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Vascular endothelial dysfunction induced by 3-bromofluoranthene via MAPK-mediated-NFκB pro-inflammatory pathway and intracellular ROS generation Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-18 Chien-Ying Lee, Sheng-Wen Wu, Jiann-Jou Yang, Wen-Ying Chen, Chun-Jung Chen, Hsin-Hung Chen, Yi-Chia Lee, Chun-Hung Su, Yu-Hsiang Kuan
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The rat acute oral toxicity of trifluoromethyl compounds (TFMs): a computational toxicology study combining the 2D-QSTR, read-across and consensus modeling methods Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-16 Xinyi Lu, Xin Wang, Shuo Chen, Tengjiao Fan, Lijiao Zhao, Rugang Zhong, Guohui Sun
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Repeated-dose toxicity and toxicokinetic study of isobutylparaben in rats subcutaneously treated for 13 weeks Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-15 Jung Dae Lee, Jin-Sook Bae, Hyang Yeon Kim, Si-Whan Song, Jong-Choon Kim, Byung-Mu Lee, Kyu-Bong Kim
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Genotoxicity and safety pharmacology of the rVSVInd(GML)-mspSGtc vaccine against SARS-CoV-2 in Sprague–Dawley rats and Beagle dogs Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-12 Sang-Jin Park, Heeseon Park, Seng-Min Back, Young Ju Lee, Joung‐Wook Seo, Dabi Kim, Jeong Hwa Lee, Chaewon Kwak, Kang-Hyun Han, Hwa-Young Son, Yong-Bum Kim
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The role of genetic polymorphisms for inducing genotoxicity in workers occupationally exposed to benzene: a systematic review Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-10 Thiago Guedes Pinto, Thayza Aires Dias, Ana Claudia Muniz Renno, Milena de Barros Viana, Daniel Araki Ribeiro
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Correction to: Cytotoxicity of Prymnesium parvum extracts and prymnesin analogs on epithelial fish gill cells RTgill-W1 and the human colon cell line HCEC-1CT Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-09 Elisabeth Varga, Hélène-Christine Prause, Matthias Riepl, Nadine Hochmayr, Deniz Berk, Eva Attakpah, Endre Kiss, Nikola Medić, Giorgia Del Favero, Thomas Ostenfeld Larsen, Per Juel Hansen, Doris Marko
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Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-07 Ji-Eun Seo, Yuan Le, Javier Revollo, Jaime Miranda-Colon, Hannah Xu, Page McKinzie, Nan Mei, Tao Chen, Robert H. Heflich, Tong Zhou, Timothy Robison, Jessica A. Bonzo, Xiaoqing Guo
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Dissecting the networks underlying diverse brain disorders after prenatal glucocorticoid overexposure Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-06 Baixiu Zheng, Yanrong Zheng, Weiwei Hu, Zhong Chen
New human life begins in the uterus in a period of both extreme plasticity and sensitivity to environmental disturbances. The fetal stage is also a vital period for central nervous system development, with experiences at this point profoundly and permanently shaping brain structure and function. As such, some brain disorders may originate in utero. Glucocorticoids, a class of essential stress hormones
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Validation of putative biomarkers of furan exposure through quantitative analysis of furan metabolites in urine of F344 rats exposed to stable isotope labeled furan Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-04 C. Kalisch, M. Reiter, M. Krieger, L. Wüst, C. Klotz, R. Dekant, D. W. Lachenmeier, O. Scherf-Clavel, A. Mally
Humans are chronically exposed to furan, a potent liver toxicant and carcinogen that occurs in a variety of heat-processed foods. Assessment of human exposure based on the furan content in foods is, however, subject to some uncertainty due to the high volatility of furan. Biomarker monitoring is thus considered an alternative or complementary approach to furan exposure assessment. Previous work suggested
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Calcium channel inhibitor and extracellular calcium improve aminoglycoside-induced hair cell loss in zebrafish Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-02 Liao-Chen Chen, Hwei-Hsien Chen, Ming-Huan Chan
