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Design, Synthesis, and Mechanistic Studies of (R)-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase ACS Chem. Biol. (IF 4.0) Pub Date : 2024-04-17 Allison N. Devitt, Abigail L. Vargas, Wei Zhu, Benjamin James Des Soye, Fatma Ayaloglu Butun, Tyler Alt, Nicholas Kaley, Glaucio M. Ferreira, Graham Moran, Neil L. Kelleher, Dali Liu, Richard B. Silverman
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Discovery of a Tunable Heterocyclic Electrophile 4-Chloro-pyrazolopyridine That Defines a Unique Subset of Ligandable Cysteines ACS Chem. Biol. (IF 4.0) Pub Date : 2024-04-17 Hong-Rae Kim, David P. Byun, Kalyani Thakur, Jennifer Ritchie, Yixin Xie, Ronald Holewinski, Kiall F. Suazo, Mckayla Stevens, Hope Liechty, Ravichandra Tagirasa, Yihang Jing, Thorkell Andresson, Steven M. Johnson, Euna Yoo
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Cytochrome P450 Mining for Bufadienolide Diversification ACS Chem. Biol. (IF 4.0) Pub Date : 2024-04-16 Xiaolai Lei, Xiaozheng Wang, Weiliang Xiong, Han Xiao, Yingchun Wu, Tingting Huang, Rubing Liang, Yiming Li, Shuangjun Lin
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Lanmodulin’s EF 2–3 Domain: Insights from Infrared Spectroscopy and Simulations ACS Chem. Biol. (IF 4.0) Pub Date : 2024-04-15 Eman A. Alasadi, Wonseok Choi, Xiaobing Chen, Joseph A. Cotruvo, Jr, Carlos R. Baiz
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Selection of Peptide–Bismuth Bicycles Using Phage Display ACS Chem. Biol. (IF 4.0) Pub Date : 2024-04-15 Ruo-Nan He, Meng-Jie Zhang, Bin Dai, Xu-Dong Kong
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Craspase Orthologs Cleave a Nonconserved Site in Target Protein Csx30 ACS Chem. Biol. (IF 4.0) Pub Date : 2024-04-11 Sam P. B. van Beljouw, Anna C. Haagsma, Konstantinos Kalogeropoulos, Martin Pabst, Stan J. J. Brouns
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Discovery and Derivatization of Tridecaptin Antibiotics with Altered Host Specificity and Enhanced Bioactivity ACS Chem. Biol. (IF 4.0) Pub Date : 2024-04-11 Nataliia V. Machushynets, Karol Al Ayed, Barbara R. Terlouw, Chao Du, Ned P. Buijs, Joost Willemse, Somayah S. Elsayed, Julian Schill, Vincent Trebosc, Michel Pieren, Francesca M. Alexander, Stephen A. Cochrane, Mark R. Liles, Marnix H. Medema, Nathaniel I. Martin, Gilles P. van Wezel
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Virtual Screening of a Chemically Diverse “Superscaffold” Library Enables Ligand Discovery for a Key GPCR Target ACS Chem. Biol. (IF 4.0) Pub Date : 2024-04-10 Katharina Grotsch, Anastasiia V. Sadybekov, Sydney Hiller, Saheem Zaidi, Dmitry Eremin, Austen Le, Yongfeng Liu, Evan Carlton Smith, Christos Illiopoulis-Tsoutsouvas, Joice Thomas, Shubhangi Aggarwal, Julie E. Pickett, Cesar Reyes, Elias Picazo, Bryan L. Roth, Alexandros Makriyannis, Vsevolod Katritch, Valery V. Fokin
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Protein-Based Tools for Studying Neuromodulation ACS Chem. Biol. (IF 4.0) Pub Date : 2024-04-06 Wenjing Wang
