biomonitoring of metal-based nanomaterials: their use in primary prevention and health surveillance Nanotoxicology (IF 5.0) Pub Date : 2024-03-04 Beatrice Bocca, Beatrice Battistini
Metal-based nanomaterials (MNMs) have gained particular interest in nanotechnology industry. They are used in various industrial processes, in biomedical applications or to improve functional prope...
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Chronic toxicity of core–shell SiC/TiO2 (nano)-particles to Daphnia magna under environmentally relevant food rations in the presence of humic acid Nanotoxicology (IF 5.0) Pub Date : 2024-02-29 Kornelia Serwatowska, Tom A. P. Nederstigt, Willie J. G. M. Peijnenburg, Martina G. Vijver
To date, research on the toxicity and potential environmental impacts of nanomaterials has predominantly focused on relatively simple and single-component materials, whilst more complex nanomateria...
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Recent progress in the EU classification of the health hazards associated with certain multiwall carbon nanotubes (MWCNTs): what about the other MWCNTs? Nanotoxicology (IF 5.0) Pub Date : 2024-02-27 Henrik Wolff, Ulla Vogel
Published in Nanotoxicology (Ahead of Print, 2024)
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Potent lung tumor promotion by inhaled MWCNT Nanotoxicology (IF 5.0) Pub Date : 2024-02-29 Dale W. Porter, Marlene S. Orandle, Ann Hubbs, Lauren M. Staska, David Lowry, Michael Kashon, Michael G. Wolfarth, Walter McKinney, Linda M. Sargent
In the lung, carcinogenesis is a multi-stage process that includes initiation by a genotoxic agent, promotion that expands the population of cells with damaged DNA to form a tumor, and progression ...
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Assessment of acute and subacute toxicity, pharmacokinetics, and biodistribution of eugenol nanoparticles after oral exposure in Wistar rats Nanotoxicology (IF 5.0) Pub Date : 2024-02-13 Pramod G. Nagaraju, Ashwini S., Pooja J. Rao, Poornima Priyadarshini
The present study aimed to assess the safety, toxicity, biodistribution, and pharmacokinetics of eugenol nanoparticles (EONs) following oral administration in Wistar rat models. In the acute toxici...
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Cationic solid lipid nanoparticles (SLN) complexed with plasmid DNA enhance prostate cancer cells (PC-3) migration Nanotoxicology (IF 5.0) Pub Date : 2024-02-01 Fernanda Garcia-Fossa, Marcelo Bispo de Jesus
Nanotechnology applications in biomedicine have increased in recent decades, primarily as therapeutic agents, drugs, and gene delivery systems. Among the nanoparticles used in medicine, we highligh...
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An analysis on control banding-based methods used for occupational risk assessment of nanomaterials Nanotoxicology (IF 5.0) Pub Date : 2024-01-18 Soqrat Omari Shekaftik, Nafiseh Nasirzadeh, Mahdi Mohammadiyan, Saman Mohammadpour
Despite all benefits of nanomaterials, their unique characteristics made them an emerging hazard in workplaces, which need to be assessed for their potential risks. So, the aim of this study was to...
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Evaluation of mucosal immune profile associated with Zileuton nanocrystal-formulated BCS-II drug upon oral administration in Sprague Dawley rats Nanotoxicology (IF 5.0) Pub Date : 2024-01-18 Sangeeta Khare, Rajan Jog, Anshel Bright, Diane J. Burgess, Sushanta K. Chakder, Kuppan Gokulan
Nanocrystal drug formulation involves several critical manufacturing procedures that result in complex structures to improve drug solubility, dissolution, bioavailability, and consequently the effi...
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Lung toxicity, deposition, and clearance of thermal spray coating particles with different metal profiles after inhalation in rats Nanotoxicology (IF 5.0) Pub Date : 2024-01-18 James M. Antonini, Vamsi Kodali, Terence G. Meighan, Walter McKinney, Jared L. Cumpston, Howard D. Leonard, James B. Cumpston, Sherri Friend, Stephen S. Leonard, Ronnee Andrews, Patti C. Zeidler-Erdely, Aaron Erdely, Eun Gyung Lee, Aliakbar A. Afshari
Thermal spray coating is a process in which molten metal is sprayed onto a surface. Little is known about the health effects associated with these aerosols. Sprague-Dawley rats were exposed to aero...
