Although the interaction between phages and bacteria has already been well described, it only recently emerged that human viruses also interact with bacteria in the mammalian gut. We studied whether this interaction could occur in tap water and thus confer enteric viruses protection against temperature and the classical disinfection treatments used in drinking water production. We demonstrated that the addition of lipopolysaccharide or peptidoglycan of bacterial origin to enterovirus provides thermal protection through stabilization of the viral capsid. This interaction plays a role when viruses are exposed to disinfection that targets the capsid, but less so when the virus genome is directly targeted. The interaction seems to be serotype-specific, suggesting that the capsid protein sequence could be important. The protection is linked to a direct association between viral particles and bacterial compounds as observed by microscopy. These results show that bacterial compounds present in the environment can affect virus inactivation.

中文翻译：

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人类肠道病毒与微生物化合物的相互作用：对病毒持久性和消毒处理的影响

尽管已经很好地描述了噬菌体与细菌之间的相互作用，但直到最近才发现人类病毒也与哺乳动物肠道中的细菌相互作用。我们研究了这种相互作用是否会在自来水中发生，从而赋予肠道病毒防御温度的能力以及饮用水生产中使用的经典消毒方法​​。我们证明向肠道病毒中添加细菌来源的脂多糖或肽聚糖可通过稳定病毒衣壳提供热保护。当病毒暴露于针对衣壳的消毒时，这种相互作用起着作用，而当病毒基因组被直接靶向时，这种相互作用起的作用较小。相互作用似乎是血清型特异性的，表明衣壳蛋白序列可能很重要。如通过显微镜观察到的，该保护作用与病毒颗粒和细菌化合物之间的直接缔合有关。这些结果表明环境中存在的细菌化合物会影响病毒的灭活。