Aminoglycosides are commonly used antibiotics for treatment of gram-negative bacterial infections, however, they might act on inner ear, leading to hair-cell death and hearing loss. Currently, there is no targeted therapy for aminoglycoside ototoxicity, since the underlying mechanisms of aminoglycoside-induced hearing impairments are not fully defined. This study aimed to investigate whether the calcium
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Excavatolide C/cisplatin combination induces antiproliferation and drives apoptosis and DNA damage in bladder cancer cells Arch. Toxicol. (IF 6.1) Pub Date : 2024-05-01
Abstract Excavatolide C (EXCC), a marine coral-derived compound, exhibits an antiproliferation effect on bladder cancer cells. The present study evaluated the improvement in the antiproliferation ability of EXCC by co-treatment with cisplatin in bladder cancer cells. EXCC/cisplatin (12.5 and 1 μg/mL) showed higher antiproliferation effects on bladder cancer cells than single treatments (EXCC or cisplatin
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Multi-organ developmental toxicity and its characteristics in fetal mice induced by dexamethasone at different doses, stages, and courses during pregnancy Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-24 Xiaoqi Zhao, Hao Xiao, Xiaomin Li, Lu Zhu, Yu Peng, Huijun Chen, Liaobin Chen, Dan Xu, Hui Wang
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Formation of potentially toxic metabolites of drugs in reactions catalyzed by human drug-metabolizing enzymes Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-23
Abstract Data are presented on the formation of potentially toxic metabolites of drugs that are substrates of human drug metabolizing enzymes. The tabular data lists the formation of potentially toxic/reactive products. The data were obtained from in vitro experiments and showed that the oxidative reactions predominate (with 96% of the total potential toxication reactions). Reductive reactions (e.g
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CircRNA: a rising therapeutic strategy for lung injury induced by pulmonary toxicants Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-18
Abstract Lung injury has been a serious medical problem that requires new therapeutic approaches and biomarkers. Circular RNAs (circRNAs) are non-coding RNAs (ncRNAs) that exist widely in eukaryotes. CircRNAs are single-stranded RNAs that form covalently closed loops. CircRNAs are significant gene regulators that have a role in the development, progression, and therapy of lung injury by controlling
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Role of the complement system in kidney cell death induced by Loxosceles venom Sphingomyelinases D Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-18
Abstract Envenomation by Loxosceles spiders can result in local and systemic pathologies. Systemic loxoscelism, which can lead to death, is characterized by intravascular hemolysis, platelet aggregation, and acute kidney injury. Sphingomyelinase D (SMase D) in Loxosceles spider venom is responsible for both local and systemic pathologies, and has been shown to induce metalloprotease activity. As the
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The estimation of acute oral toxicity (LD50) of G-series organophosphorus-based chemical warfare agents using quantitative and qualitative toxicology in silico methods Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-17 Maciej Noga, Agata Michalska, Kamil Jurowski
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Cytogenotoxicity and inflammatory response in liver of rats exposed to different doses of cannabis nano emulsions Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-17 Thiago Guedes Pinto, Barbara dos Anjos Rosario, Andrea Cristina de Moraes Malinverni, Rosana Xavier, Yasmin Alaby Martins Ferreira, Luciana Pellegrini Pisani, Pedro Everson Alexandre de Aquino, Glauce Socorro de Barros Viana, Daniel Vitor de Souza, Milena de Barros Viana, Daniel Araki Ribeiro
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Flavonoids commonly induce hormetic responses Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-01
Abstract The present paper provides a new perspective of previously published findings by Siwak (Food Chem 141:1227–1241, 2013) which showed that 15 structurally diverse flavonoids reduced toxicity (i.e., enhanced cell viability) from hypochlorite using the MTT assay within a pre-conditioning experimental protocol, with each agent showing a similar biphasic concentration response relationship. We use
