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Genetic Deletion of β-Arrestin 2 From the Subfornical Organ and Other Periventricular Nuclei in the Brain Alters Fluid Homeostasis and Blood Pressure Hypertension (IF 8.3) Pub Date : 2024-04-17 Natalia M. Mathieu, Eden E. Tan, John J. Reho, Daniel T. Brozoski, Patricia C. Muskus, Ko-Ting Lu, Kelsey K. Wackman, Justin L. Grobe, Pablo Nakagawa, Curt D. Sigmund
BACKGROUND:ANG (angiotensin II) elicits dipsogenic and pressor responses via activation of the canonical Gαq (G-protein component of the AT1R [angiotensin type 1 receptor])-mediated AT1R in the subfornical organ. Recently, we demonstrated that ARRB2 (β-arrestin 2) global knockout mice exhibit a higher preference for salt and exacerbated pressor response to deoxycorticosterone acetate salt. However
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Dissociation of Hypertension and Renal Damage After Cessation of High-Salt Diet in Dahl Rats Hypertension (IF 8.3) Pub Date : 2024-04-15 Sergey N. Arkhipov, Tang-Dong S. Liao, D’Anna L. Potter, Kevin R. Bobbitt, Veniamin Ivanov, Pablo A. Ortiz, Tengis S. Pavlov
BACKGROUND:Every year, thousands of patients with hypertension reduce salt consumption in the efforts to control their blood pressure. However, hypertension has a self-sustaining character in a significant part of the population. We hypothesized that chronic hypertension leads to irreversible renal damage that remains after removing the trigger, causing an elevation of the initial blood pressure.METHODS:Dahl
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Atrial Fibrillation Screening During Routine Automated Office, Home, and Ambulatory Blood Pressure Measurement: A Diagnostic Test Accuracy Systematic Review and Meta-Analysis Hypertension (IF 8.3) Pub Date : 2024-04-11 Konstantinos G. Kyriakoulis, Anastasios Kollias, Ariadni Menti, Panagiotis Chardouvelis, George S. Stergiou
BACKGROUND:Atrial fibrillation (AF) is often asymptomatic and undiagnosed. As AF and hypertension often coexist, opportunistic AF detection during routine automated blood pressure (BP) measurement appears to be an attractive screening method.METHODS:A systematic literature search was conducted to identify studies assessing the diagnostic test accuracy of office, home, or 24-hour ambulatory BP measuring
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Recommendations for the Use of Dietary Fiber to Improve Blood Pressure Control Hypertension (IF 8.3) Pub Date : 2024-04-08 Hamdi A. Jama, Matthew Snelson, Aletta E. Schutte, Jane Muir, Francine Z. Marques
According to several international, regional, and national guidelines on hypertension, lifestyle interventions are the first-line treatment to lower blood pressure (BP). Although diet is one of the major lifestyle modifications described in hypertension guidelines, dietary fiber is not specified. Suboptimal intake of foods high in fiber, such as in Westernized diets, is a major contributing factor
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Interplay Between Plasma Glycine and Branched-Chain Amino Acids Contributes to the Development of Hypertension and Coronary Heart Disease Hypertension (IF 8.3) Pub Date : 2024-04-08 Mateusz Dziedzic, Ewelina Józefczuk, Tomasz J. Guzik, Mateusz Siedlinski
BACKGROUND:Higher levels of plasma glycine are linked to a reduced risk, while increased levels of total branched-chain amino acids (tBCAAs) are associated with a higher risk of essential hypertension (HTN) and coronary heart disease (CHD). As these metabolic components are interconnected, analyzing the tBCAAs/glycine ratio may help to understand their interplay in the pathogenesis of cardiovascular
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Impact of Renal Denervation on Urinary Peptide-Based Biomarkers in Hypertension Hypertension (IF 8.3) Pub Date : 2024-04-04 Lucas Lauder, Justyna Siwy, Emmanouil Mavrogeorgis, Felix Keller, Michael Kunz, Angelika Wachter, Insa Emrich, Michael Böhm, Harald Mischak, Felix Mahfoud
BACKGROUND:Catheter-based renal denervation (RDN) reduces blood pressure in hypertension. Urinary peptides are associated with cardiovascular and renal disease and provide prognostic information. We aimed to investigate the effect of RDN on urinary peptide-based biomarker panels associated with chronic kidney and heart disease and to identify urinary peptides affected by RDN.METHODS:This single-arm
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Maintenance of Normal Blood Pressure From Middle to Older Age: Results From the Atherosclerosis Risk in Communities Study Hypertension (IF 8.3) Pub Date : 2024-04-03 Kathryn Foti, Josef Coresh, Paul K. Whelton, Kunihiro Matsushita, Shakia T. Hardy, Kristi Reynolds, C. Barrett Bowling, Keenan A. Walker, Anna Kucharska-Newton, B. Gwen Windham, Michael Griswold, Joseph E. Schwartz, Paul Muntner
BACKGROUND:It is unknown whether maintaining normal blood pressure (BP) from middle to older age is associated with improved health outcomes.METHODS:We estimated the proportion of Atherosclerosis Risk in Communities study participants who maintained normal BP from 1987 to 1989 (visit 1) through 1996 to 1998 and 2011 to 2013 (over 4 and 5 visits, respectively). Normal BP was defined as systolic BP <120
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The 2023 Lewis K. Dahl Memorial Lecture: Angiotensin-Converting Enzyme 2 Posttranslational Modifications—Implications for Hypertension and SARS-CoV-2 Infection Hypertension (IF 8.3) Pub Date : 2024-04-03 Mona Elgazzaz, Catalin Filipeanu, Eric Lazartigues
ACE2 (angiotensin-converting enzyme 2), a multifunctional transmembrane protein, is well recognized as an important member of the (RAS) renin–angiotensin system with important roles in the regulation of cardiovascular function by opposing the harmful effects of Ang-II (angiotensin II) and AT1R (Ang-II type 1 receptor) activation. More recently, ACE2 was found to be the entry point for the SARS-CoV-2
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Blood Pressure Lowering in Patients With Central Hypertension: A randomized Clinical Trial Hypertension (IF 8.3) Pub Date : 2024-04-02 James E. Sharman, Petr Otahal, Michael Stowasser, Tony Stanton, Christopher M. Reid, Mark Nolan, Philip Roberts-Thomson, Kazuaki Negishi, Robert Greenough, Simon Stewart, Thomas H. Marwick, Walter P. Abhayaratna
BACKGROUND:Cuff blood pressure (BP) is recommended for guiding hypertension management. However, central BP has been proposed as a superior clinical measurement. This study aimed to determine whether controlling hypertension as measured by central BP was beneficial in reducing left ventricular mass index beyond control of standard cuff hypertension.METHODS:This multicenter, open-label, blinded-end
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Coronary Microvascular Function Following Severe Preeclampsia Hypertension (IF 8.3) Pub Date : 2024-04-02 Michael C. Honigberg, Katherine E. Economy, Maria A. Pabón, Xiaowen Wang, Claire Castro, Jenifer M. Brown, Sanjay Divakaran, Brittany N. Weber, Leanne Barrett, Anna Perillo, Anina Y. Sun, Tajmara Antoine, Faranak Farrohi, Brenda Docktor, Emily S. Lau, Doreen DeFaria Yeh, Pradeep Natarajan, Amy A. Sarma, Robert M. Weisbrod, Naomi M. Hamburg, Jennifer E. Ho, Jason D. Roh, Malissa J. Wood, Nandita S.
