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Decabromodiphenyl ether exposure reduces dabrafenib sensitivity of papillary thyroid carcinoma harboring BRAFV600E mutation through the EGFR-CRAF-MAPK pathway: An in vitro study Toxicology (IF 4.5) Pub Date : 2024-04-17 Xinpei Wang, Xiujie Cui, Yi Wang, Qianqian Wang, Feifei Sun, Zhiyan Liu
Decabromodiphenyl ether (BDE209) has been demonstrated to be associated with thyroid dysfunction and thyroid carcinoma risk as a widely used brominated flame retardants. Although dabrafenib has been confirmed to be a promising therapeutic agent for papillary thyroid carcinoma (PTC) harboring mutation, the rapid acquired dabrafenib resistance has brought a great challenge to clinical improvement and
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The p21+ perinecrotic hepatocytes produce the chemokine CXCL14 after a severe acetaminophen overdose promoting hepatocyte injury and delaying regeneration Toxicology (IF 4.5) Pub Date : 2024-04-12 David S. Umbaugh, Nga T. Nguyen, Sawyer H. Smith, Anup Ramachandran, Hartmut Jaeschke
Fifty percent of all acute liver failure (ALF) cases in the United States are due to acetaminophen (APAP) overdose. Assessment of canonical features of liver injury, such as plasma alanine aminotransferase activities are poor predictors of acute liver failure (ALF), suggesting the involvement of additional mechanisms independent of hepatocyte death. Previous work demonstrated a severe overdose of APAP
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Nanomaterials-induced programmed cell death: Focus on mitochondria Toxicology (IF 4.5) Pub Date : 2024-04-12 Shijia Qiao, Yiyuan Kang, Xiner Tan, Xinru Zhou, Can Zhang, Shulin Lai, Jia Liu, Longquan Shao
Nanomaterials are widely utilized in several domains, such as everyday life, societal manufacturing, and biomedical applications, which expand the potential for nanomaterials to penetrate biological barriers and interact with cells. Multiple studies have concentrated on the particular or improper utilization of nanomaterials, resulting in cellular death. The primary mode of cell death caused by nanotoxicity
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The effects of micro- and nanoplastics on the central nervous system: A new threat to humanity? Toxicology (IF 4.5) Pub Date : 2024-04-11 Yanxu Zheng, Shengchao Xu, Jingyu Liu, Zhixiong Liu
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Differential susceptibility of BRL cells with/without insulin resistance and the role of endoplasmic reticulum stress signaling pathway in response to acrylamide-exposure toxicity effects in vitro Toxicology (IF 4.5) Pub Date : 2024-04-09 Yuchao Guo, Houlin Mao, Danni Gong, Nuo Zhang, Dandan Gu, Emmanuel Sunday Okeke, Weiwei Feng, Yao Chen, Guanghua Mao, Ting Zhao, Liuqing Yang
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Long-term use of etomidate disrupts the intestinal homeostasis and nervous system in mice Toxicology (IF 4.5) Pub Date : 2024-04-09 Siming Ding, Kan Li, Xing Han, Wenting Lin, Yingjun Qin, Renjuan Cao, Yuan Ren
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Long-term Bisphenol S exposure induced gut microbiota dysbiosis, obesity, hepatic lipid accumulation, intestinal lesions and dyslipidemia in mice Toxicology (IF 4.5) Pub Date : 2024-04-06 Yulang Chi, Lin Zhu, Yihui Wang, Cai Peng, Yi Lin, Shouping Ji, Jie Wei
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Lnc-Clic5 as a sponge for miR-212–5p to inhibit cow barn PM2.5-induced apoptosis in rat alveolar macrophages Toxicology (IF 4.5) Pub Date : 2024-04-05 Ke Sun, Yize Sun, Xiaohui Du, Xiqing Zhang, Zhenhua Ma, Yunhang Gao, Xiaojun Liang
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Maternal exposure to beta-Cypermethrin disrupts placental development by dysfunction of trophoblast cells from oxidative stress Toxicology (IF 4.5) Pub Date : 2024-04-04 Xiaoli Tang, Yanqing Geng, Rufei Gao, Zhuxiu Chen, Xinyi Mu, Yan Zhang, Xin Yin, Yidan Ma, Xuemei Chen, Fangfang Li, Junlin He
