For the first time, an overview of dendrimers in combination with natural products and analogues as anti-cancer agents is presented. This reflects the development of drug delivery systems, such as dendrimers, to tackle cancers. The most significant advantages of using dendrimers in nanomedicine are their high biocompatibility, good water solubility, and their entry – with or without encapsulated, complexed or conjugated drugs – through an endocytosis process. This strategy has accelerated over the years in order to develop nanosystems as nanocarriers, to decrease the intrinsic toxicity of anti-cancer agents, to decrease the drug side effects, to increase the efficacy of the treatment, and consequently to improve patient compliance.

中文翻译：

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树状聚合物与天然产物和类似物的组合作为抗癌剂

首次概述了树枝状聚合物与天然产物和类似物作为抗癌剂的组合。这反映了用于治疗癌症的药物递送系统（例如树状聚合物）的发展。在纳米药物中使用树状聚合物的最显着优势是它们的高生物相容性，良好的水溶性以及它们通过内吞作用进入（无论是否加入胶囊，复合或共轭药物）。多年来，为了发展纳米系统作为纳米载体，降低抗癌药的内在毒性，降低药物副作用，提高治疗效果并因此改善患者依从性，该策略已得到加速。