BACKGROUND:Preeclampsia is a pregnancy-specific hypertensive disorder associated with an imbalance in circulating proangiogenic and antiangiogenic proteins. Preclinical evidence implicates microvascular dysfunction as a potential mediator of preeclampsia-associated cardiovascular risk.METHODS:Women with singleton pregnancies complicated by severe antepartum-onset preeclampsia and a comparator group
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MFAP4-Deficiency Aggravates Age-Induced Changes in Resistance Artery Structure, While Ameliorating Hypertension Hypertension (IF 8.3) Pub Date : 2024-04-02 Kimmie B. Christensen, Şeyda Ünsal, Morten F. Ebbesen, Line Hemstra, Anders Schlosser, Kristoffer Rosenstand, Pernille B.L. Hansen, Boye L. Jensen, Maria Bloksgaard, Ulf Simonsen, Grith L. Sorensen
BACKGROUND:Abnormalities of resistance arteries may play essential roles in the pathophysiology of aging and hypertension. Deficiency of the vascular extracellular matrix protein MFAP4 (microfibrillar-associated protein 4) has previously been observed as protective against aberrant arterial remodeling. We hypothesized that MFAP4-deficiency would reduce age- and hypertension-dependent arterial changes
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Sympathetic Pathophysiology in Hypertension Origins: The Path to Renal Denervation Hypertension (IF 8.3) Pub Date : 2024-04-01 Murray D. Esler, John W. Osborn, Markus P. Schlaich
The importance of the sympathetic nervous system in essential hypertension has been recognized in 2 eras. The first was in early decades of the 20th century, through to the 1960s. Here, the sympathetic nervous system was identified as a target for the treatment of hypertension, and an extensive range of antiadrenergic therapies were developed. Then, after a period of lapsed interest, in a second era
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Salt-Sensitive Hypertension and the Kidney Hypertension (IF 8.3) Pub Date : 2024-03-28 Mitsuhiro Nishimoto, Karen Griffin, Brandi M. Wynne, Toshiro Fujita
Salt-sensitive hypertension (SS-HT) is characterized by blood pressure elevation in response to high dietary salt intake and is considered to increase the risk of cardiovascular and renal morbidity. Although the mechanisms responsible for SS-HT are complex, the kidneys are known to play a central role in the development of SS-HT and the salt sensitivity of blood pressure (SSBP). Moreover, several factors
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Genetic and Epigenetic Mechanisms Regulating Blood Pressure and Kidney Dysfunction Hypertension (IF 8.3) Pub Date : 2024-03-28 Kailash N. Pandey
The pioneering work of Dr Lewis K. Dahl established a relationship between kidney, salt, and high blood pressure (BP), which led to the major genetic-based experimental model of hypertension. BP, a heritable quantitative trait affected by numerous biological and environmental stimuli, is a major cause of morbidity and mortality worldwide and is considered to be a primary modifiable factor in renal
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Knocking Out Sodium Glucose–Linked Transporter 5 Prevents Fructose-Induced Renal Oxidative Stress and Salt-Sensitive Hypertension Hypertension (IF 8.3) Pub Date : 2024-03-28 Beau R. Forester, Ronghao Zhang, Brett Schuhler, Autumn Brostek, Agustin Gonzalez-Vicente, Jeffrey L. Garvin
BACKGROUND:A fructose high-salt (FHS) diet increases systolic blood pressure and Ang II (angiotensin II)–stimulated proximal tubule (PT) superoxide (O2−) production. These increases are prevented by scavenging O2− or an Ang II type 1 receptor antagonist. SGLT4 (sodium glucose-linked cotransporters 4) and SGLT5 are implicated in PT fructose reabsorption, but their roles in fructose-induced hypertension
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Increased Risk of Gestational Hypertension by Periconceptional Exposure to Ambient Air Pollution and Effect Modification by Prenatal Depression Hypertension (IF 8.3) Pub Date : 2024-03-27 Zhongzheng Niu, Rima Habre, Tingyu Yang, Xinci Chen, Mario Vigil, Karina Barragan, Fred Lurmann, Nathan R. Pavlovic, Brendan H. Grubbs, Claudia M. Toledo-Corral, Jill Johnston, Genevieve F. Dunton, Deborah Lerner, Nathana Lurvey, Laila Al-Marayati, Sandrah P. Eckel, Carrie V. Breton, Theresa M. Bastain, Shohreh F. Farzan
BACKGROUND:Air pollution has been associated with gestational hypertension (GH) and preeclampsia, but susceptible windows of exposure and potential vulnerability by comorbidities, such as prenatal depression, remain unclear.METHODS:We ascertained GH and preeclampsia cases in a prospective pregnancy cohort in Los Angeles, CA. Daily levels of ambient particles (with a diameter of ≤10 μm [PM10] or ≤2
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Neural Circuits Underlying Reciprocal Cardiometabolic Crosstalk: 2023 Arthur C. Corcoran Memorial Lecture Hypertension (IF 8.3) Pub Date : 2024-03-27 Kamal Rahmouni
The interplay of various body systems, encompassing those that govern cardiovascular and metabolic functions, has evolved alongside the development of multicellular organisms. This evolutionary process is essential for the coordination and maintenance of homeostasis and overall health by facilitating the adaptation of the organism to internal and external cues. Disruption of these complex interactions
