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Baseline higher hair cortisol moderated some effects in a healthy lifestyle intervention Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-04-15 Jiying Ling, Monica R. Ordway, Nanhua Zhang
Children and families from socioeconomically marginalized background experience high levels of stress, especially persistent chronic stress, due to unstable housing, employment, and food insecurity. Although consistent evidence supports a stress-obesity connection, little research has examined the potential moderation role of stress in childhood obesity interventions. Therefore, this study aimed to
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Effects of testosterone dose on depression-like behavior among castrated adult male rats Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-04-15 Zhongyu Ren, Ling Xiao, Yinping Xie, Zhengyuan Huang, Shanshan Lin, Lujia Si, Gaohua Wang
Previous research has shown a decrease in serum testosterone levels in male patients with depression. In recent years, the results of testosterone replacement therapy (TRT) to improve depression have been mixed. Using the classic CUMS model, we induced depressive-like behaviors in rats and observed a decrease in their serum testosterone levels along with an increase in androgen receptor expression
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The Leuven Prolonged Acute Stress Test (L-PAST): A novel paradigm to induce a subjective and glucocorticoid stress response for at least ninety minutes Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-04-12 Danique La Torre, Boushra Dalile, Tim Vanuytsel, Lukas Van Oudenhove, Kristin Verbeke
Laboratory stress tests typically administer stress acutely, ranging from 3 to 15 minutes. However, everyday stressors usually last longer than ten minutes (e.g., examination stressors, work stressors, and social stressors. Moreover, in some studies, it may be relevant to induce stress for a longer period to affect certain psychological or physiological parameters. To this end, we developed a novel
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From the early scars to the vicissitudes of old age: A bibliometric analysis revealing childhood adversity and aging Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-04-09 Kaixi Ding, Ming Lei
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Serum brain-derived neurotrophic factor, Val66Met polymorphism and open-label SSRI treatment response in Major Depressive Disorder Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-04-06 Anna J.T. Smit, Gwyneth W.Y. Wu, Ryan Rampersaud, Victor I. Reus, Owen M. Wolkowitz, Synthia H. Mellon
Brain-derived neurotrophic factor (BDNF) has been implicated in the therapeutic action of antidepressants and possibly in the pathophysiology of Major Depressive Disorder (MDD). Clinical studies of peripheral blood levels of BDNF in MDD have provided conflicting results, and there are also conflicting reports regarding the predictive value of peripheral BDNF levels for antidepressant treatment response
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Incredible years parenting program buffers prospective association between parent-reported harsh parenting and epigenetic age deceleration in children with externalizing behavior Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-04-06 Nicole Creasey, Patty Leijten, Geertjan Overbeek, Marieke S. Tollenaar
Harsh parenting has been shown to increase the risk of physical and mental health problems in later life. To improve our understanding of these risks and how they can be mitigated, we investigated associations of harsh parenting with a clinically relevant biomarker, epigenetic age deviation (EAD), using data from a randomized-control trial of the Incredible Years (IY) parenting program. This study
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Childhood trauma and hair cortisol response over the year following onset of a chronic life event stressor Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-04-04 Anna L. Marsland, Emily Jones, Rebecca G. Reed, Catherine P. Walsh, Brianna N. Natale, Emily K. Lindsay, Linda J. Ewing
Childhood trauma may contribute to poor lifelong health in part through programming of the HPA-axis response to future life stressors. To date, empirical evidence shows an association of childhood trauma with dysregulation of the HPA-axis and blunted cortisol reactivity to stressors. Here, we conduct an initial examination of childhood trauma as a moderator of changes over time in perceived stress
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The association between maternal prenatal hair cortisol concentration and preterm birth: A systematic review and meta-analysis Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-04-03 Richard G. Künzel, Merna Elgazzar, Paul A. Bain, Clemens Kirschbaum, Stefania Papatheodorou, Bizu Gelaye
