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RNA-mediated epigenetic regulation in exercised heart: Mechanisms and opportunities for intervention Mol. Aspects Med. (IF 10.6) Pub Date : 2024-04-22 Lijun Wang, Wensi Wan, Shuang Zhang, Tarun Keswani, Guoping Li, Junjie Xiao
Physical exercise has been widely acknowledged as a beneficial lifestyle alteration and a potent non-pharmacological treatment for heart disease. Extensive investigations have revealed the beneficial effects of exercise on the heart and the underlying mechanisms involved. Exercise is considered one of the key factors that can lead to epigenetic alterations. The increasing number of identified molecules
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Biomarkers of frailty Mol. Aspects Med. (IF 10.6) Pub Date : 2024-04-16 Mariam El Assar, Isabel Rodríguez-Sánchez, Alejandro Álvarez-Bustos, Leocadio Rodríguez-Mañas
Several biomarkers have been proposed to identify frailty, a multisystemic age-related syndrome. However, the complex pathophysiology and the absence of a consensus on a comprehensive and universal definition make it challenging to pinpoint a singular biomarker or set of biomarkers that conclusively characterize frailty. This review delves into the main laboratory biomarkers, placing special emphasis
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Delineating the contribution of ageing and physical activity to changes in mitochondrial characteristics across the lifespan Mol. Aspects Med. (IF 10.6) Pub Date : 2024-04-15 Matthew J-C. Lee, Nicholas J. Saner, Alessandra Ferri, Esther García-Domínguez, James R. Broatch, David J. Bishop
Ageing is associated with widespread physiological changes prominent within all tissues, including skeletal muscle and the brain, which lead to a decline in physical function. To tackle the growing health and economic burdens associated with an ageing population, the concept of healthy ageing has become a major research priority. Changes in skeletal muscle mitochondrial characteristics have been suggested
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Obesity and male fertility disorders Mol. Aspects Med. (IF 10.6) Pub Date : 2024-04-08 Rossella Cannarella, Andrea Crafa, Roberto Curto, Rosita A. Condorelli, Sandro La Vignera, Aldo E. Calogero
Often associated with obesity, male infertility represents a widespread condition that challenges the wellbeing of the couple. In this article, we provide a comprehensive and critical analysis of studies exploring the association between obesity and male reproductive function, to evaluate the frequency of this association, and establish the effects of increased body weight on conventional and biofunctional
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Frontiers in sarcopenia: Advancements in diagnostics, molecular mechanisms, and therapeutic strategies Mol. Aspects Med. (IF 10.6) Pub Date : 2024-04-06 Dequan Liu, Shijin Wang, Shuang Liu, Qifei Wang, Xiangyu Che, Guangzhen Wu
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A pipeline for the development and analysis of extracellular vesicle-based transcriptomic biomarkers in molecular diagnostics Mol. Aspects Med. (IF 10.6) Pub Date : 2024-03-29 Christian Grätz, Martina Schuster, Florian Brandes, Agnes S. Meidert, Benedikt Kirchner, Marlene Reithmair, Gustav Schelling, Michael W. Pfaffl
Extracellular vesicles are shed by every cell type and can be found in any biofluid. They contain different molecules that can be utilized as biomarkers, including several RNA species which they protect from degradation. Here, we present a pipeline for the development and analysis of extracellular vesicle-associated transcriptomic biomarkers that our group has successfully applied multiple times. We
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DNA melting analysis Mol. Aspects Med. (IF 10.6) Pub Date : 2024-03-15 Carl T. Wittwer, Andrew C. Hemmert, Jana O. Kent, Nick A. Rejali
Melting is a fundamental property of DNA that can be monitored by absorbance or fluorescence. PCR conveniently produces enough DNA to be directly monitored on real-time instruments with fluorescently labeled probes or dyes. Dyes monitor the entire PCR product, while probes focus on a specific locus within the amplicon. Advances in amplicon melting include high resolution instruments, saturating DNA