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Toxicity study of pro-angiogenic casein manganese oxide nanoparticles: an in vitro and in vivo approach Nanotoxicology (IF 5.0) Pub Date : 2024-01-18 Shagufta Haque, Sanchita Tripathy, Yogesh Chandra, Kathirvel Muralidharan, Chitta Ranjan Patra
Recently, we have demonstrated casein manganese oxide nanoparticles (CMnNP) that exhibit pro-angiogenic property established through different in vitro and in vivo experiments. The CMnNP was explor...
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N6-methyladenosine (M6A) in fetal offspring modifies mitochondrial gene expression following gestational nano-TiO2 inhalation exposure Nanotoxicology (IF 5.0) Pub Date : 2024-01-05 Amina Kunovac, Quincy A. Hathaway, Dharendra Thapa, Andrya J. Durr, Andrew D. Taylor, Saira Rizwan, Daud Sharif, Stephen J. Valentine, John M. Hollander
N6-methyladenosine (m6A) is the most prominent epitranscriptomic modification to RNA in eukaryotes, but it’s role in adaptive changes within the gestational environment are poorly understood. We pr...
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Correction Nanotoxicology (IF 5.0) Pub Date : 2023-12-14
Published in Nanotoxicology (Vol. 17, No. 8-9, 2023)
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Biodistribution and histological analysis of iron oxide-dextran nanoparticles in wistar rats Nanotoxicology (IF 5.0) Pub Date : 2023-12-14 Gary Hannon, Anna Bogdanska, Anna Keogh, Stephen P. Finn, Oliviero L. Gobbo, Adriele Prina-Mello
Iron oxide nanoparticles (IONP) are showing promise in many biomedical applications. One of these- magnetic hyperthermia- utilizes externally applied alternating magnetic fields and tumor-residing ...
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A bibliometric analysis of the recent achievements in pulmonary safety of nanoparticles Nanotoxicology (IF 5.0) Pub Date : 2023-12-14 Karina Falkiewicz, Izabela Fryca, Krzesimir Ciura, Alicja Mikolajczyk, Karolina Jagiello, Tomasz Puzyn
Assessing research activity is an important step for planning future initiatives oriented toward filling the remaining gaps in a field. Therefore, the objective of the current study was to review r...
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Multiparametric in vitro genotoxicity assessment of different variants of amorphous silica nanomaterials in rat alveolar epithelial cells Nanotoxicology (IF 5.0) Pub Date : 2023-12-01 Fátima Brandão, Carla Costa, Maria João Bessa, Vanessa Valdiglesias, Bryan Hellack, Andrea Haase, Sónia Fraga, João Paulo Teixeira
The hazard posed to human health by inhaled amorphous silica nanomaterials (aSiO2 NM) remains uncertain. Herein, we assessed the cyto- and genotoxicity of aSiO2 NM variants covering different sizes...
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Artificial augmented dataset for the enhancement of nano-QSARs models. A methodology based on topological projections Nanotoxicology (IF 5.0) Pub Date : 2023-12-01 Irini Furxhi, Michal Kalapus, Anna Costa, Tomasz Puzyn
Nanoinformatics demands accurate predictive models to assess the potential hazards of nanomaterials (NMs). However, limited data availability and the diverse nature of NMs physicochemical propertie...
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Correction Nanotoxicology (IF 5.0) Pub Date : 2023-12-01
Published in Nanotoxicology (Vol. 17, No. 6-7, 2023)
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Correction Nanotoxicology (IF 5.0) Pub Date : 2023-12-01
Published in Nanotoxicology (Vol. 17, No. 6-7, 2023)
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Genotoxicity assessment of titanium dioxide nanoparticles using a standard battery of in vivo assays Nanotoxicology (IF 5.0) Pub Date : 2023-12-01 Nana Sun, Xiaopeng Zhang, Chunlai Liang, Haibo Liu, Yuan Zhi, Jin Fang, Huiling Wang, Zhou Yu, Xudong Jia
As one representative of nanometal oxides, titanium dioxide nanoparticles (TiO2-NPs) have been widely used, particularly in the food industry. The genotoxicity of TiO2-NPs has attracted great atten...
