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The Co-oligomers of Aβ42 and Human Islet Amyloid Polypeptide Exacerbate Neurotoxicity and Alzheimer-like Pathology at Cellular Level Neuroscience (IF 3.3) Pub Date : 2024-04-09 Jiajun Deng, Bin Liu, Qian Tao, Yanyu Luo, Yi Zhu, Xinxin Huang, Feng Yue
The Aβ hypothesis has long been central to Alzheimer's disease (AD) theory, with a recent surge in attention following drug approvals targeting Aβ plaque clearance. Aβ42 oligomers (AβO) are key neurotoxins. While β-amyloid (Aβ) buildup is a hallmark of AD, postmortem brain analyses have unveiled human islet amyloid polypeptide (hIAPP) deposition in AD patients, suggesting a potential role in Alzheimer's
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Corrigendum to “Basolateral Amygdala Functional Connectivity in Alexithymia: Linking Interoceptive Sensibility and Cognitive Empathy” [Neuroscience 539 (2024) 12–20] Neuroscience (IF 3.3) Pub Date : 2024-04-06 Xianrui Li, Chuyao Peng, Facai Qin, Qian Luo, Zhiting Ren, Xueyang Wang, Qiuyang Feng, Cheng Liu, Yang Li, Dongtao Wei, Jiang Qiu
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Growth Hormone Secretagogue Receptor (GHSR) Signaling in the Ventral Tegmental Area (VTA) Mediates Feeding Produced by Chronic Social Defeat Stress in Male Mice Neuroscience (IF 3.3) Pub Date : 2024-04-06 Andrea Smith, Trevor Rodrigues, Caroline Wallace, Karen Mezher, Brenna MacAulay, Rebecca Prowse, Lindsay Hyland, Alfonso Abizaid
Ghrelin, a hormone secreted by the stomach, binds to the growth hormone secretagogue receptor (GHSR) in various brain regions to produce a number of behavioral effects that include increased feeding motivation. During social defeat stress, ghrelin levels rise in correlation with increased feeding and potentially play a role in attenuating the anxiogenic effects of social defeat. One region implicated
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Late Positivity Correlates with Subjective Reports: Evidence from the Low-frequency and High-frequency Reporting Tasks Neuroscience (IF 3.3) Pub Date : 2024-04-03 Muwang Ye, Anhui Wang, Haiyang Liang, Xiaowen Liu
Identifying the neural correlates of consciousness (NCCs) is an important way to understand the fundamental nature of consciousness. By recording event-related potentials (ERPs) using EEG, researchers have found three potential electrophysiological NCCs: early positive correlate of consciousness (enhanced P1), visual awareness negativity (VAN), and late positivity (LP). However, LP may reflect post-perceptual
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Therapeutic Potential of Natural Compounds in Subarachnoid Haemorrhage Neuroscience (IF 3.3) Pub Date : 2024-04-03 Jiacong Tan, Huaxin Zhu, Yanyang Zeng, Jiawei Li, Yeyu Zhao, Meihua Li
Subarachnoid hemorrhage (SAH) is a common and fatal cerebrovascular disease with high morbidity, mortality and very poor prognosis worldwide. SAH can induce a complex series of pathophysiological processes, and the main factors affecting its prognosis are early brain injury (EBI) and delayed cerebral ischemia (DCI). The pathophysiological features of EBI mainly include intense neuroinflammation, oxidative
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Mechanism of NLRP3 Inflammasome in Epilepsy and Related Therapeutic Agents Neuroscience (IF 3.3) Pub Date : 2024-04-03 Juan Chen, Yuan Gao, Ning Liu, Dongmei Hai, Wei Wei, Yue Liu, Xiaobing Lan, Xueqin Jin, Jianqiang Yu, Lin Ma
Epilepsy is one of the most widespread and complex diseases in the central nervous system (CNS), affecting approximately 65 million people globally, an important factor resulting in neurological disability-adjusted life year (DALY) and progressive cognitive dysfunction. Medication is the most essential treatment. The currently used drugs have shown drug resistance in some patients and only control