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Identification of key neuronal mechanisms triggered by dimethyl fumarate in SH-SY5Y human neuroblastoma cells through a metabolomic approach Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-01
Abstract Dimethyl fumarate (DMF) is an old drug used for psoriasis treatment that has recently been repurposed to treat relapse–remitting multiple sclerosis, mostly due to its neuro- and immunomodulatory actions. However, mining of a pharmacovigilance database recently ranked DMF as the second pharmaceutical most associated with cognitive adverse events. To our best knowledge, the signaling mechanisms
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ATF4 in cellular stress, ferroptosis, and cancer Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-01
Abstract Activating transcription factor 4 (ATF4), a member of the ATF/cAMP response element-binding (CREB) family, plays a critical role as a stress-induced transcription factor. It orchestrates cellular responses, particularly in the management of endoplasmic reticulum stress, amino acid deprivation, and oxidative challenges. ATF4's primary function lies in regulating gene expression to ensure cell
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Prediction of cytochrome P450-mediated bioactivation using machine learning models and in vitro validation Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-16 Xin-Man Hu, Yan-Yao Hou, Xin-Ru Teng, Yong Liu, Yu Li, Wei Li, Yan Li, Chun-Zhi Ai
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Elevated aerobic glycolysis driven by p62-mTOR axis promotes arsenic-induced oncogenic phenotypes in human mammary epithelial cells Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-14 Yongfang Li, Jiao Liu, Dianqi Yao, Zijun Guo, Xuheng Jiang, Chengwen Zhang, Litong Qu, Yuyan Liu, Yuxin Hu, Lanyue Gao, Yi Wang, Yuanyuan Xu
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Toxicokinetics of homosalate in humans after dermal application: applicability of oral-route data for exposure assessment by human biomonitoring Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-14 Katharina E. Ebert, Peter Griem, Tobias Weiss, Thomas Brüning, Heiko Hayen, Holger M. Koch, Daniel Bury
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Use of human predictive patch test (HPPT) data for the classification of skin sensitization hazard and potency Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-14
Abstract Since the 1940s, patch tests in healthy volunteers (Human Predictive Patch Tests, HPPTs) have been used to identify chemicals that cause skin sensitization in humans. Recently, we reported the results of a major curation effort to support the development of OECD Guideline 497 on Defined Approaches (DAs) for skin sensitization (OECD in Guideline No. 497: Defined Approaches on Skin Sensitisation
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Cellular senescence gene TACC3 associated with colorectal cancer risk via genetic and DNA methylated alteration Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-14 Hengyang Shen, Yang Chen, Menghuan Xu, Jieyu Zhou, Changzhi Huang, Zhenling Wang, Yu Shao, Hongqiang Zhang, Yunfei Lu, Shuwei Li, Zan Fu
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Combined use of multiparametric high-content-screening and in vitro circadian reporter assays in neurotoxicity evaluation Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-14
Abstract Accumulating evidence indicates that chronic circadian rhythm disruption is associated with the development of neurodegenerative diseases induced by exposure to neurotoxic chemicals. Herein, we examined the relationship between cellular circadian rhythm disruption and cytotoxicity in neural cells. Moreover, we evaluated the potential application of an in vitro cellular circadian rhythm assay
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Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-14 Klaudia Jomova, Suliman Y. Alomar, Saleh H. Alwasel, Eugenie Nepovimova, Kamil Kuca, Marian Valko
