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Role of transient receptor potential ankyrin 1 in idiopathic pulmonary fibrosis: modulation of M2 macrophage polarization Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-18 Yi Yang, Zhenyu Xiao, Weijie Yang, Yangyang Sun, Xin Sui, Xueyang Lin, Xinyi Yang, Zhenghao Bao, Ziqi Cui, Yingkai Ma, Weidong Li, Shengran Wang, Jun Yang, Yongan Wang, Yuan Luo
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Vascular mimicry as a facilitator of melanoma brain metastasis Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-18 Olivia K. Provance, Victor O. Oria, Thuy T. Tran, Jasmine I. Caulfield, Christopher R. Zito, Adam Aguirre-Ducler, Kurt A. Schalper, Harriet M. Kluger, Lucia B. Jilaveanu
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Dodecyl creatine ester therapy: from promise to reality Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-17 Aloïse Mabondzo, Jiddeke van de Kamp, Saadet Mercimek-Andrews
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The impact of nanomaterials on autophagy across health and disease conditions Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-17 Ida Florance, Marco Cordani, Parya Pashootan, Mohammad Amin Moosavi, Ali Zarrabi, Natarajan Chandrasekaran
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RUNX transcription factors are essential in maintaining epididymal epithelial differentiation Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-17 Mervi Toriseva, Ida Björkgren, Arttu Junnila, Arfa Mehmood, Jesse Mattsson, Inka Raimoranta, Bongki Kim, Asta Laiho, Matthias Nees, Laura Elo, Matti Poutanen, Sylvie Breton, Petra Sipilä
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When DNA-damage responses meet innate and adaptive immunity Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-17 Jie Tong, Jiangwei Song, Wuchao Zhang, Jingbo Zhai, Qingli Guan, Huiqing Wang, Gentao Liu, Chunfu Zheng
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Linc-NSC affects cell differentiation, apoptosis and proliferation in mouse neural stem cells and embryonic stem cells in vitro and in vivo Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-14 Lili Guo, Dan Zou, Wenqiao Qiu, Fan Fei, Lihua Chen, Wenjin Chen, Huan Xiong, Xinda Li, Yangyang Wang, Mingjun Gao, Jianwei Zhu, Jin Zhang, Yunsen He, Mou Gao, Ruxiang Xu
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Identification of the role of DAB2 and CXCL8 in uterine spiral artery remodeling in early-onset preeclampsia Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-13 Yu Liu, Lili Du, Shifeng Gu, Jingying Liang, Minshan Huang, Lijun Huang, Siying Lai, Shuang Zhang, Zhaowei Tu, Wei Sun, Dunjin Chen, Jingsi Chen
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Functional myelin in cognition and neurodevelopmental disorders Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-13 Hasni Khelfaoui, Cristobal Ibaceta-Gonzalez, Maria Cecilia Angulo
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Tumor-associated macrophage-derived exosomal miR21-5p promotes tumor angiogenesis by regulating YAP1/HIF-1α axis in head and neck squamous cell carcinoma Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-11 Quan Yan, Jing Liu, Yiding Liu, Zhihao Wen, Dong Jin, Fu Wang, Lu Gao
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Epigenomic insights into common human disease pathology Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-11 Christopher G. Bell
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Sex differences in DNA methylation across gestation: a large scale, cross-cohort, multi-tissue analysis Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-10 Darina Czamara, Linda Dieckmann, Marius Lahti-Pulkkinen, Cristiana Cruceanu, Wolfgang Henrich, Andreas Plagemann, Katri Räikkönen, Thorsten Braun, Elisabeth B. Binder, Jari Lahti, Sonja Entringer
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Bioengineered MSCCxcr2 transdifferentiated keratinocyte-like cell-derived organoid potentiates skin regeneration through ERK1/2 and STAT3 signaling in diabetic wound Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-10 Subholakshmi Choudhury, Neha R. Dhoke, Shilpa Chawla, Amitava Das
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PALB2-mutated human mammary cells display a broad spectrum of morphological and functional abnormalities induced by increased TGFβ signaling Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-10 Hanna Tuppurainen, Niina Laurila, Marjut Nätynki, Leila Eshraghi, Anna Tervasmäki, Louisa Erichsen, Claus Storgaard Sørensen, Katri Pylkäs, Robert Winqvist, Hellevi Peltoketo