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Cancer-associated muscle weakness - From triggers to molecular mechanisms Mol. Aspects Med. (IF 10.6) Pub Date : 2024-03-07 Emily Shorter, Viktor Engman, Johanna T. Lanner
Skeletal muscle weakness is a debilitating consequence of many malignancies. Muscle weakness has a negative impact on both patient wellbeing and outcome in a range of cancer types and can be the result of loss of muscle mass (i.e. muscle atrophy, cachexia) and occur independently of muscle atrophy or cachexia. There are multiple cancer specific triggers that can initiate the progression of muscle weakness
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E3 ubiquitin ligase WWP2 as a promising therapeutic target for diverse human diseases Mol. Aspects Med. (IF 10.6) Pub Date : 2024-03-02 Shilong You, Jiaqi Xu, Yushan Guo, Xiaofan Guo, Ying Zhang, Naijin Zhang, Guozhe Sun, Yingxian Sun
Mammalian E3 ubiquitin ligases have emerged in recent years as critical regulators of cellular homeostasis due to their roles in targeting substrate proteins for ubiquitination and triggering subsequent downstream signals. In this review, we describe the multiple roles of WWP2, an E3 ubiquitin ligase with unique and important functions in regulating a wide range of biological processes, including DNA
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Organ Fibrosis: Emerging diagnostic and therapeutic strategies Mol. Aspects Med. (IF 10.6) Pub Date : 2024-02-26 Maurizio Parola, Massimo Pinzani
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Circulating tumor cells as liquid biopsy markers in cancer patients Mol. Aspects Med. (IF 10.6) Pub Date : 2024-02-21 Daniel J. Smit, Klaus Pantel
Over the past decade, novel methods for enrichment and identification of cancer cells circulating in the blood have been established. Blood-based detection of cancer cells and other tumor-associated products can be summarized under the term of Liquid Biopsy. Circulating tumor cells (CTCs) have been used for diagnosis, risk stratification and treatment selection as well as treatment monitoring in several
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Single-cell and spatial transcriptomics: Bridging current technologies with long-read sequencing Mol. Aspects Med. (IF 10.6) Pub Date : 2024-02-17 Chengwei Ulrika Yuan, Fu Xiang Quah, Martin Hemberg
Single-cell technologies have transformed biomedical research over the last decade, opening up new possibilities for understanding cellular heterogeneity, both at the genomic and transcriptomic level. In addition, more recent developments of spatial transcriptomics technologies have made it possible to profile cells in their tissue context. In parallel, there have been substantial advances in sequencing
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Principles of digital sequencing using unique molecular identifiers Mol. Aspects Med. (IF 10.6) Pub Date : 2024-02-16 Daniel Andersson, Firaol Tamiru Kebede, Mandy Escobar, Tobias Österlund, Anders Ståhlberg
Massively parallel sequencing technologies have long been used in both basic research and clinical routine. The recent introduction of digital sequencing has made previously challenging applications possible by significantly improving sensitivity and specificity to now allow detection of rare sequence variants, even at single molecule level. Digital sequencing utilizes unique molecular identifiers
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Recent advances in intestinal fibrosis Mol. Aspects Med. (IF 10.6) Pub Date : 2024-02-14 Marco Vincenzo Lenti, Giovanni Santacroce, Giacomo Broglio, Carlo Maria Rossi, Antonio Di Sabatino
Despite many progresses have been made in the treatment of inflammatory bowel disease, especially due to the increasing number of effective therapies, the development of tissue fibrosis is a very common occurrence along the natural history of this condition. To a certain extent, fibrogenesis is a physiological and necessary process in all those conditions characterised by chronic inflammation. However
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Digital PCR for the characterization of reference materials Mol. Aspects Med. (IF 10.6) Pub Date : 2024-02-14 Megan H. Cleveland, Hua-Jun He, Mojca Milavec, Young-Kyung Bae, Peter M. Vallone, Jim F. Huggett