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Recent advances and current challenges of new approach methodologies in developmental and adult neurotoxicity testing Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-13 Melania Maria Serafini, Sara Sepehri, Miriam Midali, Marth Stinckens, Marta Biesiekierska, Anna Wolniakowska, Alexandra Gatzios, Elise Rundén-Pran, Edyta Reszka, Marina Marinovich, Tamara Vanhaecke, Joanna Roszak, Barbara Viviani, Tanima SenGupta
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Involvement of per- and polyfluoroalkyl compounds in tumor development Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-13 Maija Pesonen, Kirsi Vähäkangas
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Acetaminophen overdose causes a breach of the blood–bile barrier in mice but not in rats Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-11
Abstract Acetaminophen (APAP) is known to cause a breach of the blood–bile barrier in mice that, via a mechanism called futile bile acid (BA) cycling, increases BA concentrations in hepatocytes above cytotoxic thresholds. Here, we compared this mechanism in mice and rats, because both species differ massively in their susceptibility to APAP and compared the results to available human data. Dose and
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Future in the past: paternal reprogramming of offspring phenotype and the epigenetic mechanisms Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-09 Di Wu, Kejia Zhang, Kaifeng Guan, Faheem Ahmed Khan, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Fei Sun, Chunjie Huang
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Circular RNA MKLN1 promotes epithelial-mesenchymal transition in pulmonary fibrosis by regulating the miR-26a/b-5p/CDK8 axis in human alveolar epithelial cells and mice models Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-09 Yong Zhu, Xiaoxiao Meng, Xian Zhu, Jiaxiang Zhang, Hui lv, Feiyao Wang, Jinfeng Wang, Cheng Chen, Mengting Chen, Dapeng Wang, Wei Jin, Rui Tian, Ruilan Wang
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A-series agent A-234: initial in vitro and in vivo characterization Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-06 Martina Hrabinova, Jaroslav Pejchal, Vendula Hepnarova, Lubica Muckova, Lucie Junova, Jakub Opravil, Jana Zdarova Karasova, Tomas Rozsypal, Alzbeta Dlabkova, Helena Rehulkova, Tomas Kucera, Zbyněk Vecera, Filip Caisberger, Monika Schmidt, Ondrej Soukup, Daniel Jun
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YES1 as a potential target to overcome drug resistance in EGFR-deregulated non-small cell lung cancer Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-05
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The acute toxicity of Novichok's degradation products using quantitative and qualitative toxicology in silico methods Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-05 Maciej Noga, Agata Michalska, Kamil Jurowski
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Genetic variants in m5C modification genes are associated with survival of patients with HBV-related hepatocellular carcinoma Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-04 Bowen Chen, Moqin Qiu, Rongbin Gong, Yingchun Liu, Zihan Zhou, Qiuping Wen, Xiaoxia Wei, Xiumei Liang, Yanji Jiang, Peiqin Chen, Yuying Wei, Qiongguang Huang, Qiuyan Mo, Qiuling Lin, Hongping Yu
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In vitro and in vivo protective potential of quercetin-3-glucuronide against lipopolysaccharide-induced pulmonary injury through dual activation of nuclear factor-erythroid 2 related factor 2 and autophagy Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-04 Pei-Rong Yu, Chiao-Yun Tseng, Cheng-Chin Hsu, Jing-Hsien Chen, Hui-Hsuan Lin
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Integrated data from intravital imaging and HPLC–MS/MS analysis reveal large interspecies differences in AFB1 metabolism in mice and rats Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-04
Abstract Large interspecies differences between rats and mice concerning the hepatotoxicity and carcinogenicity of aflatoxin B1 (AFB1) are known, with mice being more resistant. However, a comprehensive interspecies comparison including subcellular liver tissue compartments has not yet been performed. In this study, we performed spatio-temporal intravital analysis of AFB1 kinetics in the livers of