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Applications of Tissue Clearing in Central and Peripheral Nerves Neuroscience (IF 3.3) Pub Date : 2024-04-01 Cheng He, Ye Yuan, Chuanhui Gong, Xueying Wang, Guangming Lyu
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Effect of Myelin Debris on the Phenotypic Transformation of Astrocytes after Spinal Cord Injury in Rats Neuroscience (IF 3.3) Pub Date : 2024-04-01 Jianwei Lv, Hang Yu, Fangli Shan, Jianan Ye, Ao Li, Juehua Jing, Meige Zheng, Dasheng Tian
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RBM3 Ameliorates Acute Brain Injury-induced Inflammation and Oxidative Stress by Stabilizing GAS6 mRNA Through Nrf2 Signaling Pathway Neuroscience (IF 3.3) Pub Date : 2024-03-29 Pingqing Lin, Chengshi Lin, Liangbiao Diao
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Alzheimer's Disease-associated Region-specific Decrease of Vesicular Glutamate Transporter Immunoreactivity in the Medial Temporal Lobe and Superior Temporal Gyrus Neuroscience (IF 3.3) Pub Date : 2024-03-27 Oliver W.G. Wood, Josh Walby, Jason H. Yeung, Stephen Ke, Thulani H. Palpagama, Clinton Turner, Henry J. Waldvogel, Richard L.M. Faull, Andrea Kwakowsky
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder for which there are very limited treatment options. Dysfunction of the excitatory neurotransmitter system is thought to play a major role in the pathogenesis of this condition. Vesicular glutamate transporters (VGLUTs) are key to controlling the quantal release of glutamate. Thus, expressional changes in disease can have implications
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Dihydroartemisinin Protects Mice from CUMS-induced Depression-like Behaviors by Regulating Gut Microbes Neuroscience (IF 3.3) Pub Date : 2024-03-27 Chong Tang, Haiming Liu, Hui Zou, Meilei Su, Honglei Yin, Meihua Sun, Yuhan Zhao, Junlong Guo, Xiaoling Lai, Xiang Xue, Enze Li
Depression is one of the most common forms of psychopathology, which is associated with gut microbiota dysfunction. Dihydroartemisinin (DHA) has been shown to regulate gut microbiota and ameliorate neuropathies, but whether it can be used to treat depression remains unclear. Our study found that DHA treatment raised the preference for sugar water in chronic unpredictable mild stress (CUMS)-induced
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Relationship Between the Parietal Cortex and Task Switching: Transcranial Direct Current Stimulation Combined with an Event-related Potential Study Neuroscience (IF 3.3) Pub Date : 2024-03-26 Ziyu Wang, Yi Zhao, Xuqun You, Jimin Liang
Task switching refers to a set of cognitive processes involved in shifting attention from one task to another. In recent years, researchers have applied transcranial direct current stimulation (tDCS) to investigate the causal relationship between the parietal cortex and task switching. However, results from available studies are highly inconsistent. This may be due to the unclear understanding of the
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Alterations of Perineuronal Net Expression and Abnormal Social Behavior and Whisker-dependent Texture Discrimination in Mice Lacking the Autism Candidate Gene Engrailed 2 Neuroscience (IF 3.3) Pub Date : 2024-03-25 Lorenzo Mattioni, Anna Barbieri, Andrea Grigoli, Luigi Balasco, Yuri Bozzi, Giovanni Provenzano
GABAergic interneurons and perineuronal nets (PNNs) are important regulators of plasticity throughout life and their dysfunction has been implicated in the pathogenesis of several neuropsychiatric conditions, including autism spectrum disorders (ASD). PNNs are condensed portions of the extracellular matrix (ECM) that are crucial for neural development and proper formation of synaptic connections.
