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3‐Dimensional Hydrogel Culture System Recapitulates Key Tuberculosis Phenotypes and Demonstrates Pyrazinamide Efficacy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-24 Vishal K. Gupta, Vijaya V. Vaishnavi, Mario L. Arrieta‐Ortiz, Abhirami P.S., Jyothsna K.M., Sharumathi Jeyasankar, Varun Raghunathan, Nitin S. Baliga, Rachit Agarwal
The mortality caused by tuberculosis (TB) infections is a global concern, and there is a need to improve our understanding of the disease. Current in vitro infection models to study the disease have limitations, such as short investigation durations and divergent transcriptional signatures. This study aims to overcome these limitations by developing a 3D collagen culture system that mimics the biomechanical
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STMP and PVPA as Templating Analogues of Noncollagenous Proteins Induce Intrafibrillar Mineralization of type I Collagen via PCCP Process Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-24 Yiru Wang, Yizhou Zhang, Zhe Shen, Yuan Qiu, Chaoyang Wang, Zhifang Wu, Minjuan Shen, Changyu Shao, Ruikang Tang, Matthias Hannig, Baiping Fu, Zihuai Zhou
The phosphorylated noncollagenous proteins (NCPs) play a vital role in manipulating biomineralization, while the mechanism of phosphorylation of NCPs in intrafibrillar mineralization of collagen fibril has not been completely deciphered. Poly(vinylphosphonic acid) (PVPA) and sodium trimetaphosphate (STMP) as templating analogues of NCPs induce hierarchical mineralization in cooperation with indispensable
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Organ Neuroprosthetics: Connecting Transplanted and Artificial Organs with the Nervous System Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-24 Silvestro Micera, Arianna Menciassi, Luisella Cianferotti, Emanuele Gruppioni, Vincenzo Lionetti
Implantable neural interfaces with the central and peripheral nervous systems are currently used to restore sensory, motor, and cognitive functions in disabled people with very promising results. They have also been used to modulate autonomic activities to treat diseases such as diabetes or hypertension. Here, this study proposes to extend the use of these technologies to (re‐)establish the connection
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Membrane Fusion Liposomes Deliver Antifibrotic and Chemotherapeutic Drugs Sequentially to Enhance Tumor Treatment Efficacy by Reshaping Tumor Microenvironment Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-24 Nan Jia, Qi Wang, Wenpan Li, Dawei Chen, Haiyang Hu
The intricate tumor microenvironment in triple‐negative breast cancer (TNBC) hampers chemotherapy and immunotherapy efficacy due to dense extracellular matrix (ECM) by tumor‐associated fibroblasts (TAFs). Nanoparticle‐based therapies, especially “all in one” nanoparticles, have shown great potential in combined drug delivery strategies to reshape the tumor microenvironment and enhance therapeutic efficiency
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Artificial Intelligence‐driven Platform: Unveiling Critical Hepatic Molecular Alterations in Hepatocellular Carcinoma Development Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-24 Miao Jiang, Pengyun Wu, Yuwei Zhang, Mengling Wang, Mingjie Zhang, Zhaoxiang Ye, Xuejun Zhang, Cai Zhang
Since most Hepatocellular Carcinoma (HCC) typically arises as a consequence of long‐term liver damage, the hepatic molecular characteristics are closely related to the occurrence of HCC. Gaining comprehensive information about the location, morphology, and hepatic molecular alterations related to HCC is essential for accurate diagnosis. However, there is a dearth of technological advancements capable
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Delivery of miRNAs Using Porous Silicon Nanoparticles Incorporated into 3D Hydrogels Enhances MSC Osteogenesis by Modulation of Fatty Acid Signalling and Silicon Degradation Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-24 Surakshya Shrestha, Terence Tieu, Marcin Wojnilowicz, Nicolas H. Voelcker, John S. Forsythe, Jessica E. Frith
Bone tissue engineering strategies incorporating mesenchymal stromal cells (MSC), hydrogels and osteoinductive signals offer great promise for bone repair and regeneration. Commonly used osteoinductive signals such as growth factors face challenges in clinical translation due to their high cost, low stability and potential immunogenicity. Therefore, interest is growing in the delivery of microRNAs