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Toxicity of particles derived from combustion of Ethiopian traditional biomass fuels in human bronchial and macrophage-like cells Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-01 Sarah McCarrick, Mathilde N. Delaval, Ulrike M. Dauter, Annette M. Krais, Anastasiia Snigireva, Asmamaw Abera, Karin Broberg, Axel C. Eriksson, Christina Isaxon, Anda R. Gliga
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Effect of cell treatment procedures on in vitro genotoxicity assessment Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-01
Abstract So far, the majority of in vitro toxicological experiments are conducted after an acute 24 h treatment that does not represent a realistic human chemical exposure. Recently, new in vitro approaches have been proposed to study the chemical toxicological effect over several days in order to be more predictive of a representative exposure scenario. In this study, we investigated the genotoxic
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Effects of marine biotoxins on drug-metabolizing cytochrome P450 enzymes and their regulation in mammalian cells Arch. Toxicol. (IF 6.1) Pub Date : 2024-02-28 Leonie T. D. Würger, Jimmy Alarcan, Albert Braeuning
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Demonstrating the reliability of in vivo metabolomics based chemical grouping: towards best practice Arch. Toxicol. (IF 6.1) Pub Date : 2024-02-18 Mark R. Viant, E. Amstalden, T. Athersuch, M. Bouhifd, S. Camuzeaux, D. M. Crizer, P. Driemert, T. Ebbels, D. Ekman, B. Flick, V. Giri, M. Gómez-Romero, V. Haake, M. Herold, A. Kende, F. Lai, P. E. G. Leonards, P. P. Lim, G. R. Lloyd, J. Mosley, C. Namini, J. R. Rice, S. Romano, C. Sands, M. J. Smith, T. Sobanski, A. D. Southam, L. Swindale, B. van Ravenzwaay, T. Walk, R. J. M. Weber, F. M. Zickgraf
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In vitro and in vivo metabolic activation and hepatotoxicity of chlorzoxazone mediated by CYP3A Arch. Toxicol. (IF 6.1) Pub Date : 2024-02-18 Chen Sun, Mingyu Zhang, Chunjing Guan, Weiwei Li, Ying Peng, Jiang Zheng
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Characterization of pathological changes in the olfactory system of mice exposed to methylmercury Arch. Toxicol. (IF 6.1) Pub Date : 2024-02-17 Yuta Iijima, Ryohei Miki, Nobumasa Takasugi, Masatake Fujimura, Takashi Uehara
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Modular air–liquid interface aerosol exposure system (MALIES) to study toxicity of nanoparticle aerosols in 3D-cultured A549 cells in vitro Arch. Toxicol. (IF 6.1) Pub Date : 2024-02-10 M. J. Küstner, D. Eckstein, D. Brauer, P. Mai, J. Hampl, F. Weise, B. Schuhmann, G. Hause, F. Glahn, H. Foth, A. Schober
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Investigating the applicability domain of the hiPSC-based PluriLum assay: an embryotoxicity assessment of chemicals and drugs Arch. Toxicol. (IF 6.1) Pub Date : 2024-02-04 Andreas Frederik Treschow, Maria João Valente, Karin Lauschke, Bjørn Holst, Anders Reenberg Andersen, Anne Marie Vinggaard
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Cardiovascular responses of adult male Sprague–Dawley rats following acute organophosphate intoxication and post-exposure treatment with midazolam with or without allopregnanolone Arch. Toxicol. (IF 6.1) Pub Date : 2024-02-02 Shiyue Pan, Donald A. Bruun, Pamela J. Lein, Chao-Yin Chen
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Distinct concentration-dependent oxidative stress profiles by cadmium in a rat kidney proximal tubule cell line Arch. Toxicol. (IF 6.1) Pub Date : 2024-01-30 Wing-Kee Lee, Stephanie Probst, Bettina Scharner, Timo Deba, Faouzi Dahdouh, Frank Thévenod
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Molecular signatures of angiogenesis inhibitors: a single-embryo untargeted metabolomics approach in zebrafish Arch. Toxicol. (IF 6.1) Pub Date : 2024-01-29 Pia Wilhelmi, Volker Haake, Franziska M. Zickgraf, Varun Giri, Philipp Ternes, Peter Driemert, Julia Nöth, Stefan Scholz, Marta Barenys, Burkhard Flick, Barbara Birk, Hennicke Kamp, Robert Landsiedel, Dorothee Funk-Weyer
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The phosphylated butyrylcholinesterase-derived tetrapeptide GlyGluSerAla proves exposure to organophosphorus agents with enantioselectivity Arch. Toxicol. (IF 6.1) Pub Date : 2024-01-24 Tamara Kranawetvogl, Markus Siegert, Dirk Steinritz, Horst Thiermann, Harald John
