A universal genotyping–microarray constructed by ligating a universal fluorescence-probe with SNP-encoded flaps cleaved from multiplex invasive reactions,Chemical Communications

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A universal genotyping–microarray constructed by ligating a universal fluorescence-probe with SNP-encoded flaps cleaved from multiplex invasive reactions
Chemical Communications ( IF 4.9 ) Pub Date : 2017-11-10 00:00:00 , DOI: 10.1039/c7cc06649j
Zhiyao Chen _{1,

2,

3,

4,

5} , Liyan Miao _{5,

6,

7,

8} , Yunlong Liu _{1,

2,

3,

4,

5} , Tianhui Dong _{1,

2,

3,

4,

5} , Xueping Ma _{1,

2,

3,

4,

5} , Xiaoxiang Guan _{1,

2,

3,

4,

5} , Guohua Zhou _{1,

2,

3,

4,

5} , Bingjie Zou _{1,

2,

3,

4,

5}

Affiliation

To achieve a microarray universal to any SNP, we proposed a new way to construct a genotyping–microarray by ligating a universal fluorescence-probe with SNP-encoded flaps cleaved from invasive reactions on a slide surface. Our proposed microarray is labor-saving and cost-saving in setting up a new experiment for genotyping multiple SNPs, which is related to personalized medicine.

中文翻译：

通用基因分型-微阵列通过将通用荧光探针与从多重侵袭反应中裂解的SNP编码的皮瓣连接而构建

为了实现对任何SNP通用的微阵列，我们提出了一种新的方法来构建基因分型微阵列，方法是将通用荧光探针与SNP编码的皮瓣连接起来，该皮瓣从载玻片表面的侵入性反应中裂解而来。我们提出的微阵列在建立一个新的对多个SNP基因型进行基因分型的实验中节省了人力和成本，这与个性化医学有关。

更新日期：2017-11-20

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