The risk of preterm birth (PTB) increases when experiencing stress during pregnancy. Chronic stress has been associated with a dysregulation of the hypothalamic-pituitary-adrenal axis, for which hair cortisol concentration (HCC) is a promising biomarker. However, previous studies on the association between HCC and PTB yielded inconsistent results. This systematic review and meta-analysis synthesized
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Association between peripheral plasma cytokine levels and suicidal ideation in first-episode, drug-naïve major depressive disorder Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-04-02 Xue Tian, Ye-qing Dong, Jia-yu Yuan, Ying Gao, Chu-hao Zhang, Mei-juan Li, Jie Li
Inflammatory processes could potentially impact both mood and suicide risk, however, the relationship between cytokines and suicidal ideation remains unclear. This study aimed to investigate the association between plasma levels of cytokines and suicidal ideation in population with major depressive disorders (MDD). A cross-sectional study was performed to assess the peripheral plasma levels of interleukin-1β
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Parental status and markers of brain and cellular age: A 3D convolutional network and classification study Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-04-02 Ann-Marie G. de Lange, Esten H. Leonardsen, Claudia Barth, Louise S. Schindler, Arielle Crestol, Madelene C. Holm, Sivaniya Subramaniapillai, Dónal Hill, Dag Alnæs, Lars T. Westlye
Recent research shows prominent effects of pregnancy and the parenthood transition on structural brain characteristics in humans. Here, we present a comprehensive study of how parental status and number of children born/fathered links to markers of brain and cellular ageing in 36,323 UK Biobank participants (age range 44.57–82.06 years; 52% female). To assess global effects of parenting on the brain
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Hypothalamic-pituitary-adrenal axis hyperactivity is normalized after successful intermittent theta-burst stimulation in resistant depressed patients Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-03-30 Fabrice Duval, Marie-Claude Mokrani, Vlad Danila, Thomas Weiss, Felix Gonzalez Lopera, Mihaela Tomsa
The present pilot study assessed the effects of multi-session intermittent theta-burst stimulation (iTBS) applied to the left dorsolateral prefrontal cortex in 17 treatment resistant depressed inpatients (TRDs) showing cortisol non-suppression to the overnight dexamethasone suppression test (DST) at baseline (i.e., maximum post-DST cortisol [COR] level > 130 nmol/L). After 20 iTBS sessions, the DST
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The cortisol/DHEA ratio mediates the association between early life stress and externalizing problems in adolescent boys Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-03-28 Yoonji Lee, Gwendolyn Zoob Donahue, Jessica L. Buthmann, Jessica P. Uy, Ian H. Gotlib
Despite evidence that early life stress (ELS) can influence the functioning of the hypothalamic-pituitary-adrenal (HPA) axis and increase maladaptive behaviors in adolescence, less attention has been paid to the role of the coordinated effects of the two primary adrenal hormones, cortisol and dehydroepiandrosterone (DHEA), in these associations. 138 typically developing adolescents (76 females) reported
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Corrigendum to “The effect of an internet-based intervention for depression on cortisol and alpha-amylase” [Psychoneuroendocrinology 152 (2023) 106082] Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-03-27 S. Laufer, L. Schulze, S. Engel, H. Klusmann, N. Skoluda, U.M. Nater, C. Knaevelsrud, S. Schumacher
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Corrigendum to “Genetic variability in the oxytocin system is linked to individual differences in cuddliness among human infants”, [Psychoneuroendocrinology, vol. 159, January 2024, 106419] Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-03-27 Tobias Grossmann, Merle T. Fairhurst
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Stress during pregnancy and fetal serum BDNF in cord blood at birth Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-03-27 Eva Kathrin Lamadé, Bruno Pedraz-Petrozzi, Ole Lindner, Pascal Meininger, Michaela Coenen, Stephanie H. Witt, Marcella Rietschel, Helene Dukal, Maria Gilles, Stefan A. Wudy, Rainer Hellweg, Michael Deuschle
Adverse environments during pregnancy impact neurodevelopment including cognitive abilities of the developing children. The mediating biological alterations are not fully understood. Maternal stress may impact the neurotrophic regulation of the offspring as early as in utero and at birth. Brain-derived neurotrophic factor (BDNF) is essential for neurodevelopment. Short-term higher levels of BDNF in
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Corrigendum to “Associations between psychological distress and hair cortisol during pregnancy and the early postpartum: A meta-analysis” [Psychoneuroendocrinology 147 (2023) 105969] Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-03-23 Jennifer E. Khoury, Laurdn Giles, Hargun Kaur, Dylan Johnson, Andrda Gonzalez, Leslie Atkinson