Well-characterized reference materials support harmonization and accuracy when conducting nucleic acid-based tests (such as qPCR); digital PCR (dPCR) can measure the absolute concentration of a specific nucleic acid sequence in a background of non-target sequences, making it ideal for the characterization of nucleic acid-based reference materials. National Metrology Institutes are increasingly using
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Are we getting closer to a successful neoantigen cancer vaccine? Mol. Aspects Med. (IF 10.6) Pub Date : 2024-02-13 Karen Manoutcharian, Goar Gevorkian
Although significant advances in immunotherapy have revolutionized the treatment of many cancer types over the past decade, the field of vaccine therapy, an important component of cancer immunotherapy, despite decades-long intense efforts, is still transmitting signals of promises and awaiting strong data on efficacy to proceed with regulatory approval. The field of cancer vaccines faces standard challenges
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Current and emerging sequencing-based tools for precision cancer medicine Mol. Aspects Med. (IF 10.6) Pub Date : 2024-02-07 Anders Edsjö, David Gisselsson, Johan Staaf, Louise Holmquist, Thoas Fioretos, Lucia Cavelier, Richard Rosenquist
Current precision cancer medicine is dependent on the analyses of a plethora of clinically relevant genomic aberrations. During the last decade, next-generation sequencing (NGS) has gradually replaced most other methods for precision cancer diagnostics, spanning from targeted tumor-informed assays and gene panel sequencing to global whole-genome and whole-transcriptome sequencing analyses. The shift
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Emerging diagnostic and therapeutic challenges for skin fibrosis in systemic sclerosis Mol. Aspects Med. (IF 10.6) Pub Date : 2024-02-06 David Abraham, Alain Lescoat, Richard Stratton
Systemic sclerosis (also called scleroderma, SSc) is a chronic autoimmune disorder characterized by excessive collagen deposition leading to skin fibrosis and various internal organ manifestations. The emergent diagnostics and therapeutic strategies for scleroderma focus on early detection and targeted interventions to improve patient outcomes and quality of life. Diagnostics for SSc have evolved significantly
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Improving the quality of quantitative polymerase chain reaction experiments: 15 years of MIQE Mol. Aspects Med. (IF 10.6) Pub Date : 2024-01-29 S, t, e, p, h, e, n, , A, ., , B, u, s, t, i, n
The quantitative polymerase chain reaction (qPCR) is fundamental to molecular biology. It is not just a laboratory technique, qPCR is a bridge between research and clinical practice. Its theoretical foundations guide the design of experiments, while its practical implications extend to diagnostics, treatment, and research advancements in the life sciences, human and veterinary medicine, agriculture
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Association between glaucoma susceptibility with combined defects in mitochondrial oxidative phosphorylation and fatty acid beta oxidation Mol. Aspects Med. (IF 10.6) Pub Date : 2024-01-11 Zulvikar Syambani Ulhaq, Guido Barbieri Bittencourt, Gita Vita Soraya, Lola Ayu Istifiani, Syafrizal Aji Pamungkas, Yukiko Ogino, Dian Kesumapramudya Nurputra, William Ka Fai Tse
Glaucoma is one of the leading causes of visual impairment and blindness worldwide, and is characterized by the progressive damage of retinal ganglion cells (RGCs) and the atrophy of the optic nerve head (ONH). The exact cause of RGC loss and optic nerve damage in glaucoma is not fully understood. The high energy demands of these cells imply a higher sensitivity to mitochondrial defects. Moreover,
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Introductory remarks Mol. Aspects Med. (IF 10.6) Pub Date : 2024-01-03 Diego Sbardella, Francesco Oddone, Massimiliano Coletta
Abstract not available
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Corrigendum to “The changing epidemiology of fungal infections” [Mol. Aspect. Med. 94 (2023) 101215] Mol. Aspects Med. (IF 10.6) Pub Date : 2023-12-27 Cornelia Lass-Flörl, Stephan Steixner
Abstract not available
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Reviewing the significance of dendritic cell vaccines in interrupting breast cancer development Mol. Aspects Med. (IF 10.6) Pub Date : 2023-12-26 Namrata Gautam, Ganesan Ramamoorthi, Nicholas Champion, Hyo S. Han, Brian J. Czerniecki