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Subtype Identification of Surgically Curable Primary Aldosteronism During Treatment With Mineralocorticoid Receptor Blockade Hypertension (IF 8.3) Pub Date : 2024-03-25 Giovanni Pintus, Teresa Maria Seccia, Laurence Amar, Michel Azizi, Anna Riester, Martin Reincke, Jiří Widimský, Mitsuhide Naruse, Tomaz Kocjan, Aurelio Negro, Gregory Kline, Akiyo Tanabe, Fumitoshi Satoh, Lars Christian Rump, Oliver Vonend, Peter J. Fuller, Jun Yang, Nicholas Yong Nian Chee, Steven B. Magill, Zulfiya Shafigullina, Marcus Quinkler, Anna Oliveras, Bo-Ching Lee, Chin-Chen Chang, Vin-Cent
BACKGROUND:Current guidelines and consensus documents recommend withdrawal of mineralocorticoid receptor antagonists (MRAs) before primary aldosteronism (PA) subtyping by adrenal vein sampling (AVS), but this practice can cause severe hypokalemia and uncontrolled high blood pressure. Our aim was to investigate if unilateral PA can be identified by AVS during MRA treatment.METHODS:We compared the rate
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Association Between Orthostatic Hypertension and Frailty Among Older Patients With Hypertension Hypertension (IF 8.3) Pub Date : 2024-03-21 Jung-Yeon Choi, Dong Ryeol Ryu, Hae-Young Lee, Ju-Hee Lee, Youjin Hong, Sue K. Park, Jang Hoon Lee, Seok-Jae Hwang, Kye Hun Kim, Sun Hwa Lee, Song Yi Kim, Jae-Hyeong Park, Sang-Hyun Kim, Hack-Lyoung Kim, Jung Hyun Choi, Cheol-Ho Kim, Myeong-Chan Cho, Kwang-il Kim
BACKGROUND:Frailty frequently coexists with hypertension in older patients. We aimed to evaluate the association between frailty and positional change in blood pressure, especially orthostatic hypertension.METHODS:Participants were recruited from 12 University hospitals in South Korea. Using a digital device, trained research nurses measured blood pressure in the supine and standing positions. Physical
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Mechanisms of Vascular Inflammation and Potential Therapeutic Targets: A Position Paper From the ESH Working Group on Small Arteries Hypertension (IF 8.3) Pub Date : 2024-03-21 Francisco J. Rios, Carolina de Ciuceis, Georgios Georgiopoulos, Antonios Lazaridis, Ryszard Nosalski, George Pavlidis, Simon Tual-Chalot, Claudia Agabiti-Rosei, Livia L. Camargo, Edyta Dąbrowska, Fosca Quarti-Trevano, Marcin Hellmann, Stefano Masi, Mariarosaria Lopreiato, Georgios Mavraganis, Alessandro Mengozzi, Augusto C. Montezano, Konstantinos Stavropoulos, Pawel J. Winklewski, Jacek Wolf, Sarah
Inflammatory responses in small vessels play an important role in the development of cardiovascular diseases, including hypertension, stroke, and small vessel disease. This involves various complex molecular processes including oxidative stress, inflammasome activation, immune-mediated responses, and protein misfolding, which together contribute to microvascular damage. In addition, epigenetic factors
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Long-Term Blood Pressure Reductions Following Catheter-Based Renal Denervation: A Systematic Review and Meta-Analysis Hypertension (IF 8.3) Pub Date : 2024-03-20 Gianni Sesa-Ashton, Janis M. Nolde, Ida Muente, Revathy Carnagarin, Vaughan G. Macefield, Tye Dawood, Elisabeth A. Lambert, Gavin W. Lambert, Antony Walton, Murray D. Esler, Markus P. Schlaich
BACKGROUND:Renal denervation is a recognized adjunct therapy for hypertension with clinically significant blood pressure (BP)-lowering effects. Long-term follow-up data are critical to ascertain durability of the effect and safety. Aside from the 36-month follow-up data available from randomized control trials, recent cohort analyses extended follow-up out to 10 years. We sought to analyze study-level
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Coarctation Duration and Severity Predict Risk of Hypertension Precursors in a Preclinical Model and Hypertensive Status Among Patients Hypertension (IF 8.3) Pub Date : 2024-03-19 Arash Ghorbannia, Hilda Jurkiewicz, Lith Nasif, Abdillahi Ahmed, Jennifer Co-Vu, Mehdi Maadooliat, Ronald K. Woods, John F. LaDisa Jr
BACKGROUND:Coarctation of the aorta (CoA) often leads to hypertension) posttreatment. Evidence is lacking for the current >20 mm Hg peak-to-peak blood pressure (BP) gradient (BPGpp) guideline, which can cause aortic thickening, stiffening, and dysfunction. This study sought to find the BPGpp severity and duration that avoid persistent dysfunction in a preclinical model and test if predictors translate
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Renal Autotransplantation for Uncontrolled Hypertension in Nonatherosclerotic Renal Artery Stenosis—2 Case Reports and a Brief Review of the Literature Hypertension (IF 8.3) Pub Date : 2024-03-20 James Goodman, Spoorthy Kulkarni, Viknesh Selvarajah, Nicholas Hilliard, Neil Russell, Ian B. Wilkinson
Fibromuscular dysplasia is the most common cause of renovascular hypertension in young adults under 40 years old. It is potentially amenable to renal artery angioplasty, which frequently normalizes blood pressure. However, limited options exist if angioplasty is not technically possible, or restenosis occurs. Here, we describe 2 patients who presented with hypertension secondary to renal artery stenosis
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Kidney Renin–Angiotensin System: Lost in a RAS Cascade Hypertension (IF 8.3) Pub Date : 2024-03-20 Steven D. Crowley, L. Gabriel Navar, Minolfa C. Prieto, Susan B. Gurley, Thomas M. Coffman