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A novel fatty acid analogue triggers CD36–GPR120 interaction and exerts anti-inflammatory action in endotoxemia Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-10 Pierre-Marie Boutanquoi, Amira Sayed Khan, Lidia Cabeza, Lucas Jantzen, Thomas Gautier, Semen Yesylevskyy, Christophe Ramseyer, David Masson, Vincent Van Waes, Aziz Hichami, Naim Akhtar Khan
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LncRNA CARMN inhibits abdominal aortic aneurysm formation and vascular smooth muscle cell phenotypic transformation by interacting with SRF Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-10 Shenrong Liu, Haobin Zhou, Dunzheng Han, Haoyu Song, Yuanqing Li, Shangfei He, Yipeng Du, Kai Wang, Xingfu Huang, Xin Li, Zheng Huang
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Metabolic profiling identifies Qrich2 as a novel glutamine sensor that regulates microtubule glutamylation and mitochondrial function in mouse sperm Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-10 Guohui Zhang, Juncen Guo, Haoxuan Yang, Qing Li, Fei Ye, Yuelin Song, Dongsheng Xiong, Jiuzhi Zeng, Weiwei Zhi, Shuiqiao Yuan, Yunyun Lv, Tongtong Li, Yan Wang, Lu Liao, Dong Deng, Weixin Liu, Wenming Xu
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The E3 ubiquitin ligase ITCH negatively regulates intercellular communication via gap junctions by targeting connexin43 for lysosomal degradation Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-10 Max Zachrisson Totland, Lars Mørland Knudsen, Nikoline Lander Rasmussen, Yasufumi Omori, Vigdis Sørensen, Vilde C. Wivestad Elster, Jakob Mørkved Stenersen, Mathias Larsen, Caroline Lunder Jensen, Anna A. Zickfeldt Lade, Emilie Bruusgaard, Sebastian Basing, Kushtrim Kryeziu, Andreas Brech, Trond Aasen, Ragnhild A. Lothe, Edward Leithe
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CCDC28A deficiency causes sperm head defects, reduced sperm motility and male infertility in mice Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-10 Hongbin Zhou, Zhihua Zhang, Ronggui Qu, Hongying Zhu, Yuxi Luo, Qun Li, Jian Mu, Ran Yu, Yang Zeng, Biaobang Chen, Qing Sang, Lei Wang
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Rhes, a striatal enriched protein, regulates post-translational small-ubiquitin-like-modifier (SUMO) modification of nuclear proteins and alters gene expression Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-08 Oscar Rivera, Manish Sharma, Sunayana Dagar, Neelam Shahani, Uri Nimrod Ramĺrez-Jarquĺn, Gogce Crynen, Pabalu Karunadharma, Francis McManus, Eric Bonneil, Thibault Pierre, Srinivasa Subramaniam
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Kinesin KIF3A regulates meiotic progression and spindle assembly in oocyte meiosis Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-08 Jing-Cai Liu, Zhen-Nan Pan, Jia-Qian Ju, Yuan-Jing Zou, Meng-Hao Pan, Yue Wang, Xin Wu, Shao-Chen Sun
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NFKBIZ regulates NFκB signaling pathway to mediate tumorigenesis and metastasis of hepatocellular carcinoma by direct interaction with TRIM16 Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-06 Danfeng Guo, Ming Zhang, Tingju Wei, Xiaodan Zhang, Xiaoyi Shi, Hongwei Tang, Mingjie Ding, Jie Li, Shuijun Zhang, Wenzhi Guo
Hepatocellular carcinoma (HCC) is a malignant tumor with high incidence and mortality rates. NFKBIZ, a member of the nuclear factor kappa B inhibitory family, is closely related to tumor progression. However, the precise role of NFKBIZ in HCC remains unclear. To explore this, we conducted a series of experiments from clinic to cells. Western blot and qPCR revealed a significant downregulation of NFKBIZ
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Unearthing FLVCR1a: tracing the path to a vital cellular transporter Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-06 Veronica Fiorito, Emanuela Tolosano
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CRL4DCAF13 E3 ubiquitin ligase targets MeCP2 for degradation to prevent DNA hypermethylation and ensure normal transcription in growing oocytes Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-05 Peipei Ren, Xiaomei Tong, Junjian Li, Huifang Jiang, Siya Liu, Xiang Li, Mengru Lai, Weijie Yang, Yan Rong, Yingyi Zhang, Jiamin Jin, Yerong Ma, Weiwei Pan, Heng-Yu Fan, Songying Zhang, Yin-Li Zhang
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iRhom2 regulates ectodomain shedding and surface expression of the major histocompatibility complex (MHC) class I Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-04