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Immunomodulatory Peptides for Tumor Treatment Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-24 Yang Song, Longtianyang Lei, Xingyu Cai, Hua Wei, Cui‐yun Yu
Peptides exhibit various biological activities, including biorecognition, cell targeting, and tumor penetration, and can stimulate immune cells to elicit immune responses for tumor immunotherapy. Peptide self‐assemblies and peptide‐functionalized nanocarriers can reduce the effect of various biological barriers and the degradation by peptidases, enhancing the efficiency of peptide delivery and improving
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Teicoplanin‐decorated Reduced Graphene Oxide Incorporated Silk Protein Hybrid Hydrogel for Accelerating Infectious Diabetic Wound Healing and Preventing Diabetic Foot Osteomyelitis Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-24 Bianza Moise Bakadia, Ruizhu Zheng, Abeer Ahmed Qaed Ahmed, Zhijun Shi, Bakamona Lina Babidi, Sun Tun, Ying Li, Guang Yang
Developing hybrid hydrogel dressings with anti‐inflammatory, antioxidant, angiogenetic, and antibiofilm activities with higher bone tissue penetrability to accelerate diabetic wound healing and prevent diabetic foot osteomyelitis (DFO) is highly desirable in managing diabetic wounds. Herein, the glycopeptide teicoplanin is used for the first time as a green reductant to chemically reduce graphene oxide
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Engineered Cell Membrane‐Coated Nanoparticles: New Strategies in Glioma Targeted Therapy and Immune Modulation Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-23 Yilei Ma, Jia Yi, Jing Ruan, Jiahui Ma, Qinsi Yang, Kun Zhang, Maolan Zhang, Guoming Zeng, Libo Jin, Xiaobei Huang, Jianshu Li, Haifeng Yang, Wei Wu, Da Sun
Gliomas, the most prevalent primary brain tumors, pose considerable challenges due to their heterogeneity, intricate tumor microenvironment (TME), and blood‐brain barrier (BBB), which restrict the effectiveness of traditional treatments like surgery and chemotherapy. This review provides an overview of engineered cell membrane technologies in glioma therapy, with a specific emphasis on targeted drug
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Hypoxia‐Responsive Hydrogen‐Bonded Organic Framework‐Mediated Protein Delivery for Cancer Therapy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-23 Xu He, Jian Wang, Xiao Liu, Qingyu Niu, Zhiqiang Li, Banglin Chen, Qingqing Xiong
The efficient delivery of therapeutic proteins to tumor sites is a promising cancer treatment modality. Hydrogen‐bonded organic frameworks (HOFs) have been successfully used for the protective encapsulation of proteins; however, easy precipitation and lack of controlled release of existing HOFs limit their further application for protein delivery in vivo. In this study, a hypoxia‐responsive HOF, self‐assembled
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Mesoporous Silica Nanoparticles as an Ideal Platform for Cancer Immunotherapy: Recent Advances and Future Directions. Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-23 Varsha Godakhindi, Mubin Tarannum, Sudip Kumar Dam, Juan L. Vivero‐Escoto
Cancer immunotherapy has recently transformed the traditional approaches against various cancer malignancies. Immunotherapy includes systemic and local treatments to enhance immune responses against cancer; and involves strategies such as immune checkpoints, cancer vaccines, immune modulatory agents, mimetic antigen‐presenting cells, and adoptive cell therapy. Despite promising results, these approaches
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An Elastin‐derived composite matrix for enhanced vascularized and innervated bone tissue reconstruction: from material development to preclinical evaluation Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-23 Nadia Mahmoudi, Micaela Roque, Bruno Paiva Dos Santos, Hugo Oliveira, Robin Siadous, Sylvie Rey, Elisabeth Garanger, Sébastien Lecommandoux, Sylvain Catros, Bertrand Garbay, Joëlle Amédée Vilamitjana
