Survival outcome for elderly patients with newly diagnosed diffuse large B-cell lymphoma remains suboptimal in the rituximab era. In this systematic review, we summarize available evidence relevant to the inclusion of anthracycline in upfront chemoimmunotherapy for these elderly patients and highlight the need of prospective clinical trials. With limited prospective data, we find that pretreatment comprehensive geriatric assessment accurately predicts survival and treatment-related toxicities, suggesting its potential role in guiding overall treatment decision-making.

中文翻译：

---

蒽环类药物和综合老年评估对弥漫性大 B 细胞淋巴瘤老年患者的作用

在利妥昔单抗时代，新诊断的弥漫性大 B 细胞淋巴瘤老年患者的生存结果仍然欠佳。在这篇系统评价中，我们总结了与将蒽环类药物纳入这些老年患者的前期化学免疫治疗相关的现有证据，并强调了前瞻性临床试验的必要性。由于前瞻性数据有限，我们发现治疗前综合老年评估可准确预测生存期和治疗相关毒性，表明其在指导整体治疗决策方面具有潜在作用。