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Skin Cancer Risk Is Increased by Somatic Mutations Detected Noninvasively in Healthy-Appearing Sun-Exposed Skin J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-03-19 Kulvinder Kaur, Rizi Ai, Allyson G. Perry, Bae Riley, Emma L. Roberts, Erica N. Montano, Jessica Han, Joanna Roacho, Brenda Garcia Lopez, Maral K. Skelsey, Maria V. Childs, James N. Childs, John Dobak, Claudia Ibarra, Burkhard Jansen, Loren E. Clarke, Steven Stone, John W. Whitaker
Skin cancer risk is increased by exposure to UVR. Because UVR exposure accumulates over time and lighter skin is more susceptible to UVR, age and skin tone are risk factors for skin cancer. However, measurements of somatic mutations in healthy-appearing skin have not been used to calculate skin cancer risk. In this study, we developed a noninvasive test that quantifies somatic mutations in healthy-appearing
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Efficacy and Safety of Rilzabrutinib in Pemphigus: PEGASUS Phase 3 Randomized Study J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-03-16 Dedee F. Murrell, Frédéric Caux, Aikaterini Patsatsi, Owen Hagino, Lidia Rudnicka, Snejina Vassileva, Soner Uzun, Jenny Ye, Karl Yen, Puneet Arora, Steven G. Gourlay, Pascal Joly, Victoria P. Werth
Trial design: Pemphigus is a rare but life-threatening autoimmune disease requiring long-term treatment that minimizes corticosteroid (CS) exposure while providing consistent disease control. The phase 2 pemphigus study of oral, reversible, covalent Bruton tyrosine kinase inhibitor rilzabrutinib demonstrated rapid and sustained efficacy with well-tolerated safety. Methods: Adults (aged 18–80 years)
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Advances in Skin-on-a-Chip Technologies for Dermatological Disease Modeling J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-03-16 Seo Won Cho, Hamza Malick, Soo Jung Kim, Alessandro Grattoni
Skin-on-a-chip (SoC) technologies are emerging as a paradigm shift in dermatology research by replicating human physiology in a dynamic manner not achievable by current animal models. Although animal models have contributed to successful clinical trials, their ability to predict human outcomes remains questionable, owing to inherent differences in skin anatomy and immune response. Covering areas including
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Time Is Running Out: The Circadian Clock Suggests Sex and Aging Differences in Human Epidermis J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-03-16 Rachel Bernstein, Shobhan Gaddameedhi
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Endothelial Dysfunction in Psoriasis: An Integrative Review J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-03-15 Qingyang Li, Bingyu Pang, Erle Dang, Gang Wang
Vascular endothelial cells (ECs), the inner layer of blood vessels, were previously considered to be a passive lining that facilitates cellular and molecular exchange. However, recent studies have revealed that ECs can respond to various stimuli and actively regulate vascular function and skin inflammation. Specific subtypes of ECs are known to have significant roles in a diverse range of physiological
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Emerging Role of Fibroblasts in Vitiligo: A Formerly Underestimated Rising Star J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-03-15 Yue Wu, Yiwen Yang, Yi Lin, Yuecen Ding, Ziqi Liu, Leihong Xiang, Mauro Picardo, Chengfeng Zhang
Vitiligo is a disfiguring depigmentation disorder characterized by loss of melanocytes. Although numerous studies have been conducted on the pathogenesis of vitiligo, the underlying mechanisms remain unclear. Although most studies have focused on melanocytes and keratinocytes, growing evidence suggests the involvement of dermal fibroblasts, residing deeper in the skin. This review aims to elucidate
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Calpain inhibition protects against UVB-induced degradation of dermal-epidermal junction-associated proteins J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-03-13 Iva Doleckova, Tinka Vidovic, Lenka Jandova, Christine Gretzmeier, Alexander A. Navarini, Michael R. MacArthur, Orcun Goksel, Alexander Nyström, Collin Y. Ewald
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Modeling Wound Chronicity In Vivo: The Translational Challenge to Capture the Complexity of Chronic Wounds J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-03-13 Anna-Lisa Pignet, Marlies Schellnegger, Andrzej Hecker, Lars-Peter Kamolz, Petra Kotzbeck