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Development of Midbrain Dopaminergic Neurons and the Advantage of Using hiPSCs as a Model System to Study Parkinson’s Disease Neuroscience (IF 3.3) Pub Date : 2024-03-22 Jennifer Sally Samson, Anuradha Ramesh, Venkatachalam Deepa Parvathi
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Resting-state Functional Connectivity of the Motor and Cognitive Areas is Preserved in Masters Athletes Neuroscience (IF 3.3) Pub Date : 2024-03-22 Alexandra Potvin-Desrochers, Alisha Atri, Julien Clouette, Russell T. Hepple, Tanja Taivassalo, Caroline Paquette
Aging is characterized by a decline in physical and cognitive functions, often resulting in decreased quality of life. Physical activity has been suggested to potentially slow down various aspects of the aging process, a theory that has been supported by studies of Masters Athletes (MA). For example, MA usually have better cognitive and physical functions than age-matched sedentary and healthy older
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Electroacupuncture Alleviates Post-stroke Cognitive Impairment Through Inhibiting miR-135a-5p/mTOR/NLRP3 Axis-mediated Autophagy Neuroscience (IF 3.3) Pub Date : 2024-03-22 Jianchang Luo, Jiawang Lang, Wenbin Xu, Luodan Wang, Zhipeng Zhao, Jie Jia, Boxu Lang
Post-stroke cognitive impairment is a significant challenge with limited treatment options. Electroacupuncture (EA) has shown promise in improving cognitive function after stroke. Our study explores the underlying mechanism of EA in alleviating cognitive impairment through the inhibition of autophagy. We utilized a rat model of stroke induced by middle cerebral artery occlusion (MCAO) to evaluate the
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What Role Does Striatal Dopamine Play in Goal-directed Action? Neuroscience (IF 3.3) Pub Date : 2024-03-21 Genevra Hart, Thomas J. Burton, Bernard W. Balleine
Evidence suggests that dopamine activity provides a US-related prediction error for Pavlovian conditioning and the reinforcement signal supporting the acquisition of habits. However, its role in goal-directed action is less clear. There are currently few studies that have assessed dopamine release as animals acquire and perform self-paced instrumental actions. Here we briefly review the literature
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Abnormal Brachial Plexus Differentiation from Routine Magnetic Resonance Imaging: An AI-based Approach Neuroscience (IF 3.3) Pub Date : 2024-03-21 Weiguo Cao, Benjamin M. Howe, Darryl E. Wright, Sumana Ramanathan, Nicholas G. Rhodes, Panagiotis Korfiatis, Kimberly K. Amrami, Robert J. Spinner, Timothy L. Kline
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Repetitive Transcranial Magnetic Stimulation Combined with Sling Exercise Modulates the Motor Cortex in Patients with Chronic Low Back Pain Neuroscience (IF 3.3) Pub Date : 2024-03-21 Xin Li, Songwei Lu, Le Ge, Zhicheng Li, Rong Chen, Yao Zu, Ruochen Fu, Le Li, Chuhuai Wang
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The Predictive Potential of Heart Rate Variability for Depression Neuroscience (IF 3.3) Pub Date : 2024-03-20 Shir Galin, Hanna Keren
Heart rate variability (HRV),a measure of the fluctuations in the intervals between consecutive heartbeats, is an indicator of changes in the autonomic nervous system. A chronic reduction in HRV has been repeatedly linked to clinical depression. However, the chronological and mechanistic aspects of this relationship, between the neural, physiological, and psychopathological levels, remain unclear.