Renin was discovered more than a century ago. Since then, the functions of the renin–angiotensin system in the kidney have been the focus of intensive research revealing its importance in regulation of renal physiology and in the pathogenesis of heart, vascular, and kidney diseases. Inhibitors of renin–angiotensin system components are now foundational therapies for a range of kidney and cardiovascular
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Treatment of Sleep Apnea and Reduction in Blood Pressure: The Role of Heart Rate Response and Hypoxic Burden Hypertension (IF 8.3) Pub Date : 2024-03-20 Ludovico Messineo, Scott Sands, Christopher Schmickl, Gonzalo Labarca, Wen-Hsin Hu, Neda Esmaeili, Daniel Vena, Laura Gell, Nicole Calianese, Atul Malhotra, Daniel J. Gottlieb, Andrew Wellman, Susan Redline, Ali Azarbarzin
BACKGROUND:Obstructive sleep apnea is associated with increased blood pressure (BP). Obstructive sleep apnea treatment reduces BP with substantial variability, not explained by the apnea-hypopnea index, partly due to inadequate characterization of obstructive sleep apnea’s physiological consequences, such as oxygen desaturation, cardiac autonomic response, and suboptimal treatment efficacy. We sought
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Prognostic Relevance of Short-Term Blood Pressure Variability. The Spanish ABPM Registry Hypertension (IF 8.3) Pub Date : 2024-03-20 Alejandro de la Sierra, Bryan Williams, Michael Bursztyn, Gianfranco Parati, George Stergiou, Ernest Vinyoles, Julián Segura, Manuel Gorostidi, Luis M. Ruilope
BACKGROUND:The prognostic relevance of short-term blood pressure (BP) variability in hypertension is not clearly established. We aimed to evaluate the association of short-term BP variability, with all-cause and cardiovascular mortality in a large cohort of patients with hypertension.METHODS:We selected 59 124 patients from the Spanish Ambulatory Blood Pressure Monitoring Registry from 2004 to 2014
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Association Between Gestational Diabetes Mellitus and Hypertension: A Systematic Review and Meta-Analysis of Cohort Studies With a Quantitative Bias Analysis of Uncontrolled Confounding Hypertension (IF 8.3) Pub Date : 2024-03-19 Xinyue Liu, Roch Nianogo, Carla Janzen, Zhe Fei, Marissa Seamans, Renee Wen, Xiang Li, Liwei Chen
BACKGROUND:Whether individuals with gestational diabetes (GDM) had an increased risk of hypertension remains unclear. We conducted a systematic literature review and meta-analysis to examine the association between GDM and hypertension and performed a quantitative bias analysis to quantify the impact of uncontrolled confounding due to antenatal psychological stress.METHODS:We searched databases (PUBMED
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Role of Raptor Gene Variants in Hypertension: Influence on Blood Pressure Independent of Salt Intake in White Population Hypertension (IF 8.3) Pub Date : 2024-03-18 Hayat Aljaibeji, Mahyar Heydarpour, Ana Maria Stanton, Jonathan S. Williams, Luminita H. Pojoga, Jose R. Romero, Gordon H. Williams
BACKGROUND:The mTOR (mechanistic target of rapamycin) is an essential regulator of fundamental biological processes. mTOR forms 2 distinct complexes, mTORC1 (mTOR complex 1) when it binds with RAPTOR (Regulatory-associated Protein of mTOR) and mTORC2 (mTOR complex 2) when it associates with RICTOR (Rapamycin-insesitive companion of mTOR). Due to the previous link between the mTOR pathway, aldosterone
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Identification of Circulating Plasma Proteins as a Mediator of Hypertension-Driven Cardiac Remodeling: A Mediation Mendelian Randomization Study Hypertension (IF 8.3) Pub Date : 2024-03-15 Yuanlong Hu, Lin Lin, Lei Zhang, Yuan Li, Xinhai Cui, Mengkai Lu, Zhiyuan Zhang, Xiuya Guan, Muxin Zhang, Jiaqi Hao, Xiaojie Wang, Jiaming Huan, Wenqing Yang, Chao Li, Yunlun Li
BACKGROUND:This study focused on circulating plasma protein profiles to identify mediators of hypertension-driven myocardial remodeling and heart failure.METHODS:A Mendelian randomization design was used to investigate the causal impact of systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure on 82 cardiac magnetic resonance traits and heart failure risk. Mediation analyses
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Cytokines, C-Reactive Protein, and Risk of Incident Hypertension in the REGARDS Study Hypertension (IF 8.3) Pub Date : 2024-03-15 Timothy B. Plante, Stephen P. Juraschek, George Howard, Virginia J. Howard, Russell P. Tracy, Nels C. Olson, Suzanne E. Judd, Debora Kamin Mukaz, Neil A. Zakai, D. Leann Long, Mary Cushman
BACKGROUND:Hypertension is a highly prevalent cardiovascular disease risk factor that may be related to inflammation. Whether adverse levels of specific inflammatory cytokines relate to hypertension is unknown. The present study sought to determine whether higher levels of IL (interleukin)-1β, IL-6, TNF (tumor necrosis factor)-α, IFN (interferon)-γ, IL-17A, and CRP (C-reactive protein) are associated
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Association of Blood Pressure With Brain White Matter Microstructural Integrity Assessed With MRI Diffusion Tensor Imaging in Healthy Young Adults Hypertension (IF 8.3) Pub Date : 2024-03-15 Junyeon Won, Pauline Maillard, Kevin Shan, John Ashely, Danilo Cardim, David C. Zhu, Rong Zhang
BACKGROUND:High blood pressure (BP) in middle-aged and older adults is associated with a brain white matter (WM) microstructural abnormality. However, little evidence is available in healthy young adults. We investigated the associations between high BP and WM microstructural integrity in young adults.METHODS:This study included 1015 healthy young adults (542 female, 22–37 years) from the Human Connectome