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mTORC1 - TFEB pathway was involved in sodium arsenite induced lysosomal alteration, oxidative stress and genetic damage in BEAS-2B cells Toxicology (IF 4.5) Pub Date : 2024-04-03 Di Ouyang, Yiren Xiong, Zuqing Hu, Jiayi He, Shanshan He, Renyi Liu, Zhenjie Gao, Dalin Hu
The mechanistic target of rapamycin (RAPA) complex 1 (mTORC1) - transcription factor EB (TFEB) pathway plays a crucial role in response to nutritional status, energy and environmental stress for maintaining cellular homeostasis. But there is few reports on its role in the toxic effects of arsenic exposure and the related mechanisms. Here, we show that the exposure of bronchial epithelial cells (BEAS-2B)
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Toxicological assessment of photoactivated tetra-cationic porphyrin molecules under white light exposure in a Caenorhabditis elegans model Toxicology (IF 4.5) Pub Date : 2024-04-03 Gabriela Vitória de Oliveira, Marcell Valandro Soares, Larissa Marafiga Cordeiro, Aline Franzen da Silva, Luiza Venturini, Larissa Ilha, Fabiane Bicca Obetine Baptista, Tássia Limana da Silveira, Félix Alexandre Antunes Soares, Bernardo Almeida Iglesias
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Exploring a mechanism-based approach for the identification of endocrine disruptors using Adverse Outcome Pathways (AOPs) and New Approach Methodologies (NAMs) : A perfluorooctane sulfonic acid case study Toxicology (IF 4.5) Pub Date : 2024-04-03 Linus Wiklund, Marek Pípal, Jana Weiss, Anna Beronius
Endocrine disruptors (EDs) pose a serious threat to human health and the environment and require a comprehensive evaluation to be identified. The identification of EDs require a substantial amount of data, both in vitro and in vivo, due to the current scientific criteria in the EU. At the same time, the EU strives to reduce animal testing due to concerns regarding animal welfare and sensitivity of
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Integrated In-Silico and In Vitro analysis to Decipher the contribution of bisphenol-A in cervical cancer Toxicology (IF 4.5) Pub Date : 2024-03-29 Nadeem Ghani Khan, Divya Adiga, Padmalatha Satwadi Rai, Shama Prasada Kabekkodu
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Understanding the impact of nanoplastics on reproductive health: Exposure pathways, mechanisms, and implications Toxicology (IF 4.5) Pub Date : 2024-03-28 Jingfan Ye, Yun Ren, Yanhui Dong, Dongwei Fan
Microplastic pollution is a pressing global environmental concern with particular urgency surrounding the issue of nanoplastic particles. Plastic products exhibit a remarkable persistence in natural ecosystems, resisting easy degradation. Nanoplastics, characterized by their diminutive size, possess distinct properties when compared to their larger counterparts, which could potentially render them
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Germ-free status but not subacute polychlorinated biphenyl (PCB) exposure altered hepatic phosphatidylcholine and ether-phosphatidylcholine levels in mice Toxicology (IF 4.5) Pub Date : 2024-03-27 Xueshu Li, Hui Wang, Hui Wang, Amanda J. Bullert, Julia Yue Cui, Kai Wang, Hans-Joachim Lehmler
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Protective effect of dental pulp stem cells' conditioned medium against cisplatin-induced testicular damage in rats Toxicology (IF 4.5) Pub Date : 2024-03-23 Afsaneh Hokmabadi, Esmaeil Ranjbar, Fatemeh Alipour, Alireza Ebrahimzadeh-Bideskan, Jalil Tavakol Afshari, Mohammad Morteza Rezaei, Reyhaneh Shafieian
Cisplatin is a highly effective chemotherapy drug used to treat most solid tumors. However, one of its side effects is testicular toxicity, which can lead to fertility abnormalities. This study investigated the effectiveness of dental pulp mesenchymal stem cells conditioned medium (DPSC-CM) on cisplatin-induced testicular toxicity. In this study, 36 eight-week-old male Wistar rats were randomly divided
