An efficient and practical aerobic benzylic sp³ C–H oxidation as a key step towards the domino multi-component synthesis of 2,4,5-trisubstituted imidazoles has been reported. This green methodology employs an inexpensive catalytic copper/oxygen system and proceeds under mild reaction conditions. A variety of substituted imidazoles are prepared in moderate to excellent yields from α-methylene ketones using this innovative methodology.

中文翻译：

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铜催化需氧苄SP ³ C-H的氧化介导的2,4,5-三取代的咪唑的合成经由一个多米诺多组分反应

据报道，有效，实用的好氧苄基sp ³ C-H氧化是迈向2,4,5-三取代的咪唑多米诺骨牌多组分合成的关键步骤。这种绿色方法使用廉价的催化铜/氧系统，并在温和的反应条件下进行。使用这种创新方法，可以从α-亚甲基酮以中等到极好的收率制备各种取代的咪唑。