In an aging society with common lifestyle-associated health issues such as obesity and diabetes, chronic wounds pose a frequent challenge that physicians face in everyday clinical practice. Therefore, nonhealing wounds have attracted much scientific attention. Several in vitro and in vivo models have been introduced to deepen our understanding of chronic wound pathogenesis and amplify therapeutic strategies
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SPRY1 Deficiency in Keratinocytes Induces Follicular Melanocyte Stem Cells Migration to Epidermis through p53/Stem Cell Factor/C-KIT Signaling J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-03-08 Ying-Zhe Cui, Fan Xu, Yuan Zhou, Zhao-Yuan Wang, Xing-Yu Yang, Ni-Chang Fu, Xi-Bei Chen, Yu-Xin Zheng, Xue-Yan Chen, Li-Ran Ye, Ying-Ying Li, Xiao-Yong Man
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Genetic Analysis of Perceived Youthfulness Reveals Differences in How Men's and Women’s Age Is Assessed J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-03-07 Nathan Ingold, Mathias Seviiri, Jue-Sheng Ong, Scott Gordon, Rachel E. Neale, David C. Whiteman, Catherine M. Olsen, Stuart MacGregor, Matthew H. Law
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Monocyte-to-High-Density Lipoprotein Ratio Is Associated with Systemic Inflammation, Insulin Resistance, and Coronary Subclinical Atherosclerosis in Psoriasis: Results from 2 Observational Cohorts J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-03-07 Emilio Berna-Rico, Carlota Abbad-Jaime de Aragon, Asuncion Ballester-Martinez, Javier Perez-Bootello, Jorge Solis, Leticia Fernandez-Friera, Mar Llamas-Velasco, Maria Castellanos-Gonzalez, Maria G. Barderas, Carlos Azcarraga-Llobet, Emilio Garcia-Mouronte, Belen de Nicolas-Ruanes, Jorge Naharro-Rodriguez, Pedro Jaen-Olasolo, Joel M. Gelfand, Nehal N. Mehta, Alvaro Gonzalez-Cantero
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CASZ1 is Essential for Skin Epidermal Terminal Differentiation J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-03-06 Stephenie H. Droll, Benny J. Zhang, Maxwell C. Levine, Celia Xue, Patric J. Ho, Xiaomin Bao
The barrier function of skin epidermis is crucial for our bodies to interface with the environment. As epidermis continuously turns over throughout the lifetime, this barrier must be actively maintained by regeneration. Although several transcription factors have been established as essential activators in epidermal differentiation, it is unclear if additional factors remain to be identified. Here
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Tumor-Intrinsic Galectin-3 Suppresses Melanoma Metastasis J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-03-06 Norhan B.B. Mohammed, Lee Seng Lau, Joseph Souchak, Shi Qiu, Manmeet S. Ahluwalia, Iman Osman, Charles J. Dimitroff
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S100A9 Exacerbates the Inflammation in Rosacea through Toll-Like Receptor 4/MyD88/NF-κB Signaling Pathway J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-03-04 Yan Le, Jiawen Zhang, Yi Lin, Jie Ren, Leihong Xiang, Chengfeng Zhang
Rosacea is a chronic inflammatory skin disorder characterized by immune response–dependent erythema and pustules. S100A9, a proinflammatory alarmin, has been associated with various inflammation-related diseases. However, the specific role of S100A9 in rosacea remains unexplored. Therefore, our objective was to unravel the role of S100A9 in the pathogenesis of rosacea and its underlying molecular mechanisms
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Similar alterations of the stratum corneum ceramide profile in atopic dermatitis, psoriasis and ichthyosis: results from a systematic review and meta-analysis. J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-03-04 Jannik Rousel, Catherine Mergen, Jan W. Schoones, Tessa Niemeyer-van der Kolk, Martijn B.A. van Doorn, Joke A. Bouwstra, Jeroen van Smeden, Robert Rissmann, the Next Generation ImmunoDermatology Consortium
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Epidemiology and Comorbidities of Mucous Membrane Pemphigoid: A National Cohort Study J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-03-04 Päivi Leisti, Laura Huilaja, Jari Jokelainen, Outi Varpuluoma, Kaisa Tasanen
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Excoriation Disorder Is Characterized by Systemic Glutamatergic Dysfunction J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-03-04 Zachary A. Bordeaux, Sriya V. Reddy, Emily Z. Ma, Hannah Cornman, Thomas Pritchard, Melika Marani, Weiying Lu, Shenghao Guo, Cissy Zhang, Pratik Khare, Anne Le, Madan M. Kwatra, Shawn G. Kwatra