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Chlorpyrifos impairs sperm parameters and number of Sertoli and Leydig cells in rats after exposure during the peripubertal period Toxicology (IF 4.5) Pub Date : 2024-03-23 Ivana Regina da Costa, Débora Hipólito Quadreli, Lucas Marcelo Meira da Silva, Fábio Goulart de Andrade, Glaura Scantamburlo Alves Fernandes
Chlorpyrifos is an organophosphate insecticide used to control pests in crops. Thus, humans are constantly exposed through ingestion of contaminated food or water, inhalation of contaminated air, and through the skin. The juvenile and peripubertal periods comprise a window of development of the reproductive system, sensitive to toxic agents. Considering the scarcity of data on exposure to the insecticide
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Effect of modified citrus pectin on galectin-3 inhibition in cisplatin-induced cardiac and renal toxicity Toxicology (IF 4.5) Pub Date : 2024-03-22 Diego D. Santos, Nycole M. Belote, Gisela R.S. Sasso, Rebeca D. Correia-Silva, Paulo C. Franco, Artur Francisco da Silva Neto, Fernanda T. Borges, Lila M. Oyama, Cristiane D. Gil
This study evaluated the effect of pharmacological inhibition of galectin 3 (Gal-3) with modified citrus pectin (MCP) on the heart and kidney in a model of cisplatin-induced acute toxicity. Male Wistar rats were divided into four groups ( = 6/group): SHAM, which received sterile saline intraperitoneally (i.p.) for three days; CIS, which received cisplatin i.p. (10 mg/kg/day) for three days; MCP, which
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Reproductive toxicity of cadmium stress in male animals Toxicology (IF 4.5) Pub Date : 2024-03-22 Zikun Zhang, Qi Wang, Xiaoge Gao, Xu Tang, Huan Xu, Wenqiang Wang, Xin Lei
Cadmium (Cd) is a common heavy metal pollutant in the environment, and the widespread use of products containing Cd compounds in industry has led to excessive levels in the environment, which enter the animal body through the food chain, thus seriously affecting the reproductive development of animals. Related studies have reported that Cd severely affects spermatogonia development and spermatogenesis
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Environmental toxicants and nephrotoxicity: Implications on mechanisms and therapeutic strategies Toxicology (IF 4.5) Pub Date : 2024-03-20 Rachna Yadav, Dinesh Kumar, Jiten Singh, Ashok Jangra
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Comparative toxicological analysis of two pristine carbon nanomaterials (graphene oxide and aminated graphene oxide) and their corresponding degraded forms using human in vitro models Toxicology (IF 4.5) Pub Date : 2024-03-20 Sandra de la Parra, Natalia Fernández-Pampín, Sebastiano Garroni, Matteo Poddighe, Dalia de la Fuente-Vivas, Rocío Barros, Sonia Martel-Martín, Santiago Aparicio, Carlos Rumbo, Juan Antonio Tamayo-Ramos
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High-throughput screening of respiratory hazards: Exploring lung surfactant inhibition with 20 benchmark chemicals Toxicology (IF 4.5) Pub Date : 2024-03-20 James Y. Liu, Ian C. George, Saber Hussain, Christie M. Sayes
As environmental air quality worsens and respiratory health injuries and diseases increase, it is essential to enhance our ability to develop better methods to identify potential hazards. One promising approach in emerging toxicology involves the utilization of lung surfactant as a model that addresses the limitations of conventional toxicology methods by incorporating the biophysical aspect of inhalation
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Single-cell and multi-omics analyses highlight cancer-associated fibroblasts-induced immune evasion and epithelial mesenchymal transition for smoking bladder cancer Toxicology (IF 4.5) Pub Date : 2024-03-16 Jiajin Wu, Fang Gao, Rui Meng, Huiqin Li, Zhenguang Mao, Yanping Xiao, Qiuyi Pu, Mulong Du, Zhengdong Zhang, Qiang Shao, Rui Zheng, Meilin Wang
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A review on toxicity mechanism and risk factors of nanoparticles in respiratory tract Toxicology (IF 4.5) Pub Date : 2024-03-15 Vidyasri Khadanga, Purna Chandra Mishra
