A novel homobimetallic nickel complex for the asymmetric direct Mannich reaction of imines: a practical method on a multi-gram scale,Chemical Communications

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A novel homobimetallic nickel complex for the asymmetric direct Mannich reaction of imines: a practical method on a multi-gram scale
Chemical Communications ( IF 4.9 ) Pub Date : 2017-11-09 00:00:00 , DOI: 10.1039/c7cc06468c
Shixiong Zhang _{1,

2,

3,

4} , Ping Deng _{1,

2,

3,

4} , Jing Zhou _{1,

2,

3,

4} , Mouxiong Liu _{1,

2,

3,

4} , Guojuan Liang _{1,

2,

3,

4} , Yan Xiong _{4,

5,

6,

7} , Hui Zhou _{1,

2,

3,

4}

Affiliation

A novel dinuclear Ni complex has been developed for the direct Mannich reaction of malonates with N-tosyl aryl imines with a low catalyst loading (0.1–0.05 mol%) on a preparative scale (5–50 mmol). The structure of the active species was verified via control experiments, ESI-HRMS, and DFT calculations.

中文翻译：

亚胺不对称直接曼尼希反应的新型同双金属镍配合物：多克规模的实用方法

已开发出一种新型的双核镍络合物，用于制备级（5-50 mmol）的低催化剂负载量（0.1-0.05 mol％）的丙二酸酯与N-甲苯磺酰基芳基亚胺的直接曼尼希反应。通过控制实验，ESI-HRMS和DFT计算验证了活性物质的结构。

更新日期：2017-11-17

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