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The effects of yohimbine and hydrocortisone on selective attention to fearful faces: An fMRI study Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-03-21 Sophie Metz, Leon Mengering, Renée Lipka, Catarina Rosada, Christian Otte, Hauke Heekeren, Katja Wingenfeld
Selective attention to salient emotional information can enable an advantage in the face of danger. The present study aims to investigate the influence of the stress neuromodulators, norepinephrine and cortisol, on selective attention processes to fearful faces and its neuronal activation. We used a randomized, double-blind, placebo-controlled design. 167 healthy men between 18 and 35 years (mean [SD]
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Placental corticotrophin-releasing hormone trajectories in pregnancy: Associations with postpartum depressive symptoms Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-03-21 Isabel F. Almeida, Gabrielle R. Rinne, Mary Coussons-Read, Christine Dunkel Schetter
Depressive symptoms following birth are common and can have adverse effects for mothers, children, and families. Changes in hypothalamic-pituitary-adrenal (HPA) axis regulation during pregnancy may be implicated in the development of postpartum depressive symptoms, particularly changes in placental corticotropinreleasing hormone (pCRH). However, few studies have tested how dynamic pCRH changes over
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Maternal probiotic Lactocaseibacillus rhamnosus HN001 treatment alters postpartum anxiety, cortical monoamines, and the gut microbiome Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-03-19 Joseph S. Lonstein, Taryn A. Meinhardt, Pavlina Pavlidi, Nikos Kokras, Christina Dalla, Thierry D. Charlier, Jodi L. Pawluski
Peripartum mood and anxiety disorders (PMADs) affect 15–20% of peripartum women and are well known to disrupt infant caregiving. A recent study in humans reported that anxiety and depressive symptoms were alleviated by peripartum treatment with the probiotic, HN001 The current study determined the effects of chronic HN001 (HN001) treatment on postpartum affective and caregiving behaviors in a laboratory
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A phase II randomised controlled trial of intranasal oxytocin in anorexia nervosa Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-03-19 Sarah Maguire, Alice Kesby, Rachel Brownlow, Glenn E. Hunt, Marcellinus Kim, Claire McAulay, Jessica R. Grisham, Iain S. McGregor, Anastasia Suraev, Richard C. Kevin, Janice Russell
Anorexia nervosa (AN) is an eating disorder (ED) with high mortality rates and limited response to existing treatments, prompting the need to identify effective agents and adjuncts. There is evidence for an emerging role for the neuropeptide oxytocin (OT) in the pathophysiology of AN, with studies showing a perturbed oxytocinergic system in patients with AN. Preliminary evidence has demonstrated that
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Hydrocortisone reduces altruistic punishment in healthy men Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-03-15 Julia Strojny, Bernadette von Dawans, Hartmut Schächinger, Gregor Domes
Psychosocial stress modulates social cognition and behavior in humans. One potentially mediating factor is cortisol as part of the human endocrine stress response. With a double-blind, placebo-controlled between-subject study design, we tested possible dose-dependent effects of hydrocortisone (0 mg, 5 mg and 20 mg) in 85 healthy males. During a socio-economic decision-making task we measured trust
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Adipokines in depressed women with and without adverse childhood experiences Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-03-15 Eugenia Kulakova, Berk Uesekes, Julian Hellmann-Regen, Carsten Spitzer, Linn K. Kuehl, Christian Otte, Katja Wingenfeld
Adverse childhood experiences (ACE) elevate the risk of both major depressive disorder (MDD) and metabolic diseases. The underlying pathophysiology might include alterations of adipokine levels as a consequence of ACE. In this study, we used a full-factorial design to investigate the levels of select adipokines in women with ACE-only (n = 23), MDD-only (n = 27), ACE+MDD (n = 25) and healthy controls
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Refugee health and physiological profiles in transitional settlements in Serbia and Kenya: Comparative evidence for effects of gender and social support Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-03-12 Lee T. Gettler, Jelena Jankovic-Rankovic, Rieti G. Gengo, Geeta N. Eick, Marcela Pfaff Nash, Ewoton Newton Arumah, Adan Mohammed Boru, Said Ahmed Ali, Samuel S. Urlacher, Jerrold S. Meyer, J. Josh Snodgrass, Rahul C. Oka
