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Effect of HIV-1 low-level viraemia during antiretroviral therapy on treatment outcomes in WHO-guided South African treatment programmes: a multicentre cohort study.
The Lancet ( IF 168.9 ) Pub Date : 2018-Feb-01 , DOI: 10.1016/s1473-3099(17)30681-3
Lucas E Hermans , Michelle Moorhouse , Sergio Carmona , Diederick E Grobbee , L Marije Hofstra , Douglas D Richman , Hugo A Tempelman , Willem D F Venter , Annemarie M J Wensing

Antiretroviral therapy (ART) that enables suppression of HIV replication has been successfully rolled out at large scale to HIV-positive patients in low-income and middle-income countries. WHO guidelines for these regions define failure of ART with a lenient threshold of viraemia (HIV RNA viral load ≥1000 copies per mL). We investigated the occurrence of detectable viraemia during ART below this threshold and its effect on treatment outcomes in a large South African cohort.

中文翻译:

在世卫组织指导的南非治疗计划中,抗逆转录病毒治疗期间HIV-1低水平病毒血症对治疗结果的影响:一项多中心队列研究。

能够抑制HIV复制的抗逆转录病毒疗法(ART)已成功地大规模推广到低收入和中等收入国家的HIV阳性患者。世界卫生组织针对这些区域的指南将ART的失败定义为宽容的病毒血症阈值(HIV RNA病毒载量≥1000拷贝/ mL)。我们调查了在此阈值以下的ART期间可检测到的病毒血症的发生及其对南非一个大型队列研究的治疗效果的影响。
更新日期:2018-01-26
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