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Ventral Tegmental Area Excitatory Neurons Impact Reward-driven Behavior by Modulating Infralimbic Cortical Firing Neuroscience (IF 3.3) Pub Date : 2024-03-20 Tolulope Adeyelu, Tashonda Vaughn, Olalekan M. Ogundele
The functional dichotomy of anatomical regions of the medial prefrontal cortex (mPFC) has been tested with greater certainty in punishment-driven tasks, and less so in reward-oriented paradigms. In the infralimbic cortex (IL), known for behavioral suppression (STOP), tasks linked with reward or punishment are encoded through firing rate decrease or increase, respectively. Although the ventral tegmental
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Txnrd2 Attenuates Early Brain Injury by Inhibition of Oxidative Stress and Endoplasmic Reticulum Stress via Trx2/Prx3 Pathway after Intracerebral Hemorrhage in Rats Neuroscience (IF 3.3) Pub Date : 2024-03-20 Xuanbei Liu, Enhui Hong, Jiayu Xie, Jiangwei Li, Boyun Ding, Yongsheng Chen, Zhennan Xia, Weiping Jiang, Hongzhu Lv, Bo Yang, Yizhao Chen
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Repeated Morphine Exposure Alters Temporoamonic-CA1 Synaptic Plasticity in Male Rat Hippocampus Neuroscience (IF 3.3) Pub Date : 2024-03-20 Sohrab Anvari, Mohammad Javan, Javad Mirnajafi-Zadeh, Yaghoub Fathollahi
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Exploring the Differences Between an Immature and a Mature Human Auditory System Through Auditory Late Responses in Quiet and in Noise Neuroscience (IF 3.3) Pub Date : 2024-03-19 Fauve Duquette-Laplante, Benoît Jutras, Noémie Néron, Sandra Fortin, Amineh Koravand
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Mechanisms of Action Anticipation in Table Tennis Players: A Multivoxel Pattern Analysis Study Neuroscience (IF 3.3) Pub Date : 2024-03-19 Qingchun Ji, Likai Liu, Yingzhi Lu, Chenglin Zhou, Yingying Wang
An exceptional ability to accurately anticipate an opponent’s action is paramount for competitive athletes and highlights their experiential mastery. Despite conventional associations of action observation with specific brain regions, neuroimaging discrepancies persist. To explore the brain regions and neural mechanisms undergirding action anticipation, we compared distinct brain activation patterns
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Neonatal Hypoxia-Ischemia alters Brain-Derived Contactin-2-Positive Extracellular Vesicles in the Mouse Plasma Neuroscience (IF 3.3) Pub Date : 2024-03-19 Shirelle X. Liu, Daniela G. Villacis Calderon, Zia L. Maxim, Montana M. Beeson, Raghavendra Rao, Phu V. Tran
Neonatal encephalopathy (NE) impairs white matter development and results in long-term neurodevelopmental deficits. Leveraging prior findings of altered neuronal proteins carried by brain-derived extracellular vesicles (EVs) that are marked by a neural-specific cell surface glycoprotein Contactin-2 (CNTN2) in NE infants, the present study aimed to determine the correlation between brain and circulating
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Corrigendum to “Pathological changes in hippocampal neuronal circuits underlie age-associated neurodegeneration and memory loss: Positive clue toward SAD” [Neuroscience 301 (2015) 90–105] Neuroscience (IF 3.3) Pub Date : 2024-03-19 P. Moorthi, P. Premkumar, R. Priyanka, K.S. Jayachandran, M. Anusuyadevi
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Hsa_circ_0018401 and miR-127-5p Expressions Are Diagnostic and Prognostic Markers for Traumatic Brain Injury (TBI) in Trauma Patients Neuroscience (IF 3.3) Pub Date : 2024-03-16 Xiancun Ma, Huimin Wang, Gaige Ye, Xin Zheng, Yu Wang
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Armcx1 Reduces Neurological Damage Via a Mitochondrial Transport Pathway Involving Miro1 After Traumatic Brain Injury Neuroscience (IF 3.3) Pub Date : 2024-03-16 Qiuying Li, Haibo Ni, Qin Rui, Jiasheng Ding, Xianghu Kong, Xugang Kan, Rong Gao, Hongbo Shen
Armcx1 is a member of the ARMadillo repeat-Containing protein on the X chromosome (ARMCX) family, which is recognized to have evolutionary conserved roles in regulating mitochondrial transport and dynamics. Previous research has shown that Armcx1 is expressed at higher levels in mice after axotomy and in adult retinal ganglion cells after crush injury, and this protein increases neuronal survival and