Breast cancer is a heterogeneous disease and is the most prevalent cancer in women. According to the U.S breast cancer statistics, about 1 in every 8 women develop an invasive form of breast cancer during their lifetime. Immunotherapy has been a significant advancement in the treatment of cancer with multiple studies reporting favourable patient outcomes by modulating the immune response to cancer
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Invited review liver fibrosis in NAFLD/NASH: From pathophysiology towards diagnostic and therapeutic strategies Mol. Aspects Med. (IF 10.6) Pub Date : 2023-12-05 Maurizio Parola, Massimo Pinzani
Liver fibrosis, as an excess deposition of extracellular matrix (ECM) components, results from chronic liver injury as well as persistent activation of inflammatory response and of fibrogenesis. Liver fibrosis is a major determinant for chronic liver disease (CLD) progression and in the last two decades our understanding on the major molecular and cellular mechanisms underlying the fibrogenic progression
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Rodent genetically modified models of glaucoma Mol. Aspects Med. (IF 10.6) Pub Date : 2023-11-30 Yunhua Loo, Anita Sook Yee Chan, Chiea Chuen Khor, Tin Aung, Zhenxun Wang
Glaucoma, one of the leading causes of irreversible blindness worldwide, is a complex and heterogenous disease. While environmental factors are important, it is well-recognized that the disease has a strong heritable component. With the advent of large-cohort genome wide association studies, a myriad of genetic risk loci has been linked to different forms of glaucoma. Animal models have been an indispensable
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Genetic rodent models of glaucoma in representing disease phenotype and insights into the pathogenesis Mol. Aspects Med. (IF 10.6) Pub Date : 2023-11-27 Renu Agarwal, Igor Iezhitsa
Genetic rodent models are widely used in glaucoma related research. With vast amount of information revealed by human studies about genetic correlations with glaucoma, use of these models is relevant and required. In this review, we discuss the glaucoma endophenotypes and importance of their representation in an experimental animal model. Mice and rats are the most popular animal species used as genetic
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Practical issues related to non-Aspergillus invasive mold infections Mol. Aspects Med. (IF 10.6) Pub Date : 2023-11-26 Marcio Nucci, Simone A. Nouér
Infection by non-Aspergillus molds has been increasingly reported. The management of such infections is challenging both for diagnosis and treatment, including the need of well-trained mycologists to properly identify rare fungi, difficulties in distinguishing between contamination, colonization and infection, the lack of randomized studies comparing different drugs or regimens, poor activity of available
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Novel frontiers in neuroprotective therapies in glaucoma: Molecular and clinical aspects Mol. Aspects Med. (IF 10.6) Pub Date : 2023-11-24 Alessandra Boccaccini, Dario Cavaterra, Carmela Carnevale, Lucia Tanga, Stefano Marini, Alessio Bocedi, Pedro M. Lacal, Gianluca Manni, Grazia Graziani, Diego Sbardella, Grazia Raffaella Tundo
In the last years, neuroprotective therapies have attracted the researcher interests as modern and challenging approach for the treatment of neurodegenerative diseases, aimed at protecting the nervous system from injuries. Glaucoma is a neurodegenerative disease characterized by progressive excavation of the optic nerve head, retinal axonal injury and corresponding vision loss that affects millions
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Pulmonary fibrosis: Emerging diagnostic and therapeutic strategies Mol. Aspects Med. (IF 10.6) Pub Date : 2023-11-24 Brintha Selvarajah, Manuela Platé, Rachel C. Chambers
Fibrosis is the concluding pathological outcome and major cause of morbidity and mortality in a number of common chronic inflammatory, immune-mediated and metabolic diseases. The progressive deposition of a collagen-rich extracellular matrix (ECM) represents the cornerstone of the fibrotic response and culminates in organ failure and premature death. Idiopathic pulmonary fibrosis (IPF) represents the