This comprehensive review focuses on various dimensions of nanoparticle toxicity, emphasizing toxicological characteristics, assessment techniques, and examinations of relevant studies on the effects on biological systems. The primary objective is to comprehend the potential risks associated with nanoparticles and to provide efficient strategies for mitigating them by consolidating current research
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Metabolism-dependent mutagenicity of two structurally similar tobacco-specific nitrosamines (N-nitrosonornicotine and N-nitrosoanabasine) in human cells, partially different CYPs being activating enzymes Toxicology (IF 4.5) Pub Date : 2024-03-13 Yijing Chen, Zongying Yang, Zhao Zhou, Ellery J. Liu, Wenwen Luo, Zhini He, Weili Han, Yungang Liu
-nitrosonornicotine (NNN) and -nitrosoanabasine (NAB) are both tobacco-specific nitrosamines bearing two heterocyclic amino groups, NAB bearing an extra -CH- group (conferring a hexa- rather than penta-membered cycle) but with significantly decreased carcinogenicity. However, their activating enzymes and related mutagenicity remain unclear. In this study, the chemical-CYP interaction was analyzed by
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Genotoxic and cytotoxic effects of aflatoxin on the reproductive system: Focus on cell cycle dynamics and apoptosis in testicular tissue Toxicology (IF 4.5) Pub Date : 2024-03-12 Cyrus Jalili, Rahele Ranjbar Shamsi, Bita Amiri, Seyran Kakebaraie, Faramarz Jalili, Touraj Zamir Nasta
Aflatoxins (AFs) are inevitable environmental contaminants that are detrimental to human and animal health. AFs interfere with metabolic processes, metabolizing into different hydroxylated derivatives in the liver, as well as mechanistically induce ROS accumulation, S-phase arrest, DNA damage, and cell apoptosis. Chronic consumption of aflatoxin-contaminated foods can adversely affect the male reproductive
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Metabolic alterations and mitochondrial dysfunction in human airway BEAS-2B cells exposed to vanadium pentoxide Toxicology (IF 4.5) Pub Date : 2024-03-11 Xiaojia He, Matthew Ryan Smith, Zachery R. Jarrell, ViLinh Thi Ly, Yongliang Liang, Choon-Myung Lee, Michael Orr, Young-Mi Go, Dean P. Jones
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Prediction of acute methanol poisoning prognosis using machine learning techniques Toxicology (IF 4.5) Pub Date : 2024-03-06 Mitra Rahimi, Sayed Masoud Hosseini, Seyed Ali Mohtarami, Babak Mostafazadeh, Peyman Erfan Talab Evini, Mobin Fathy, Arya Kazemi, Sina Khani, Seyed Mohammad Mortazavi, Amirali Soheili, Seyed Mohammad Vahabi, Shahin Shadnia
Methanol poisoning is a global public health concern, especially prevalent in developing nations. This study focuses on predicting the severity of methanol intoxication using machine learning techniques, aiming to improve early identification and prognosis assessment. The study, conducted at Loghman Hakim Hospital in Tehran, Iran. The data pertaining to individuals afflicted with methanol poisoning
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Influence of lead-induced toxicity on the inflammatory cytokines Toxicology (IF 4.5) Pub Date : 2024-03-05 P. Harshitha, Kalpita Bose, Herman Sunil Dsouza
Lead (Pb) is a hazardous heavy metal that is pervasive in the human environment as a result of anthropogenic activity, and poses serious health risks, particularly in children. Due to its innumerable unique physical and chemical properties, it has various applications; therefore, it has become a common environmental pollutant. Lead may cause oxidative stress, and accumulating evidence indicates that
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Bee venom genotoxicity on Saccharomyces cerevisiae cells – The role of mitochondria and YAP1 transcription factor Toxicology (IF 4.5) Pub Date : 2024-03-03 Teodora Todorova, Krassimir Boyadzhiev, Martin Dimitrov, Petya Parvanova
The present work aims to clarify the genotype differences of a model organism in response to bee venom.
