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Longitudinal Associations Between Optimism and Objective Measures of Physical Functioning in Women JAMA Psychiatry (IF 25.8) Pub Date : 2024-03-20 Hayami K. Koga, Francine Grodstein, David R. Williams, JoAnn E. Manson, Hilary A. Tindle, Aladdin H. Shadyab, Yvonne L. Michael, Nazmus Saquib, Michelle J. Naughton, Anne-Josee Guimond, Laura D. Kubzansky
ImportanceIdentifying factors contributing to sustained physical functioning is critical for the health and well-being of the aging population, especially as physical functioning may precede and predict subsequent health outcomes. Prior work suggests optimism may protect health, but less is known about the association between optimism and objective physical functioning measures as individuals age.ObjectiveTo
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Baseline Antipsychotic Dose and Transition to Psychosis in Individuals at Clinical High Risk JAMA Psychiatry (IF 25.8) Pub Date : 2024-03-20 Andrea Raballo, Michele Poletti, Antonio Preti
ImportanceEmerging meta-analytical evidence indicates that baseline exposure to antipsychotics is associated with an increased risk of transitioning to psychosis in individuals at clinical high-risk for psychosis (CHR-P) and that such effect is not a result of pretest risk enrichment. However, to maximize its translational utility for prognostic stratification in clinical practice, testing for the
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Decoding Suicide Decedent Profiles and Signs of Suicidal Intent Using Latent Class Analysis JAMA Psychiatry (IF 25.8) Pub Date : 2024-03-20 Yunyu Xiao, Kaiwen Bi, Paul Siu-Fai Yip, Julie Cerel, Timothy T. Brown, Yifan Peng, Jyotishman Pathak, J. John Mann
ImportanceSuicide rates in the US increased by 35.6% from 2001 to 2021. Given that most individuals die on their first attempt, earlier detection and intervention are crucial. Understanding modifiable risk factors is key to effective prevention strategies.ObjectiveTo identify distinct suicide profiles or classes, associated signs of suicidal intent, and patterns of modifiable risks for targeted prevention
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Adolescent Psychedelic Use and Psychotic or Manic Symptoms JAMA Psychiatry (IF 25.8) Pub Date : 2024-03-13 Otto Simonsson, Miriam A. Mosing, Walter Osika, Fredrik Ullén, Henrik Larsson, Yi Lu, Laura W. Wesseldijk
ImportanceWhile psychedelic-assisted therapy has shown promise in the treatment of certain psychiatric disorders, little is known about the potential risk of psychotic or manic symptoms following naturalistic psychedelic use, especially among adolescents.ObjectiveTo investigate associations between naturalistic psychedelic use and self-reported psychotic or manic symptoms in adolescents using a genetically
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Bright Light Therapy as Add-On to Inpatient Treatment in Youth With Moderate to Severe Depression JAMA Psychiatry (IF 25.8) Pub Date : 2024-03-13 Tanja Legenbauer, Inken Kirschbaum-Lesch, Carina Jörke, Michael Kölch, Olaf Reis, Christoph Berger, Alexander Dück, Michael Schulte-Markwort, Inga Becker-Hebly, Stefanie Bienioschek, Jennifer Schroth, Christian Ruckes, Oliver Deuster, Martin Holtmann
ImportanceMajor depressive disorder is one of the most common mental disorders among adolescents, entailing severe, long-term psychosocial impairment and a high risk of chronicity. In view of the large number of patients requiring treatment, along with insufficient treatment responses with small effect sizes, innovative adjunctive treatment strategies are urgently needed.ObjectiveTo investigate whether
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Mental Health Impairment and Outpatient Mental Health Care of US Children and Adolescents JAMA Psychiatry (IF 25.8) Pub Date : 2024-03-13 Mark Olfson, Chandler McClellan, Samuel H. Zuvekas, Melanie Wall, Carlos Blanco
ImportanceDespite a federal declaration of a national child and adolescent mental health crisis in 2021, little is known about recent national trends in mental health impairment and outpatient mental health treatment of US children and adolescents.ObjectiveTo characterize trends in mental health impairment and outpatient mental health care among US children and adolescents from 2019 to 2021 across
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Oxidative Stress-Induced Damage to RNA and DNA and Mortality in Individuals with Psychiatric Illness JAMA Psychiatry (IF 25.8) Pub Date : 2024-03-06 Anders Jorgensen, Ivan Brandslund, Christina Ellervik, Trine Henriksen, Allan Weimann, Mikkel Porsborg Andersen, Christian Torp-Pedersen, Per Kragh Andersen, Martin Balslev Jorgensen, Henrik Enghusen Poulsen