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Therapeutic Inertia With Initial Low-Dose Quadruple Combination Therapy for Hypertension: Results From the QUARTET Trial Hypertension (IF 8.3) Pub Date : 2024-03-13 Nelson Wang, Amy von Huben, Simone Marschner, Mark Nelson, Janis M. Nolde, Markus Schlaich, Gemma Figtree, Graham Hillis, Tim Usherwood, Christopher Reid, John Chalmers, Shirley Jansen, Emily R. Atkins, Laurent Billot, Clara Chow, Anthony Rodgers, On behalf of the QUARTET Investigators
BACKGROUND:Low-dose combinations are a promising intervention for improving blood pressure (BP) control but their effects on therapeutic inertia are uncertain.METHODS:Analysis of 591 patients randomized to an ultra-low-dose quadruple pill or initial monotherapy. The episode of therapeutic inertia was defined as a patient visit with a BP of >140/90 mm Hg without intensification of antihypertensive treatment
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Rationale of the Inclusion of β-Blockers Among Major Antihypertensive Drugs in the 2023 European Society of Hypertension Guidelines Hypertension (IF 8.3) Pub Date : 2024-03-13 Giuseppe Mancia, Mattias Brunström, Michel Burnier, Guido Grassi, Andrzej Januszewicz, Sverre E. Kjeldsen, Maria L. Muiesan, Costas Thomopoulos, Konstantinos Tsioufis, Reinhold Kreutz
We address the reasons why, unlike other guidelines, in the 2023 guidelines of the European Society of Hypertension β-blockers (BBs) have been regarded as major drugs for the treatment of hypertension, at the same level as diuretics, calcium channel blockers, and blockers of the renin-angiotensin system. We argue that BBs, (1) reduce blood pressure (the main factor responsible for treatment-related
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Potassium-Switch Signaling Pathway Dictates Acute Blood Pressure Response to Dietary Potassium Hypertension (IF 8.3) Pub Date : 2024-03-11 Paul A. Welling, Robert Little, Lama Al-Qusairi, Eric Delpire, David H. Ellison, Robert A. Fenton, P. Richard Grimm
BACKGROUND:Potassium (K+)-deficient diets, typical of modern processed foods, increase blood pressure (BP) and NaCl sensitivity. A K+-dependent signaling pathway in the kidney distal convoluted tubule, coined the K+ switch, that couples extracellular K+ sensing to activation of the thiazide-sensitive NaCl cotransporter (NCC) and NaCl retention has been implicated, but causality has not been established
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Secondary Analysis of the Salt Substitute and Stroke Study (SSaSS): Effects of Potassium-Enriched Salt on Cardiac Outcomes Hypertension (IF 8.3) Pub Date : 2024-03-11 Jie Yu, Clare Arnott, Qiang Li, Gian Luca Di Tanna, Maoyi Tian, Liping Huang, Xuejun Yin, Xinyi Zhang, Sallie-Anne Pearson, Darwin R. Labarthe, Paul Elliott, Lijing L. Yan, Bo Zhou, Yangfeng Wu, Bruce Neal
Background:The SSaSS (Salt Substitute and Stroke Study) has shown that use of a potassium-enriched salt lowers the risk of stroke, total cardiovascular events, and premature death. The effects on cause-specific cardiac outcomes are reported here.Methods:SSaSS was an unblinded, cluster-randomised trial assessing the effects of potassium-enriched salt compared with regular salt among 20 995 Chinese adults
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Association of Blood Pressure With Brain Ages: A Cohort Study of Gray and White Matter Aging Discrepancy in Mid-to-Older Adults From UK Biobank Hypertension (IF 8.3) Pub Date : 2024-03-11 Jing Du, Yuangang Pan, Jiyang Jiang, Yue Liu, Ben C.P. Lam, Aletta E. Schutte, Ivor W. Tsang, Perminder S. Sachdev, Wei Wen
BACKGROUND:Gray matter (GM) and white matter (WM) impairments are both associated with raised blood pressure (BP), although whether elevated BP is differentially associated with the GM and WM aging process remains inadequately examined.METHODS:We included 37 327 participants with diffusion-weighted imaging (DWI) and 39 630 participants with T1-weighted scans from UK Biobank. BP was classified into
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Associations of Proteomics With Hypertension and Systolic Blood Pressure: KORA S4/F4/FF4 and KORA-Age1/Age2 Cohort Studies Hypertension (IF 8.3) Pub Date : 2024-03-06 Jie-sheng Lin, Agnese Petrera, Stefanie M. Hauck, Christian L. Müller, Annette Peters, Barbara Thorand
BACKGROUND:Hypertension, a complex condition, is primarily defined based on blood pressure readings without involving its pathophysiological mechanisms. We aimed to identify biomarkers through a proteomic approach, thereby enhancing the future definition of hypertension with insights into its molecular mechanisms.METHODS:The discovery analysis included 1560 participants, aged 55 to 74 years at baseline
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Ovariectomy-Induced Arterial Stiffening Differs From Vascular Aging and Is Reversed by GPER Activation Hypertension (IF 8.3) Pub Date : 2024-03-06 Isabella M. Kilanowski-Doroh, Alexandra B. McNally, Tristen Wong, Bruna Visniauskas, Sophia A. Blessinger, Ariane Imulinde Sugi, Chase Richard, Zaidmara Diaz, Alec Horton, Christopher A. Natale, Benard O. Ogola, Sarah H. Lindsey
