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RSC主编推荐:有机领域精彩文章快览(免费阅读原文)

英国皇家化学会(RSC)是一个拥有175年历史的面向全球化学家的非营利会员制机构,旗下拥有43种期刊,其中很多在化学领域有很高影响力。为了进一步帮助广大读者追踪科技前沿热点,X-MOL团队与英国皇家化学会合作,推出英国皇家化学会期刊主编推荐的精彩文章快览,本期文章属“有机领域”,英文点评来自英国皇家化学会期刊的主编。如果大家对我们的解读有更多的补充和点评,欢迎在文末写评论发表您的高见!


Chemical Science (IF: 8.668)



1. Challenges and opportunities for alkane functionalisation using molecular catalysts

Chem. Sci., 2018, Advance Article

DOI: 10.1039/C7SC03610H



Researchers in Shanghai provide an overview of methods for alkane functionalisation, highlighting the factors that affect region-selectivity for different protocols. Methods discussed include radical-initiated C-H functionalisation, carbene/nitrene insertion and transition-metal catalysed C-H bond activation. The group also present the challenges of existing techniques and future directions in this field.


中科院上海有机所的研究者对烷烃官能化的方法进行综述,重点介绍了不同合成方法中影响区域选择性的因素。涵盖的方法包括自由基引发的C-H键官能化、卡宾/氮烯插入以及过渡金属催化的C-H键活化,同时还提出了该领域现有技术的挑战和未来的发展方向。


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2. Amide synthesis via nickel-catalysed reductive aminocarbonylation of aryl halides with nitroarenes

Chem. Sci., 2018, Advance Article

DOI: 10.1039/C7SC03950F



Scientists in Switzerland report the development of nickel catalysis for the first three-component reactions of aryl halides, Co2(CO)8, and nitroarenes under reactive conditions to produce aryl amides. The group demonstrated the broad scope of (hetero)aryl iodides and bromides, and nitro(hetero)arenes, and the high group compatibility that can be used in this methodology. These findings have the potential to be used to streamline the synthesis of aryl amides.


瑞士的科学家报道了镍催化在首个三组分反应中的应用——芳基卤化物、Co2(CO)8和硝基芳香烃在特定反应条件下生成芳基酰胺。该研究团队展示了该方法对(杂)芳基碘化物和溴化物以及硝基(杂)芳香烃的普适性和高度的官能团兼容性。该反应可用于简化芳基酰胺的合成。


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Organic Chemistry Frontiers (IF: 4.955)



1. Nickel-catalyzed direct difluoromethylation of aryl boronic acids with BrCF2H

Org. Chem. Front., 2018, Advance Article

DOI: 10.1039/C7QO00934H



A nickel-catalyzed direct difluoromethylation of aryl boronic acids has been developed for the first time, demonstrating good efficiency, mild conditions, and good functional-group compatibility. The key to success is the combination of different kinds of readily available nitrogen and phosphine ligands with a nickel source, which can generate a variety of easily tunable catalysts in situ to promote the difluoromethylation of a broad scope of aryl boronic acids.


中国科学技术大学的研究者首次报道了镍催化芳基硼酸的直接二氟甲基化反应,该反应具有良好的反应效率、温和的反应条件以及良好的官能团兼容性。其成功的关键在于镍源与不同种类易得的氮/膦配体结合,原位生成各种易调控的催化剂,促进多种芳基硼酸的二氟甲基化反应发生。


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2. Formation of tetrasubstituted C–C double bonds via olefin metathesis: challenges, catalysts, and applications in natural product synthesis

Org. Chem. Front., 2018, Advance Article

DOI: 10.1039/C7QO00800G



Until recently, the formation of tetrasubstituted double bonds via olefin metathesis is considered as a very challenging topic. Although much attention has already been given in the last two decades to improve this transformation, none are universally attractive so far. This field is still quite open and looking for a simple and general solution that suits all challenging substrates. In this context, this review is an attempt to provide a broad but digestible overview of tetrasubstituted C–C double bond formation via olefin metathesis, with an emphasis on the recent developments achieved in this area. These developments are actually signifying the great potential for further advancement of this exhilarating research field.


迄今为止,通过烯烃复分解反应形成四取代双键仍旧是非常具有挑战性的课题。尽管在过去二十年里,人们十分关注改进这一转化的相关研究,但是到目前为止,还没有任何一种方法能获得普遍的认同。该研究领域相对开放,仍然在寻找一种简单而通用的解决方案应对所有具有挑战性的底物。本篇综述尝试通过概括性但容易理解的方式对烯烃复分解反应形成四取代碳碳双键进行总结,并重点介绍该领域取得的最新进展。这些进展标志着该研究领域具有巨大的发展潜力。


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