Sulfated liposaccharides are known inhibitors of telomerase and here we describe the synthesis of a series of sulfated liposaccharides inspired by the natural product axinelloside A, reported to act as an inhibitor of human telomerase. We established a robust and scalable synthetic route to galactosyl liposaccharides capitalizing on a series of regioselective acylation reactions with 2-decenoic acid and imidazolium sulfate esters.

中文翻译：

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受端粒酶抑制剂阿奇诺糖苷A启发的硫酸化脂糖

硫酸化的脂糖是端粒酶的已知抑制剂，在这里我们描述了一系列天然产物axinelloside A激发的一系列硫酸化的脂糖的合成，据报道，该产物可作为人类端粒酶的抑制剂。我们利用2-癸烯酸和硫酸咪唑鎓酯的一系列区域选择性酰化反应，建立了一种健壮且可扩展的半乳糖基脂糖合成路线。