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Utilizing Siamese 4D-AlzNet and Transfer Learning to Identify Stages of Alzheimer’s Disease Neuroscience (IF 3.3) Pub Date : 2024-03-16 Atif Mehmood, Farah Shahid, Rizwan Khan, Mostafa M. Ibrahim, Zhonglong Zheng
Alzheimer's disease (AD) is the general form of dementia, leading to a progressive neurological disorder characterized by memory loss due to brain cell damage. Artificial Intelligence (AI) assists in the early identification and prediction of AD patients, determining future risks and benefits for radiologists and doctors to save time and cost. Since deep learning (DL) approaches work well with massive
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Dissociating the Influence of Limb Posture and Visual Feedback Shifts on the Adaptation to Novel Movement Dynamics Neuroscience (IF 3.3) Pub Date : 2024-03-13 Justin J. Fitzgerald, Weiwei Zhou, Steven M. Chase, Wilsaan M. Joiner
Accurate movements of the upper limb require the integration of various forms of sensory feedback (e.g., visual and postural information). The influence of these different sensory modalities on reaching movements has been largely studied by assessing endpoint errors after selectively perturbing sensory estimates of hand location. These studies have demonstrated that both vision and proprioception make
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Directed Functional Connectivity Changes of Triple Networks for Stable and Progressive Mild Cognitive Impairment Neuroscience (IF 3.3) Pub Date : 2024-03-13 Darui Zheng, Yiming Ruan, Xuan Cao, Wenxuan Guo, Xulian Zhang, Wenzhang Qi, Qianqian Yuan, Xuhong Liang, Da Zhang, Qingling Huang, Chen Xue, the Alzheimer's Disease Neuroimaging Initiative
Mild cognitive impairment includes two distinct subtypes, namely progressive mild cognitive impairment and stable mild cognitive impairment. While alterations in extensive functional connectivity have been observed in both subtypes, limited attention has been given to directed functional connectivity. A triple network, composed of the central executive network, default mode network, and salience network
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Pathways for Naturalistic Looking Behavior in Primate II. Superior Colliculus Integrates Parallel Top-down and Bottom-up Inputs Neuroscience (IF 3.3) Pub Date : 2024-03-13 Richard Veale, Mayu Takahashi
Volitional signals for gaze control are provided by multiple parallel pathways converging on the midbrain superior colliculus (SC), whose deeper layers output to the brainstem gaze circuits. In the first of two papers (Takahashi and Veale, 2023), we described the properties of gaze behavior of several species under both laboratory and natural conditions, as well as the current understanding of the
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Microglial AT1R Conditional Knockout Ameliorates Hypoperfusive Cognitive Impairment by Reducing Microglial Inflammatory Responses Neuroscience (IF 3.3) Pub Date : 2024-03-13 Deyue Li, Qiao Zhang, Xia Yang, Guoqing Zhang, Jinping Wang, Rong Zhang, Yong Liu
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Spinal lymphatic dysfunction aggravates the recovery process after spinal cord injury Neuroscience (IF 3.3) Pub Date : 2024-03-08 Rui-Guang Zhang, Bo-Wen Zheng, Jing Zhang, Ming-yu Hao, Yu-Hang Diao, Xiao- Jun Hu, Xuan-Hui Liu, Tao Zhu, Zi-Long Zhao, Hong-Tao Rong
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Purinergic Astrocyte Signaling Driven by TNF-α After Cannabidiol Administration Restores Normal Synaptic Remodeling Following Traumatic Brain Injury Neuroscience (IF 3.3) Pub Date : 2024-03-08 Tenghan Ling, Aiping Yin, Yan Cao, Jiali Li, Hengxi Li, Ying Zhou, Xiaobing Guo, Jinghui Li, Ruilin Zhang, Haiying Wu, Ping Li
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Revealing Novel Genes Related to Parkinson's Disease Pathogenesis and Establishing an associated Model Neuroscience (IF 3.3) Pub Date : 2024-03-07 Hao-wei Deng, Bin-ru Li, Shao-dan Zhou, Chun Luo, Bing-hua Lv, Zi-mei Dong, Chao Qin, Rui-ting Hu