ImportanceAll-cause mortality and the risk for age-related medical disease is increased in individuals with psychiatric illness, but the underlying biological mechanisms are not known. Oxidative stress on nucleic acids (DNA and RNA; NA-OXS) is a molecular driver of aging and a potential pathophysiological mechanism in a range of age-related disorders.ObjectiveTo study the levels of markers of NA-OXS
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Virtual Reality and Transcranial Direct Current Stimulation for Posttraumatic Stress Disorder JAMA Psychiatry (IF 25.8) Pub Date : 2024-03-06 Mascha van ’t Wout-Frank, Amanda R. Arulpragasam, Christiana Faucher, Emily Aiken, M. Tracie Shea, Richard N. Jones, Benjamin D. Greenberg, Noah S. Philip
ImportancePosttraumatic stress disorder (PTSD) is a common psychiatric disorder that is particularly difficult to treat in military veterans. Noninvasive brain stimulation has significant potential as a novel treatment to reduce PTSD symptoms.ObjectiveTo test whether active transcranial direct current stimulation (tDCS) plus virtual reality (VR) is superior to sham tDCS plus VR for warzone-related
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Adverse Childhood Experiences and Adult Mental Health Outcomes JAMA Psychiatry (IF 25.8) Pub Date : 2024-03-06 Hilda Björk Daníelsdóttir, Thor Aspelund, Qing Shen, Thorhildur Halldorsdottir, Jóhanna Jakobsdóttir, Huan Song, Donghao Lu, Ralf Kuja-Halkola, Henrik Larsson, Katja Fall, Patrik K. E. Magnusson, Fang Fang, Jacob Bergstedt, Unnur Anna Valdimarsdóttir
ImportanceExposure to adverse childhood experiences (ACEs) has consistently been associated with multiple negative mental health outcomes extending into adulthood. However, given that ACEs and psychiatric disorders cluster within families, it remains to be comprehensively assessed to what extent familial confounding contributes to associations between ACEs and clinically confirmed adult psychiatric
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Psychomotor Slowing in Psychosis and Inhibitory Repetitive Transcranial Magnetic Stimulation JAMA Psychiatry (IF 25.8) Pub Date : 2024-02-28 Sebastian Walther, Danai Alexaki, Florian Weiss, Daniel Baumann-Gama, Alexandra Kyrou, Melanie G. Nuoffer, Florian Wüthrich, Stephanie Lefebvre, Niluja Nadesalingam
ImportancePsychomotor slowing is a frequent symptom of psychosis, impairing gross and fine motor behavior. It is associated with poor outcomes and functioning, and no treatment is available.ObjectiveTo investigate whether 15 sessions of inhibitory repetitive transcranial magnetic stimulation (rTMS) may reduce psychomotor slowing.Design, Setting, and ParticipantsThis was a 4-arm, double-blind, randomized
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Cognitive Function and Variability in Antipsychotic Drug–Naive Patients With First-Episode Psychosis JAMA Psychiatry (IF 25.8) Pub Date : 2024-02-28 Maria Lee, Martin Cernvall, Jacqueline Borg, Pontus Plavén-Sigray, Cornelia Larsson, Sophie Erhardt, Carl M. Sellgren, Helena Fatouros-Bergman, Simon Cervenka
ImportanceCognitive impairment contributes significantly to clinical outcome and level of function in individuals with psychotic disorders. These impairments are present already at psychosis onset at a group level; however, the question of heterogeneity in cognitive function among patients has not been systematically investigated.ObjectiveTo provide an updated quantification of cognitive impairment
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Prioritizing Maternal Mental Health in Addressing Morbidity and Mortality JAMA Psychiatry (IF 25.8) Pub Date : 2024-02-21 Katherine L. Wisner, Caitlin Murphy, Megan M. Thomas
ImportanceThe rate of maternal mortality in the United States is 2-fold to 3-fold greater than that in other high-income countries. While many national initiatives have been developed to combat maternal mortality, these efforts often fail to include mental illness.ObjectiveTo highlight the underrecognized contribution of mental illness to maternal mortality, which is nearly double that of postpartum
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Acupuncture for Combat-Related Posttraumatic Stress Disorder JAMA Psychiatry (IF 25.8) Pub Date : 2024-02-21 Michael Hollifield, An-Fu Hsiao, Tyler Smith, Teresa Calloway, Tanja Jovanovic, Besa Smith, Kala Carrick, Seth D. Norrholm, Andrea Munoz, Ruth Alpert, Brianna Caicedo, Nikki Frousakis, Karen Cocozza
ImportanceCurrent interventions for posttraumatic stress disorder (PTSD) are efficacious, yet effectiveness may be limited by adverse effects and high withdrawal rates. Acupuncture is an emerging intervention with positive preliminary data for PTSD.ObjectiveTo compare verum acupuncture with sham acupuncture (minimal needling) on clinical and physiological outcomes.Design, Setting, and ParticipantsThis