When armed conflict compels people to flee from their homelands, they embark on protracted journeys during which they experience wide ranging physical, social, and psychological challenges. Few studies have focused on refugee psychosocial and physiological profiles during the transitional phase of forced migration that often involves temporary sheltering. Transient refugees’ experiences can vary substantially
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Pregnancy renders anatomical changes in hypothalamic substructures of the human brain that relate to aspects of maternal behavior Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-03-12 Klara Spalek, Milou Straathof, Lal Koyuncu, Håkon Grydeland, Anouk van der Geest, Sophie R. van‘t Hof, Eveline A. Crone, Erika Barba-Müller, Susana Carmona, Damiaan Denys, Christian K. Tamnes, Sarah Burke, Elseline Hoekzema
Animal studies have shown that pregnancy is associated with neural adaptations that promote maternal care. The hypothalamus represents a central structure of the mammalian maternal brain and hormonal priming of specific hypothalamic nuclei plays a key role in the induction and expression of maternal behavior. In humans, we have previously demonstrated that becoming a mother involves changes in grey
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Stress biomarkers and child development in young children in Bangladesh Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-03-11 Zachary Butzin-Dozier, Andrew N. Mertens, Sophia T. Tan, Douglas A. Granger, Helen O. Pitchik, Dora Il'yasova, Fahmida Tofail, Md. Ziaur Rahman, Ivan Spasojevic, Idan Shalev, Shahjahan Ali, Mohammed Rabiul Karim, Sunny Shahriar, Syeda Luthfa Famida, Gabrielle Shuman, Abul K. Shoab, Salma Akther, Md. Saheen Hossen, Palash Mutsuddi, Mahbubur Rahman, Leanne Unicomb, Kishor K. Das, Liying Yan, Ann Meyer
Hundreds of millions of children in low- and middle-income countries are exposed to chronic stressors, such as poverty, poor sanitation and hygiene, and sub-optimal nutrition. These stressors can have physiological consequences for children and may ultimately have detrimental effects on child development. This study explores associations between biological measures of chronic stress in early life and
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Interpersonal violence exposure and inflammation during adolescence and young adulthood Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-03-11 Eric D. Finegood, Rachel Weissman-Tsukamoto, Phoebe Lam, Edith Chen, Gregory E. Miller
Exposure to violence increases young peoples’ risk of developing mental and physical health problems. Chronic stress-related upregulation of innate immune system activity and the development of low-grade inflammation may partially underlie this health risk. However, much of the previous research has been limited to cross-sectional studies utilizing between-person analytic designs, susceptible to confounding
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It’s all in the hair: Association between changes in hair cortisol concentrations in reaction to the COVID-19 pandemic and post-traumatic stress symptoms in children over time Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-03-09 Alexe Bilodeau-Houle, Catherine Raymond, Marie-France Marin
After exposure to a stressful/traumatic event, some individuals will develop post-traumatic stress symptoms (PTSS). In adults, low cortisol levels appear to be a risk factor for the development of PTSS. Indeed, both lower pre-trauma cortisol levels and low cortisol levels in the aftermath of a traumatic event have been associated with greater PTSS. In contrast, studies conducted in children showed
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Higher interleukin-6 is associated with greater momentary social connection in close relationships in daily life Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-03-08 Tatum A. Jolink, Taylor N. West, Gabriella M. Alvarez, Megan N. Cardenas, Mallory J. Feldman, Sara B. Algoe, Keely A. Muscatell
Recent evidence has documented associations between higher levels of inflammation and social approach behaviors toward close others in laboratory-based tasks. Yet it is unknown if this translates to interactions with close others in daily life. Given that momentary experiences of social connection have both relational and health consequences, this is a critical gap in our knowledge. To address the
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Trauma film viewing and intrusive memories: Relationship between salivary alpha amylase, endocannabinoids, and cortisol Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-03-08 Matthew P. O’Donohue, Khalisa Amir Hamzah, David Nichols, Luke J. Ney
The endogenous cannabinoid (ECB) system is a small molecule lipid signalling system that is involved in stress response activation and is associated with PTSD, but it is unclear whether salivary ECBs are part of the sympathetic nervous system response to stress. We conducted an adapted trauma film paradigm, where participants completed a cold pressor test (or control) while watching a 10-minute trauma