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Ferrostatin‑1 alleviates liver injury via decreasing ferroptosis following ricin toxin poisoning in rat Toxicology (IF 4.5) Pub Date : 2024-03-02 Ruijiao Lin, Zijie Jia, Hongbing Chen, Hongli Xiong, Cunhao Bian, Xin He, Bi Wei, Junfeng Fu, Minzhu Zhao, Jianbo Li
Ricin is a highly toxic plant toxin that can cause multi-organ failure, especially liver dysfunction, and is a potential bioterrorism agent. Despite the serious public health challenge posed by ricin, effective therapeutic for ricin-induced poisoning is currently unavailable. Therefore, it is important to explore the mechanism of ricin poisoning and develop appropriate treatment protocols accordingly
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Influence of polystyrene nanoparticles on the toxicity of tetrabromobisphenol A in human intestinal cell lines Toxicology (IF 4.5) Pub Date : 2024-03-02 Patricia Soto-Bielicka, Ana Peropadre, Soledad Sanz-Alférez, María José Hazen, Paloma Fernández Freire
Research and regulatory efforts in toxicology are increasingly focused on the development of suitable non-animal methodologies for human health risk assessment. In this work we used human intestinal Caco-2 and HT29/MTX cell lines to address the potential risks of mixtures of the emerging contaminants tetrabromobisphenol A (TBBPA) and commercial polystyrene nanoparticles (PSNPs). We employed different
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Virtual display of targets: A new level to rise the current understanding of ochratoxin A toxicity from a molecular standpoint Toxicology (IF 4.5) Pub Date : 2024-03-02 Florinda Perugino, Lorenzo Pedroni, Gianni Galaverna, Chiara Dall’Asta, Luca Dellafiora
Ochratoxin A (OTA) is a mycotoxin spread worldwide contaminating several food and feed commodities and rising concerns for humans and animals. OTA toxicity has been thoroughly assessed over the last 60 years revealing a variety of adverse effects, including nephrotoxicity, hepatotoxicity and possible carcinogenicity. However, the underpinning mechanisms of action have yet to be completely displayed
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Targeting SIRT1, NLRP3 inflammasome, and Nrf2 signaling with chrysin alleviates the iron-triggered hepatotoxicity in rats Toxicology (IF 4.5) Pub Date : 2024-03-01 Samyah T. Alanazi, Samir A. Salama, Ahmed Magdy El-ebiary, Abdulelah K. Altowairqi, Atheer T. Alharthi, Shahad M. Alzahrani, Shomokh H. Althagafi, Reema A. Alotaibi, Ahmed Abd-Eltawab Tammam
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Uncovering the toxicity mechanisms of a series of carboxylic acids in liver cells through computational and experimental approaches Toxicology (IF 4.5) Pub Date : 2024-02-28 Rita Ortega-Vallbona, Rebeca Méndez, Laia Tolosa, Sylvia E. Escher, José V. Castell, Rafael Gozalbes, Eva Serrano-Candelas
Hepatotoxicity poses a significant concern in drug design due to the potential liver damage that can be caused by new drugs. Among common manifestations of hepatotoxic damage is lipid accumulation in hepatic tissue, resulting in liver steatosis or phospholipidosis. Carboxylic derivatives are prone to interfere with fatty acid metabolism and cause lipid accumulation in hepatocytes. This study investigates
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Hazard and risk characterization of 56 structurally diverse PFAS using a targeted battery of broad coverage assays using six human cell types Toxicology (IF 4.5) Pub Date : 2024-02-27 Lucie C. Ford, Hsing-Chieh Lin, Han-Hsuan D. Tsai, Yi-Hui Zhou, Fred A. Wright, Alexander Sedykh, Ruchir R. Shah, Weihsueh A. Chiu, Ivan Rusyn
Per- and poly-fluoroalkyl substances (PFAS) are extensively used in commerce leading to their prevalence in the environment. Due to their chemical stability, PFAS are considered to be persistent and bioaccumulative; they are frequently detected in both the environment and humans. Because of this, PFAS as a class (composed of hundreds to thousands of chemicals) are contaminants of very high concern
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Cuproptosis-associated hub gene identification and immune cell infiltration patterns in silicosis Toxicology (IF 4.5) Pub Date : 2024-02-23 Ruimin Ma, Di Sun, Yuanying Wang, Xiaoxi Huang, Qiao Ye