Despite progress in bone tissue engineering, reconstruction of large bone defects remains an important clinical challenge. Here, we developed a biomaterial designed to recruit bone cells, endothelial cells, and neuronal fibers within the same matrix, enabling bone tissue regeneration. The bioactive matrix is based on modified elastin‐like polypeptides (ELPs) grafted with laminin‐derived adhesion peptides
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Electrospun Poly‐L‐Lactic Acid Membranes Promote M2 Macrophage Polarization by Regulating the PCK2/AMPK/mTOR Signaling Pathway Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-23 Daiyuan Tang, Bing Han, Chengkai He, Yunrong Xu, Zhui Liu, Weizhou Wang, Zaitian Huang, Zhenping Xiao, Fei He
Electrospun membranes have been widely used in tissue engineering. Regretfully, there is limited research on how its morphological characteristics precisely regulate macrophage activation and immune response. Therefore, we prepared electrospun poly‐L‐lactic acid (PLLA) membranes with different alignments (align and random) and diameters (nanoscale and microscale) to investigate the effects of different
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Computational Fluid Dynamic (CFD) Analysis of Bioprinting Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-22 Umar Naseef Mohamed Fareez, Syed Ali Arsal Naqvi, Makame Mahmud, Mikail Temirel
The rapid evolution of healthcare and technology has given rise to advancements in the fields of bioprinting, tissue engineering, and regenerative medicine. 3D bioprinting has emerged as an alternative to traditional practices by offering the potential to create functional tissues. Traditional tissue engineering has faced challenges due to irregular cell distribution on scaffolds, limited cell density
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Strontium/Silicon/Calcium‐Releasing Hierarchically Structured 3D‐Printed Scaffolds Accelerate Osteochondral Defect Repair Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-22 Cheng Ji Li, Jeong‐Hui Park, Gang Shi Jin, Nandin Mandakhbayar, Donghyeon Yeo, Jun Hee Lee, Jung‐Hwan Lee, Hye Sung Kim, Hae‐Won Kim
Articular cartilage defects are a global challenge, causing substantial disability. Repairing large defects is problematic, often exceeding cartilage's self‐healing capacity and damaging bone structures. To tackle this problem, we develop a scaffold‐mediated therapeutic ion delivery system. These scaffolds are constructed from poly(ε‐caprolactone) and strontium (Sr)‐doped bioactive nanoglasses (SrBGn)
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Covalent Polymer‐RNA Conjugates for Potent Activation of the RIG‐I Pathway Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-22 Christian R. Palmer, Lucinda E. Pastora, Blaise R. Kimmel, Hayden M. Pagendarm, Alexander J. Kwiatkowski, Payton T. Stone, Karan Arora, Nora Francini, Olga Fedorova, Anna M. Pyle, John T. Wilson
RNA ligands of retinoic acid‐inducible gene I (RIG‐I) are a promising class of oligonucleotide therapeutic with broad potential as antiviral agents, vaccine adjuvants, and cancer immunotherapies. However, their translation has been limited by major drug delivery barriers, including poor cellular uptake, nuclease degradation, and an inability to access the cytosol where RIG‐I is localized. Here we address
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Macrophage‐Derived Nanosponges Adsorb Cytokines and Modulate Macrophage Polarization for Renal Cell Carcinoma Immunotherapy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-22 Yao Jiang, Disen Nie, Zhihao Hu, Chao Zhang, Lingdi Chang, Yu Li, Zhengxuan Li, Wei Hu, Hongji Li, Sikai Li, Chao Xu, Shaojie Liu, Fa Yang, Weihong Wen, Donghui Han, Keying Zhang, Weijun Qin
Renal cell carcinoma (RCC) is a hot tumor infiltrated by large numbers of CD8+ T cells and is highly sensitive to immunotherapy. However, tumor‐associated macrophages (TAMs), mainly M2 macrophages, tend to undermine the efficacy of immunotherapy and promote the progression of RCC. Here, we fabricated macrophage‐derived nanosponges by M2 macrophage membrane‐coated PLGA, which could chemotaxis to the
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Injectable Inflammation‐Responsive Hydrogels for Microenvironmental Regulation of Intervertebral Disc Degeneration Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-22 Lei Liu, Wantao Wang, Lin Huang, Yiwen Xian, Wenzheng Ma, Lei Zhao, Yixi Li, Zhaomin Zheng, Hongmei Liu, Decheng Wu