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Impact of physico-chemical properties on the toxicological potential of reduced graphene oxide in human bronchial epithelial cells Nanotoxicology (IF 5.0) Pub Date : 2023-10-17 Adriana Rodríguez-Garraus, Clara Passerino, Gerard Vales, Michela Carlin, Satu Suhonen, Aurelia Tubaro, Julio Gómez, Marco Pelin, Julia Catalán
The increasing use of graphene-based materials (GBM) requires their safety evaluation, especially in occupational settings. The same physico-chemical (PC) properties that confer GBM extraordinary f...
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Facile fabrication of biocompatible injectable blended polymeric hydrogel with bioactive nanoformulation to improving cardiac tissue regeneration efficiency after myocardial infarction for nursing care potential applications Nanotoxicology (IF 5.0) Pub Date : 2023-10-17 Qinqin Sun, Jia Yao, Zhijun Zhang, Juan Li, Xue Zhang, Hui Wang, Xufang Du, Min Li, Ying Zhao
Recent years, cardiac vascular disease has arisen owing to acute myocardial infarction (MI) and heart failure leading to death worldwide. Various treatments are available for MI in modern medicine ...
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Development and evaluation of cell membrane-based biomimetic nanoparticles loaded by Clostridium perfringens epsilon toxin: a novel vaccine delivery platform for Clostridial-associated diseases Nanotoxicology (IF 5.0) Pub Date : 2023-09-11 Mokarameh Pudineh Moarref, Mojtaba Alimolaei, Tara Emami, Mohammad Kazem Koohi
As Clostridium perfringens (C. perfringens) epsilon toxin (ETX) ranks as the third most potent clostridial toxin after botulinum and tetanus toxins, vaccination is necessary for creatures that can ...
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Study on myocardial toxicity induced by lead halide perovskites nanoparticles Nanotoxicology (IF 5.0) Pub Date : 2023-09-09 Rendong He, Xuefeng Ding, Tingjun Zhang, Linqiang Mei, Shuang Zhu, Chengyan Wang, You Liao, Dongmei Wang, Hao Wang, Junsong Guo, Xiaolan Guo, Yan Xing, Zhanjun Gu, Houxiang Hu
Lead halide perovskites (LHPs) are outstanding candidates for next-generation optoelectronic materials, with considerable prospects of use and commercial value. However, knowledge about their toxic...
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The effect of natural biomolecules on yttrium oxide nanoparticles from a Daphnia magna survival rate perspective Nanotoxicology (IF 5.0) Pub Date : 2023-07-10 Egle Kelpsiene, Tingru Chang, Aliaksandr Khort, Katja Bernfur, Inger Odnevall, Tommy Cedervall, Jing Hua
Abstract The attention to rare earth oxide nanoparticles (NPs), including yttrium oxide (Y2O3), has increased in many fields due to their unique structural characteristics and functional properties. The aim of our study was to investigate the mechanisms by which bio-corona formation on Y2O3 NPs affects their environmental fate and toxicity. The Y2O3 NPs induced toxicity to freshwater filter feeder
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Harmonizing nanomaterial exposure methodologies in ecotoxicology: the effects of two innovative nanoclays in the freshwater microalgae Raphidocelis subcapitata Nanotoxicology (IF 5.0) Pub Date : 2023-07-15 Fábio Campos, Patrícia V. Silva, Amadeu M. V. M. Soares, Roberto Martins, Susana Loureiro
Layered double hydroxides (LDHs) are innovative nanomaterials (NMs) with a typical nanoclay structure (height <40 nm) consisting of layers of metallic cations and hydroxides stabilized by anions an...