Recent research has hinted at a potential connection between silicosis, a fibrotic lung disease caused by exposure to crystalline silica particles, and cuproptosis. The aim of the study was to explore how cuproptosis-related genes (CRGs) may influence the development of silicosis and elucidate the underlying mechanisms. An analysis of genes associated with both silicosis and cuproptosis was conducted
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Recreational MDMA doses do not elicit hepatotoxicity in HepG2 spheroids under normo- and hyperthermia Toxicology (IF 4.5) Pub Date : 2024-02-23 Arthur L. de Oliveira, Raul G. Miranda, Daniel J. Dorta
MDMA (3,4-methylenedioxymethamphetamine), an entactogen with empathogenic and prosocial effects, is widely used in music festivals and other festive settings. High MDMA doses have been associated with drug-induced liver injury and cases of hyperthermia. Although the latter condition is thought to increase MDMA hepatotoxicity, this correlation remains poorly explored for recreational MDMA doses. On
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Insights into the mechanism of transcription factors in Pb2+-induced apoptosis Toxicology (IF 4.5) Pub Date : 2024-02-21 Jingchong Guo, Ruikang Li, Zhuqing Ouyang, Jiawen Tang, Wei Zhang, Hui Chen, Qian Zhu, Jing Zhang, Gaochun Zhu
The health risks associated with exposure to heavy metals, such as Pb, are increasingly concerning the public. Pb can cause significant harm to the human body through oxidative stress, autophagy, inflammation, and DNA damage, disrupting cellular homeostasis and ultimately leading to cell death. Among these mechanisms, apoptosis is considered crucial. It has been confirmed that transcription factors
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Characterization and applicability of a novel physiologically relevant 3D-tetraculture bronchial model for in vitro assessment of respiratory sensitization Toxicology (IF 4.5) Pub Date : 2024-02-17 Artur Christian Garcia da Silva, Izadora Caroline Furtado de Mendonça, Marize Campos Valadares
Chemical Respiratory Allergy (CRA) is triggered after exposure to Low Molecular Weight (LMW) sensitizers and manifests clinically as asthma and rhinitis. From a risk/toxicity assessment point of view, there are few methods, none of them validated, for evaluating the respiratory sensitization potential of chemicals once the -based models usually employed for inhalation toxicity addressment do not comprise
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The m6A reader IGF2BP1 attenuates the stability of RPL36 and cell proliferation to mediate benzene hematotoxicity by recognizing m6A modification Toxicology (IF 4.5) Pub Date : 2024-02-16 Jingyu Wang, Xiaoli Guo, Yujiao Chen, Wei Zhang, Jing Ren, Ai Gao
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Exposure to TCBPA stimulates the growth of arterial smooth muscle cells through the activation of the ROS/NF-κB/NLRP3 signaling pathway Toxicology (IF 4.5) Pub Date : 2024-02-16 Huanyu Qiao, Bo Yang, Xiaoshuo Lv, Yongmin Liu
Tetrachlorobisphenol A (TCBPA) and Tetrabromobisphenol S (TBBPS) are organic compounds widely used in industrial production, including in plastic and textile manufacturing. Presently, residual TCBPA is commonly detected in the environment as well as in human and animal sera. Therefore, it is imperative to assess the potential toxicological effects of TCBPA on organismal health. A series of biochemical
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Toxicovigilance 2.0 – modern approaches for the hazard identification and risk assessment of toxicants in human beings: A review Toxicology (IF 4.5) Pub Date : 2024-02-16 Łukasz Niżnik, Joanna Toporowska-Kaźmierak, Karolina Jabłońska, Natalia Głąb, Sabina Stach, Julia Florek, Marta Sowińska, Aleksandra Adamczyk, Kamil Jurowski
The attempt to define toxicovigilance can be based on defining its fundamental principles: prevention of infections with toxic substances, collecting information on poisonings, both in terms of their sources and side effects, and confirming poisonings, with the aim of improving treatment. Substances referred to include both those originating from animal bites, ingested inadvertently, and those resulting
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Multiple organs injury and myocardial energy metabolism disorders induced by isoproterenol Toxicology (IF 4.5) Pub Date : 2024-02-16 Xiao-ting Zhang, Xu Zhang, Meng-wei Wang, Chen Zhang, Rui Weng, Xu Xu, Zu-xi Gu, Jian-ping Gao