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Ferroptosis regulation through Nrf2 and implications for neurodegenerative diseases Arch. Toxicol. (IF 6.1) Pub Date : 2024-01-24 Yao Xiang, Xiaohua Song, Dingxin Long
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Utility of in vivo metabolomics to support read-across for UVCB substances under REACH Arch. Toxicol. (IF 6.1) Pub Date : 2024-01-24 H. Kamp, N. Aygun Kocabas, F. Faulhammer, N. Synhaeve, E. Rushton, B. Flick, V. Giri, S. Sperber, L. G. Higgins, M. G. Penman, B. van Ravenzwaay, M. Rooseboom
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The cytotoxicity of microcystin-LR: ultrastructural and functional damage of cells Arch. Toxicol. (IF 6.1) Pub Date : 2024-01-22
Abstract Microcystin-LR (MC-LR) is a toxin produced by cyanobacteria, which is widely distributed in eutrophic water bodies and has multi-organ toxicity. Previous cytotoxicity studies have mostly elucidated the effects of MC-LR on intracellular-related factors, proteins, and DNA at the molecular level. However, there have been few studies on the adverse effects of MC-LR on cell ultrastructure and function
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Sex differences in the tumor promoting effects of tobacco smoke in a cRaf transgenic lung cancer disease model Arch. Toxicol. (IF 6.1) Pub Date : 2024-01-21
Abstract Tobacco smoke (TS) is the leading cause for lung cancer (LC), and female smokers are at a greater risk for LC. Yet, the underlying causes are unknown. We performed whole genome scans in TS exposed wild type and histologically characterized tumor lesions of cRaf transgenic mice. We constructed miRNA-gene and transcription factor-miRNA/gene regulatory networks and determined sex-specific gene
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Artificial intelligence (AI)—it’s the end of the tox as we know it (and I feel fine)* Arch. Toxicol. (IF 6.1) Pub Date : 2024-01-20 Nicole Kleinstreuer, Thomas Hartung
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Sex-related differences in delayed doxorubicin-induced cardiac dysfunction in C57BL/6 mice Arch. Toxicol. (IF 6.1) Pub Date : 2024-01-20
Abstract Cancer survivors may experience long-term cardiovascular complications due to chemotherapeutic drugs such as doxorubicin (DOX). The exact mechanism of delayed DOX-induced cardiotoxicity has not been fully elucidated. Sex is an important risk factor for DOX-induced cardiotoxicity. In the current study, we identified sex differences in delayed DOX-induced cardiotoxicity and determined the underlying
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Exposure limits for indoor volatile substances concerning the general population: The role of population-based differences in sensory irritation of the eyes and airways for assessment factors Arch. Toxicol. (IF 6.1) Pub Date : 2024-01-19 Stefan Kleinbeck, Peder Wolkoff
Assessment factors (AFs) are essential in the derivation of occupational exposure limits (OELs) and indoor air quality guidelines. The factors shall accommodate differences in sensitivity between subgroups, i.e., workers, healthy and sick people, and occupational exposure versus life-long exposure for the general population. Derivation of AFs itself is based on empirical knowledge from human and animal
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Probing the hair detectability of prohibited substances in sports: an in vivo-in silico-clinical approach and analytical implications compared with plasma, urine, and faeces Arch. Toxicol. (IF 6.1) Pub Date : 2024-01-15 Shao-Hsin Hung, Hung-Lin Kan, Chun-Wei Tung, Yi-Ching Lin, Ting-Ting Chen, Ciao Tian, William Chih-Wei Chang
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Quantitative determination of the intracellular uptake of silica nanoparticles using asymmetric flow field flow fractionation coupled with ICP mass spectrometry and their cytotoxicity in HepG2 cells Arch. Toxicol. (IF 6.1) Pub Date : 2024-01-14 Yu-ki Tanaka, Yasumitsu Ogra
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Cytotoxicity of Prymnesium parvum extracts and prymnesin analogs on epithelial fish gill cells RTgill-W1 and the human colon cell line HCEC-1CT Arch. Toxicol. (IF 6.1) Pub Date : 2024-01-11 Elisabeth Varga, Hélène-Christine Prause, Matthias Riepl, Nadine Hochmayr, Deniz Berk, Eva Attakpah, Endre Kiss, Nikola Medić, Giorgia Del Favero, Thomas Ostenfeld Larsen, Per Juel Hansen, Doris Marko