Parkinson's disease (PD) represents a multifaceted neurological disorder whose genetic underpinnings warrant comprehensive investigation. This study focuses on identifying genes integral to PD pathogenesis and evaluating their diagnostic potential. Initially, we screened for differentially expressed genes (DEGs) between PD and control brain tissues within a dataset comprising larger number of specimens
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The Landscape of Publishing in Neuroscience: Honouring Our Scientific Heritage and Shaping the Future of Research Neuroscience (IF 3.3) Pub Date : 2024-03-05 Francesca Cirulli, Sarah J. Spencer, Chen Zhang
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Bilateral Whisker Representations in the Primary Somatosensory Cortex in Robo3cKO Mice Are Reflected in the Primary Motor Cortex Neuroscience (IF 3.3) Pub Date : 2024-03-05 Vassiliy Tsytsarev, Céline Plachez, Shuxin Zhao, Daniel H. O'Connor, Reha S. Erzurumlu
In Robo3cKO mice, midline crossing defects of the trigeminothalamic projections from the trigeminal principal sensory nucleus result in bilateral whisker maps in the somatosensory thalamus and consequently in the face representation area of the primary somatosensory (S1) cortex (Renier et al., 2017; Tsytsarev et al., 2017). We investigated whether this bilateral sensory representation in the whisker-barrel
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Greater Pattern Similarity between Mother Tongue and Second Language in the Right ATL Facilitates Understanding of Written Language Neuroscience (IF 3.3) Pub Date : 2024-03-05 Jie Dong, Hao Yan, Leilei Mei, Gang Wang, Jing Qu, Xinyi Liu, Shanshan Xu, Wenjing Jiang, Aoke Zheng, Genyi Feng
Previous research has mapped out the brain regions that respond to semantic stimuli presented visually and auditorily, but there is debate about whether semantic representation is modality-specific (only written or only spoken) or modality-invariant (both written and spoken). The mechanism of semantic representation underlying native (L1) and second language (L2) comprehension in different modalities
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Taming Complexity from the Interface: Simplifying Neuroscience Neuroscience (IF 3.3) Pub Date : 2024-03-05 Igor Branchi
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Ischaemic Stroke, Thromboembolism and Clot Structure Neuroscience (IF 3.3) Pub Date : 2024-03-05 Katherine Stanton, Helen Philippou, Robert AS Ariëns
Ischaemic stroke is a major cause of morbidity and mortality worldwide. Blood clotting and thromboembolism play a central role in the pathogenesis of ischaemic stroke. An increasing number of recent studies indicate changes in blood clot structure and composition in patients with ischaemic stroke. In this review, we aim to summarise and discuss clot structure, function and composition in ischaemic
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Epigenetic Mechanism of SETD1B-mediated Histone Methylation in Cognitive Impairment Induced by Sevoflurane Anesthesia in Neonatal Mice Neuroscience (IF 3.3) Pub Date : 2024-03-04 Zhao Wang, Jing Zhang, Qian Tang, Yujie Tan
Sevoflurane (Sev) anesthesia is associated with cognitive deficits and neurotoxicity. This study explores the epigenetic mechanism of SET domain containing 1B (SETD1B) in Sev-induced cognitive impairment in neonatal mice. Neonatal mice (C57BL/6, = 72) were exposed to 3% Sev for 2 h per day at P6, 7, and 8, and the control neonatal mice were only separated from the mother for 2 h. The mice were divided
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Autokinesis Reveals a Threshold for Perception of Visual Motion Neuroscience (IF 3.3) Pub Date : 2024-03-02 Yihao Liu, Jing Tian, Alejandro Martin-Gomez, Qadeer Arshad, Mehran Armand, Amir Kheradmand
In natural viewing conditions, the brain can optimally integrate retinal and extraretinal signals to maintain a stable visual perception. These mechanisms, however, may fail in circumstances where extraction of a motion signal is less viable such as impoverished visual scenes. This can result in a phenomenon known as autokinesis in which one may experience apparent motion of a small visual stimulus
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Effects of Dietary Fiber on Short Chain Fatty Acid Receptor mRNA in Microglia and Serotonergic Neurons in the Mouse Brain Neuroscience (IF 3.3) Pub Date : 2024-02-29 Janna B. Hart, Robert K. Poon, Robert E. Ward, Korry J. Hintze, Sara M. Freeman