The study sought to assess the detrimental effects of isoproterenol (ISO) on major organs and investigate the potential reversibility of these adverse reactions in mice. Male mice were divided into normal control, 0.2 mg/kg.d and 3.0 mg/kg.d ISO groups, and were subcutaneously administered of the respective doses for 14 consecutive days. Subsequently, a recovery period experiment was conducted, replicating
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Metformin inhibits OCTN1- and OCTN2-mediated hepatic accumulation of doxorubicin and alleviates its hepatotoxicity in mice Toxicology (IF 4.5) Pub Date : 2024-02-15 Mingyang Chen, Yaodong Yi, Binxin Chen, Hengbin Zhang, Minlei Dong, Luexiang Yuan, Hui Zhou, Huidi Jiang, Zhiyuan Ma
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Identification of toxicity-induced biomarkers in human non-immune airway cells exposed to respiratory sensitizers: A mechanistic approach Toxicology (IF 4.5) Pub Date : 2024-02-14 Artur Christian Garcia da Silva, Sérgio de Morais Carvalho Filho, Izadora Caroline Furtado de Mendonça, Marize Campos Valadares
Occupational asthma covers a group of work-related diseases whose clinical manifestations include airway hyperresponsiveness and airflow limitation. Although the chemical respiratory allergy (CRA) induced by Low Molecular Weight (LMW) sensitizers is a major concern, especially in terms of the regulatory framework, to date there are no methods available for preclinically addressing this toxicological
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Could the gut microbiota be capable of making individuals more or less susceptible to environmental toxicants? Toxicology (IF 4.5) Pub Date : 2024-02-13 Marcella S.A. Santiago, Maria Christina W. Avellar, Juliana E. Perobelli
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A novel three-dimensional Nrf2 reporter epidermis model for skin sensitization assessment Toxicology (IF 4.5) Pub Date : 2024-02-09 K. Brandmair, D. Dising, D. Finkelmeier, A. Schepky, J. Kuehnl, J. Ebmeyer, A. Burger-Kentischer
Skin sensitization assessment has progressed from the use of animal models towards the application of New Approach Methodologies (NAMs). Several skin sensitization NAMs are accepted for regulatory use, but a majority relies on submerged cell cultures that limit their applicability domain, posing challenges for testing hydrophobic chemicals and mixtures. A newly developed three-dimensional (3D) Nrf2
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miR-15b-5p promotes HgCl2-induced chicken embryo kidney cells ferroptosis by targeting β-TrCP-mediated ATF4 ubiquitin degradation Toxicology (IF 4.5) Pub Date : 2024-02-06 Hong-Yu Fu, Yue Li, Han Cui, Jiu-Zhi Li, Wan-Xue Xu, Xi Wang, Rui-Feng Fan
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Notoginsenoside R1 attenuates bupivacaine induced neurotoxicity by activating Jak1/Stat3/Mcl1 pathway Toxicology (IF 4.5) Pub Date : 2024-02-04 Yu Yang, Jiwen Wu, Shicheng Feng, Hao Yu, Chuanxin Liu, Shuai Wang
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Restoration of nerve agent impaired neuromuscular transmission in rat diaphragm by bispyridinium non-oximes – Structure-activity relationships Toxicology (IF 4.5) Pub Date : 2024-02-03 Niko Amend, Christopher M. Timperley, Mike Bird, A. Christopher Green, Franz Worek, Thomas Seeger
Organophosphate (OP) poisoning is currently treated with atropine, oximes and benzodiazepines. The nicotinic signs, i.e., respiratory impairment, can only be targeted indirectly via the use of oximes as reactivators of OP-inhibited acetylcholinesterase. Hence, compounds selectively targeting nicotinic acetylcholine receptors (nAChRs) might fundamentally improve current treatment options. The bispyridinium
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Differential eigengene network analysis reveals benzo[a]pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin consensus regulatory network in human liver cell line HepG2 Toxicology (IF 4.5) Pub Date : 2024-02-02 Bojana Stanic, Nataša Sukur, Nemanja Milošević, Jelena Markovic Filipovic, Kristina Pogrmic-Majkic, Nebojsa Andric