Abstract Proteolytic release of transmembrane proteins from the cell surface, the so called ectodomain shedding, is a key process in inflammation. Inactive rhomboid 2 (iRhom2) plays a crucial role in this context, in that it guides maturation and function of the sheddase ADAM17 (a disintegrin and metalloproteinase 17) in immune cells, and, ultimately, its ability to release inflammatory mediators such
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Aberrant splicing of CaV1.2 calcium channel induced by decreased Rbfox1 enhances arterial constriction during diabetic hyperglycemia Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-04 Wei Hou, Shumin Yin, Pengpeng Li, Ludan Zhang, Tiange Chen, Dongxia Qin, Atta Ul Mustafa, Caijie Liu, Miaomiao Song, Cheng Qiu, Xiaoqing Xiong, Juejin Wang
Diabetic hyperglycemia induces dysfunctions of arterial smooth muscle, leading to diabetic vascular complications. The CaV1.2 calcium channel is one primary pathway for Ca2+ influx, which initiates vasoconstriction. However, the long-term regulation mechanism(s) for vascular CaV1.2 functions under hyperglycemic condition remains unknown. Here, Sprague–Dawley rats fed with high-fat diet in combination
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Phosphorylation of the compartmentalized PKA substrate TAF15 regulates RNA–protein interactions Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-03 Andreas Feichtner, Florian Enzler, Valentina Kugler, Katharina Hoppe, Sophia Mair, Leopold Kremser, Herbert Lindner, Roland G. Huber, Ulrich Stelzl, Eduard Stefan, Omar Torres-Quesada
Spatiotemporal-controlled second messengers alter molecular interactions of central signaling nodes for ensuring physiological signal transmission. One prototypical second messenger molecule which modulates kinase signal transmission is the cyclic-adenosine monophosphate (cAMP). The main proteinogenic cellular effectors of cAMP are compartmentalized protein kinase A (PKA) complexes. Their cell-type
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EP300/CREBBP acetyltransferase inhibition limits steroid receptor and FOXA1 signaling in prostate cancer cells Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-02 Jasmin Huttunen, Niina Aaltonen, Laura Helminen, Kirsi Rilla, Ville Paakinaho
The androgen receptor (AR) is a primary target for treating prostate cancer (PCa), forming the bedrock of its clinical management. Despite their efficacy, resistance often hampers AR-targeted therapies, necessitating new strategies against therapy-resistant PCa. These resistances involve various mechanisms, including AR splice variant overexpression and altered activities of transcription factors like
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Positive regulation of Vav1 by Themis controls CD4 T cell pathogenicity in a mouse model of central nervous system inflammation Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-02 Remi Marrocco, Isabelle Bernard, Emeline Joulia, Rebecca Barascud, Anne S. Dejean, Renaud Lesourne, Abdelhadi Saoudi
The susceptibility to autoimmune diseases is conditioned by the association of modest genetic alterations which altogether weaken self-tolerance. The mechanism whereby these genetic interactions modulate T-cell pathogenicity remains largely uncovered. Here, we investigated the epistatic interaction of two interacting proteins involved in T Cell Receptor signaling and which were previously associated
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Peripheral T-cell responses of EphB2- and EphB3-deficient mice in a model of collagen-induced arthritis Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-04-01 Sara Montero-Herradón, Javier García-Ceca, Marta Villarejo-Torres, Agustín G. Zapata
Both EphB2- and EphB3-deficient mice exhibit profound histological alterations in the thymic epithelial network but few changes in T-cell differentiation, suggesting that this organization would be sufficient to produce functional T lymphocytes. Also, other antigen-presenting cells involved in immunological education could substitute the thymic epithelium. Accordingly, we found an increased frequency
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Regulation and function of transposable elements in cancer genomes Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-31 Michael Lee, Syed Farhan Ahmad, Jian Xu
Over half of human genomic DNA is composed of repetitive sequences generated throughout evolution by prolific mobile genetic parasites called transposable elements (TEs). Long disregarded as “junk” or “selfish” DNA, TEs are increasingly recognized as formative elements in genome evolution, wired intimately into the structure and function of the human genome. Advances in sequencing technologies and