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MiR-5622-3p inhibits ZCWPW1 to induce apoptosis in silica-exposed mice and spermatocyte cells Nanotoxicology (IF 5.0) Pub Date : 2023-06-14 Moxuan Zhao, Guiqing Zhou, Jingjing Wang, Yue Zhang, Jinglong Xue, Jianhui Liu, Junhong Xie, Lihua Ren, Xianqing Zhou
Abstract Silica nanoparticles (SiNPs) could cause damage to spermatogenesis, and microRNAs were reported to be associated with male reproduction. This research was designed to explore the toxic impacts of SiNPs induced in male reproduction through miR-5622-3p. In vivo, 60 mice were randomized into the control group and SiNPs group, in which they were exposed to SiNPs for 35 days and then recovered
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Toxicity dose descriptors from animal inhalation studies of 13 nanomaterials and their bulk and ionic counterparts and variation with primary particle characteristics Nanotoxicology (IF 5.0) Pub Date : 2023-06-10 Niels Hadrup, Nicklas Sahlgren, Nicklas R. Jacobsen, Anne T. Saber, Karin S. Hougaard, Ulla Vogel, Keld A. Jensen
Abstract This study collects toxicity data from animal inhalation studies of some nanomaterials and their bulk and ionic counterparts. To allow potential grouping and interpretations, we retrieved the primary physicochemical and exposure data to the extent possible for each of the materials. Reviewed materials are compounds (mainly elements, oxides and salts) of carbon (carbon black, carbon nanotubes
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Dependence of diamond nanoparticle cytotoxicity on physicochemical parameters: comparative studies of glioblastoma, breast cancer, and hepatocellular carcinoma cell lines Nanotoxicology (IF 5.0) Pub Date : 2023-06-01 Barbara Wójcik, Katarzyna Zawadzka, Sławomir Jaworski, Marta Kutwin, Malwina Sosnowska, Agnieszka Ostrowska, Marta Grodzik, Artur Małolepszy, Marta Mazurkiewicz-Pawlicka, Mateusz Wierzbicki
Abstract Reports on the cytotoxicity of diamond nanoparticles (ND) are ambiguous and depend on the physicochemical properties of the material and the tested cell lines. Thus, the aim of this research was to evaluate the influence of thirteen types of diamond nanoparticles, differing in production method, size, and surface functional groups, on their cytotoxicity against four tumor cell lines (T98G
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Food-grade titanium dioxide translocates across the buccal mucosa in pigs and induces genotoxicity in an in vitro model of human oral epithelium Nanotoxicology (IF 5.0) Pub Date : 2023-05-17 Julien Vignard, Aurelie Pettes-Duler, Eric Gaultier, Christel Cartier, Laurent Weingarten, Antje Biesemeier, Tatjana Taubitz, Philippe Pinton, Cecilia Bebeacua, Laurent Devoille, Jacques Dupuy, Elisa Boutet-Robinet, Nicolas Feltin, Isabelle P. Oswald, Fabrice H. Pierre, Bruno Lamas, Gladys Mirey, Eric Houdeau
Abstract The whitening and opacifying agent titanium dioxide (TiO2) is used worldwide in various foodstuffs, toothpastes and pharmaceutical tablets. Its use as a food additive (E171 in EU) has raised concerns for human health. Although the buccal mucosa is the first area exposed, oral transmucosal passage of TiO2 particles has not been documented. Here we analyzed E171 particle translocation in vivo
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Multi-walled carbon nanotubes induce arachidonate 5-lipoxygenase expression and enhance the polarization and function of M1 macrophages in vitro Nanotoxicology (IF 5.0) Pub Date : 2023-04-28 Chol Seung Lim, Brandon Veltri, Michael Kashon, Dale W. Porter, Qiang Ma
Abstract Fibrogenic carbon nanotubes (CNTs) induce the polarization of M1 and M2 macrophages in mouse lungs. Polarization of the macrophages regulates the production of proinflammatory and pro-resolving lipid mediators (LMs) to mediate acute inflammation and its resolution in a time-dependent manner. Here we examined the molecular mechanism by which multi-walled CNTs (MWCNTs, Mitsui-7) induce M1 polarization
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Enhanced toxicity of 2,2-bis(chloromethyl) trimethylene bis[bis(2-chloroethyl) phosphate] (V6) by nanopolystyrene particles towards HeLa cells Nanotoxicology (IF 5.0) Pub Date : 2023-04-28 Zheng Zhong, Xin Liu, Yiming Ruan, Ziwei Li, Junxian Li, Lili Sun, Sen Hou
