A picture may speak a thousand words, but if those words fail to form a coherent sentence there is little to be learned. As cutting-edge imaging technology now provides us the tools to decipher the multitude of roles played by metals and metalloids in molecular, cellular, and developmental biology, as well as health and disease, it is time to reflect on the advances made in imaging, the limitations discovered, and the future of a burgeoning field. In this Perspective, the current state of the art is discussed from a self-imposed contrarian position, as we not only highlight the major advances made over the years but use them as teachable moments to zoom in on challenges that remain to be overcome. We also describe the steps being taken toward being able to paint a completely undisturbed picture of cellular metal metabolism, which is, metaphorically speaking, the Holy Grail of the discipline.

中文翻译：

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生物学中金属成像的前景与误区

一幅图片可能说出一千个单词，但是如果这些单词不能形成连贯的句子，那么您将学到的东西很少。如今，随着尖端的成像技术为我们提供了工具，以解读金属和准金属在分子，细胞和发育生物学以及健康和疾病中所起的多种作用，现在该反思一下成像技术的进步，发现的局限性以及新兴领域的未来。在此《观点》中，从自我强加的逆势立场出发，讨论了当前的技术现状，因为我们不仅着重强调了多年来取得的重大进展，而且将它们作为可教导的时机来着重探讨尚待克服的挑战。我们还描述了为描绘细胞金属代谢的完全不受干扰的图像而采取的步骤，即