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A novel gene-trap line reveals the dynamic patterns and essential roles of cysteine and glycine-rich protein 3 in zebrafish heart development and regeneration Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-31
Abstract Mutations in cysteine and glycine-rich protein 3 (CSRP3)/muscle LIM protein (MLP), a key regulator of striated muscle function, have been linked to hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in patients. However, the roles of CSRP3 in heart development and regeneration are not completely understood. In this study, we characterized a novel zebrafish gene-trap line, gSAIzGFFM218A
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Unraveling the role of Xist in X chromosome inactivation: insights from rabbit model and deletion analysis of exons and repeat A Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-29 Mingming Liang, Lichao Zhang, Liangxue Lai, Zhanjun Li
X chromosome inactivation (XCI) is a process that equalizes the expression of X-linked genes between males and females. It relies on Xist, continuously expressed in somatic cells during XCI maintenance. However, how Xist impacts XCI maintenance and its functional motifs remain unclear. In this study, we conducted a comprehensive analysis of Xist, using rabbits as an ideal non-primate model. Homozygous
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De novo GRIN variants in M3 helix associated with neurological disorders control channel gating of NMDA receptor Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-28 Yuchen Xu, Rui Song, Riley E. Perszyk, Wenjuan Chen, Sukhan Kim, Kristen L. Park, James P. Allen, Kelsey A. Nocilla, Jing Zhang, Wenshu XiangWei, Anel Tankovic, Ellington D. McDaniels, Rehan Sheikh, Ruth K. Mizu, Manish M. Karamchandani, Chun Hu, Hirofumi Kusumoto, Joseph Pecha, Gerarda Cappuccio, John Gaitanis, Jennifer Sullivan, Vandana Shashi, Slave Petrovski, Robin-Tobias Jauss, Hyun Kyung Lee
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Aberrant activated Notch1 promotes prostate enlargement driven by androgen signaling via disrupting mitochondrial function in mouse Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-28 Jin-Wen Kang, Jia-Peng He, Ying-Nan Liu, Yu Zhang, Shan-Shan Song, Qi-Xin Xu, Shu-Wen Wei, Lei Lu, Xiang-Qi Meng, Lin Xu, Bin Guo, Ren-Wei Su
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Discovery and verification of mmu_Circ_26986/hsa_Circ_0072463 as a potential biomarker and intervention target for sepsis-associated acute kidney injury Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-28
Abstract Approximately 60% of septic patients developed acute kidney injury (AKI). The mortality rate of septic AKI (SA-AKI) is two to three times higher than that of septic without AKI (SA-non-AKI). The actual functions and mechanisms of CircRNAs in the pathophysiology of SA-AKI remain incompletely understood. Herein, we observed that the mmu_Circ_26986 could be induced by lipopolysaccharide (LPS)
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Obesogenic diet in pregnancy disrupts placental iron handling and ferroptosis and stress signalling in association with fetal growth alterations Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-25 Jonas Zaugg, Jorge Lopez-Tello, Barbara Musial, Owen R. Vaughan, Abigail L. Fowden, Christiane Albrecht, Amanda N. Sferruzzi-Perri
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Macrophage re-programming by JAK inhibitors relies on MAFB Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-25 Baltasar López-Navarro, Miriam Simón-Fuentes, Israel Ríos, María Teresa Schiaffino, Alicia Sanchez, Mónica Torres-Torresano, Alicia Nieto-Valle, Isabel Castrejón, Amaya Puig-Kröger
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The exon junction complex is required for DMD gene splicing fidelity and myogenic differentiation Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-21 Dylan Da Cunha, Julie Miro, Charles Van Goethem, Cécile Notarnicola, Gérald Hugon, Gilles Carnac, Mireille Cossée, Michel Koenig, Sylvie Tuffery-Giraud
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cGAS-STING pathway mediates activation of dendritic cell sensing of immunogenic tumors Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-21 Guohao Li, Xiangqian Zhao, Zuda Zheng, Hucheng Zhang, Yundi Wu, Yangkun Shen, Qi Chen