Abstract 2,2-bis(chloromethyl) trimethylene bis[bis(2-chloroethyl) phosphate] (V6) has been widely used as an additive in a variety of plastics due to its extremely low toxicity. However, we showed in the study that once mixed with nanopolystyrene particles (NPs), the nontoxic V6 could exhibit significant toxicity to HeLa cells. The enhanced toxicity was much higher than the toxicity of NPs alone and
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Needlelike, short and thin multi-walled carbon nanotubes: comparison of effects on wild type and p53+/− rat lungs Nanotoxicology (IF 5.0) Pub Date : 2023-04-26 Hélène Barthel, Sylvie Sébillaud, Mylène Lorcin, Henrik Wolff, Stéphane Viton, Frédéric Cosnier, Laurent Gaté, Carole Seidel
Abstract Carbon nanotubes (CNTs) are nanomaterials presenting an occupational inhalation risk during production or handling. The International Agency for Research on Cancer classified one CNT, Mitsui-7 (MWNT-7), as ‘possibly carcinogenic to humans’. In recognition of their similarities, a proposal has been submitted to the risk assessment committee of ECHA to classify all fibers with ‘Fibre Paradigm’
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Assessing regulated cell death modalities as an efficient tool for in vitro nanotoxicity screening: a review Nanotoxicology (IF 5.0) Pub Date : 2023-04-21 Anton Tkachenko, Anatolii Onishchenko, Valeriy Myasoedov, Svetlana Yefimova, Ondrej Havranek
Abstract Nanomedicine is a fast-growing field of nanotechnology. One of the major obstacles for a wider use of nanomaterials for medical application is the lack of standardized toxicity screening protocols for assessing the safety of newly synthesized nanomaterials. In this review, we focus on less frequently studied nanomaterials-induced regulated cell death (RCD) modalities, including eryptosis,
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TiO2 nanostructures – a double edged sword: current progress on their role in stem cells’ differentiation, cancer therapy, and their toxicity issues Nanotoxicology (IF 5.0) Pub Date : 2023-04-19 Saravanan Ramesh, Kavitha Govarthanan, Arunkumar Palaniappan
Abstract Titanium dioxide (TiO2)-based nanostructures have wide applications in cosmetics, toothpastes, pharmaceuticals, coatings, papers, inks, plastics, food products, textiles, and many others. Recently, they have also been found to have huge potential as stem cells’ differentiation agents as well as stimuli-responsive drug delivery systems in cancer therapy. In this review, we present some of the
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Ferritinophagy was involved in long-term SiNPs exposure induced ferroptosis and liver fibrosis Nanotoxicology (IF 5.0) Pub Date : 2023-04-05 Qingqing Liang, Yuexiao Ma, Fenghong Wang, Mengqi Sun, Lisen Lin, Tianyu Li, Junchao Duan, Zhiwei Sun
Abstract SiNPs could induce liver fibrosisinvivo, but the mechanism was not completely clear. This study focused on exploring whether long-term SiNPs exposure at human-related exposure dosage could lead to ferritinophagy-mediated ferroptosis and liver fibrosis. In vivo, long-term SiNPs exposure induced liver fibrosis inrats accompanied by ferritinophagy and ferroptosis in hepatocytes. Interestingly
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Radiation impacts on toxicity of cobalt–chromium (CoCr) implant debris Nanotoxicology (IF 5.0) Pub Date : 2023-03-31 Kevin L. Trout, Sanghamitra Majumdar, Anil K. Patri, Tariq Fahmi
Abstract Particulate and soluble debris are generated by mechanical and non-mechanical degradation of implanted medical devices. Debris containing cobalt and chromium (CoCr) is known to cause adverse biological reactions. Implant-related complications are often diagnosed using radiography, which results in more frequent patient exposure to ionizing radiation. The aim of this study was to evaluate the
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A harmonized protocol for an international multicenter prospective study of nanotechnology workers: the NanoExplore cohort Nanotoxicology (IF 5.0) Pub Date : 2023-03-16 Irina Guseva Canu, Ekaterina Plys, Camille Velarde Crézé, Carlos Fito, Nancy B. Hopf, Athena Progiou, Chiara Riganti, Jean-Jacques Sauvain, Giulia Squillacioti, Guillaume Suarez, Pascal Wild, Enrico Bergamaschi
