Soon after difenacoum began to be used, resistance to this rodenticide was detected in rats in northeast Hampshire and northwest Berkshire in England. Resistance to difenacoum has been reported to be stronger in rats from Berkshire than in rats from Hampshire. Surprisingly, after the discovery of the vitamin K epoxide reductase complex subunit 1 (Vkorc1) gene, rats from Berkshire and Hampshire were all shown to be homozygous for the L120Q mutation in Vkorc1.

中文翻译：

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在维生素K环氧化物还原酶复合物亚基1（Vkorc1）基因的L120Q突变纯合的伯克希尔大鼠中观察到的高抗地芬诺表型参与了高抗地芬诺表型的代谢。

在开始使用地非那科后不久，在英格兰汉普郡东北部和西北伯克郡的老鼠中发现了对这种灭鼠剂的抗药性。据报道，来自伯克希尔郡的大鼠对地芬那铵的抵抗力强于来自汉普郡的大鼠。令人惊讶地，后维生素K环氧化物的发现还原酶复合体亚基1（VKORC1）基因，来自伯克郡和汉普大鼠均显示出是纯合的突变L120Q VKORC1。