Chronic local inflammation and excessive cell apoptosis in nucleus pulposus (NP) tissue are the main causes of intervertebral disc degeneration (IDD). Stimuli‐responsive hydrogels have great potential in the treatment of IDD by facilitating localized and controlled drug delivery. Herein, we develop an injectable drug‐loaded dual stimuli‐responsive adhesive hydrogel for microenvironmental regulation
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Conjugation of IL‐33 to Microporous Annealed Particle Scaffolds Enhances Type 2‐Like Immune Responses in Vitro and in Vivo Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-22 Colleen A. Roosa, Samantha L. Lempke, Riley T. Hannan, Ethan Nicklow, Jeffrey M. Sturek, Sarah E. Ewald, Donald Griffin
The inflammatory foreign body response (FBR) is the main driver of biomaterial implant failure. Current strategies to mitigate the onset of a FBR include modification of the implant surface, release of anti‐inflammatory drugs, and cell‐scale implant porosity. The microporous annealed particle (MAP) scaffold platform is an injectable, porous biomaterial composed of individual microgels which are annealed
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Cascade nanoreactor employs mitochondrial‐directed chemodynamic and δ‐ALA‐mediated photodynamic synergy for deep‐seated oral cancer therapy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-20 Qiqi Yin, Yanli Yao, Handan Zhang, Jie Zhang, Jiaming Gao, Lin Weng, Tao Liu, Shuyang Sun, Xin Chen
The management of oral squamous cell carcinoma (OSCC) poses significant challenges, leading to organ impairment and ineffective treatment of deep‐seated tumors, adversely affecting patient prognosis. We introduced a cascade nanoreactor that integrates photodynamic therapy (PDT) and chemodynamic therapy (CDT) for comprehensive multimodal OSCC treatment. Utilizing iron oxide nanoparticles and mesoporous
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Stimuli‐Mediated Macrophage Switching, Unraveling the Dynamics at the Nanoplatforms‐Macrophage Interface Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-19 Keya Ganguly, Rachmi Luthfikasari, Aayushi Randhawa, Sayan Deb Dutta, Tejal V. Patil, Rumi Acharya, Ki‐Taek Lim
Macrophages play an essential role in immunotherapy and tissue regeneration owing to their remarkable plasticity and diverse functions. Recent bioengineering developments have focused on using external physical stimuli such as electric and magnetic fields, temperature, and compressive stress, among others, on micro/nanostructures to induce macrophage polarization, thereby increasing their therapeutic
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Multimodal Technologies for Closed‐Loop Neural Modulation and Sensing Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-19 Lizhu Li, Bozhen Zhang, Wenxin Zhao, David Sheng, Lan Yin, Xing Sheng, Dezhong Yao
Existing methods for studying neural circuits and treating neurological disorders are typically based on physical and chemical cues to manipulate and record neural activities. These approaches often involve predefined, rigid, and unchangeable signal patterns, which cannot be adjusted in real time according to the patient's condition or neural activities. With the continuous development of neural interfaces
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A 700 nm LED light activated Ru(II) complex destroys tumor cytoskeleton via photosensitization and photocatalysis Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-18 Anyi Dao, Shiyan Chen, Li Pan, Qingyan Ren, Xun Wang, Haorui Wu, Qiufang Gong, Zeduan Chen, Shaomin Ji, Jiaxi Ru, HaoTu Zhu, Chao Liang, Pingyu Zhang, Haiping Xia, Huaiyi Huang
Photoactivable chemotherapy (PACT) using metallic complexes provides spatiotemporal selectivity over drug activation for targeted anticancer therapy. However, the poor absorption in near-infrared (NIR) light region of most metallic complexes renders tissue penetration challenging. Herein, we present an NIR light triggered di-nuclear photoactivable Ru(II) complex (Ru2) and comprehensively investigated
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Reversible Host–Guest Crosslinks in Supramolecular Hydrogels for On‐Demand Mechanical Stimulation of Human Mesenchymal Stem Cells (Adv. Healthcare Mater. 10/2024) Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-17 Philipp Linke, Natalie Munding, Esther Kimmle, Stefan Kaufmann, Kentaro Hayashi, Masaki Nakahata, Yoshinori Takashima, Masaki Sano, Martin Bastmeyer, Thomas Holstein, Sascha Dietrich, Carsten Müller‐Tidow, Akira Harada, Anthony D. Ho, Motomu Tanaka