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The Promises and Perils of Foundation Models in Dermatology J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-03-04 Haiwen Gui, Jesutofunmi A. Omiye, Crystal T. Chang, Roxana Daneshjou
Foundation models (FM), which are large-scale artificial intelligence (AI) models that can complete a range of tasks, represent a paradigm shift in AI. These versatile models encompass large language models, vision-language models, and multimodal models. Although these models are often trained for broad tasks, they have been applied either out of the box or after additional fine tuning to tasks in
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Phosphodiesterase 4 Inhibitors, Basophils, and Atopic Dermatitis J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-03-03 Mrinmoy Das, Saikat Mukherjee, Raif S. Geha
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Staphylococcus aureus: The Bug Behind the Itch in Atopic Dermatitis J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-29 Richard L. Gallo, Alexander R. Horswill
Pruritus or itch is a defining symptom of atopic dermatitis (AD). The origins of itch are complex, and it is considered both a defense mechanism and a cause of disease that leads to inflammation and psychological stress. Considerable progress has been made in understanding the processes that trigger itch, particularly the pruritoceptive origins that are generated in the skin. This perspective review
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Embryonic NIPP1 Depletion in Keratinocytes Triggers a Cell Cycle Arrest and Premature Senescence in Adult Mice J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-29 Marloes C.M. Jonkhout, Tijs Vanhessche, Mónica Ferreira, Iris Verbinnen, Fabienne Withof, Gerd Van der Hoeven, Kathelijne Szekér, Zahra Azhir, Wen-Hui Lien, Aleyde Van Eynde, Mathieu Bollen
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Circulating Monocytes Are Predictive and Responsive in Moderate-to-Severe Plaque Psoriasis Subjects Treated with Apremilast J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-29 Emma L. Larson, Dustin P. DeMeo, Andrew B. Young, Seunghee Margevicius, Joseph Rutter, Amanda L. Davies, Craig A. Rohan, Neil J. Korman, Jeffrey B. Travers, Thomas S. McCormick, Kevin D. Cooper
Monocytes play a critical role in the inflammation associated with psoriasis, and their abnormalities have been reported as biomarkers of cardiovascular event risk, a psoriasis comorbidity. Monocytic cells in chronic inflammatory disorders express elevated levels of cAMP phosphodiesterase. Restoring cAMP levels using the oral cAMP phosphodiesterase-4 inhibitor, apremilast, improves clinical outcomes
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Somatic Loss-of-Function PIK3R1 and Activating Nonhotspot PIK3CA Mutations Associated with Capillary Malformation with Dilated Veins J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-29 Martina De Bortoli, Angela Queisser, Van Cuong Pham, Anne Dompmartin, Raphaël Helaers, Simon Boutry, Cathy Claus, An-Katrien De Roo, Frank Hammer, Pascal Brouillard, Salim Abdelilah-Seyfried, Laurence M. Boon, Miikka Vikkula
Common capillary malformations are red vascular skin lesions, most commonly associated with somatic activating or mutations. We focused on capillary malformations lacking such a mutation to identify previously unreported genetic causes. We used targeted next-generation sequencing on 82 lesions. Bioinformatic analysis allowed the identification of 9 somatic pathogenic variants in and , encoding for
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Topical Ruxolitinib in the Treatment of Necrobiosis Lipoidica: A Prospective, Open-Label Study J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-27 Angelina S. Hwang, Jacob A. Kechter, Xing Li, Alysia Hughes, Kevin J. Severson, Blake Boudreaux, Puneet Bhullar, Shams Nassir, Miranda Yousif, Nan Zhang, Richard J. Butterfield, Steven Nelson, Xianying Xing, Lam C. Tsoi, Samantha Zunich, Aleksandar Sekulic, Mark Pittelkow, Johann E. Gudjonsson, Aaron Mangold
Necrobiosis Lipoidica (NL) is a rare granulomatous disease. There are few effective treatments for NL. We sought to investigate the efficacy and safety of the JAK 1/2 inhibitor, ruxolitnib, in the treatment of NL and identify biomarkers associated with disease and treatment response. We conducted an open-label, phase 2 study of ruxolitinib in 12 patients with NL. We performed transcriptomic analysis
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Skin Innervation J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-24 Sonja Ständer, Martin Schmelz