Abstract Nanotechnology applications are fast-growing in many industrial fields. Consequently, health effects of engineered nanomaterials (ENMs) should be investigated. Within the EU-Life project NanoExplore, we developed a harmonized protocol of an international multicenter prospective cohort study of workers in ENM-producing companies. This article describes the development of the protocol, sample
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Polyethyleneimine/polyethylene glycol–conjugated gold nanoparticles as nanoscale positive/negative controls in nanotoxicology: testing in frog embryo teratogenesis assay–Xenopus and mammalian tissue culture system Nanotoxicology (IF 5.0) Pub Date : 2023-03-15 Yoo-Seok Hwang, Daeho So, Moonsup Lee, Jaeho Yoon, Vytas Reipa, Alessandro Tona, Feng Yi, Bryant C. Nelson, David A. LaVan, Vincent A. Hackley, Ira O. Daar, Tae Joon Cho
Abstract Despite the great potential of using positively charged gold nanoparticles (AuNPs) in nanomedicine, no systematic studies have been reported on their synthesis optimization or colloidal stability under physiological conditions until a group at the National Institute of Standards and Technology recently succeeded in producing remarkably stable polyethyleneimine (PEI)-coated AuNPs (Au-PEI).
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Assessment of genotoxicity induced by subchronic exposure to graphene in HaCaT human skin cell line Nanotoxicology (IF 5.0) Pub Date : 2023-03-11 Javier Frontiñan-Rubio, Sonia García-Carpintero, Viviana Jehová González, Ester Vázquez, Mario Durán-Prado
Abstract The applications of graphene-based materials (GBMs) and their processing involve prolonged contact with cellular barriers such as human skin. Even though the potential cytotoxicity of graphene has been studied in recent years, the impact of long-term graphene exposure has rarely been explored. We tested in the HaCaT epithelial cells, in vitro, the effect of subchronic treatments with sublethal
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Efficient predictions of cytotoxicity of TiO2-based multi-component nanoparticles using a machine learning-based q-RASAR approach Nanotoxicology (IF 5.0) Pub Date : 2023-03-08 Arkaprava Banerjee, Supratik Kar, Souvik Pore, Kunal Roy
Abstract The availability of experimental nanotoxicity data is in general limited which warrants both the use of in silico methods for data gap filling and exploring novel methods for effective modeling. Read-Across Structure-Activity Relationship (RASAR) is an emerging cheminformatic approach that combines the usefulness of a QSAR model and similarity-based Read-Across predictions. In this work, we
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Predicting the toxicity of nanoparticles using artificial intelligence tools: a systematic review Nanotoxicology (IF 5.0) Pub Date : 2023-03-08 Alireza Banaye Yazdipour, Hoorie Masoorian, Mahnaz Ahmadi, Niloofar Mohammadzadeh, Seyed Mohammad Ayyoubzadeh
Abstract Nanoparticles have been used extensively in different scientific fields. Due to the possible destructive effects of nanoparticles on the environment or the biological systems, their toxicity evaluation is a crucial phase for studying nanomaterial safety. In the meantime, experimental approaches for toxicity assessment of various nanoparticles are expensive and time-consuming. Thus, an alternative
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A comprehensive proteomics analysis of the response of Pseudomonas aeruginosa to nanoceria cytotoxicity Nanotoxicology (IF 5.0) Pub Date : 2023-03-02 Lidija Izrael Živković, Nico Hüttmann, Vanessa Susevski, Ana Medić, Vladimir Beškoski, Maxim V. Berezovski, Zoran Minić, Ljiljana Živković, Ivanka Karadžić
Abstract The increased commercial use and spread of nanoceria raises concerns about the risks associated with its effects on living organisms. Although Pseudomonas aeruginosa may be ubiquitous in nature, it is largely found in locations closely linked with human activity. P. aeruginosa san ai was used as a model organism for a deeper understanding of the interaction between biomolecules of the bacteria