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Amplified and Specific Staining of Protein Dimerization on Cell Membrane Catalyzed by Responsively Installed DNA Nanomachines for Cancer Diagnosis (Adv. Healthcare Mater. 10/2024) Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-17 Zhenqiang Wang, Xiyue Xie, Kaifei Jin, Daqing Xia, Jing Zhu, Jixi Zhang
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Size-dependent Blue Emission from Europium-doped Strontium Fluoride Nanoscintillators for X-Ray Activated Photodynamic Therapy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-17 Natasha Policei Marques, Mileni M. Isikawa, Zeinaf Muradova, Toby Morris, Ross Berbeco, Eder J. Guidelli
Successful implementation of X-ray-activated photodynamic therapy (X-PDT) is challenging because most photosensitizers (PSs) absorb light in the blue region, but few nanoscintillators produce efficient blue scintillation. Here, we developed efficient blue-emitting SrF2:Eu scintillating nanoparticles. Our optimized synthesis conditions resulted in cubic nanoparticles with ∼$\sim $32 nm diameter and
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Ferrous/Ferric Ions Crosslinked Type II Collagen Multifunctional Hydrogel for Advanced Osteoarthritis Treatment (Adv. Healthcare Mater. 10/2024) Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-17 Lili Wang, Xian Chen, Shenghong Wang, Jianrui Ma, Xiaxia Yang, Hongli Chen, Jianxi Xiao
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A Novel Conductive Polypyrrole‐Chitosan Hydrogel Containing Human Endometrial Mesenchymal Stem Cell‐Derived Exosomes Facilitated Sustained Release for Cardiac Repair (Adv. Healthcare Mater. 10/2024) Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-17 Changping Yan, Xinzhu Wang, Qi Wang, Haiyan Li, Huifang Song, Jingli Zhou, Zexu Peng, Wenjuan Yin, Xuemei Fan, Kun Yang, Bingrui Zhou, Yuxiang Liang, Zengyu Jiang, Yuwei Shi, Sanyuan Zhang, Sheng He, Ren‐Ke Li, Jun Xie
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Material‐Intrinsic NIR‐Fluorescence Enables Image‐Guided Surgery for Ceramic Fracture Removal (Adv. Healthcare Mater. 10/2024) Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-17 Robert Nißler, Elena Totter, Sebastian G. Walter, Justus T. Metternich, Oscar Cipolato, Dimitri Nowack, Alexander Gogos, Inge K. Herrmann
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Novel‐Ink‐Based Direct Ink Writing of Ti6Al4V Scaffolds with Sub‐300 µm Structural Pores for Superior Cell Proliferation and Differentiation (Adv. Healthcare Mater. 10/2024) Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-17 Chao Xu, Yan Xu, Hao Chen, Qing Han, Wenzheng Wu, Lu Zhang, Qingping Liu, Jincheng Wang, Luquan Ren
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Metabolic Control During Macrophage Polarization by a Citrate-Functionalized Scaffold for Maintaining Bone Homeostasis Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-16 Xiaopei Wu, Yuhao Xia, Honglian Dai, Chuhang Hong, Yanan Zhao, Wenying Wei, Dian Zheng
Metabolites, as markers of phenotype at the molecular level, can regulate the function of DNA, RNA, and proteins through chemical modifications or interactions with large molecules. Citrate is an important metabolite that affects macrophage polarization and osteoporotic bone function. Therefore, a better understanding of the precise effect of citrate on macrophage polarization may provide an effective
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Molecularly Imprinted Macroporous Hydrogel Promotes Bone Regeneration via Osteogenic Induction and Osteoclastic Inhibition Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-16 Jingxiao Chen, Yihan Jing, Yanhong Liu, Yongxi Luo, Yutong He, Xiaozhong Qiu, Qingbin Zhang, Huiyong Xu
Macroporous hydrogels offer physical supportive spaces and bio-instructive environment for the seeded cells, where cell-scaffold interactions directly influence cell fates and subsequently affect tissue regeneration post-implantation. Effectively modifying bioactive motifs at the inner pore surface provides appropriate niches for cell-scaffold interactions. A molecular imprinting method and sacrificial