Short-chain fatty acids (SCFAs) are bioactive lipids that are released into the colon as a metabolite of bacterial fermentation of dietary fibers. Beyond their function in the gastrointestinal tract, SCFAs can also have effects inthe brain, as a part of the gut-brain axis. Recent investigations into potential therapeutic interventions via the manipulation of the gut microbiome—and thus their SCFA metabolites—has
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Nrdp1-mediated Macrophage Phenotypic Regulation Promotes Functional Recovery in Mice with Mild Neurological Impairment after Intracerebral Hemorrhage Neuroscience (IF 3.3) Pub Date : 2024-02-29 Xiyao Wu, Zhiling Chen, Qiuming Chen, Chuangan Lin, Xiangrong Zheng, Bangqing Yuan
Neuregulin receptor degradation protein 1 (Nrdp1) is a ring finger E3 ubiquitin ligase involved in some inflammation through ubiquitination, including macrophage polarization following cerebral hemorrhage. However, there is limited understanding regarding the mechanisms through which Nrdp1 modulates macrophage polarization and the potential impact of this modulation on neurological function. Using
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BDNF in Neuropathic Pain; the Culprit that Cannot be Apprehended Neuroscience (IF 3.3) Pub Date : 2024-02-28 Peter A. Smith
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The Interaction between ADK and SCG10 Regulate the Repair of Nerve Damage Neuroscience (IF 3.3) Pub Date : 2024-02-28 Tianjun Chen, Zhiwan Chen, Ping Wu, Jianxian Luo, Qiuling Liu, Hua Yang, Cheng Peng, Guowei Zhang, Hongsheng Lin, Zhisheng Ji
The cytoskeleton must be remodeled during neurite outgrowth, and Superior Cervical Ganglion 10 (SCG10) plays a critical role in this process by depolymerizing Microtubules (MTs), conferring highly dynamic properties to the MTs. However, the precise mechanism of action of SCG10 in the repair of injured neurons remains largely uncertain. Using transcriptomic identification, we discovered that SCG10 expression
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Electroacupuncture Enhances the Functional Connectivity of Limbic System to Neocortex in the 5xFAD Mouse Model of Alzheimer's Disease Neuroscience (IF 3.3) Pub Date : 2024-02-28 Mingzhu Xu, Run Lin, Huaneng Wen, Yixiao Wang, John Wong, Zhihua Peng, Lu Liu, Binbin Nie, Jing Luo, Xiaoyu Tang, Shaoyang Cui
Our previous study revealed that acupuncture may exhibit therapeutic effects on Alzheimer's disease (AD) through the activation of metabolism in memory-related brain regions. However, the underlying functional mechanism remains poorly understood and warrants further investigation. In this study, we used resting-state functional magnetic resonance imaging (rsfMRI) to explore the potential effect of
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Apoptosis Due to After-effects of Acute Ethanol Exposure in Brain Cortex: Intrinsic and Extrinsic Signaling Pathways Neuroscience (IF 3.3) Pub Date : 2024-02-28 Analía G. Karadayian, Analia Czerniczyniec, Silvia Lores-Arnaiz
Alcohol hangover is the combination of negative mental and physical symptoms which can be experienced after a single episode of alcohol consumption, starting when blood alcohol concentration approaches zero. We previously demonstrated that hangover provokes mitochondrial dysfunction, oxidative stress, imbalance in antioxidant defenses, and impairment in cellular bioenergetics. Chronic and acute ethanol
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Changes in Community Structure of Brain Dynamic Functional Connectivity States in Mild Cognitive Impairment Neuroscience (IF 3.3) Pub Date : 2024-02-28 Hongwei Wang, Zhihao Zhu, Hui Bi, Zhongyi Jiang, Yin Cao, Suhong Wang, Ling Zou
Recent researches have noted many changes of short-term dynamic modalities in mild cognitive impairment (MCI) patients' brain functional networks. In this study, the dynamic functional brain networks of 82 MCI patients and 85 individuals in the normal control (NC) group were constructed using the sliding window method and Pearson correlation. The window size was determined using single-scale time-dependent