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Gene therapies and gene product-based drug candidates for normalizing and preserving tissue functions in animal models of ocular hypertension and glaucoma Mol. Aspects Med. (IF 10.6) Pub Date : 2023-11-15 Najam A. Sharif
More than 76 million people worldwide are afflicted with the neurodegenerative eye diseases described and grouped together as glaucoma. A common feature amongst the many forms of glaucoma is chronically elevated intraocular pressure (IOP) within the anterior chamber of the eye that physically damages the retina, optic nerve and parts of the brain connected with visual perception. The mediators of the
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Ubiquitin proteasome system and glaucoma: A survey of genetics and molecular biology studies supporting a link with pathogenic and therapeutic relevance Mol. Aspects Med. (IF 10.6) Pub Date : 2023-11-10 Irene Pandino, Sara Giammaria, Gabriele Antonio Zingale, Gloria Roberti, Manuele Michelessi, Massimo Coletta, Gianluca Manni, Luca Agnifili, Alice Verticchio Vercellin, Alon Harris, Francesco Oddone, Diego Sbardella
Glaucoma represents a group of progressive neurodegenerative diseases characterized by the loss of retinal ganglion cells (RGCs) and their axons with subsequent visual field impairment. The disease develops through largely uncharacterized molecular mechanisms, that are likely to occur in different localized cell types, either in the anterior (e.g., trabecular meshwork cells) or posterior (e.g., Muller
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Computational methods in glaucoma research: Current status and future outlook Mol. Aspects Med. (IF 10.6) Pub Date : 2023-11-03 Minjae J. Kim, Cole A. Martin, Jinhwa Kim, Monica M. Jablonski
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Vaccines for HPV-associated diseases Mol. Aspects Med. (IF 10.6) Pub Date : 2023-11-04 Jeffrey M. Skolnik, Matthew P. Morrow
Human papillomavirus (HPV) infection represents a significant global health concern owing to its role in the etiology of conditions ranging from benign low-grade lesions to cancers of the cervix, head and neck, anus, vagina, vulva, and penis. Prophylactic vaccination programs, primarily targeting adolescent girls, have achieved dramatic reductions in rates of HPV infection and cervical cancer in recent
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Advances in understanding glaucoma pathogenesis: A multifaceted molecular approach for clinician scientists Mol. Aspects Med. (IF 10.6) Pub Date : 2023-10-27 Eren Ekici, Sasan Moghimi
Glaucoma, a leading cause of irreversible blindness worldwide, is a spectrum of neurodegenerative diseases characterized by the gradual deterioration of retinal ganglion cells (RGCs) and optic neuropathy. With complex etiology, glaucoma's major risk factors include elevated intraocular pressure (IOP), advanced age, ethnicity, systemic vascular factors, and genetic predisposition. By 2040, glaucoma
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The role of the microbiota in glaucoma Mol. Aspects Med. (IF 10.6) Pub Date : 2023-10-21 Ling Huang, Yiwen Hong, Xiangyu Fu, Haishan Tan, Yongjiang Chen, Yujiao Wang, Danian Chen
Glaucoma is a common irreversible vision loss disorder because of the gradual loss of retinal ganglion cells (RGCs) and the optic nerve axons. Major risk factors include elder age and high intraocular pressure (IOP). However, high IOP is neither necessary nor sufficient to cause glaucoma. Some non-IOP signaling cascades can mediate RGC degeneration. In addition, gender, diet, obesity, depression, or
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Signalling pathways and cell death mechanisms in glaucoma: Insights into the molecular pathophysiology Mol. Aspects Med. (IF 10.6) Pub Date : 2023-10-17 Devaraj Basavarajappa, Caridad Galindo-Romero, Vivek Gupta, Marta Agudo-Barriuso, Veer B. Gupta, Stuart L. Graham, Nitin Chitranshi
Glaucoma is a complex multifactorial eye disease manifesting in retinal ganglion cell (RGC) death and optic nerve degeneration, ultimately causing irreversible vision loss. Research in recent years has significantly enhanced our understanding of RGC degenerative mechanisms in glaucoma. It is evident that high intraocular pressure (IOP) is not the only contributing factor to glaucoma pathogenesis. The