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Unique Advantages of Dendrimers‐Structured Mesoporous Silica Nanoparticles over Traditional Hollow ones in Delivering Bcl2‐Functional Converting Peptide for Multidrug Resistant Cancer Treatment Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-16 Yuehuang Wu, Fangmei Ma, Lixue Yu, Ruimiao Lin, Sijin Lin, Zhihan Guo, Min Zhou, Mingyu Li, Yi Zhang, Jingjing Xie
Innovative silica nanomaterials have made the significant advancements in curative therapy against cancers with multidrug resistance (MDR). The study on different‐nanostructured mesoporous silica nanoparticles (MSNs) with discrepant pore sizes affecting biomacromolecules in resisting cancer MDR hasn't been reported yet. In this study, a systematic comparison of 6 nm‐pore sized hollow‐structured MSNs
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Modelling Structural Elements and Functional Responses to Lymphatic‐Delivered Cues in a Murine Lymph Node on a Chip Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-16 Corrado Mazzaglia, Hafsa Munir, Iek M. Le, Magda Gerigk, Yan Yan Shery Huang, Jacqueline D. Shields
Lymph nodes (LNs) are organs of the immune system, critical for maintenance of homeostasis and initiation of immune responses, yet there are few models that accurately recapitulate LN functions in vitro. To tackle this issue, an engineered murine LN (eLN) was developed, replicating key cellular components of the mouse LN; incorporating primary murine lymphocytes, fibroblastic reticular cells (FRCs)
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Biofabrication Directions in Recapitulating the Immune System‐on‐a‐Chip Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-16 Robine Janssen, Laura Benito‐Zarza, Pim Cleijpool, Marta G Valverde, Silvia M Mihăilă, Shanna Bastiaan‐Net, Johan Garssen, Linette E.M. Willemsen, Rosalinde Masereeuw
Ever since the implementation of microfluidics in the biomedical field, in vitro models have experienced unprecedented progress that has led to a new generation of highly complex miniaturized cell culture platforms, known as Organs‐on‐a‐Chip (OoC). These devices aim to emulate biologically relevant environments, encompassing perfusion and other mechanical and/or biochemical stimuli, to recapitulate
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Cuproptosis: Advances in Stimulus‐Responsive Nanomaterials for Cancer Therapy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-16 Jiacheng Lu, Yuqing Miao, Yuhao Li
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Pyridine-2,6-Dicarboxamide Proligands and their Cu(II)/Zn(II) Complexes Targeting Staphylococcus Aureus for the Attenuation of In Vivo Dental Biofilm Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-15 Kajal Chaudhary, Bhumika Agrahari, Bhumika Biswas, Niranjan Chatterjee, Ayushi Chaudhary, Ashwini Kumar, Himanshu Sonker, Sayari Dewan, Deepanshi Saxena, Abdul Akhir, Nidhi Malhotra, Sidharth Chopra, Santosh Misra, Saravanan Matheswaran, Ritika Gautam Singh
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Triplet-Triplet Annihilation Upconversion-Based Photolysis: Applications in Photopharmacology Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-13 Maxime Klimezak, Juliane Chaud, Anaïs Brion, Frédéric Bolze, Benoit Frisch, Béatrice Heurtault, Antoine Kichler, Alexandre Specht
The emerging field of photopharmacology is a promising chemobiological methodology for optical control of drug activities that could ultimately solve the off-target toxicity outside the disease location of many drugs for the treatment of a given pathology. The use of photolytic reactions looks very attractive for a light-activated drug release but requires to develop photolytic reactions sensitive
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Fabrication and Characterization of PDMS Waveguides for Flexible Optrodes Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-12 Linda Rudmann, Daniel Scholz, Marie T. Alt, Alexander Dieter, Eva Fiedler, Tobias Moser, Thomas Stieglitz
With the growth of optogenetic research, the demand for optical probes tailored to specific applications is ever rising. Specifically, for applications like the coiled cochlea of the inner ear, where planar, stiff and non‐conformable probes can hardly be used, transitioning from commonly used stiff glass fibers to flexible probes is required, especially for long‐term use. Following this demand, Polydimethylsiloxane