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Metabolic Investigation and Auxiliary Enzyme Modelization of the Pyrrocidine Pathway Allow Rationalization of Paracyclophane-Decahydrofluorene Formation ACS Chem. Biol. (IF 4.0) Pub Date : 2024-04-04 Youwei Chen, Steffi Sewsurn, Séverine Amand, Caroline Kunz, Nicolas Pietrancosta, Kevin Calabro, Didier Buisson, Stéphane Mann
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Bioinformatics-Guided Reconstitution of Biosynthetic Machineries of Fungal Eremophilane Sesquiterpenes ACS Chem. Biol. (IF 4.0) Pub Date : 2024-04-03 Yoshiro Sato, Xinge Shi, Ying Ye, Saori Domon, Junya Takino, Taro Ozaki, Chengwei Liu, Hideaki Oikawa, Atsushi Minami
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Phospholipids Differentially Regulate Ca2+ Binding to Synaptotagmin-1 ACS Chem. Biol. (IF 4.0) Pub Date : 2024-04-02 Sophie A. S. Lawrence, Carla Kirschbaum, Jack L. Bennett, Corinne A. Lutomski, Tarick J. El-Baba, Carol. V. Robinson
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Reversible Covalent Inhibition─Desired Covalent Adduct Formation by Mass Action ACS Chem. Biol. (IF 4.0) Pub Date : 2024-04-03 Disha Patel, Zil E Huma, Dustin Duncan
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Enhancing the Small-Scale Screenable Biological Space beyond Known Chemogenomics Libraries with Gray Chemical Matter─Compounds with Novel Mechanisms from High-Throughput Screening Profiles ACS Chem. Biol. (IF 4.0) Pub Date : 2024-04-02 Jason R. Thomas, Claude Shelton, IV, Jason Murphy, Scott Brittain, Mark-Anthony Bray, Peter Aspesi, John Concannon, Frederick J. King, Robert J. Ihry, Daniel J. Ho, Martin Henault, Andrea Hadjikyriacou, Marilisa Neri, Frederic D. Sigoillot, Helen T. Pham, Matthew Shum, Louise Barys, Michael D. Jones, Eric J. Martin, Anke Blechschmidt, Sébastien Rieffel, Thomas J. Troxler, Felipa A. Mapa, Jeremy L.
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In Vitro Characterization of an O-Specific Glycosyltransferase Involved in Flagellin Glycosylation ACS Chem. Biol. (IF 4.0) Pub Date : 2024-04-01 Daisuke Fujinami, Ayumi Mizui, Azusa Miyata, Sohei Ito
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Chemical Scaffolds for the Clinical Development of Mutant-Selective and Reversible Fourth-Generation EGFR-TKIs in NSCLC ACS Chem. Biol. (IF 4.0) Pub Date : 2024-03-29 Emiliano Laudadio, Luca Mangano, Cristina Minnelli
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Correction to “A Fluorescence Polarization Assay for Macrodomains Facilitates the Identification of Potent Inhibitors of the SARS-CoV-2 Macrodomain” ACS Chem. Biol. (IF 4.0) Pub Date : 2024-03-26 Ananya Anmangandla, Sadhan Jana, Kewen Peng, Shamar D. Wallace, Saket R. Bagde, Bryon S. Drown, Jiashu Xu, Paul J. Hergenrother, J. Christopher Fromme, Hening Lin
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Antimicrobial Lasso Peptide Cloacaenodin Utilizes a Unique TonB-Dependent Transporter to Access Susceptible Bacteria ACS Chem. Biol. (IF 4.0) Pub Date : 2024-03-25 Drew V. Carson, Reecan J. Juarez, Truc Do, Zhongyue J. Yang, A. James Link