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The antiviral response triggered by the cGAS/STING pathway is subverted by the foot-and-mouth disease virus proteases Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-20
Abstract Propagation of viruses requires interaction with host factors in infected cells and repression of innate immune responses triggered by the host viral sensors. Cytosolic DNA sensing pathway of cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) is a major component of the antiviral response to DNA viruses, also known to play a relevant role in response to infection by
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Single-cell analysis of age-related changes in leukocytes of diabetic mouse hindpaws Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-19 James M. Nichols, Hoang Vu Pham, Eric F. Lee, Rajasekaran Mahalingam, Andrew J. Shepherd
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Neonatal GABAergic transmission primes vestibular gating of output for adult spatial navigation Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-19 Qiufen Jiang, Kenneth Lap-Kei Wu, Xiao-Qian Hu, Man-Him Cheung, Wenqiang Chen, Chun-Wai Ma, Daisy Kwok-Yan Shum, Ying-Shing Chan
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USP28 promotes tumorigenesis and cisplatin resistance by deubiquitinating MAST1 protein in cancer cells Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-18
Abstract Cisplatin is a chemotherapy drug that causes a plethora of DNA lesions and inhibits DNA transcription and replication, resulting in the induction of apoptosis in cancer cells. However, over time, patients develop resistance to cisplatin due to repeated treatment and thus the treatment efficacy is limited. Therefore, identifying an alternative therapeutic strategy combining cisplatin treatment
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Molecular engineering of a spheroid-penetrating phage nanovector for photodynamic treatment of colon cancer cells Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-17 Eleonora Turrini, Luca Ulfo, Paolo Emidio Costantini, Roberto Saporetti, Matteo Di Giosia, Michela Nigro, Annapaola Petrosino, Lucia Pappagallo, Alena Kaltenbrunner, Andrea Cantelli, Valentina Pellicioni, Elena Catanzaro, Carmela Fimognari, Matteo Calvaresi, Alberto Danielli
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YAP1-CPNE3 positive feedback pathway promotes gastric cancer cell progression Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-17
Abstract Hippo-Yes-associated protein 1 (YAP1) plays an important role in gastric cancer (GC) progression; however, its regulatory network remains unclear. In this study, we identified Copine III (CPNE3) was identified as a novel direct target gene regulated by the YAP1/TEADs transcription factor complex. The downregulation of CPNE3 inhibited proliferation and invasion, and increased the chemosensitivity
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Txnip regulates the Oct4-mediated pluripotency circuitry via metabolic changes upon differentiation Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-15 Sojung Kwak, Cho Lok Song, Yee Sook Cho, Inpyo Choi, Jae-Eun Byun, Haiyoung Jung, Jungwoon Lee
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Lamin B1 curtails early human papillomavirus infection by safeguarding nuclear compartmentalization and autophagic capacity Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-14
Abstract Human papillomavirus (HPV) infection is a primary cause of cervical and head-and-neck cancers. The HPV genome enters the nucleus during mitosis when the nuclear envelope disassembles. Given that lamins maintain nuclear integrity during interphase, we asked to what extent their loss would affect early HPV infection. To address this question, we infected human cervical cancer cells and keratinocytes
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High-content method for mechanosignaling studies using IsoStretcher technology and quantitative Ca2+ imaging applied to Piezo1 in cardiac HL-1 cells Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-14 Anna-Lena Merten, Ulrike Schöler, Yang Guo, Fabian Linsenmeier, Boris Martinac, Oliver Friedrich, Sebastian Schürmann
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A novel mouse model for N-terminal truncated Aβ2-x generation through meprin β overexpression in astrocytes Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-13