All layers and appendages of the skin are densely innervated by afferent and efferent neurons providing sensory information and controlling skin perfusion and sweating. In mice, neuronal functions have been comprehensively linked to unique single-cell expression patterns and to characteristic arborization of nerve endings in skin and dorsal horn, whereas for humans, specific molecular markers for functional
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Ex Vivo Patient-Derived Explant Model for Neurofibromatosis Type 1–Related Cutaneous Neurofibromas J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-22 Jamie L. Grit, Lisa Turner, Curt J. Essenburg, Kristin L. Gallik, Patrick S. Dischinger, Nathan D. Shurlow, Matthew J. Pate, Carrie R. Graveel, Matthew R. Steensma
Cutaneous neurofibromas (CNFs) are benign tumors that occur in the dermis of individuals with the inherited tumor predisposition disorder, neurofibromatosis type 1. CNFs cause disfigurement, pain, burning, and itching, resulting in substantially reduced QOL in patients with neurofibromatosis type 1. CNFs are benign tumors that exhibit cellular and molecular heterogeneity, making it difficult to develop
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Trends in Age at Melanoma Diagnosis according to Thickness and Histologic Subtype Have Implications for Causality and Control J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-22 Catherine M. Olsen, Nirmala Pandeya, David C. Whiteman
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The Aryl Hydrocarbon Receptor Regulates Epidermal Differentiation through Transient Activation of TFAP2A J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-22 Jos P.H. Smits, Jieqiong Qu, Felicitas Pardow, Noa J.M. van den Brink, Diana Rodijk-Olthuis, Ivonne M.J.J. van Vlijmen-Willems, Simon J. van Heeringen, Patrick L.J.M. Zeeuwen, Joost Schalkwijk, Huiqing Zhou, Ellen H. Van den Bogaard
The aryl hydrocarbon receptor (AHR) is an evolutionary conserved environmental sensor identified as an indispensable regulator of epithelial homeostasis and barrier organ function. Molecular signaling cascade and target genes upon AHR activation and their contribution to cell and tissue function are however not fully understood. Multiomics analyses using human skin keratinocytes revealed that upon
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Applying Multiomics to Basosquamous Carcinoma J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-22 Gavin R. Long, Arinnae I. Kurdian, Scott X. Atwood
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How Efforts to Understand Somatic Mosaicism Will Impact Dermatology J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-21 Ryland D. Mortlock, Keith A. Choate
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Autophagy during Severe Acute Respiratory Syndrome Coronavirus 2 Induced Leukocytoclastic Vasculitis: New Insights J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-21 Nesrine Brahimi, Vincent Piguet
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Decreased CD19+CD24hiCD38hi Regulatory B Cells in Alopecia Areata J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-21 Jong Yeong Lee, Hyo Jung Lim, Sang-Hyun Kim, Geon-Jong Lee, Kyung-Hwa Nam, Jin Park, Jin Kyeong Choi
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KLF2 Orchestrates Pathological Progression of Infantile Hemangioma through Hemangioma Stem Cell Fate Decisions J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-19 Qiming Chen, Hao Rong, Ling Zhang, Yanan Wang, Qian Bian, Jiawei Zheng
Infantile hemangioma (IH) is the most prevalent vascular tumor during infancy, characterized by a rapid proliferation phase of disorganized blood vessels and spontaneous involution. IH possibly arises from a special type of multipotent stem cells called hemangioma stem cells (HemSCs), which could differentiate into endothelial cells, pericytes, and adipocytes. However, the underlying mechanisms that
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Whole-Body Positron Emission Tomography with 18F-Fluorodeoxyglucose/Magnetic Resonance Imaging as a Screening Tool for the Detection of Malignant Transformation in Individuals with Neurofibromatosis Type 1 J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-17 Laura Fertitta, Arnaud Jannic, Ouidad Zehou, Christina Bergqvist, Salah Ferkal, Sabine Moryousef, Lionel Lerman, Sébastien Mulé, Alain Luciani, Blanche Bapst, Khaled Ezzedine, Nicolas Ortonne, Emmanuel Itti, Pierre Wolkenstein
Malignant peripheral nerve sheath tumors (MPNSTs) are the leading cause of death in patients with neurofibromatosis type 1. They can result from premalignant neurofibromas, including neurofibromas with atypia and atypical neurofibromatous neoplasms of uncertain biologic potential. Some phenotypic characteristics have been described as associated with their development. The aim of this study was to