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Heterojunction-Mediated Co-Adjustment of Band Structure and Valence State for Achieving Selective Regulation of Semiconductor Nanozymes Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-12 Jiahao Huang, Xiaodan Jia, Yue Wang, Yue Qiao, Xiue Jiang
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Nanofiber Peptides for Bacterial Trapping: A Novel Approach to Antibiotic Alternatives in Wound Infections Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-12 Hao Yang, Jiufeng Wang, Xue Wang, Siyu Wang, Jieru Xu, Qiang Shan, Jingyi Wang, Xi Ma, Yaohong Zhu
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Hybrid Bioactive Hydrogel Promotes Liver Regeneration through the Activation of Kupffer Cells and ECM Remodeling After Partial Hepatectomy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-12 Yixiao Pan, Zhigang Zheng, Xueliang Zhang, Shupeng Liu, Shiya Zhuansun, Shiming Gong, Shilun Li, Hongye Wang, Yiwen Chen, Taihua Yang, Huimin Wu, Feng Xue, Qiang Xia, Kang He
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The Past, Present, and Future of Tubular Melt Electrowritten Constructs to Mimic Small Diameter Blood Vessels – A Stable Process? Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-12 Michael Bartolf‐Kopp, Tomasz Jungst
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Immunomodulation Using BMP-7 and IL-10 to Enhance the Mineralization Capacity of Bone Progenitor Cells in a Fracture Hematoma-Like Environment Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-10 Matthias Guido Wiesli, Matthias Werner Huber, Bernhard Weisse, Robert Zboray, Stefanie Kiderlen, Arlyng González-Vázquez, Katharina Maniura-Weber, Markus Rottmar, William Arthur Lackington
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An Electron Donor–Acceptor Structured Rhenium(I) Complex Photo-Sensitizer Evokes Mutually Reinforcing "Closed-Loop" Ferroptosis and Immunotherapy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-10 Qingyan Ren, Haobing Wang, Dan Li, Anyi Dao, Jiajun Luo, Deliang Wang, Pingyu Zhang, Huaiyi Huang
The hypoxic microenvironment of solid tumors severely lowers the efficacy of oxygen-dependent photodynamic therapy (PDT). The development of hypoxia-tolerant photosensitizers for PDT is an urgent requirement. In this study, a novel rhenium complex (Re-TTPY) to develop a “closed-loop” therapy based on PDT-induced ferroptosis and immune therapy is reported. Due to its electron donor–acceptor (D–A) structure
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Graphene Quantum Dots Eradicate Resistant and Metastatic Cancer Cells by Enhanced Interfacial Inhibition Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-10 Yan Su, Kai Ye, Jinyan Hu, Zhenlin Zhang, Yang Wang, Bijiang Geng, Dengyu Pan, Longxiang Shen
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Spatiotemporal Concurrent PARP Inhibitor Sensitization Based on Radiation-Responsive Nanovesicles for Lung Cancer Chemoradiotherapy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-10 Fei Kang, Meng Niu, Zijian Zhou, Mingru Zhang, Hehe Xiong, Fantian Zeng, Jing Wang, Xiaoyuan Chen
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Engineering Microorganisms for Cancer Immunotherapy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-10 Dingkang Liu, Lichao Yu, Haibo Rong, Lubin Liu, Jun Yin
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Stiffness Mediated-Mechanosensation of Airway Smooth Muscle Cells on Linear Stiffness Gradient Hydrogels Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-09 Yong Hwee Tan, Kimberley C. W. Wang, Ian L. Chin, Rowan W. Sanderson, Jiayue Li, Brendan F. Kennedy, Peter B. Noble, Yu Suk Choi
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Engineering Wet‐resistant and Osteogenic Nanocomposite Adhesive to Control Bleeding and Infection after Median Sternotomy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-09 Mahshid Shokri, Mahshid Kharaziha, Hossein Ahmadi Tafti, Faezeh Dalili, Rouhollah Mehdinavaz Aghdam, Mohamadreza Baghaban Eslaminejad
Median sternotomy surgery stands as one of the prevailing strategies in cardiac surgery. In this study, the cutting‐edge bone adhesive is designed, inspired by the impressive adhesive properties found in mussels and sandcastle worms. We have created an osteogenic nanocomposite coacervate adhesive by integrating a cellulose‐polyphosphodopamide interpenetrating network, quaternized chitosan, and zinc