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Comparison of toxicity and cellular responses following pulmonary exposure to different types of nanofibers Nanotoxicology (IF 5.0) Pub Date : 2023-02-20 Min-Sung Kang, Gwang-Hee Lee, Mi-Jin Yang, Myeong-Chang Sung, Hyoung-Yun Han, Byoung-Seok Lee, Bosung Baek, Dong-Wan Kim, Eun-Jung Park
Abstract Pulmonary effects of inhaled microfibers are an emerging public health concern. In this study, we investigated toxicity following pulmonary exposure to synthetic polyethylene oxide fibroin (PEONF) and silk fibroin (SFNF) nanofibers and the cellular responses. When instilled intratracheally weekly for four weeks, body weight gain was significantly reduced in female mice exposed to the higher
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Algal extracellular polymeric substances (algal-EPS) for mitigating the combined toxic effects of polystyrene nanoplastics and nano-TiO2 in Chlorella sp. Nanotoxicology (IF 5.0) Pub Date : 2023-02-14 Lokeshwari Natarajan, M. Annie Jenifer, Willie J. G. M. Peijnenburg, Amitava Mukherjee
Abstract The continuous release of nanoparticles and nanoplastics into the marine environment necessitates the examination of their combined effects in marine organisms. Natural Organic Matter (NOM) can significantly influence the behavior of nanomaterials in the marine environment. The present study explores the effects of algal Extracellular Polymeric Substances (EPS) in reducing the combined toxic
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Biomarkers of oxidative stress in urine and plasma of operators at six Singapore printing centers and their association with several metrics of printer-emitted nanoparticle exposures Nanotoxicology (IF 5.0) Pub Date : 2023-02-12 Dhimiter Bello, Lucia Chanetsa, Costas A. Christophi, Dilpreet Singh, Magdiel Inggrid Setyawati, David C. Christiani, Sanjay H. Chotirmall, Kee Woei Ng, Philip Demokritou
Abstract Inhalation of nanoparticles emitted from toner-based printing equipment (TPE), such as laser printers and photocopiers, also known as PEPs, has been associated with systemic inflammation, hypertension, cardiovascular disease, respiratory disorders, and genotoxicity. Global serum metabolomics analysis in 19 healthy TPE operators found 52 dysregulated biomolecules involved in upregulation of
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Photocatalytic activity of nanoparticles: the development of the standardized measurement for physiological conditions Nanotoxicology (IF 5.0) Pub Date : 2023-02-02 Vytas Reipa, Nam Wong Song, Minjeong Kwak, Min Beom Heo, Tae Geol Lee, Paul Westerhoff, Yuqiang Bi, Blaza Toman, Vincent A. Hackley, Haruhisa Kato, Yosuke Tabei, Kanokwan Nontapot, Yonghyun Choi, Jonghoon Choi
Abstract Recently a new International Standard for testing nanomaterial photocatalytic activity under physiological conditions was issued by Technical Committee 229 (Nanotechnologies) of the International Organization for Standardization (ISO 20814:2019 Nanotechnologies-Testing the photocatalytic activity of nanoparticles for NADH oxidation). The document offers a robust, high throughput photocatalytic
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Evaluation of cytotoxicity and biodistribution of mesoporous carbon nanotubes (pristine/-OH/-COOH) to HepG2 cells in vitro and healthy mice in vivo Nanotoxicology (IF 5.0) Pub Date : 2023-01-26 Yujing Du, Zhipei Chen, M. Irfan Hussain, Ping Yan, Chunli Zhang, Yan Fan, Lei Kang, Rongfu Wang, Jianhua Zhang, Xiaona Ren, Changchun Ge
Abstract Mesoporous carbon nanotubes (mCNTs) hold great promise interests, owing to their superior nano-platform properties for biomedicine. To fully utilize this potential, the toxicity and biodistribution of pristine and surface-modified mCNTs (-OH/-COOH) should preferentially be addressed. The results of cell viability suggested that pristine mCNTs induced cell death in a concentration-dependent
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Comparison of tyrosine-modified low molecular weight branched and linear polyethylenimines for siRNA delivery Nanotoxicology (IF 5.0) Pub Date : 2023-01-25 Małgorzata Kubczak, Sylwia Michlewska, Michael Karimov, Alexander Ewe, Achim Aigner, Maria Bryszewska, Maksim Ionov