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One Carbon to Rule Them All: Formaldehyde is a One-Carbon Signal Connecting One-Carbon Metabolism and Epigenetic Methylation ACS Chem. Biol. (IF 4.0) Pub Date : 2024-03-26 Logan Tenney, Vanha N. Pham, Christopher J. Chang
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Evaluation of the Cytosolic Uptake of HaloTag Using a pH-Sensitive Dye ACS Chem. Biol. (IF 4.0) Pub Date : 2024-03-25 JoLynn B. Giancola, Jonathan B. Grimm, Joomyung V. Jun, Yana D. Petri, Luke D. Lavis, Ronald T. Raines
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DNA-Encoded Library Technology─A Catalyst for Covalent Ligand Discovery ACS Chem. Biol. (IF 4.0) Pub Date : 2024-03-25 Paige Dickson
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Lipid-Restricted Culture Media Reveal Unexpected Cancer Cell Sensitivities ACS Chem. Biol. (IF 4.0) Pub Date : 2024-03-20 Ralston B. Goldfarb, Matthew J. Atala Pleshinger, David F. Yan, Drew J. Adams
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Discovery of a Gut Bacterial Metabolic Pathway that Drives α-Synuclein Aggregation ACS Chem. Biol. (IF 4.0) Pub Date : 2024-03-22 Lizett Ortiz de Ora, Julia M. Balsamo, Kylie S. Uyeda, Elizabeth N. Bess
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Characterization of Chemical Interactions between Clinical Drugs and the Oral Bacterium, Corynebacterium matruchotii, via Bioactivity-HiTES ACS Chem. Biol. (IF 4.0) Pub Date : 2024-03-21 Da Yeong Lee, Jonghwan Kim, Gyu Sung Lee, Sehwan Park, Jeongwon Song, Bum Soo Lee, Seoung Rak Lee, Ki Hyun Kim, Chung Sub Kim
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Integrated Proteomics Characterization of NLRP3 Inflammasome Inhibitor MCC950 in Monocytic Cell Line Confirms Direct MCC950 Engagement with Endogenous NLRP3 ACS Chem. Biol. (IF 4.0) Pub Date : 2024-03-21 Heng Zhao, Praveen Kumar, Tiago Jose Paschoal Sobreira, Mackenzie Smith, Steven Novick, Anders Johansson, Anna Luchniak, Andrew Zhang, Kevin J Woollard, Niklas Larsson, Aarti Kawatkar
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Discovery of a Covalent Inhibitor Selectively Targeting the Autophosphorylation Site of c-Src Kinase ACS Chem. Biol. (IF 4.0) Pub Date : 2024-03-21 Huimin Zhang, Dounan Xu, Hongchan Huang, Hao Jiang, Linghao Hu, Liping Liu, Ge Sun, Jing Gao, Yuanqing Li, Cuicui Xia, Shijie Chen, Hu Zhou, Xiangqian Kong, Mingliang Wang, Cheng Luo
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Geometric Antibody Engineering Reveals the Spatial Factor on the Efficacy of Bispecific T Cell Engagers ACS Chem. Biol. (IF 4.0) Pub Date : 2024-03-16 Yu Zhang, Zhe Yang, Dilizhatai Saimi, Xiaowen Shen, Junqing Ye, Bingke Yu, Noah Pefaur, Justin M. Scheer, Andrew E. Nixon, Zhixing Chen
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Introducing Our Authors ACS Chem. Biol. (IF 4.0) Pub Date : 2024-03-15 Katie Nieves
This article has not yet been cited by other publications.