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Ethnoracial Risk Variation Across the Psychosis Continuum in the US JAMA Psychiatry (IF 25.8) Pub Date : 2024-02-21 Els van der Ven, Thomas M. Olino, Katharina Diehl, Stephanie M. Nuñez, Griffin Thayer, Miranda A. Bridgwater, Sabrina Ereshefsky, Christie Musket, Sarah Hope Lincoln, R. Tyler Rogers, Mallory J. Klaunig, Emily Soohoo, Jordan E. DeVylder, Rebecca E. Grattan, Jason Schiffman, Lauren M. Ellman, Tara A. Niendam, Deidre M. Anglin
ImportanceStudies suggest a higher risk of schizophrenia diagnoses in Black vs White Americans, yet a systematic investigation of disparities that include other ethnoracial groups and multiple outcomes on the psychosis continuum is lacking.ObjectiveTo identify ethnoracial risk variation in the US across 3 psychosis continuum outcomes (ie, schizophrenia and other psychotic disorders, clinical high risk
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Lifetime Suicide Attempts in Otherwise Psychiatrically Healthy Individuals JAMA Psychiatry (IF 25.8) Pub Date : 2024-02-21 Maria A. Oquendo, Melanie Wall, Shuai Wang, Mark Olfson, Carlos Blanco
ImportanceNot all people who die by suicide have a psychiatric diagnosis; yet, little is known about the percentage and demographics of individuals with lifetime suicide attempts who are apparently psychiatrically healthy. If such suicide attempts are common, there are implications for suicide risk screening, research, policy, and nosology.ObjectiveTo estimate the percentage of people with lifetime
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Genetic and Clinical Correlates of AI-Based Brain Aging Patterns in Cognitively Unimpaired Individuals JAMA Psychiatry (IF 25.8) Pub Date : 2024-02-14 Ioanna Skampardoni, Ilya M. Nasrallah, Ahmed Abdulkadir, Junhao Wen, Randa Melhem, Elizabeth Mamourian, Guray Erus, Jimit Doshi, Ashish Singh, Zhijian Yang, Yuhan Cui, Gyujoon Hwang, Zheng Ren, Raymond Pomponio, Dhivya Srinivasan, Sindhuja Tirumalai Govindarajan, Paraskevi Parmpi, Katharina Wittfeld, Hans J. Grabe, Robin Bülow, Stefan Frenzel, Duygu Tosun, Murat Bilgel, Yang An, Daniel S. Marcus, Pamela
ImportanceBrain aging elicits complex neuroanatomical changes influenced by multiple age-related pathologies. Understanding the heterogeneity of structural brain changes in aging may provide insights into preclinical stages of neurodegenerative diseases.ObjectiveTo derive subgroups with common patterns of variation in participants without diagnosed cognitive impairment (WODCI) in a data-driven manner
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Variations in Suicide Risk and Risk Factors After Hospitalization for Depression in Finland, 1996-2017 JAMA Psychiatry (IF 25.8) Pub Date : 2024-02-14 Kari Aaltonen, Reijo Sund, Christian Hakulinen, Sami Pirkola, Erkki Isometsä
ImportanceAlthough incidence of suicide in depression varies remarkably temporally, risk factors have been modeled as constant and remain uncharted in the short term. How effectively factors measured at one point in time predict risk at different time points is unknown.ObjectiveTo examine the absolute risk and risk factors for suicide in hospitalized patients with depression starting from the first
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Sex-Specific Pathways From Prenatal Maternal Inflammation to Adolescent Depressive Symptoms JAMA Psychiatry (IF 25.8) Pub Date : 2024-02-07 Emily Lipner, Naoise Mac Giollabhui, Elizabeth C. Breen, Barbara A. Cohn, Nickilou Y. Krigbaum, Piera M. Cirillo, Thomas M. Olino, Lauren B. Alloy, Lauren M. Ellman
ImportancePrenatal maternal inflammation has been associated with major depressive disorder in offspring in adulthood as well as with internalizing and externalizing symptoms in childhood; however, the association between prenatal inflammation and offspring depression in adolescence has yet to be examined.ObjectiveTo determine whether maternal levels of inflammatory biomarkers during pregnancy are
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Worldwide Prevalence and Disability From Mental Disorders Across Childhood and Adolescence JAMA Psychiatry (IF 25.8) Pub Date : 2024-01-31 Christian Kieling, Claudia Buchweitz, Arthur Caye, Juliana Silvani, Stephanie H. Ameis, André R. Brunoni, Katherine T. Cost, Darren B. Courtney, Katholiki Georgiades, Kathleen Ries Merikangas, Joanna L. Henderson, Guilherme V. Polanczyk, Luis Augusto Rohde, Giovanni A. Salum, Peter Szatmari
