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A biocatalytic cascade for the amination of unfunctionalised cycloalkanes
Organic & Biomolecular Chemistry ( IF 3.2 ) Pub Date : 2017-11-10 00:00:00 , DOI: 10.1039/c7ob02569f
Michele Tavanti 1, 2, 3, 4, 5 , Juan Mangas-Sanchez 1, 2, 3, 4, 5 , Sarah L. Montgomery 1, 2, 3, 4, 5 , Matthew P. Thompson 1, 2, 3, 4, 5 , Nicholas J. Turner 1, 2, 3, 4, 5
Affiliation  

Here we describe a one-pot, three-enzyme, cascade involving a cytochrome P450 monooxygenase, an alcohol dehydrogenase and a reductive aminase for the synthesis of secondary amines from cycloalkanes. Amine product concentrations of up to 19.6 mM were achieved. The preparative scale amination of cyclohexane was also demonstrated with a space–time yield of 2 g L−1 d−1.

中文翻译:

用于未官能化环烷烃胺化的生物催化级联

在这里,我们描述了一种一锅三酶级联反应,涉及一种细胞色素P450单加氧酶,一种醇脱氢酶和一种还原性氨化酶,用于从环烷烃合成仲胺。胺产品浓度达到了19.6 mM。还证明了环己烷的制备规模胺化反应的时空产率为2 g L -1 d -1
更新日期:2017-11-17
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