BACKGROUND:Arterial stiffness is a cardiovascular risk factor and dramatically increases as women transition through menopause. The current study assessed whether a mouse model of menopause increases arterial stiffness in a similar manner to aging and whether activation of the G-protein–coupled estrogen receptor could reverse stiffness.METHODS:Female C57Bl/6J mice were ovariectomized at 10 weeks of
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Hypertension, Neurodegeneration, and Cognitive Decline Hypertension (IF 8.3) Pub Date : 2024-03-01 Anthony Pacholko, Costantino Iadecola
Elevated blood pressure is a well-established risk factor for age-related cognitive decline. Long linked to cognitive impairment on vascular bases, increasing evidence suggests a potential association of hypertension with the neurodegenerative pathology underlying Alzheimer disease. Hypertension is well known to disrupt the structural and functional integrity of the cerebral vasculature. However, the
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Mineralocorticoid Receptors in Vascular Smooth Muscle: Blood Pressure and Beyond Hypertension (IF 8.3) Pub Date : 2024-03-01 Nicholas D. Camarda, Jaime Ibarrola, Lauren A. Biwer, Iris Z. Jaffe
After half a century of evidence suggesting the existence of mineralocorticoid receptors (MR) in the vasculature, the advent of technology to specifically knockout the MR from smooth muscle cells (SMCs) in mice has elucidated contributions of SMC-MR to cardiovascular function and disease, independent of the kidney. This review summarizes the latest understanding of the molecular mechanisms by which
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Revisiting Cardiovascular Benefits of Blood Pressure Reduction in Primary and Secondary Prevention: Focus on Targets and Residual Risk—A Systematic Review and Meta-Analysis Hypertension (IF 8.3) Pub Date : 2024-02-23 Eleni Manta, Costas Thomopoulos, Maria Kariori, Dimitrios Polyzos, Constantinos Mihas, Dimitrios Konstantinidis, Dimitrios Farmakis, Giuseppe Mancia, Konstantinos Tsioufis
BACKGROUND:Previous meta-analyses resurrected the debated statement “the lower, the better” following blood pressure (BP)-lowering treatment. We investigated the benefits of BP-lowering treatment at different BP targets by prevention category.METHODS:The meta-analysis protocol was registered at the International Prospective Register of Systematic Reviews (CRD42022379249). The database included 115
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Mortality and Cardiovascular End Points In Relation to the Aortic Pulse Wave Components: An Individual-Participant Meta-Analysis Hypertension (IF 8.3) Pub Date : 2024-02-23 Gavin R. Norton, De-Wei An, Lucas S. Aparicio, Yu-Ling Yu, Fang-Fei Wei, Teemu J. Niiranen, Chen Liu, Katarzyna Stolarz-Skrzypek, Wiktoria Wojciechowska, Antti M. Jula, Marek Rajzer, Dries S. Martens, Peter Verhamme, Yan Li, Kalina Kawecka-Jaszcz, Tim S. Nawrot, Jan A. Staessen, Angela J. Woodiwiss, The International Database of Central Arterial Properties for Risk Stratification Investigators‡
BACKGROUND:Wave separation analysis enables individualized evaluation of the aortic pulse wave components. Previous studies focused on the pressure height with overall positive but differing results. In the present analysis, we assessed the associations of the pressure of forward and backward (Pfor and Pref) pulse waves with prospective cardiovascular end points, with extended analysis for time to
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Trends in All-Cause, Cardiovascular, and Noncardiovascular Mortality Among US Adults With Hypertension Hypertension (IF 8.3) Pub Date : 2024-02-23 Eunhee Choi, Daichi Shimbo, Ligong Chen, Kathryn Foti, Lama Ghazi, Shakia T. Hardy, Paul Muntner
Background:Death certificate data indicate that hypertension may have increased as a contributing cause of death among US adults. Hypertension is not commonly recorded on death certificates although it contributes to a substantial proportion of cardiovascular disease (CVD) deaths.Methods:We estimated changes in all-cause, CVD, and non-CVD mortality over 5 years of follow-up among 4 cohorts of US adults
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Sodium, Interstitium, Lymphatics and Hypertension—A Tale of Hydraulics Hypertension (IF 8.3) Pub Date : 2024-02-22 Giacomo Rossitto, Giovanni Bertoldi, Joseph M. Rutkowski, Brett M. Mitchell, Christian Delles
Blood pressure is regulated by vascular resistance and intravascular volume. However, exchanges of electrolytes and water between intra and extracellular spaces and filtration of fluid and solutes in the capillary beds blur the separation between intravascular, interstitial and intracellular compartments. Contemporary paradigms of microvascular exchange posit filtration of fluids and solutes along
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Overview of the Evolution of Hypertension: From Ancient Chinese Emperors to Today Hypertension (IF 8.3) Pub Date : 2024-02-22 George L. Bakris, Michael A. Weber
Hypertension is one of the most commonly treated conditions in modern medical practice, but despite its long history, it was largely ignored until the midpoint of the 20th century. This article will review the origins of elevated blood pressure from when it was first appreciated in 2600 BC to its most recent emerging treatments. Awareness of sustained elevations in blood pressure goes back to the Chinese
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Sympathetic Neural Control at Rest and During the Cold Pressor Test in Patients With Heart Failure With Preserved Ejection Fraction Hypertension (IF 8.3) Pub Date : 2024-02-22 Ryosuke Takeda, Sarah L. Hissen, John D. Akins, Takuro Washio, Christopher M. Hearon Jr, James P. MacNamara, Satyam Sarma, Benjamin D. Levine, Paul J. Fadel, Qi Fu