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Assessment of the Cutaneous Hormone Landscapes and Microbiomes in Vulvar Lichen Sclerosus J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-17 Hunter J. Pyle, Jessica C. Evans, Methinee Artami, Prithvi Raj, Srisha Sridharan, Carlos Arana, Kaitlyn M. Eckert, Jeffrey G. McDonald, Tamia A. Harris-Tryon, Melissa M. Mauskar
Vulvar lichen sclerosus (VLS) is a progressive skin disease of unknown etiology. In this longitudinal case-control exploratory study, we evaluated the hormonal and microbial landscapes in 18 postmenopausal women (mean [SD] age: 64.4 [8.4] years) with VLS and controls. We reevaluated the patients with VLS after 10–14 weeks of daily topical class I steroid. We found that groin cutaneous estrone was lower
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FLG Knockdown–Related Skin–Lung Crosstalk Biologically Underpins an Filaggrin-Related Childhood Asthma Subtype J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-17 Somnath Mukhopadhyay, Sara J. Brown
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Atopic Dermatitis Itch: Scratching for an Explanation J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-16 Georgia Biazus Soares, Takashi Hashimoto, Gil Yosipovitch
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Bone Marrow–Derived ABCC6 Is an Essential Regulator of Ectopic Calcification In Pseudoxanthoma Elasticum J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-15 Christopher Brampton, Viola Pomozi, Yannick Le Corre, Janna Zoll, Gilles Kauffenstein, Chi Ma, Peter R. Hoffmann, Ludovic Martin, Olivier Le Saux
Physiological calcification of soft tissues is a common occurrence in aging and various acquired and inherited disorders. sequence variations cause the calcification phenotype of pseudoxanthoma elasticum (PXE) as well as some cases of generalized arterial calcification of infancy, which is otherwise caused by defective ENPP1. is primarily expressed in the liver, which has given the impression that
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Immune Profiling of Dermatologic Adverse Events from Checkpoint Blockade Using Tissue Cyclic Immunofluorescence: A Pilot Study J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-14 Zoltan Maliga, Daniel Y. Kim, Ai-Tram N. Bui, Jia-Ren Lin, Anna K. Dewan, Saagar Jadeja, George F. Murphy, Ajit J. Nirmal, Christine G. Lian, Peter K. Sorger, Nicole R. LeBoeuf
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A Top-Notch Target J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-14 Alexander Nyström, Jörn Dengjel
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Neuronal BST2: A Pruritic Mediator alongside Protease-Activated Receptor 2 in the IL-27–Driven Itch Pathway J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-13 Yanqing Li, Weiwei Chen, Xingyun Zhu, Huiyuan Mei, Martin Steinhoff, Joerg Buddenkotte, Jinhai Wang, Wenhao Zhang, Zhenghui Li, Xiaolong Dai, Chunxu Shan, Jiafu Wang, Jianghui Meng
Chronic itch is a common and complex symptom often associated with skin diseases such as atopic dermatitis (AD). Although IL-27 is linked to AD, its role and clinical significance in itch remain undefined. We sought to investigate IL-27 function in itch using tissue-specific transgenic mice, various itch models, behavior scoring, RNA sequencing, and cytokine/kinase array. Our findings show that IL-27
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Casting for Proteins in Psoriatic Inflammation Hooks Glycyl-tRNA Synthetases (GARS) J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-12 Sam T. Hwang, Scott I. Simon
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Nanopore sequencing enables allelic phasing of FLG loss-of-function variants, intragenic copy number variation and methylation status in atopic dermatitis and ichthyosis vulgaris J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-08 Colin Wong, Cheng-Yong Tham, Lin Yang, Miles C. Benton, Vipin Narang, Simon Denil, Kaibo Duan, Yik Weng Yew, Bernett Lee, Paola Florez de Sessions, John E.A. Common
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Costimulatory Molecule CD226 Regulates Atopic Dermatitis in a Mouse Model J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-06 Wei Qiao, Chujun Duan, Jingchang Ma, Wei Hu, Yang Xie, Lu Yang, Tingting Wang, Shuwen Wu, Xuemei Li, Yuling Wang, Kun Cheng, Yun Zhang, Yuan Zhang, Ran Zhuang