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Neurometabolic and Brain Functional Alterations Associated with Cognitive Impairment in Patients with Myasthenia Gravis: A Combined 1H-MRS and fMRI Study Neuroscience (IF 3.3) Pub Date : 2024-02-28 Xiaoling Zhou, Yang Yang, Feng Zhu, Xiang Chen, Yunfei Zhu, Tiantian Gui, Yonggang Li, Qun Xue
Whether patients with myasthenia gravis (MG) exhibit cognitive impairment is controversial. Also the underlying mechanisms are unknown. We aimed to investigate alterations in cognitive function, neurometabolite levels, and brain function in patients with MG and to explore the associations between abnormal regional brain functional activity, neurometabolite concentrations in the MPFC and left thalamus
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Transient Receptor Potential Ankyrin 1-dependent Activation of Extracellular Signal-regulated Kinase 2 in the Cerebral Cortices Contributes to Cortical Spreading Depolarization Neuroscience (IF 3.3) Pub Date : 2024-02-27 Haoyang Li, Chenyi Wang, Ziyang Gong, Lingdi Nie, Jiaxin Xu, Minyan Wang
Extracellular signal-regulated kinase (ERK) are serine/threonine-selective proteins and ERK1/2 can be phosphorylated in peripheral and central brain regions after cortical spreading depolarization (CSD) and calcitonin gene-related peptide; However, it remains unclear about whether and how ERK activity modulates CSD that correlates to migraine aura. Here, we determined the role of ERK in regulating
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Immature Status Epilepticus Alters the Temporal Relationship between Hippocampal Interictal Epileptiform Discharges and High-frequency Oscillations Neuroscience (IF 3.3) Pub Date : 2024-02-23 Konstantinos Kalogeropoulos, Caterina Psarropoulou
The aim was to investigate the long-term effects of a single episode of immature Status Epilepticus (SE) on the excitability of the septal and temporal hippocampus , by studying the relationship between interictal-like epileptiform discharges (IEDs) and high-frequency oscillations (HFOs; Ripples, Rs and Fast Ripples, FRs). A pentylenetetrazol-induced Status Epilepticus-(SE)-like generalized seizure
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Corrigendum to “Age-dependent Effects of Dopamine on Working Memory and Synaptic Plasticity in Hippocampal CA3-CA1 Synapses in Mice” [Neuroscience 532 (2023) 14–22] Neuroscience (IF 3.3) Pub Date : 2024-02-23 Fatemeh Bakhtiarzadeh, Koorosh Shahpasand, Amir Shojaei, Yaghoub Fathollahi, Nahid Roohi, Vicrotia Barkley, Javad Mirnajafi-Zadeh
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Attentional Correlates of Colored Lights: Considerations for Cognitive Testing Neuroscience (IF 3.3) Pub Date : 2024-02-23 Vakode Vani, Pooja Ojha, Mahesh Arjundan Gadhvi, Abhinav Dixit
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Bioinformatics and Systems Biology Approaches to Identify the Synergistic Effects of Alcohol Use Disorder on the Progression of Neurological Diseases Neuroscience (IF 3.3) Pub Date : 2024-02-23 Md. Jahangir Alam, Md Habibur Rahman, Md. Arju Hossain, Md. Robiul Hoque, Md Aktaruzzaman
Clinical investigations showed that individuals with Alcohol Use Disorder (AUD) have worse Neurological Disease (ND) development, pointing to possible pathogenic relationships between AUD and NDs. It remains difficult to identify risk factors that are predisposing between AUD and NDs. In order to fix these issues, we created the bioinformatics pipeline and network-based approaches for employing unbiased
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Effects of Gestational Exercise on Nociception, BDNF, and Irisin Levels in an Animal Model of ADHD Neuroscience (IF 3.3) Pub Date : 2024-02-22 Andréa Tosta, Ariene S. Fonseca, Débora Messeder, Sérgio T. Ferreira, Mychael V. Lourenco, Pablo Pandolfo
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Sp1 Regulates the M1 Polarization of Microglia Through the HuR/NF-κB Axis after Spinal Cord Injury Neuroscience (IF 3.3) Pub Date : 2024-02-21 Hangyu Guo, Mingyu Du, Yang Yang, Xin Lin, Yufu Wang, Helin Li, Jiyu Ren, Wenbo Xu, Jinglong Yan, Nanxiang Wang
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NEW PERSPECTIVES IN NEUROPROTECTION FOR ISCHEMIC STROKE Neuroscience (IF 3.3) Pub Date : 2024-02-21 María Pérez-Mato, Esteban López-Arias, Ana Bugallo-Casal, Clara Correa-Paz, Susana Arias, Manuel Rodríguez-Yáñez, María Santamaría-Cadavid, Francisco Campos