Abstract Polyethylenimines (PEIs) have been previously introduced for siRNA delivery. In particular, in the case of higher molecular weight PEIs, this is associated with toxicity, while low molecular weight PEIs are often insufficient for siRNA complexation. The tyrosine-modification of PEIs has been shown to enhance PEI efficacy and biocompatibility. This paper evaluates a set of tyrosine-modified
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Iron oxide nanoparticles cause surface coating- and core chemistry-dependent endothelial cell ferroptosis Nanotoxicology (IF 5.0) Pub Date : 2023-01-20 Xue Zhang, Fei Kong, Tian Wang, Xin Huang, Wanqing Li, Meichen Zhang, Tao Wen, Jian Liu, Yu Zhang, Jie Meng, Haiyan Xu
Abstract Iron oxide nanoparticles (IONPs) are mostly intended to be administrated intravenously, understanding the interaction of IONPs with vascular endothelial cells is extremely crucial for developing safe application regimes of IONPs. In this work, interactions of three kinds of IONPs to endothelial cells were investigated both in human umbilical vein endothelial cells (HUVECs) and in healthy mice
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Correction Nanotoxicology (IF 5.0) Pub Date : 2023-01-18
Published in Nanotoxicology (Vol. 16, No. 9-10, 2022)
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Silver nanoparticles suppress forskolin-induced syncytialization in BeWo cells Nanotoxicology (IF 5.0) Pub Date : 2023-01-03 Yuji Sakahashi, Kazuma Higashisaka, Ryo Isaka, Rina Izutani, Jiwon Seo, Atsushi Furuta, Akemi Yamaki-Ushijima, Hirofumi Tsujino, Yuya Haga, Akitoshi Nakashima, Yasuo Tsutsumi
Abstract Opportunities for the exposure of pregnant women to engineered nanoparticles have been increasing with the expanding use of these materials. Therefore, there are concerns that nanoparticles could have adverse effects on the establishment and maintenance of pregnancy. The effects of nanoparticles on the mother and fetus have been evaluated from this perspective, but there is still little knowledge
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Predicting the cytotoxicity of nanomaterials through explainable, extreme gradient boosting Nanotoxicology (IF 5.0) Pub Date : 2022-12-19 Allegra Conti, Luisa Campagnolo, Stefano Diciotti, Antonio Pietroiusti, Nicola Toschi
Abstract Nanoparticles (NPs) are a wide class of materials currently used in several industrial and biomedical applications. Due to their small size (1-100 nm), NPs can easily enter the human body, inducing tissue damage. NP toxicity depends on physical and chemical NP properties (e.g., size, charge and surface area) in ways and magnitudes that are still unknown. We assess the average as well as the
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Unchanged pulmonary toxicity of ZnO nanoparticles formulated in a liquid matrix for glass coating Nanotoxicology (IF 5.0) Pub Date : 2022-12-08 Anne Thoustrup Saber, Niels Hadrup, Andrew Williams, Alicja Mortensen, Jozef Szarek, Zdenka Kyjovska, Alexander Kurz, Nicklas Raun Jacobsen, Håkan Wallin, Sabina Halappanavar, Ulla Vogel
Abstract The inclusion of nanoparticles can increase the quality of certain products. One application is the inclusion of Zinc oxide (ZnO) nanoparticles in a glass coating matrix to produce a UV-absorbing coating for glass sheets. Yet, the question is whether the inclusion of ZnO in the matrix induces toxicity at low exposure levels. To test this, mice were given single intratracheal instillation of
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Amorphous silica nanoparticles caused lung injury through the induction of epithelial apoptosis via ROS/Ca2+/DRP1-mediated mitochondrial fission signaling Nanotoxicology (IF 5.0) Pub Date : 2022-11-28 Yan Li, Yawen Zhu, Bosen Zhao, Qing Yao, Hailin Xu, Songqing Lv, Ji Wang, Zhiwei Sun, Yanbo Li, Caixia Guo
Abstract The adverse effects of amorphous silica nanoparticles (SiNPs) exposure on the respiratory system were increasingly recognized, however, its potential pathogenesis still remains not fully elucidated. So, this study aimed to explore its effects on pulmonary injury, and to investigate related mechanisms. Histological investigations illustrated SiNPs triggered the lung injury, mainly manifested