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Roles of Nucleic Acids in Protein Folding, Aggregation, and Disease ACS Chem. Biol. (IF 4.0) Pub Date : 2024-03-13 Theodore J. Litberg, Scott Horowitz
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Click-Capable Phenanthriplatin Derivatives as Tools to Study Pt(II)-Induced Nucleolar Stress ACS Chem. Biol. (IF 4.0) Pub Date : 2024-03-14 Paul D. O’Dowd, Andres S. Guerrero, Katelyn R. Alley, Hannah C. Pigg, Fiona O’Neill, Justine Meiller, Chloe Hobbs, Daniel A. Rodrigues, Brendan Twamley, Finbarr O’Sullivan, Victoria J. DeRose, Darren M. Griffith
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A Humanized Mouse Model Coupled with Computational Analysis Identifies Potent Glycolipid Agonist of Invariant NKT Cells ACS Chem. Biol. (IF 4.0) Pub Date : 2024-03-13 Noemi A. Saavedra-Avila, Natalia B. Pigni, Donald R. Caldwell, Florencia Chena-Becerra, Jose Intano, Jr, Tony W. Ng, Divya Chennamadhavuni, Steven A. Porcelli, José A. Gascón, Amy R. Howell
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Substrate Promiscuity of the Triceptide Maturase XncB Leads to Incorporation of Various Amino Acids and Detection of Oxygenated Products ACS Chem. Biol. (IF 4.0) Pub Date : 2024-03-07 Chin-Soon Phan, Litao Chang, Thi Quynh Ngoc Nguyen, Angelica Faith L. Suarez, Xuen Huei Ho, Huiyi Chen, Ivan Yu Fan Koh, Brandon I. Morinaka
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Correction to “A cAMP Sensor Based on Ligand-Dependent Protein Stabilization” ACS Chem. Biol. (IF 4.0) Pub Date : 2024-03-08 Mariapaola Sidoli, Ling-chun Chen, Alexander J. Lu, Thomas J. Wandless, William S. Talbot
The original publication correctly reported the lesion in gpr161a and the corresponding genotyping primers, but the sgRNA target sequence was shown incorrectly in Table S1. The authors regret this error. The gpr161a sgRNA target sequence has been corrected in Table S1 in the Supporting Information with this Correction. The Supporting Information is available free of charge at https://pubs.acs.org/doi/10
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Advancing Kir4.2 Channel Ligand Identification through Collision-Induced Affinity Selection Mass Spectrometry ACS Chem. Biol. (IF 4.0) Pub Date : 2024-03-07 Yushu Gu, Miaomiao Liu, Linlin Ma, Ronald J. Quinn
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Uncovering the Association Mechanism between Two Intrinsically Flexible Proteins ACS Chem. Biol. (IF 4.0) Pub Date : 2024-03-05 Angy Liseth Dávalos, José David Rivera Echeverri, Denize C. Favaro, Ronaldo Junio de Oliveira, Gustavo Penteado Battesini Carretero, Caroline Lacerda, Iolanda Midea Cuccovia, Marcus Vinicius Cangussu Cardoso, Chuck S. Farah, Roberto Kopke Salinas
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Bioorthogonal Metabolic Labeling of the Virulence Factor Phenolic Glycolipid in Mycobacteria ACS Chem. Biol. (IF 4.0) Pub Date : 2024-03-05 Lindsay E. Guzmán, C. J. Cambier, Tan-Yun Cheng, Kubra F. Naqvi, Michael U. Shiloh, D. Branch Moody, Carolyn R. Bertozzi
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An Upstream G-Quadruplex DNA Structure Can Stimulate Gene Transcription ACS Chem. Biol. (IF 4.0) Pub Date : 2024-02-28 Yuqi Chen, Angela Simeone, Larry Melidis, Sergio Martinez Cuesta, David Tannahill, Shankar Balasubramanian