Background:We tested the hypothesis that patients with heart failure with preserved ejection fraction (HFpEF) would have greater muscle sympathetic nerve activity (MSNA) at rest and sympathetic reactivity during a cold pressor test compared with non–heart failure controls. Further, given the importance of the baroreflex modulation of MSNA in the control of blood pressure (BP), we hypothesized that
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Incident Cardiovascular Disease in Women With Type 1 or Type 2 Diabetes Following a Hypertensive Disorder of Pregnancy Hypertension (IF 8.3) Pub Date : 2024-02-22 Kristina Mattsson, Mats Pihlsgård, Sofia Enhörning, Simon Timpka
BACKGROUND:The extent to which a history of hypertensive disorders of pregnancy is associated with incident cardiovascular disease also among women with diabetes is unknown.METHODS:In this nationwide register-based cohort study, parous women aged 18 to 69 years with a first delivery in the Swedish Medical Birth Register, regardless of diabetic status at that time, and a subsequent clinical visit in
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Forgotten Circulation: Reduced Mesenteric Venous Capacitance in Hypertensive Rats Is Improved by Decreasing Sympathetic Activity Hypertension (IF 8.3) Pub Date : 2024-02-21 Tonja W. Emans, Davi J.A. Moraes, Alona Ben-Tal, Carolyn J. Barrett, Julian F.R. Paton, Fiona D. McBryde
BACKGROUND:The mesenteric venous reservoir plays a vital role in mediating blood volume and pressure changes and is richly innervated by sympathetic nerves; however, the precise nature of venous sympathetic regulation and its role during hypertension remains unclear. We hypothesized that sympathetic drive to mesenteric veins in spontaneously hypertensive (SH) rats is raised, increasing mean circulatory
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AI, Machine Learning, and ChatGPT in Hypertension Hypertension (IF 8.3) Pub Date : 2024-02-21 Anita T. Layton
Hypertension, a leading cause of cardiovascular disease and premature death, remains incompletely understood despite extensive research. Indeed, even though numerous drugs are available, achieving adequate blood pressure control remains a challenge, prompting recent interest in artificial intelligence. To promote the use of machine learning in cardiovascular medicine, this review provides a brief introduction
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Milestone Papers in Signal Transduction Mechanisms of Hypertension and Its Complications Hypertension (IF 8.3) Pub Date : 2024-02-19 Satoru Eguchi, Keiichi Torimoto, Adebowale Adebiyi, Praghalathan Kanthakumar, Gisele F. Bomfim, Camilla Ferreira Wenceslau, Shelby A. Dahlen, Patrick Osei-Owusu
To celebrate 100 years of AHA-supported cardiovascular disease research, this review article highlights milestone papers that have significantly contributed to the current understanding of the signaling mechanisms driving hypertension and associated cardiovascular disorders. This article also includes a few of the future research directions arising from these critical findings. To accomplish this important
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Alternative Renin-Angiotensin System Hypertension (IF 8.3) Pub Date : 2024-02-16 Michael Bader, U. Muscha Steckelings, Natalia Alenina, Robson A.S. Santos, Carlos M. Ferrario
The renin-angiotensin system is the most important peptide hormone system in the regulation of cardiovascular homeostasis. Its classical arm consists of the enzymes, renin, and angiotensin-converting enzyme, generating angiotensin II from angiotensinogen, which activates its AT1 receptor, thereby increasing blood pressure, retaining salt and water, and inducing cardiovascular hypertrophy and fibrosis
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Differential 5′-tRNA Fragment Expression in Circulating Preeclampsia Syncytiotrophoblast Vesicles Drives Macrophage Inflammation Hypertension (IF 8.3) Pub Date : 2024-02-16 William R. Cooke, Peiyong Jiang, Lu Ji, Jinyue Bai, Gabriel Davis Jones, Y. M. Dennis Lo, Christopher Redman, Manu Vatish
BACKGROUND:The relationship between placental pathology and the maternal syndrome of preeclampsia is incompletely characterized. Mismatch between placental nutrient supply and fetal demands induces stress in the syncytiotrophoblast, the layer of placenta in direct contact with maternal blood. Such stress alters the content and increases the release of syncytiotrophoblast extracellular vesicles (STB-EVs)
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T- and L-Type Calcium Channels Maintain Calcium Oscillations in the Murine Zona Glomerulosa Hypertension (IF 8.3) Pub Date : 2024-02-16 Hoang An Dinh, Marina Volkert, Ali Kerim Secener, Ute I. Scholl, Gabriel Stölting
BACKGROUND:The zona glomerulosa of the adrenal gland is responsible for the synthesis and release of the mineralocorticoid aldosterone. This steroid hormone regulates salt reabsorption in the kidney and blood pressure. The most important stimuli of aldosterone synthesis are the serum concentrations of angiotensin II and potassium. In response to these stimuli, voltage and intracellular calcium levels