The present study investigated the role of CD226 in a 2,4-dinitrochlorobenzene (DNCB)-induced mouse model of atopic dermatitis (AD). The results showed that the lack of CD226 (global and CD4 T cell-specific) significantly increased ear thickness, reddening, swelling, and scaling of the skin, as well as inflammatory cell and mast cell infiltration. qPCR results demonstrated that the mRNA expressions
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Deletion of Pak1 in CD11c positive cells confers resistance to mouse skin carcinogenesis J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-06 Kazuhiro Okumura, Takao Morinaga, Megumi Saito, Yurika Tokunaga, Keisuke Otoyama, Sora Tanaka, Eriko Isogai, Masahito Kawazu, Yosuke Togashi, Kimi Araki, Yuichi Wakabayashi
Abstract not available
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Leveraging OpenAI's Advanced Data Analysis Tool in Dermatology: Opportunities and Challenges J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-05 Neil K. Jairath, Sultan Qiblawi, George M. Jeha, Vartan Pahalyants, Ruple Jairath, Shayan Cheraghlou, Vignesh Ramachandran, Yaohui Gloria Xu, Juliet Aylward
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Fusion of Deep Learning with Conventional Imaging Processing: Does It Bring Artificial Intelligence Closer to the Clinic? J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-02 Jason R. Hagerty, Anand Nambisan, R. Joe Stanley, William V. Stoecker
Abstract not available
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Receptor Tyrosine Kinase EPHA2 Drives Epidermal Differentiation through Regulation of EGFR Signaling J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-02 Bethany E. Perez White, Calvin J. Cable, Bo Shi, Rosa Ventrella, Nihal Kaplan, Aya Kobeissi, Yuya Higuchi, Abhinav Balu, Zachary R. Murphy, Priya Kumar, Spiro Getsios
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Assessment of correctness, content omission, and risk of harm in large language model responses to dermatology continuing medical education questions J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-02 Zhuo Ran Cai, Michael L. Chen, Jiyeong Kim, Roberto A. Novoa, Leandra A. Barnes, Andrew Beam, Eleni Linos
Abstract not available
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Desmoplasia is associated with decreased cytotoxic and helper T cells and increased T cell exhaustion in cutaneous squamous cell carcinoma J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-02 Yuka Hirakawa, Qian Zhan, Sernah Essien, Kenneth K. Yu, Fadi Murad, Adriano Piris, Matthew R. Ramsey, Tobias Schatton, John A. Carucci, Chrysalyne D. Schmults
Abstract not available
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Selective Depletion of Staphylococcus aureus Restores the Skin Microbiome and Accelerates Tissue Repair after Injury J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-02 Holly N. Wilkinson, Amber R. Stafford, Michelle Rudden, Nina D.C. Rocha, Alexandria S. Kidd, Sammi Iveson, Andrea L. Bell, Jeffrey Hart, Ana Duarte, Johan Frieling, Ferd Janssen, Christian Röhrig, Bob de Rooij, Peter F. Ekhart, Matthew J. Hardman
Our skin is home to a diverse community of commensal microorganisms integral to cutaneous function. However, microbial dysbiosis and barrier perturbation increase the risk of local and systemic infection. is a particularly problematic bacterial pathogen, with high levels of antimicrobial resistance and direct association with poor healing outcome. Innovative approaches are needed to selectively kill
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Microbes, Autoimmunity, and Cancer: 69th Annual Montagna Symposium on the Biology of Skin J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-01 Robert L. Modlin, Niroshana Anandasabapathy, Daniel Kaplan, John O’Shea, Dennis Roop, Sancy Leachman
Abstract not available
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The Arrival of Artificial Intelligence Large Language Models and Vision-Language Models: A Potential to Possible Change in the Paradigm of Healthcare Delivery in Dermatology J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-01 Aditya K. Gupta, Mesbah Talukder, Tong Wang, Roxana Daneshjou, Vincent Piguet
Abstract not available
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The EGR1–Artemin Axis in Keratinocytes Enhances the Innervation of Epidermal Sensory Neurons during Skin Inflammation Induced by House Dust Mite Extract from Dermatophagoides farinae J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-02-01 Hyunjin Yeo, Sung Shin Ahn, Sukjin Ou, Sook Jung Yun, Yoongho Lim, Dongsoo Koh, Young Han Lee, Soon Young Shin
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Newly Discovered Corneodesmosin Defects in Generalized Pustular Psoriasis J. Invest. Dermatol. (IF 6.5) Pub Date : 2024-01-30 Michel Simon
Abstract not available