ImportanceThe period from childhood to early adulthood involves increased susceptibility to the onset of mental disorders, with implications for policy making that may be better appreciated by disaggregated analyses of narrow age groups.ObjectiveTo estimate the global prevalence and years lived with disability (YLDs) associated with mental disorders and substance use disorders (SUDs) across 4 age groups
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Associations of the Gut Microbiome With Treatment Resistance in Schizophrenia JAMA Psychiatry (IF 25.8) Pub Date : 2024-01-31 Svetlina S. Vasileva, Yuanhao Yang, Andrea Baker, Dan Siskind, Jacob Gratten, Darryl Eyles
ImportanceThere is growing interest in the role of gut microbiome composition in schizophrenia. However, lifestyle factors are often neglected, and few studies have investigated microbiome composition in treatment-resistant schizophrenia.ObjectiveTo explore associations between the gut microbiome and schizophrenia diagnosis, treatment resistance, clozapine response, and treatment-related adverse effects
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Prescription Stimulant Use During Pregnancy and Risk of Neurodevelopmental Disorders in Children JAMA Psychiatry (IF 25.8) Pub Date : 2024-01-24 Elizabeth A. Suarez, Brian T. Bateman, Sonia Hernandez-Diaz, Loreen Straub, Christopher J. McDougle, Katherine L. Wisner, Kathryn J. Gray, Page B. Pennell, Barry Lester, Yanmin Zhu, Helen Mogun, Krista F. Huybrechts
ImportanceUse of medications for attention-deficit/hyperactivity disorder (ADHD) during pregnancy is increasing in the US. Whether exposure to these medications in utero impacts the risk of neurodevelopmental disorders in children is uncertain.ObjectiveTo evaluate the association of childhood neurodevelopmental disorders with in utero exposure to stimulant medications for ADHD.Design, Setting, and
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Managerial and Organizational Challenges in the Age of AI JAMA Psychiatry (IF 25.8) Pub Date : 2024-01-24 Nick Obradovich, Tim Johnson, Martin P. Paulus
This Viewpoint discusses the managerial and organizational challenges that could result from the use of artificial intelligence systems in psychiatric research and care.
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Incidence Trajectories of Psychiatric Disorders After Assault, Injury, and Bereavement JAMA Psychiatry (IF 25.8) Pub Date : 2024-01-17 Yufeng Chen, Qing Shen, Paul Lichtenstein, Jaimie L. Gradus, Filip K. Arnberg, Henrik Larsson, Brian M. D’Onofrio, Fang Fang, Huan Song, Unnur A. Valdimarsdottir
ImportanceTraumatic events have been associated with elevated risks of psychiatric disorders, while the contributions of familial factors to these associations remain less clear.ObjectiveTo determine the contribution of familial factors to long-term incidence trajectories of psychiatric disorders following potentially traumatic events.Design, Setting, and ParticipantsThis cohort study evaluated 3 separate
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Systemic Racism as a Determinant of Health Inequities for People With Substance Use Disorder JAMA Psychiatry (IF 25.8) Pub Date : 2024-01-17 Oluwole Jegede, Chyrell Bellamy, Ayana Jordan
This Viewpoint describes how systemic racism is a determinant of inequities in treatment for people with substance use disorder and suggests an antiracism framework in addiction practice.
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Components and Delivery Formats of Cognitive Behavioral Therapy for Chronic Insomnia in Adults JAMA Psychiatry (IF 25.8) Pub Date : 2024-01-17 Yuki Furukawa, Masatsugu Sakata, Ryuichiro Yamamoto, Shun Nakajima, Shino Kikuchi, Mari Inoue, Masami Ito, Hiroku Noma, Hikari Nishimura Takashina, Satoshi Funada, Edoardo G. Ostinelli, Toshi A. Furukawa, Orestis Efthimiou, Michael Perlis
ImportanceChronic insomnia disorder is highly prevalent, disabling, and costly. Cognitive behavioral therapy for insomnia (CBT-I), comprising various educational, cognitive, and behavioral strategies delivered in various formats, is the recommended first-line treatment, but the effect of each component and delivery method remains unclear.ObjectiveTo examine the association of each component and delivery
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A Systematic Evaluation of Machine Learning–Based Biomarkers for Major Depressive Disorder JAMA Psychiatry (IF 25.8) Pub Date : 2024-01-10 Nils R. Winter, Julian Blanke, Ramona Leenings, Jan Ernsting, Lukas Fisch, Kelvin Sarink, Carlotta Barkhau, Daniel Emden, Katharina Thiel, Kira Flinkenflügel, Alexandra Winter, Janik Goltermann, Susanne Meinert, Katharina Dohm, Jonathan Repple, Marius Gruber, Elisabeth J. Leehr, Nils Opel, Dominik Grotegerd, Ronny Redlich, Robert Nitsch, Jochen Bauer, Walter Heindel, Joachim Gross, Benjamin Risse,