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Prenatal stress and hair cortisol in a sample of Latina women Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-03-04 Iris Becene, Gabrielle R. Rinne, Christine Dunkel Schetter, Jessica P. Hollenbach
Stress during pregnancy adversely impacts maternal and infant health. Dysregulation of the hypothalamic pituitary axis is a mediator of the relationship between stress and health. Evidence supporting an association between prenatal chronic stress and cortisol is limited, and the majority of research published has been conducted amongst White participants, who experience less chronic stress than people
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Effects of chronic intranasal oxytocin on visual attention to faces vs. natural scenes in older adults Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-03-04 Alayna Shoenfelt, Didem Pehlivanoglu, Tian Lin, Maryam Ziaei, David Feifel, Natalie C. Ebner
Aging is associated with changes in face processing, including desensitization to face cues like gaze direction and an attentional preference to faces with positive over negative emotional valence. A parallel line of research has shown that acute administration of oxytocin (OT) increases visual attention to social stimuli such as human faces. The current study examined effects of chronic OT administration
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A novel biomarker of interleukin 6 activity and clinical and cognitive outcomes in depression Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-02-29 Éimear M. Foley, Chloe Slaney, Nicholas A. Donnelly, Muzaffer Kaser, Louise Ziegler, Golam M. Khandaker
Inflammatory cytokines like interleukin-6 (IL-6) are implicated in depression, but most studies have hitherto focused on circulating levels of IL-6 rather than its activity. IL-6 trans-signalling is thought to be responsible for most of the pathogenic effects of IL-6 and is implicated in autoimmune diseases like rheumatoid arthritis. We tested the association between a multi-protein-derived measure
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Gonads under stress: A systematic review and meta-analysis on the effects of acute psychosocial stress on gonadal steroids secretion in humans Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-02-28 Gregor Domes, Katrin Linnig, Bernadette von Dawans
Animal research has shown that the hypothalamus-pituitary-gonadal (HPG) axis is inhibited by (chronic and/or severe) stress, which can lead to impaired fertility and reproductive functioning, presumably caused by the inhibition of gonadal steroid secretion and in interactions with glucocorticoids. However, what has not been clarified is how acute psychosocial stress modulates gonadal steroid secretion
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Sumatriptan attenuates fear-learning despair induced by social isolation stress in mice: Mediating role of hypothalamic-pituitary-adrenal axis Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-02-28 Kamyar Moradi, Abolfazl Badripour, Ali Moradi, Sayna Bagheri, Zahra Ebrahim Soltani, Mana Moassefi, Shahriar Faghani, Ahmad Reza Dehpour
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Neural processing of cry sounds in the transition to fatherhood: Effects of a prenatal intervention program and associations with paternal caregiving Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-02-28 Sandra Thijssen, Kim Alyousefi-van Dijk, Noor de Waal, Marinus H. van IJzendoorn, Marian J. Bakermans-Kranenburg
This study examined whether neural processing of infant cry sounds changes across the transition to fatherhood (i.e., from the prenatal to postnatal period), and examined whether an interaction-based prenatal intervention modulated these changes. Furthermore, we explored whether postnatal activation in brain regions showing transition or intervention effects was associated with sensitive care and involvement
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Mid-pregnancy allopregnanolone levels and trajectories of perinatal depressive symptoms Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-02-28 Richelle D. Björväng, Ylva Walldén, Emma Fransson, Erika Comasco, Inger Sundström-Poromaa, Alkistis Skalkidou
Perinatal depression is a major cause of disability for individuals giving birth worldwide, with detrimental effects on short- and long-term parental and child outcomes. There is emerging evidence that the neuroactive steroid hormone allopregnanolone is implicated in the pathophysiology and course of perinatal mood symptoms. However, no study thus far has examined allopregnanolone levels whilst making
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Sympathovagal quotient and resting-state functional connectivity of control networks are related to gut Ruminococcaceae abundance in healthy men Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-02-24 Ana L. Miranda-Angulo, Juan D. Sánchez-López, Daniel A. Vargas-Tejada, Valentina Hawkins-Caicedo, Juan C. Calderón, Jaime Gallo-Villegas, Juan F. Alzate-Restrepo, Jazmin X. Suarez-Revelo, Gabriel Castrillón