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Statins Prevent the Deleterious Consequences of Placental Chemerin Upregulation in Preeclampsia Hypertension (IF 8.3) Pub Date : 2024-02-15 Lunbo Tan, Ans C.M. Kluivers, Edwyn O. Cruz-López, Michelle Broekhuizen, Zhongli Chen, Rugina I. Neuman, Sam Schoenmakers, Liesbeth Ruijgrok, Daan van de Velde, Brenda C.M. de Winter, Antoon J. van den Bogaerdt, Xifeng Lu, A.H. Jan Danser, Koen Verdonk
BACKGROUND:Chemerin, an inflammatory adipokine, is upregulated in preeclampsia, and its placental overexpression results in preeclampsia-like symptoms in mice. Statins may lower chemerin.METHODS:Chemerin was determined in a prospective cohort study in women suspected of preeclampsia and evaluated as a predictor versus the sFlt-1 (soluble fms-like tyrosine kinase-1)/PlGF (placental growth factor) ratio
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Circulating Dipeptidyl Peptidase 3 Modulates Systemic and Renal Hemodynamics Through Cleavage of Angiotensin Peptides Hypertension (IF 8.3) Pub Date : 2024-02-09 Adrien Picod, Sandrine Placier, Magali Genest, Jacques Callebert, Nathan Julian, Maxime Zalc, Noma Assad, Hugo Nordin, Karine Santos, Stéphane Gaudry, Christos Chatziantoniou, Alexandre Mebazaa, Feriel Azibani
BACKGROUND:High circulating DPP3 (dipeptidyl peptidase 3) has been associated with poor prognosis in critically ill patients with circulatory failure. In such situation, DPP3 could play a pathological role, putatively via an excessive angiotensin peptides cleavage. Our objective was to investigate the hemodynamics changes induced by DPP3 in mice and the relation between the observed effects and renin–angiotensin
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Maternal Smoking and Risk of Hypertensive Disorders of Pregnancy: Effect Modification by Body Mass Index and Gestational Weight Gain Hypertension (IF 8.3) Pub Date : 2024-02-08 Morgan C. Dunn, Cande V. Ananth, Todd Rosen
BACKGROUND:Although smoking cigarettes has been shown to have a protective effect on preeclampsia, quitting smoking also results in weight gain. Weight gain leading to an obese body mass index is a risk factor for hypertensive disorders of pregnancy (HDP).METHODS:The objective of this study was to explore the relationship between smoking status, body mass index, and gestational weight gain on the risk
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Aortic Cellular Heterogeneity in Health and Disease: Novel Insights Into Aortic Diseases From Single-Cell RNA Transcriptomic Data Sets Hypertension (IF 8.3) Pub Date : 2024-02-06 Tayla A. Gibson Hughes, Malathi S. I. Dona, Christopher G. Sobey, Alexander R. Pinto, Grant R. Drummond, Antony Vinh, Maria Jelinic
Aortic diseases such as atherosclerosis, aortic aneurysms, and aortic stiffening are significant complications that can have significant impact on end-stage cardiovascular disease. With limited pharmacological therapeutic strategies that target the structural changes in the aorta, surgical intervention remains the only option for some patients with these diseases. Although there have been significant
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Unilateral Primary Aldosteronism: Long-Term Disease Recurrence After Adrenalectomy Hypertension (IF 8.3) Pub Date : 2024-02-06 Martina Tetti, Denise Brüdgam, Jacopo Burrello, Aaron M. Udager, Anna Riester, Thomas Knösel, Felix Beuschlein, William E. Rainey, Martin Reincke, Tracy Ann Williams
BACKGROUND:Primary aldosteronism (PA) is frequently caused by a unilateral aldosterone-producing adenoma with a PA-driver mutation. Unilateral adrenalectomy has a high probability of short-term biochemical remission, but long-term postsurgical outcomes are relatively undefined. Our objective was to investigate the incidence of long-term recurrence of PA in individuals with postsurgical short-term biochemical
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Tirzepatide Reduces 24-Hour Ambulatory Blood Pressure in Adults With Body Mass Index ≥27 kg/m2: SURMOUNT-1 Ambulatory Blood Pressure Monitoring Substudy Hypertension (IF 8.3) Pub Date : 2024-02-05 James A. de Lemos, Bruno Linetzky, Carel W. le Roux, Luke J. Laffin, Wanpen Vongpatanasin, Ludi Fan, Andrea Hemmingway, Nadia N. Ahmad, Mathijs C. Bunck, Adam Stefanski
Obesity is a risk factor for hypertension and cardiovascular disease. In SURMOUNT-1, tirzepatide, the glucose-dependent insulinotropic polypeptide/GLP-1 (glucagon-like peptide-1) receptor agonist approved in the United States for treatment of type 2 diabetes and obesity, provided substantial weight loss and reduced office blood pressure (BP).1 This study assessed the effect of tirzepatide on 24-hour
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Impact of Antihypertensive Medication Changes After Renal Denervation Among Different Patient Groups: SPYRAL HTN-ON MED Hypertension (IF 8.3) Pub Date : 2024-02-05 Raymond R. Townsend, Keith C. Ferdinand, David E. Kandzari, Kazuomi Kario, Felix Mahfoud, Michael A. Weber, Roland E. Schmieder, Stuart Pocock, Konstantinos Tsioufis, Shukri David, Susan Steigerwalt, Antony Walton, Ingrid Hopper, Barry Bertolet, Faisal Sharif, Karl Fengler, Martin Fahy, Douglas A. Hettrick, Sandeep Brar, Michael Böhm
BACKGROUND:The SPYRAL HTN-ON MED trial showed significant office and nighttime systolic blood pressure (BP) reductions in patients with hypertension following renal denervation (RDN) compared with sham-control patients, despite similar 24-hour BP reductions. We compared antihypertensive medication and BP changes among prespecified subpopulations.METHODS:The multicenter, randomized, sham-controlled