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Functional and Promiscuity Studies of Three-Residue Cyclophane Forming Enzymes Show Nonnative C–C Cross-Linked Products and Leader-Dependent Cyclization ACS Chem. Biol. (IF 4.0) Pub Date : 2024-02-28 Angelica Faith L. Suarez, Thi Quynh Ngoc Nguyen, Litao Chang, Yi Wei Tooh, Rubin How Sheng Yong, Li Chuan Leow, Ivan Yu Fan Koh, Huiyi Chen, Jeffery Wei Heng Koh, Arunachalam Selvanayagam, Vernon Lim, Yi En Tan, Irene Agatha, Fernaldo R. Winnerdy, Brandon I. Morinaka
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Shine–Dalgarno Accessibility Governs Ribosome Binding to the Adenine Riboswitch ACS Chem. Biol. (IF 4.0) Pub Date : 2024-02-27 Julius Blechar, Vanessa de Jesus, Boris Fürtig, Martin Hengesbach, Harald Schwalbe
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Exponential Combination of a and e/g Intracellular Peptide Libraries Identifies a Selective ATF3 Inhibitor ACS Chem. Biol. (IF 4.0) Pub Date : 2024-02-27 Miao Yu, T.M. Simon Tang, Lila Ghamsari, Graham Yuen, Claudio Scuoppo, Jim A. Rotolo, Barry J. Kappel, Jody M. Mason
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Synthesis and Enzymatic Incorporation of a Dual-App Nucleotide Probe That Reports Antibiotics-Induced Conformational Change in the Bacterial Ribosomal Decoding Site RNA ACS Chem. Biol. (IF 4.0) Pub Date : 2024-02-26 Saddam Y. Khatik, Sarupa Roy, Seergazhi G. Srivatsan
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Glyco-Engineering Cell Surfaces by Exo-Enzymatic Installation of GlcNAz and LacNAz Motifs ACS Chem. Biol. (IF 4.0) Pub Date : 2024-02-23 Fabiola V. De León González, Marie E. Boddington, Joshua M. Kofsky, Martha I. Prindl, Chantelle J. Capicciotti
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Controlling Substrate- and Stereospecificity of Condensation Domains in Nonribosomal Peptide Synthetases ACS Chem. Biol. (IF 4.0) Pub Date : 2024-02-23 Huiyun Peng, Julian Schmiederer, Xiuqiang Chen, Gianni Panagiotou, Hajo Kries
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Elucidating the Signal Transduction Mechanism of the Blue-Light-Regulated Photoreceptor YtvA: From Photoactivation to Downstream Regulation ACS Chem. Biol. (IF 4.0) Pub Date : 2024-02-22 YongLe He, Jinnette Tolentino Collado, James N. Iuliano, Helena A. Woroniecka, Christopher R. Hall, Agnieszka A. Gil, Sergey P. Laptenok, Gregory M. Greetham, Boris Illarionov, Adelbert Bacher, Markus Fischer, Jarrod B. French, Andras Lukacs, Stephen R. Meech, Peter J. Tonge
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Structure and Substrate Specificity of S-Methyl Thiourocanate Hydratase ACS Chem. Biol. (IF 4.0) Pub Date : 2024-02-22 Camille M. Vasseur, Dishani Karunasegaram, Florian P. Seebeck
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De Novo Screening and Mirror Image Isomerization of Linear Peptides Targeting α7 Nicotinic Acetylcholine Receptor ACS Chem. Biol. (IF 4.0) Pub Date : 2024-02-21 Xiuxiu Cao, Tianqi Liu, Tao Wang, Xudong Wang, Ziyan Xu, Li Zhou, Changlin Tian, Demeng Sun
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Antibacterial Marinopyrroles and Pseudilins Act as Protonophores ACS Chem. Biol. (IF 4.0) Pub Date : 2024-02-20 Gabriel Castro-Falcón, Jan Straetener, Jan Bornikoel, Daniela Reimer, Trevor N. Purdy, Anne Berscheid, Florence M. Schempp, Dennis Y. Liu, Roger G. Linington, Heike Brötz-Oesterhelt, Chambers C. Hughes
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Introducing Our Authors ACS Chem. Biol. (IF 4.0) Pub Date : 2024-02-16 Katie Nieves
This article has not yet been cited by other publications.