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Understanding the complex genetics and molecular mechanisms underlying glaucoma Mol. Aspects Med. (IF 10.6) Pub Date : 2023-10-17 Weiwei Wang, Huaizhou Wang
Glaucoma is the leading cause of irreversible blindness worldwide. Currently the only effective treatment for glaucoma is to reduce the intraocular pressure, which can halt the progression of the disease. Highlighting the importance of identifying individuals at risk of developing glaucoma and those with early-stage glaucoma will help patients receive treatment before sight loss. However, some cases
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Molecular aspects of optic nerve autophagy in glaucoma Mol. Aspects Med. (IF 10.6) Pub Date : 2023-10-14 Yasushi Kitaoka, Kana Sase
The optic nerve consists of the glia, vessels, and axons including myelin and axoplasm. Since axonal degeneration precedes retinal ganglion cell death in glaucoma, the preceding axonal degeneration model may be helpful for understanding the molecular mechanisms of optic nerve degeneration. Optic nerve samples from these models can provide information on several aspects of autophagy. Autophagosomes
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Therapeutic strategies for glaucoma and optic neuropathies Mol. Aspects Med. (IF 10.6) Pub Date : 2023-10-13 Jung Lo, Kamakshi Mehta, Armaan Dhillon, Yu-Kai Huang, Ziming Luo, Mi-Hyun Nam, Issam Al Diri, Kun-Che Chang
Glaucoma is a neurodegenerative eye disease that causes permanent vision impairment. The main pathological characteristics of glaucoma are retinal ganglion cell (RGC) loss and optic nerve degeneration. Glaucoma can be caused by elevated intraocular pressure (IOP), although some cases are congenital or occur in patients with normal IOP. Current glaucoma treatments rely on medicine and surgery to lower
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The changing epidemiology of fungal infections Mol. Aspects Med. (IF 10.6) Pub Date : 2023-10-05 Cornelia Lass-Flörl, Stephan Steixner
Invasive fungal diseases are common complications in critically ill patients and in those with significant underlying imbalanced immune systems. Fungal co-, and/or super-infections are emerging and have become a rising concern within the last few years. In Europe, cases of candidiasis and aspergillosis dominate, followed by mucormycosis in India. Epidemiological studies show an increasing trend in
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Current understanding of genetics and epigenetics in pseudoexfoliation syndrome and glaucoma Mol. Aspects Med. (IF 10.6) Pub Date : 2023-09-18 Ramani Shyam Kapuganti, Debasmita Pankaj Alone
Pseudoexfoliation is a complex, progressive, and systemic age-related disorder. The early stage of deposition of extracellular fibrillar material on ocular and extraocular tissues is termed as pseudoexfoliation syndrome (PEXS). The severe advanced stage is known as pseudoexfoliation glaucoma (PEXG), which involves increased intraocular pressure and optic nerve damage. Through genome-wide association
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Gene-environment interactions that influence CVD, lipid traits, obesity, diabetes, and hypertension appear to be able to influence gene therapy Mol. Aspects Med. (IF 10.6) Pub Date : 2023-09-11 Moataz Dowaidar
Most mind boggling diseases are accepted to be impacted by both genetic and environmental elements. As of late, there has been a flood in the improvement of different methodologies, concentrate on plans, and measurable and logical techniques to examine gene-environment cooperations (G × Es) in enormous scope studies including human populaces. The many-sided exchange between genetic elements and environmental
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Kidney fibrosis: Emerging diagnostic and therapeutic strategies Mol. Aspects Med. (IF 10.6) Pub Date : 2023-08-03 Barbara Mara Klinkhammer, Peter Boor
An increasing number of patients worldwide suffers from chronic kidney disease (CKD). CKD is accompanied by kidney fibrosis, which affects all compartments of the kidney, i.e., the glomeruli, tubulointerstitium, and vasculature. Fibrosis is the best predictor of progression of kidney diseases. Currently, there is no specific anti-fibrotic therapy for kidney patients and invasive renal biopsy remains