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The mediating role of child delay of gratification in the link between early and prolonged poverty exposure and adolescent allostatic load Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-02-18 Rebecca E.F. Gordon, Derek Kosty, Atika Khurana
Early and prolonged exposure to poverty disrupts biological processes associated with the body’s stress response system, leading to long-term negative health outcomes, including obesity, autoimmune disorders, and cardiovascular disease. Allostatic load (AL), a composite measure of chronic stress on the body, is a robust predictor of subsequent health outcomes. However, developmental research examining
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Longitudinal Assessment of Hair Cortisol as a Predictor of Psychological Symptoms During COVID-19 Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-02-17 I. Schmalbach, S. Steudte-Schmiedgen, A. Osmers, M. Witthöft, P. Drees, K. Petrowski
There is a lack of evidence regarding enduring psychoneuroendocrine changes following an initial traumatic event, particular in the presence of an ongoing stressor. The coronavirus pandemic presents an opportunity to explore this matter. Consequently, the purpose of the present study was to investigate the impact of the ongoing pandemic (2021) on individuals, who experienced a first-time motor vehicle
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Sex-specific associations between placental corticotropin releasing hormone and problem behaviors in childhood Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-02-16 Emily S. Barrett, Alexandra Sullivan, Tomomi Workman, Yuhong Zhang, Christine T. Loftus, Adam A. Szpiro, Alison Paquette, James W. MacDonald, Michael Coccia, Roger Smith, Maria Bowman, Alicia Smith, Karen Derefinko, Ruby H.N. Nguyen, Qi Zhao, Sheela Sathyanarayana, Catherine Karr, Kaja Z. LeWinn, Nicole R. Bush
Placental corticotropin-releasing hormone (pCRH) is a neuroactive peptide produced in high concentrations in mid-late pregnancy, during key periods of fetal brain development. Some evidence suggests that higher pCRH exposure during gestation is associated with adverse neurodevelopment, particularly in female offspring. In 858 mother-child dyads from the sociodemographically diverse CANDLE cohort (Memphis
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Chronic inflammation is associated with worsening working memory performance: Preliminary evidence from a diverse, longitudinal cohort of adolescents and young adults Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-02-15 Naoise Mac Giollabhui, Marin M. Kautz, Daniel P. Moriarity, Iris K.-Y. Chat, Susan Murray, Lauren M. Ellman, Lauren B. Alloy
Many depressed individuals experience cognitive difficulties that persist when depression is in remission. Inflammation is hypothesized to play a role in cognitive dysfunction in depression; however, many aspects of this relationship are not well characterized. The current study examined whether inflammation is associated with specific cognitive deficits in individuals with a history of depression
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Fatty acid desaturase 1/2 (FADS1 and FADS2), fatty acid desaturase indices, and their relationships with metabolic syndrome in female adults with first-episode schizophrenia after antipsychotic medications Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-02-09 Ying Liu, Xiaozhuang Jin
Although antipsychotics constitute the best treatment for patients with schizophrenia, this treatment class carries a high risk of metabolic disarrangements thus developing metabolic syndrome (MetS). Altered fatty acid (FA) composition and desaturase indices have been associated with several metabolic diseases, including MetS. Herein, we determined fatty acid desaturase 1 (FADS1) and FADS2 gene expressions
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Erratum to “Oxytocin modulates neural activity during early perceptual salience attribution”[ Psychoneuroendocrinology 161C (2024) 106950] Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-02-09 Andreia F. Santiago, Maciej Kosilo, Carlotta Cogoni, Vasco Diogo, Rita Jerónimo, Diana Prata
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Corrigendum to “Cross-trait genome-wide association analysis of C-reactive protein level and psychiatric disorders” [Psychoneuroendocrinology 157 (2023) 106368] Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-02-08 Guy Hindley, Ole Kristian Drange, Aihua Lin, Gleda Kutrolli, Alexey A. Shadrin, Nadine Parker, Kevin S. O’Connell, Linn Rødevand, Weiqiu Cheng, Shahram Bahrami, Naz Karadag, Børge Holen, Piotr Jaholkowski, Markos Tesfaye Woldeyohannes, Srdjan Djurovic, Anders M. Dale, Oleksandr Frei, Thor Ueland, Olav B. Smeland, Ole A. Andreassen
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Psychosocial predictors of the innate immune response to influenza vaccination Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-02-07 Kate Ryan Kuhlman, Arielle Radin, Steve W. Cole, Julienne E. Bower