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Analysis of the Valgamicin Biosynthetic Pathway Reveals a General Mechanism for Cyclopropanol Formation across Diverse Natural Product Scaffolds ACS Chem. Biol. (IF 4.0) Pub Date : 2024-02-15 Rory F. Little, Felix Trottmann, Hideki Hashizume, Miriam Preissler, Sandra Unger, Ryuichi Sawa, Hajo Kries, Sacha Pidot, Masayuki Igarashi, Christian Hertweck
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Biosynthesis of the Azoxy Compound Azodyrecin from Streptomyces mirabilis P8-A2 ACS Chem. Biol. (IF 4.0) Pub Date : 2024-02-10 Matiss Maleckis, Mario Wibowo, Tetiana Gren, Scott A. Jarmusch, Eva B. Sterndorff, Thomas Booth, Nathalie N. S. E. Henriksen, Christopher M. Whitford, Xinglin Jiang, Tue S. Jørgensen, Ling Ding, Tilmann Weber
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On the Question of CO’s Ability to Induce HO-1 Expression in Cell Culture: A Comparative Study Using Different CO Sources ACS Chem. Biol. (IF 4.0) Pub Date : 2024-02-10 Xiaoxiao Yang, Qiyue Mao, Binghe Wang
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Structure and Biosynthesis of Hectoramide B, a Linear Depsipeptide from Marine Cyanobacterium Moorena producens JHB Discovered via Coculture with Candida albicans ACS Chem. Biol. (IF 4.0) Pub Date : 2024-02-08 Thuan-Ethan Ngo, Andrew Ecker, Byeol Ryu, Aurora Guild, Ariana Remmel, Paul D. Boudreau, Kelsey L. Alexander, C. Benjamin Naman, Evgenia Glukhov, Nicole E. Avalon, Vikram V. Shende, Lamar Thomas, Samira Dahesh, Victor Nizet, Lena Gerwick, William H. Gerwick
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Targeted Extracellular Protein Degradation by Dendronized DNA Chimeras ACS Chem. Biol. (IF 4.0) Pub Date : 2024-02-08 Chenghong Zhu, Weishan Wang, Yan Wang, Weijie Zhang, Yan Zhang, Jinbo Li
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N-Terminal Proline Editing for the Synthesis of Peptides with Mercaptoproline and Selenoproline: Mechanistic Insights Lead to Greater Efficiency in Proline Native Chemical Ligation ACS Chem. Biol. (IF 4.0) Pub Date : 2024-02-07 Brice A. Ludwig, Christina R. Forbes, Neal J. Zondlo
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Unraveling Molecular Recognition of Glycan Ligands by Siglec-9 via NMR Spectroscopy and Molecular Dynamics Modeling ACS Chem. Biol. (IF 4.0) Pub Date : 2024-02-07 Unai Atxabal, Corwin Nycholat, Johannes M. Pröpster, Andrea Fernández, Iker Oyenarte, Maria Pia Lenza, Antonio Franconetti, Cátia O. Soares, Helena Coelho, Filipa Marcelo, Mario Schubert, James C. Paulson, Jesús Jiménez-Barbero, June Ereño-Orbea
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Visible Light Control over the Cytolytic Activity of a Toxic Pore-Forming Protein ACS Chem. Biol. (IF 4.0) Pub Date : 2024-02-06 Jana Volarić, Nieck J. van der Heide, Natalie L. Mutter, Douwe F. Samplonius, Wijnand Helfrich, Giovanni Maglia, Wiktor Szymanski, Ben L. Feringa
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Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct ACS Chem. Biol. (IF 4.0) Pub Date : 2024-02-05 Markus Zehe, Josef Kehrein, Curd Schollmayer, Christina Plank, Helena Kovacs, Eduardo Merino Asumendi, Ulrike Holzgrabe, Clemens Grimm, Christoph Sotriffer
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RNA-Binding Peptides Inspired by the RNA Recognition Motif ACS Chem. Biol. (IF 4.0) Pub Date : 2024-02-05 Luke K. Marshall, Albert C. Fahrenbach, Pall Thordarson
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Bioluminescent Intercalating Dyes for Ratiometric Nucleic Acid Detection ACS Chem. Biol. (IF 4.0) Pub Date : 2024-02-05 Yosta de Stigter, Harmen J. van der Veer, Bas J. H. M. Rosier, Maarten Merkx
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Synthesis and Properties of RNA Modified with Cationic Amine Internucleoside Linkage ACS Chem. Biol. (IF 4.0) Pub Date : 2024-02-05 Chandan Pal, Michael Richter, Eriks Rozners