ImportanceBiological psychiatry aims to understand mental disorders in terms of altered neurobiological pathways. However, for one of the most prevalent and disabling mental disorders, major depressive disorder (MDD), no informative biomarkers have been identified.ObjectiveTo evaluate whether machine learning (ML) can identify a multivariate biomarker for MDD.Design, Setting, and ParticipantsThis study
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Trends in Incident Prescriptions for Behavioral Health Medications in the US, 2018-2022 JAMA Psychiatry (IF 25.8) Pub Date : 2024-01-10 Grace Chai, Jing Xu, Sonal Goyal, Corinne Woods, Amy Ho, Jaejoon Song, Gerald Dal Pan
ImportanceThe COVID-19 pandemic reportedly increased behavioral health needs and impacted treatment access.ObjectiveTo assess changes in incident prescriptions dispensed for medications commonly used to treat depression, anxiety, attention-deficit/hyperactivity disorder (ADHD), and opioid use disorder (OUD), before and during the COVID-19 pandemic.Design, Setting, and ParticipantsThis was a cross-sectional
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US Veterans Affairs and Department of Defense 2023 Clinical Guideline for PTSD—Devolving Not Evolving JAMA Psychiatry (IF 25.8) Pub Date : 2024-01-10 Charles W. Hoge, Kathleen M. Chard, Rachel Yehuda
This Viewpoint discusses the updated 2023 clinical practice guidelines issued by the US Department of Veterans Affairs and the US Department of Defense regarding treatment approaches for posttraumatic stress disorder.
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Online Racial Discrimination, Suicidal Ideation, and Traumatic Stress in a National Sample of Black Adolescents JAMA Psychiatry (IF 25.8) Pub Date : 2024-01-03 Brendesha M. Tynes, Ashley Maxie-Moreman, Tuyet-Mai Ha Hoang, Henry A. Willis, Devin English
ImportanceBecause of increased suicide rates among Black youth in the past 2 decades, there is a dire need for research on suicidal ideation and risk factors in this population.ObjectiveTo examine the direct and indirect associations between online racial discrimination and suicidal ideation through posttraumatic stress disorder symptoms among Black adolescents living in the US, with consideration
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The Rapidly Shifting Ketamine Landscape in the US JAMA Psychiatry (IF 25.8) Pub Date : 2024-01-03 Samuel T. Wilkinson, Joseph J. Palamar, Gerard Sanacora
This Viewpoint discusses changes in the use of ketamine as a medical therapeutic and a recreational substance, the potential risks of use, and the need for increased research and surveillance.
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Home-Use Transcranial Direct Current Stimulation for the Treatment of a Major Depressive Episode JAMA Psychiatry (IF 25.8) Pub Date : 2024-01-03 Lucas Borrione, Beatriz A. Cavendish, Luana V. M. Aparicio, Matthias S. Luethi, Stephan Goerigk, Adriana M. Carneiro, Leandro Valiengo, Darin O. Moura, Juliana P. de Souza, Mariana Baptista, Valquiria Aparecida da Silva, Izio Klein, Paulo Suen, José Gallucci-Neto, Frank Padberg, Lais B. Razza, Marie-Anne Vanderhasselt, Paulo A. Lotufo, Isabela M. Bensenor, Felipe Fregni, Andre R. Brunoni
ImportanceTranscranial direct current stimulation (tDCS) is moderately effective for depression when applied by trained staff. It is not known whether self-applied tDCS, combined or not with a digital psychological intervention, is also effective.ObjectiveTo determine whether fully unsupervised home-use tDCS, combined with a digital psychological intervention or digital placebo, is effective for a
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Antipsychotic Medications and Mortality in Children and Young Adults. JAMA Psychiatry (IF 25.8) Pub Date : 2023-11-29 Wayne A Ray,D Catherine Fuchs,Mark Olfson,Stephen W Patrick,C Michael Stein,Katherine T Murray,James Daugherty,William O Cooper
Importance Dose-related effects of antipsychotic medications may increase mortality in children and young adults. Objective To compare mortality for patients aged 5 to 24 years beginning treatment with antipsychotic vs control psychiatric medications. Design, Setting, and Participants This was a US national retrospective cohort study of Medicaid patients with no severe somatic illness or schizophrenia
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Accurate Machine Learning Prediction in Psychiatry Needs the Right Kind of Information. JAMA Psychiatry (IF 25.8) Pub Date : 2023-11-29 Brian Kraus,Kruthika Sampathgiri,Vijay A Mittal