Experimental activation of the innate immune system has contributed significantly to both our understanding of how psychological factors influence immune function as well as how immune activity influences the brain and behavior. The annual influenza vaccine can be used to interrogate the effects of mild immune stimulation on day-to-day changes in psychological processes in human subjects that range
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Olanzapine’s effects on hypothalamic transcriptomics and kinase activity Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-02-06 Sandra Pereira, Laura N. Castellani, Chantel Kowalchuk, Khaled Alganem, Xiaolu Zhang, William G. Ryan, Raghunath Singh, Sally Wu, Emily Au, Roshanak Asgariroozbehani, Sri Mahavir Agarwal, Adria Giacca, Robert E. Mccullumsmith, Margaret K. Hahn
Olanzapine is a second-generation antipsychotic that disrupts metabolism and is associated with an increased risk of type 2 diabetes. The hypothalamus is a key region in the control of whole-body metabolic homeostasis. The objective of the current study was to determine how acute peripheral olanzapine administration affects transcription and serine/threonine kinase activity in the hypothalamus. Hypothalamus
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Cohabitation with receptive females under D2-type agonism in adulthood restores partner preference and brain dimorphism in the SDN-POA following neonatal gonadectomy in male rats Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-02-06 Miriam Barradas-Moctezuma, Deissy Herrera-Covarrubias, Luis I. García, Porfirio Carrillo, César A. Pérez-Estudillo, Jorge Manzo, James G. Pfaus, Genaro A. Coria-Avila
Perinatal testosterone, or its metabolite estradiol, organize the brain toward a male phenotype. Male rodents with insufficient testosterone during this period fail to display sexual behavior and partner preference for receptive females in adulthood. However, cohabitation with non-reproductive conspecifics under the influence of a D2 agonist facilitates the expression of conditioned partner preference
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The early development of offspring born to women with polycystic ovary syndrome: Insights from a prospective birth cohort study in Southwestern China Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-02-06 Qi Cao, Ruiying Wang, Rong Zhou, Xin Huang, Yujing Li, Huili Zhu, Xinyu Qiao, Wei Huang
This prospective cohort study aimed to investigate the effect of maternal polycystic ovary syndrome (PCOS) on the offspring early development. A total of 91 mother-child pairs, consisting of 33 PCOS and 58 non-PCOS, were recruited. Peripheral blood tests were performed during 12–16, 24–28, and 32–36 weeks of gestation. Ages & Stages Questionnaires (ASQ) were utilized to assess the motor development
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Hair cortisol concentration and its association with acute stress responses and recovery in a sample of medical students in Germany Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-02-06 Meike Heming, Peter Angerer, Jennifer Apolinário-Hagen, Stefan Liszio, Urs Markus Nater, Nadine Skoluda, Jeannette Weber
Experiencing acute and chronic stress can contribute to adverse health outcomes. Responses to acute stress differ between individuals (i.e., stress reactivity) and the experience of chronic stress has been discussed to be associated with acute stress responses and stress recovery. This study thus aims to investigate whether hair cortisol concentration (HCC), being an indicator for hypothalamus–pituitary–adrenal
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The behavioral component of sexual inhibition and its relation with testosterone levels: An fMRI study in transgender and cisgender individuals Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-02-05 M. Kennis, M. Dewitte, G. T’Sjoen, K. Stinkens, A.T. Sack, F. Duecker
Many transgender individuals report having difficulties with initiating and seeking sexual contacts. Relatively to cisgender individuals, transgender individuals are more likely to avoid sexual activity, indicating that the groups might differ in the neural underpinnings of the behavioral component of sexual inhibition. In this fMRI study, transgender ( = 33) and cisgender ( = 34) participants performed
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Corrigendum to “Prepubertal ovariectomy confers resilience to stress-induced anxiety in adult female mice” [Psychoneuroendocrinology 148 (2023) 105997] Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-02-01 E.M. Woodward, A. Ringland, J. Ackerman, L. Coutellier
Abstract not available
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Cortisol interdependence during psychotherapy in major depressive disorder Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-02-02 Eyal Levi, Galit Peysachov, Roee Admon, Sigal Zilcha-Mano