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High-Density, Conformable Conducting Polymer-Based Implantable Neural Probes for the Developing Brain Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-09 Liang Ma, Duncan J. Wisniewski, Claudia Cea, Dion Khodagholy, Jennifer N. Gelinas
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A Mesoporous Silica‐loaded Multi‐functional Hydrogel Enhanced Tendon Healing via Immunomodulatory and pro‐regenerative Effects Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-09 Renwen Wan, Zhiwen Luo, Xiaoshuang Nie, Xinting Feng, Yanwei He, Fangqi Li, Shan Liu, Wenbo Chen, Beijie Qi, Haocheng Qin, Wei Luo, Hanli Zhang, Hongyi Jiang, Junming Sun, Xuanyong Liu, Qing Wang, Xiliang Shang, Jiajun Qiu, Shiyi Chen
Tendon injuries are pervasive orthopedic injuries encountered by the general population. Nonetheless, recovery after severe injuries such as Achilles tendon injury is limited. Consequently, there is a pressing need to devise interventions, including biomaterials, that foster tendon healing. Regrettably, tissue engineering treatments have faced obstacles in crafting appropriate tissue scaffolds and
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Injectable, Electroconductive, Free Radical Scavenging Silk Fibroin/Black Phosphorus/Glycyrrhizic Acid Nanocomposite Hydrogel for Enhancing Spinal Cord Repair Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-08 Beichen Zhang, Wanshun Wang, Peng Gao, Xiang Li, Lingling Chen, Zefeng Lin, Hu Chen, Wenhao Liang, Zhiyuan Kong, Dingkun Lin, Xiaona Wu, Tao Zhang
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Homo‐dyad with outer hydration layer approach for developing NIR‐II chromophore of high stability and water‐solubility as injectable and sprayable optical probe Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-08 Zunpan She, Rong Li, Fang Zeng, Shuizhu Wu
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A Novel Coacervate Embolic Agent for Tumor Chemoembolization Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-08 Menghui Liu, Yang Sun, Yitong Zhou, Yanlv Chen, Meng Yu, Liujun Li, Leye Yan, Yajun Yuan, Jiayao Chen, Kaixiang Zhou, Hong Shan, Xin Peng
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Tunable In Situ Synthesis of Ultrathin Extracellular Matrix-Derived Membranes in Organ-on-a-Chip Devices Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-08 Jeremy D. Newton, Yuetong Song, Siwan Park, Kayshani R. Kanagarajah, Amy P. Wong, Edmond W. K. Young
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pH-Triggered Transformable Peptide Nanocarriers Extend Drug Retention for Breast Cancer Combination Therapy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-08 Xiaomeng Yuan, Xiaoying Liu, Hongjie Li, Shan Peng, Haiqin Huang, Zhe Yu, Limei Chen, Xinlu Liu, Jingkun Bai
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Polymer Backpack‐loaded Tissue Infiltrating Monocytes for Treating Cancer Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-06 Neha Kapate, Michael Dunne, Alexander P. Gottlieb, Malini Mukherji, Vineeth Chandran Suja, Supriya Prakash, Kyung Soo Park, Ninad Kumbhojkar, Jennifer L. Guerriero, Samir Mitragotri
Adoptive cell therapies are dramatically altering the treatment landscape of cancer. However, treatment of solid tumors remains a major unmet need, in part due to limited adoptive cell infiltration into the tumor and in part due to the immunosuppressive tumor microenvironment. The heterogeneity of tumors and presence of non‐responders also calls for development of antigen‐independent therapeutic approaches
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Cell Membrane‐Camouflaged Chitosan‐Polypyrrole Nanogels Co‐Deliver Drug and Gene for Targeted Chemotherapy and Bone Metastasis Inhibition of Prostate Cancer Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-06 Qiuyu Yu, Yue Gao, Waicong Dai, Danni Li, Lu Zhang, Meera Moydeen Abdul Hameed, Rui Guo, Min Liu, Xiangyang Shi, Xueyan Cao
The development of functional nanoplatforms to improve the chemotherapy outcome and inhibit distal cancer cell metastasis remains an extreme challenge in cancer management. In this work, we report a human‐derived PC‐3 cancer cell membrane‐camouflaged chitosan‐polypyrrole nanogel (CH‐PPy NG) platform, which can be loaded with chemotherapeutic drug docetaxel (DTX) and RANK siRNA for targeted chemotherapy