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Enantioselective Reactions Catalyzed by N‐Heterocyclic Carbenes
Asian Journal of Organic Chemistry ( IF 2.7 ) Pub Date : 2017-11-30 , DOI: 10.1002/ajoc.201700538
Ming Zhao 1 , Yu-Tong Zhang 1 , Jie Chen 1 , Ling Zhou 1
Affiliation  

Enantioselective organocatalysis by using N‐heterocyclic carbenes (NHCs) has emerged as a powerful strategy for the construction of complex chiral molecules. Recently, remarkable advances have been made in enantioselective NHC‐catalyzed reactions that involve diverse activation intermediates, such as Breslow intermediates, homoenolate intermediates, α,β‐unsaturated acylazoliums, azolium enolates, and azolium dienolates, which are generated by the nucleophilic addition of NHCs to aldehydes. Furthermore, NHC‐catalyzed reactions that proceed through non‐covalent bonding interactions have also been developed.

中文翻译:

N-杂环卡宾催化的对映选择性反应

通过使用N-杂环卡宾(NHC)进行对映选择性有机催化已成为构建复杂手性分子的有力策略。最近,在涉及多种活化中间体的对映选择性NHC催化反应方面取得了显着进展,例如Br​​eslow中间体,均烯酸酯中间体,α,β-不饱和酰基acy,氮烯醇烯醇盐和二烯二氮唑醇,这是通过NHC的亲核加成反应而产生的。醛。此外,还开发了通过非共价键相互作用进行的NHC催化反应。
更新日期:2017-11-30
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