Four new prenylated indole alkaloids (1–4), and four new chromone derivatives (7–10), together with six known compounds (5, 6, and 11–14), have been isolated from the mangrove sediment derived fungus Penicillium sp. SCSIO041218, cultured in the 1% NaCl PDB substrate. The structures of new compounds were determined by analysis of the NMR and MS spectroscopic data. The absolute configuration of the prenylated indole alkaloids were elucidated based on the comparison of ECDs with known analogues. The absolute configurations of the chromone derivatives were determined by time-dependent density functional theory calculations of the ECD spectra. In all of these isolated compounds, penixanthones A and B (12 and 13) exhibited antiallergic activities in vitro.

四个新的异戊二烯化的吲哚生物碱（14），和四个新的色酮衍生物（7 - 10），加上6种已知化合物（5，6，和11 - 14），已经从衍生真菌红树沉积物分离青霉sp。SCSIO041218，在1％NaCl PDB底物中培养。通过分析NMR和MS光谱数据确定新化合物的结构。基于ECD与已知类似物的比较，阐明了烯丙基化吲哚生物碱的绝对构型。苯甲酮衍生物的绝对构型由ECD光谱的时间依赖性密度泛函理论计算确定。在所有这些分离的化合物中，黄嘌呤酮A和B（12和13）在体外均表现出抗过敏​​活性。