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Transdiagnostic Ecological Momentary Intervention for Improving Self-Esteem in Youth Exposed to Childhood Adversity: The SELFIE Randomized Clinical Trial. JAMA Psychiatry (IF 25.8) Pub Date : 2023-11-29 Ulrich Reininghaus,Maud Daemen,Mary Rose Postma,Anita Schick,Iris Hoes-van der Meulen,Nele Volbragt,Dorien Nieman,Philippe Delespaul,Lieuwe de Haan,Marieke van der Pluijm,Josefien Johanna Froukje Breedvelt,Mark van der Gaag,Ramon Lindauer,Jan R Boehnke,Wolfgang Viechtbauer,David van den Berg,Claudi Bockting,Therese van Amelsvoort
Importance Targeting low self-esteem in youth exposed to childhood adversity is a promising strategy for preventing adult mental disorders. Ecological momentary interventions (EMIs) allow for the delivery of youth-friendly, adaptive interventions for improving self-esteem, but robust trial-based evidence is pending. Objective To examine the efficacy of SELFIE, a novel transdiagnostic, blended EMI for
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Attention-Deficit/Hyperactivity Disorder Medications and Long-Term Risk of Cardiovascular Diseases. JAMA Psychiatry (IF 25.8) Pub Date : 2023-11-22 Le Zhang,Lin Li,Pontus Andell,Miguel Garcia-Argibay,Patrick D Quinn,Brian M D'Onofrio,Isabell Brikell,Ralf Kuja-Halkola,Paul Lichtenstein,Kristina Johnell,Henrik Larsson,Zheng Chang
Importance Use of attention-deficit/hyperactivity disorder (ADHD) medications has increased substantially over the past decades. However, the potential risk of cardiovascular disease (CVD) associated with long-term ADHD medication use remains unclear. Objective To assess the association between long-term use of ADHD medication and the risk of CVD. Design, Setting, and Participants This case-control
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Long-Term Cardiovascular Effects of Medications for Attention-Deficit/Hyperactivity Disorder-Balancing Benefits and Risks of Treatment. JAMA Psychiatry (IF 25.8) Pub Date : 2023-11-22 Samuele Cortese,Cristiano Fava
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Pregnancy and Postpartum Drug Overdose Deaths in the US Before and During the COVID-19 Pandemic. JAMA Psychiatry (IF 25.8) Pub Date : 2023-11-22 Beth Han,Wilson M Compton,Emily B Einstein,Emerald Elder,Nora D Volkow
Importance Knowledge about characteristics of US pregnancy-associated decedents is needed to guide responses. Objective To examine individual sociodemographic characteristics and residing county's health care resources and socioeconomic factors among pregnancy-associated overdose decedents in comparison with obstetric decedents and overdose decedents who were not pregnant in the past year. Design,
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Mapping Psychomotor Behavior in the Brain. JAMA Psychiatry (IF 25.8) Pub Date : 2023-11-22 Sebastian Walther,Stephan Heckers
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Neighborhood Disadvantage and Autism Spectrum Disorder in a Population With Health Insurance. JAMA Psychiatry (IF 25.8) Pub Date : 2023-11-15 Xin Yu,Md Mostafijur Rahman,Sarah A Carter,Jane C Lin,Ting Chow,Frederick W Lurmann,Jiu-Chiuan Chen,Mayra P Martinez,Joel Schwartz,Sandrah P Eckel,Zhanghua Chen,Rob McConnell,Anny H Xiang,Daniel A Hackman
Importance Family socioeconomic status has been associated with autism spectrum disorder (ASD) diagnoses. Less is known regarding the role of neighborhood disadvantage in the United States, particularly when children have similar access to health insurance. Objective To evaluate the association between neighborhood disadvantage and the diagnosis of ASD and potential effect modification by maternal
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Concerns Regarding Strength of Conclusions in Systematic Review and Meta-Analysis of Neuroradiological Abnormalities in First-Episode Psychosis. JAMA Psychiatry (IF 25.8) Pub Date : 2023-11-15 Anil N Makam
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The Role of Socioeconomic Position in the Association Between Mental Disorders and Mortality: A Systematic Review and Meta-Analysis. JAMA Psychiatry (IF 25.8) Pub Date : 2023-11-15 Danni Chen,Linda Ejlskov,Lisbeth Mølgaard Laustsen,Nanna Weye,Christine Leonhard Birk Sørensen,Natalie C Momen,Julie Werenberg Dreier,Yan Zheng,Astrid Jensen Damgaard,John J McGrath,Henrik Toft Sørensen,Oleguer Plana-Ripoll
Importance Studies are lacking summarizing how the association between mental disorders and mortality varies by socioeconomic position (SEP), particularly considering different aspects of SEP, specific types of mental disorders, and causes of death. Objective To investigate the role of SEP in the association between mental disorders and mortality and the association between SEP and mortality among
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Climate Events, Displacement, and Mental Health-Uprooted. JAMA Psychiatry (IF 25.8) Pub Date : 2023-11-15 Lisa R Fortuna,Aida Jimenez,Michelle V Porche