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Doxorubicin and other anthracyclines in cancers: Activity, chemoresistance and its overcoming Mol. Aspects Med. (IF 10.6) Pub Date : 2023-07-27 Roberto Mattioli, Andrea Ilari, Beatrice Colotti, Luciana Mosca, Francesco Fazi, Gianni Colotti
Anthracyclines have been important and effective treatments against a number of cancers since their discovery. However, their use in therapy has been complicated by severe side effects and toxicity that occur during or after treatment, including cardiotoxicity. The mode of action of anthracyclines is complex, with several mechanisms proposed. It is possible that their high toxicity is due to the large
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Advances in vaccine development for cancer prevention and treatment in Lynch Syndrome Mol. Aspects Med. (IF 10.6) Pub Date : 2023-07-19
Lynch Syndrome (LS) is one of the most common hereditary cancer syndromes, and is caused by mutations in one of the four DNA mismatch repair (MMR) genes, namely MLH1, MSH2, MSH6 and PMS2. Tumors developed by LS carriers display high levels of microsatellite instability, which leads to the accumulation of large numbers of mutations, among which frameshift insertion/deletions (indels) within microsatellite
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The molecular aspect of anti-glaucomatous eye drops - are we harming our patients? Mol. Aspects Med. (IF 10.6) Pub Date : 2023-07-15
Glaucoma is one of the leading causes of irreversible blindness. Progression is halted with a reduction in intraocular pressure (IOP), which is most often achieved with eye drops. A major challenge in the topical treatment of glaucoma patients is the many side effects and the resulting reduced adherence. Side effects may of course be due to the molecular properties of the active pharmaceutical ingredients
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Towards modifying the genetic predisposition for glaucoma: An overview of the contribution and interaction of genetic and environmental factors Mol. Aspects Med. (IF 10.6) Pub Date : 2023-07-08 Kelsey V. Stuart, Louis R. Pasquale, Jae H. Kang, Paul J. Foster, Anthony P. Khawaja
Glaucoma, the leading cause of irreversible blindness worldwide, is a complex human disease, with both genetic and environmental determinants. The availability of large-scale, population-based cohorts and biobanks, combining genotyping and detailed phenotyping, has greatly accelerated research into the aetiology of glaucoma in recent years. Hypothesis-free genome-wide association studies have furthered
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Cardiac Fibrosis in heart failure: Focus on non-invasive diagnosis and emerging therapeutic strategies Mol. Aspects Med. (IF 10.6) Pub Date : 2023-06-27 Susana Ravassa, Begoña López, Thomas A. Treibel, Gorka San José, Blanca Losada-Fuentenebro, Leire Tapia, Antoni Bayés-Genís, Javier Díez, Arantxa González
Heart failure is a leading cause of mortality and hospitalization worldwide. Cardiac fibrosis, resulting from the excessive deposition of collagen fibers, is a common feature across the spectrum of conditions converging in heart failure. Eventually, either reparative or reactive in nature, in the long-term cardiac fibrosis contributes to heart failure development and progression and is associated with
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Neuroprotection in glaucoma: Mechanisms beyond intraocular pressure lowering Mol. Aspects Med. (IF 10.6) Pub Date : 2023-06-16 James R. Tribble, Flora Hui, Heberto Quintero, Sana El Hajji, Katharina Bell, Adriana Di Polo, Pete A. Williams
Glaucoma is a common, complex, multifactorial neurodegenerative disease characterized by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the retina. Glaucoma is the most common cause of irreversible blindness and affects ∼80 million people worldwide with many more undiagnosed. The major risk factors for glaucoma are genetics, age, and elevated intraocular pressure
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Microorganisms-derived antigens for preventive anti-cancer vaccines Mol. Aspects Med. (IF 10.6) Pub Date : 2023-06-07 Luigi Buonaguro, Beatrice Cavalluzzo, Angela Mauriello, Concetta Ragone, Anna Lucia Tornesello, Franco M. Buonaguro, Maria Lina Tornesello, Maria Tagliamonte