The current study explored cortisol interdependence between patients and therapists during psychotherapy, the possible moderating effect of patient alliance ratings on this interdependence, and the associations between cortisol interdependence and treatment outcome. While cortisol interdependence was explored in other interpersonal contexts, its presence in psychotherapy has remained unexplored. We
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PSYCHONEURENDOCRINOLOGY OF EATING DISORDERS: FINDINGS, ISSUES AND PERSPECTIVES Editorial Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-01-26 Palmiero Monteleone, Franziska Plessow, Madhusmita Misra
Abstract not available
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Longitudinal associations of plasma kynurenines and ratios with anxiety and depression scores in colorectal cancer survivors up to 12 months post-treatment Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-01-26 Daniëlle D.B. Holthuijsen, Eline H. van Roekel, Martijn J.L. Bours, Per M. Ueland, Stéphanie O. Breukink, Maryska L.G. Janssen-Heijnen, Eric T.P. Keulen, Biljana Gigic, Andrea Gsur, Klaus Meyer, Jennifer Ose, Arve Ulvik, Matty P. Weijenberg, Simone J.P.M. Eussen
Colorectal cancer (CRC) survivors often experience neuropsychological symptoms, including anxiety and depression. Mounting evidence suggests a role for the kynurenine pathway in these symptoms due to potential neuroprotective and neurotoxic roles of involved metabolites. However, evidence remains inconclusive and insufficient in cancer survivors. Thus, we aimed to explore longitudinal associations
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Infant colic and HPA axis development across childhood Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-01-26 Bonnie E. Brett, Stefania Vacaru, Roseriet Beijers, Carolina de Weerth
This study examines the long-term impact of infant colic on Hypothalamic-Pituitary-Adrenal (HPA) axis development and the moderating role of attachment security, in a low-risk Dutch sample of 193 children. We assessed infant colic at 6 weeks, circadian cortisol concentrations at ages 1, 2.5, 6, and 10 years, and attachment security at 1 year. Findings indicated that infant colic was associated with
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Effects of sociocultural stressors on maternal responsivity and the infant behavioral and neuroendocrine response to stress in families of Mexican descent Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-01-24 Christina Perez, Kimberly L. D’Anna-Hernandez
Maternal stress is consistently linked to alterations in maternal behavior and infant neurodevelopmental outcomes. As the Latino population grows in the U.S., it is increasingly important to understand how culturally relevant factors affect this relationship. This study aimed to address the role of sociocultural stressors on maternal sensitivity and markers of infant emotional regulation and the neuroendocrine
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Associations of diurnal cortisol parameters with cortisol stress reactivity and recovery: A systematic review and meta-analysis Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-01-24 Christiane Wesarg-Menzel, Ruth Marheinecke, Janneke Staaks, Veronika Engert
Researchers commonly assess the functioning of the hypothalamic-pituitary-adrenal (HPA) axis by measuring natural fluctuations of its end product cortisol throughout the day or in response to a standardized stressor. Although it is conceivable that an individual releasing relatively more cortisol when confronted with a laboratory stressor does the same in everyday life, inconsistencies remain in the
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White matter volume and treatment with selective progesterone receptor modulator in patients with premenstrual dysphoric disorder Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-01-22 Elisavet Kaltsouni, Johan Wikström, Rupert Lanzenberger, Inger Sundström-Poromaa, Erika Comasco
Premenstrual dysphoric disorder (PMDD) is a mood disorder for which selective progesterone receptor modulator (SPRM) treatment has been demonstrated to be beneficial. The neural signatures of this treatment have been so far identified as greater fronto-cingulate reactivity during aggressive response to provocation, but no changes in terms of gray matter structure. White matter has recently been found
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Is your stress my stress? A standardized randomized-controlled paradigm to study physiological stress contagion based on direct stress observation Psychoneuroendocrinology (IF 3.7) Pub Date : 2024-01-17 Alisa Auer, Lisa-Marie Walther, David Jendryczko, Leon Auer, Petra H. Wirtz
Background & objectives Existing research indicates that not only own stress leads to physiological stress reactions, but also observing stress in others. So far, a standardized paradigm to reliably induce physiological stress contagion based on direct face-to-face stress observation compared to an active non-stress observing control group is lacking. Here, we tested a standardized randomized placebo-controlled