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Concerns Regarding Strength of Conclusions in Systematic Review and Meta-Analysis of Neuroradiological Abnormalities in First-Episode Psychosis. JAMA Psychiatry (IF 25.8) Pub Date : 2023-11-15 Benjamin Dralle,Robert J Morgan
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Concerns Regarding Strength of Conclusions in Systematic Review and Meta-Analysis of Neuroradiological Abnormalities in First-Episode Psychosis. JAMA Psychiatry (IF 25.8) Pub Date : 2023-11-15 Malcolm Forbes,Stephen Stuckey,Steve Kisely
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Generalizability and Out-of-Sample Predictive Ability of Associations Between Neuromelanin-Sensitive Magnetic Resonance Imaging and Psychosis in Antipsychotic-Free Individuals. JAMA Psychiatry (IF 25.8) Pub Date : 2023-11-08 Kenneth Wengler,Seth C Baker,Anastasia Velikovskaya,Alissa Fogelson,Ragy R Girgis,Francisco Reyes-Madrigal,Seonjoo Lee,Camilo de la Fuente-Sandoval,Najate Ojeil,Guillermo Horga
Importance The link between psychosis and dopaminergic dysfunction is established, but no generalizable biomarkers with clear potential for clinical adoption exist. Objective To replicate previous findings relating neuromelanin-sensitive magnetic resonance imaging (NM-MRI), a proxy measure of dopamine function, to psychosis severity in antipsychotic-free individuals in the psychosis spectrum and to
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Public Sector Learning Health Care Systems-Improving Patient Experience, Workforce Well-Being, and Recovery Outcomes. JAMA Psychiatry (IF 25.8) Pub Date : 2023-11-08 Carlos Blanco,Robert K Heinssen,Wendy N Tenhula
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Patterns of Neural Network Functional Connectivity Associated With Mania/Hypomania and Depression Risk in 3 Independent Young Adult Samples. JAMA Psychiatry (IF 25.8) Pub Date : 2023-11-01 Maya C Schumer,Michele A Bertocci,Haris A Aslam,Simona Graur,Genna Bebko,Richelle S Stiffler,Alexander S Skeba,Tyler J Brady,Osasumwen E Benjamin,Yiming Wang,Henry W Chase,Mary L Phillips
Importance Mania/hypomania is the pathognomonic feature of bipolar disorder (BD). Established, reliable neural markers denoting mania/hypomania risk to help with early risk detection and diagnosis and guide the targeting of pathophysiologically informed interventions are lacking. Objective To identify patterns of neural responses associated with lifetime mania/hypomania risk, the specificity of such
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Genetic Liability to Posttraumatic Stress Disorder Symptoms and Its Association With Cardiometabolic and Respiratory Outcomes. JAMA Psychiatry (IF 25.8) Pub Date : 2023-11-01 Gita A Pathak,Kritika Singh,Karmel W Choi,Yu Fang,Manuela R Kouakou,Younga Heather Lee,Xiang Zhou,Lars G Fritsche,Frank R Wendt,Lea K Davis,Renato Polimanti
Importance Posttraumatic stress disorder (PTSD) has been reported to be a risk factor for several physical and somatic symptoms. However, the genetics of PTSD and its potential association with medical outcomes remain unclear. Objective To examine disease categories and laboratory tests from electronic health records (EHRs) that are associated with PTSD polygenic scores. Design, Setting, and Participants
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Perinatal Mental Health Outcomes Following Natural Disasters. JAMA Psychiatry (IF 25.8) Pub Date : 2023-11-01 Karen G Martínez-González,Evangelia Morou-Bermúdez,Carmen J Buxó
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Transition to Schizophrenia Spectrum Disorder Following Emergency Department Visits Due to Substance Use With and Without Psychosis. JAMA Psychiatry (IF 25.8) Pub Date : 2023-11-01 Daniel T Myran,Lyndsay D Harrison,Michael Pugliese,Marco Solmi,Kelly K Anderson,Jess G Fiedorowicz,Christopher M Perlman,Colleen Webber,Yaron Finkelstein,Peter Tanuseputro
Importance Episodes of substance-induced psychosis are associated with increased risk of developing a schizophrenia spectrum disorder. However, there are limited data on the transition risk for substance use without psychosis. Objectives To quantify the risk of transition to schizophrenia spectrum disorder following an incident emergency department (ED) visit for (1) substance-induced psychosis and
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Etiologic Studies of Premenstrual Disorders Require Prospective Confirmation of Affective Cyclicity-Reply. JAMA Psychiatry (IF 25.8) Pub Date : 2023-11-01 Piotr Jaholkowski,Marit Haram,Ole A Andreassen
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Sexual Dysfunction in Schizophrenia: A Systematic Review and Meta-Analysis. JAMA Psychiatry (IF 25.8) Pub Date : 2023-11-01 Théo Korchia,Vincent Achour,Mélanie Faugere,Ali Albeash,Dong Keon Yon,Laurent Boyer,Guillaume Fond