Cancer prevention is one of the aim with the highest priority in order to reduce the burden of cancer diagnosis and treatment on individuals as well as on healthcare systems. To this aim, vaccines represent the most efficient primary cancer prevention strategy. Indeed, anti-cancer immunological memory elicited by preventive vaccines might promptly expand and prevent tumor from progressing. Antigens
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Mechanisms of organ fibrosis: Emerging concepts and implications for novel treatment strategies Mol. Aspects Med. (IF 10.6) Pub Date : 2023-05-24 Isabella Lurje, Nadine T. Gaisa, Ralf Weiskirchen, Frank Tacke
Fibrosis, or tissue scarring, develops as a pathological deviation from the physiological wound healing response and can occur in various organs such as the heart, lung, liver, kidney, skin, and bone marrow. Organ fibrosis significantly contributes to global morbidity and mortality. A broad spectrum of etiologies can cause fibrosis, including acute and chronic ischemia, hypertension, chronic viral
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Antifungal prophylaxis and pre-emptive therapy: When and how? Mol. Aspects Med. (IF 10.6) Pub Date : 2023-05-17 Rosanne Sprute, Julia A. Nacov, Dionysios Neofytos, Matteo Oliverio, Juergen Prattes, Ilana Reinhold, Oliver A. Cornely, Jannik Stemler
The growing pool of critically ill or immunocompromised patients leads to a constant increase of life-threatening invasive infections by fungi such as Aspergillus spp., Candida spp. and Pneumocystis jirovecii. In response to this, prophylactic and pre-emptive antifungal treatment strategies have been developed and implemented for high-risk patient populations. The benefit by risk reduction needs to
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Vaccination against Helicobacter pylori – An approach for cancer prevention? Mol. Aspects Med. (IF 10.6) Pub Date : 2023-04-03 Verena Friedrich, Markus Gerhard
The gram-negative bacterium Helicobacter pylori is the most common chronic bacterial infection and the main cause of gastric cancer. Due to the increasing antimicrobial resistance of H. pylori, the development of an efficacious vaccine is a valid option to protect from disease or infection and ultimately prevent gastric cancer. However, despite more than 30 years of research, no vaccine has entered
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Emerging technologies in personalized medicine Mol. Aspects Med. (IF 10.6) Pub Date : 2023-02-16 Christopher E. Hopkins
A variety of technologies are emerging to help clinicians provide patient-specific diagnosis and therapies. This special edition of the Molecular Aspects of Medicine is a collection of mini reviews covering a broad range of topics, from systems to model patient variants and discover therapies (Microphysiological systems with patient derived tissue and CRISPR-humanized animal models), to new modalities
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Bioactives and human health Mol. Aspects Med. (IF 10.6) Pub Date : 2023-01-05 Cesar G. Fraga, Patricia I. Oteiza
Abstract not available
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Extracellular vesicles in the glioblastoma microenvironment: A diagnostic and therapeutic perspective Mol. Aspects Med. (IF 10.6) Pub Date : 2022-12-27 Marissa N. Russo, Lauren A. Whaley, Emily S. Norton, Natanael Zarco, Hugo Guerrero-Cázares
Glioblastoma (GBM), is the most malignant form of gliomas and the most common and lethal primary brain tumor in adults. Conventional cancer treatments have limited to no efficacy on GBM. GBM cells respond and adapt to the surrounding brain parenchyma known as tumor microenvironment (TME) to promote tumor preservation. Among specific TME, there are 3 of particular interest for GBM biology: the perivascular
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(Poly)phenols and nitrolipids: Relevant participants in nitric oxide metabolism Mol. Aspects Med. (IF 10.6) Pub Date : 2022-12-12 César G. Fraga, Andrés Trostchansky, Barbara S. Rocha, João Laranjinha, Homero Rubbo, Monica Galleano
Nitric oxide (•NO) is an essential molecule able to control and regulate many biological functions. Additionally, •NO bears a potential toxicity or damaging effects under conditions of uncontrolled production, and because of its participation in redox-sensitive pathways and oxidizing reactions. Several plant (poly)phenols present in the diet are able to regulate the enzymes producing •NO (NOSs). In