Abstract Neurotoxic amyloid-β (Aβ) peptides cause neurodegeneration in Alzheimer’s disease (AD) patients’ brains. They are released upon proteolytic processing of the amyloid precursor protein (APP) extracellularly at the β-secretase site and intramembranously at the γ-secretase site. Several AD mouse models were developed to conduct respective research in vivo. Most of these classical models overexpress
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The first A-to-I RNA editome of hemipteran species Coridius chinensis reveals overrepresented recoding and prevalent intron editing in early-diverging insects Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-13
Abstract Background Metazoan adenosine-to-inosine (A-to-I) RNA editing resembles A-to-G mutation and increases proteomic diversity in a temporal-spatial manner, allowing organisms adapting to changeable environment. The RNA editomes in many major animal clades remain unexplored, hampering the understanding on the evolution and adaptation of this essential post-transcriptional modification. Methods
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The Janus-faced functions of Apolipoproteins L in membrane dynamics Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-13 Etienne Pays
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Deubiquitinase UCHL1 promotes angiogenesis and blood–spinal cord barrier function recovery after spinal cord injury by stabilizing Sox17 Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-13
Abstract Improving the function of the blood–spinal cord barrier (BSCB) benefits the functional recovery of mice following spinal cord injury (SCI). The death of endothelial cells and disruption of the BSCB at the injury site contribute to secondary damage, and the ubiquitin–proteasome system is involved in regulating protein function. However, little is known about the regulation of deubiquitinated
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Glymphatic-lymphatic coupling: assessment of the evidence from magnetic resonance imaging of humans Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-13 Geir Ringstad, Per Kristian Eide
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Crosstalk between purinergic receptor P2Y11 and chemokine receptor CXCR7 is regulated by CXCR4 in human macrophages Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-13
Abstract P2Y11 is a G protein-coupled ATP receptor that activates IL-1 receptor (IL-1R) in a cyclic AMP dependent manner. In human macrophages, P2Y11/IL-1R crosstalk with CCL20 as a prime target is controlled by phosphodiesterase 4 (PDE4), which mediates breakdown of cyclic AMP. Here, we used gene expression analysis to identify activation of CXCR4 and CXCR7 as a hallmark of P2Y11 signaling. We found
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Role of HCN channels in the functions of basal ganglia and Parkinson’s disease Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-13 Zeng-Xin Qi, Qi Yan, Xiu-Juan Fan, Jian-Ya Peng, Hui-Xian Zhu, Yi-Miao Jiang, Liang Chen, Qian-Xing Zhuang
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PEBP4 deficiency aggravates LPS-induced acute lung injury and alveolar fluid clearance impairment via modulating PI3K/AKT signaling pathway Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-13
Abstract Acute lung injury (ALI) is a common clinical syndrome, which often results in pulmonary edema and respiratory distress. It has been recently reported that phosphatidylethanolamine binding protein 4 (PEBP4), a basic cytoplasmic protein, has anti-inflammatory and hepatoprotective effects, but its relationship with ALI remains undefined so far. In this study, we generated PEBP4 knockout (KO)
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CircAKT3 alleviates postoperative cognitive dysfunction by stabilizing the feedback cycle of miR-106a-5p/HDAC4/MEF2C axis in hippocampi of aged mice Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-13 Xuan Wang, Xiaole Tang, Pengfei Zhu, Dongyu Hua, Zheng Xie, Mingke Guo, Mengxin Que, Jing Yan, Xing Li, Qian Xia, Xiaoxiao Luo, Jiangjiang Bi, Yilin Zhao, Zhiqiang Zhou, Shiyong Li, Ailin Luo
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Lipid homeostasis is essential for oogenesis and embryogenesis in the silkworm, Bombyx mori Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-12 Fangying Yang, Xiaoyan Xu, Bo Hu, Zhongjie Zhang, Kai Chen, Ye Yu, Hua Bai, Anjiang Tan
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ALKBH1 promotes HIF-1α-mediated glycolysis by inhibiting N-glycosylation of LAMP2A Cell. Mol. Life Sci. (IF 8.0) Pub Date : 2024-03-12 Yanyan Liu, Mengmeng Li, Miao Lin, Xinjie Liu, Haolin Guo, Junyang Tan, Liubing Hu, Jianshuang Li, Qinghua Zhou