Importance In individuals with schizophrenia, antipsychotic-induced dysfunctions are frequent but often underexplored in clinical practice. Objective To synthetize the data of observational studies exploring the prevalence of sexual dysfunction in individuals with schizophrenia-spectrum disorders as well as associated factors. Data Sources A systematic literature search without language or time restrictions
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Etiologic Studies of Premenstrual Disorders Require Prospective Confirmation of Affective Cyclicity. JAMA Psychiatry (IF 25.8) Pub Date : 2023-11-01 Arianna Di Florio,Chloe Apsey,Tory A Eisenlohr-Moul
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Stress as a Risk Factor for Mental Disorders in a Gendered Environment. JAMA Psychiatry (IF 25.8) Pub Date : 2023-11-01 Carolyn M Mazure,Mathilde M Husky,Robert H Pietrzak
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Brain Networks and Adolescent Alcohol Use. JAMA Psychiatry (IF 25.8) Pub Date : 2023-11-01 Sarah W Yip,Sarah D Lichenstein,Qinghao Liang,Bader Chaarani,Alecia Dager,Godfrey Pearlson,Tobias Banaschewski,Arun L W Bokde,Sylvane Desrivières,Herta Flor,Antoine Grigis,Penny Gowland,Andreas Heinz,Rüdiger Brühl,Jean-Luc Martinot,Marie-Laure Paillère Martinot,Eric Artiges,Frauke Nees,Dimitri Papadopoulos Orfanos,Tomáš Paus,Luise Poustka,Sarah Hohmann,Sabina Millenet,Juliane H Fröhner,Michael N Smolka
Importance Alcohol misuse in adolescence is a leading cause of disability and mortality in youth and is associated with higher risk for alcohol use disorder. Brain mechanisms underlying risk of alcohol misuse may inform prevention and intervention efforts. Objective To identify neuromarkers of alcohol misuse using a data-driven approach, with specific consideration of neurodevelopmental sex differences
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Written Exposure Therapy Finds Solid Footing Alongside First-Line Psychotherapies for Posttraumatic Stress Disorder. JAMA Psychiatry (IF 25.8) Pub Date : 2023-11-01 Charles T Taylor,Murray B Stein
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Implications of the Network Theory for the Treatment of Mental Disorders: A Secondary Analysis of a Randomized Clinical Trial. JAMA Psychiatry (IF 25.8) Pub Date : 2023-11-01 Lea Schumacher,Jan Philipp Klein,Moritz Elsaesser,Martin Härter,Martin Hautzinger,Elisabeth Schramm,Levente Kriston
Importance Conceptualizing mental disorders as latent entities has been challenged by the network theory of mental disorders, which states that psychological problems are constituted by a network of mutually interacting symptoms. While the implications of the network approach for planning and evaluating treatments have been intensively discussed, empirical support for the claims of the network theory
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Written Exposure Therapy vs Prolonged Exposure Therapy in the Treatment of Posttraumatic Stress Disorder: A Randomized Clinical Trial. JAMA Psychiatry (IF 25.8) Pub Date : 2023-11-01 Denise M Sloan,Brian P Marx,Ron Acierno,Michael Messina,Wendy Muzzy,Matthew W Gallagher,Scott Litwack,Colleen Sloan
Importance Evidence-based treatments for posttraumatic stress disorder (PTSD) exist, but all require 8 to 15 sessions and thus are less likely to be completed than brief treatments. Written exposure therapy (WET) is a brief and efficacious treatment that has not been directly compared with prolonged exposure therapy (PE), a more time-intensive, exposure-based treatment. Objective To determine whether
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Evaluation of Post-COVID-19 Cognitive Dysfunction: Recommendations for Researchers. JAMA Psychiatry (IF 25.8) Pub Date : 2023-11-01 Jaqueline H Becker,Tracy D Vannorsdall,Sara L Weisenbach
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Effects of 12 Weeks of At-Home, Application-Based Exercise on Health Care Workers' Depressive Symptoms, Burnout, and Absenteeism: A Randomized Clinical Trial. JAMA Psychiatry (IF 25.8) Pub Date : 2023-11-01 Vincent Gosselin Boucher,Brook L Haight,Benjamin A Hives,Bruno D Zumbo,Aaliya Merali-Dewji,Stacey Hutton,Yan Liu,Suzanne Nguyen,Mark R Beauchamp,Agnes T Black,Eli Puterman
Importance During the COVID-19 pandemic, health care workers (HCWs) reported a significant decline in their mental health. One potential health behavior intervention that has been shown to be effective for improving mental health is exercise, which may be facilitated by taking advantage of mobile application (app) technologies. Objective To determine the extent to which a 12-week app-based exercise