Aryl hydrocarbon receptor (AHR) is one of the main mediators of the toxic effects of benzo[]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo--dioxin (TCDD). However, a vast number of BaP- and TCDD-affected genes may suggest a more complex transcriptional regulatory network driving common adverse effects of these two chemicals. Unlike TCDD, BaP is rapidly metabolized in the liver, yielding products with
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Deep Learning Algorithm Based on Molecular Fingerprint for Prediction of Drug‐Induced Liver Injury Toxicology (IF 4.5) Pub Date : 2024-02-01 Qiong Yang, Shuwei Zhang, Yan Li
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Development of a hierarchical support vector regression-based in silico model for the prediction of the cysteine depletion in DPRA Toxicology (IF 4.5) Pub Date : 2024-02-01 Giang H. Ta, Ching-Feng Weng, Max K. Leong
Topical and transdermal treatments have been dramatically growing recently and it is crucial to consider skin sensitization during the drug discovery and development process for these administration routes. Various tests, including animal and non-animal approaches, have been devised to assess the potential for skin sensitization. Furthermore, numerous models have been created, providing swift and cost-effective
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Ochratoxin A stimulates release of IL-1β, IL–18 and CXCL8 from cultured human microglia Toxicology (IF 4.5) Pub Date : 2024-02-01 Irene Tsilioni, Theoharis C. Theoharides
Exposure to mycotoxins has been associated with the development of neuropsychiatric symptoms and Ochratoxin A (OTA) has emerged as one of the main mycotoxins associated with neurotoxicity. However, the mechanism via OTA exerts its neurotoxic effects is not well understood, especially the importance of activated microglia and their contribution to neuroinflammation. Here we report the effect of OTA
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Exploring the dynamics of the ABCB1 membrane transporter P-glycoprotein in the presence of ATP and active/non-active compounds through molecular dynamics simulations Toxicology (IF 4.5) Pub Date : 2024-01-24 Liadys Mora Lagares, Yunierkis Pérez-Castillo, Marjana Novič
P-glycoprotein (Pgp) is a member of the ATP-binding cassette family of transporters that confers multidrug resistance to cancer cells and is actively involved in the pharmacokinetics and toxicokinetics of a big variety of drugs. Extensive studies have provided insights into the binding of many compounds, but the precise mechanism of translocation across the membrane remains unknown; in this context
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Silver nanoparticles induce endothelial cytotoxicity through ROS-mediated mitochondria-lysosome damage and autophagy perturbation: The protective role of N-acetylcysteine Toxicology (IF 4.5) Pub Date : 2024-01-28 Jing He, Yunyun Ma, Xudong Niu, Jiansheng Pei, Ru Yan, Fangjing Xu, Jing Ma, Xiaojuan Ma, Shaobin Jia, Wanrui Ma
Silver nanoparticles (AgNPs) are used increasingly often in the biomedical field, but their potential deleterious effects on the cardiovascular system remain to be elucidated. The primary aim of this study was to evaluate the toxic effects, and the underlying mechanisms of these effects, of AgNPs on human umbilical vein endothelial cells (HUVECs), as well as the protective role of N-acetylcysteine
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Dimethyl fumarate induces cardiac developmental toxicity in zebrafish via down-regulation of oxidative stress Toxicology (IF 4.5) Pub Date : 2024-01-23 Mengqi Wan, Jiejun Liu, Dou Yang, Zhonghao Xiao, Xue Li, Jieping Liu, Ling Huang, Fasheng Liu, Shouhua Zhang, Qiang Tao, Juhua Xiao, Zigang Cao
Dimethyl fumarate (DMF) is an immunosuppressant commonly used to treat multiple sclerosis and other autoimmune diseases. Despite known side effects such as lymphopenia, the effect of DMF on cardiac development remains unclear. To assess this, we used zebrafish to evaluate the cardiac developmental toxicity of DMF. Our study showed that DMF reduced the survival rate of zebrafish embryos, with those
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Sex differences in 4-tert-octylphenol toxicokinetics: Exploration of sex as an effective covariate through an in vivo modeling approach Toxicology (IF 4.5) Pub Date : 2024-01-20 Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee