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Neurobehavioral assessment of rats exposed to pristine polystyrene nanoplastics upon oral exposure
Chemosphere ( IF 8.8 ) Pub Date : 2017-11-16 , DOI: 10.1016/j.chemosphere.2017.11.076
Mohammad Rafiee , Leila Dargahi , Akbar Eslami , Elmira Beirami , Mahsa Jahangiri-rad , Siamak Sabour , Fatemeh Amereh

The increasing use of plastics has raised concerns about pollution of freshwater by these polymeric materials. Knowledge about their potential effects on environmental and public health is limited. Recent publications have suggested that the degradation of plastics will result in the release of nano-sized plastic particles to the environment. Therefore, it is of utmost importance to gain knowledge about whether and how nanoplastics affect living organisms. The present study aimed to analyse potential neurobehavioral effects of polystyrene nanoparticles (PS-NPs) after long-term exposure on rat. Potential effects of PS-NPs were investigated using four test dosages (1, 3, 6, and 10 mg PS-NPs/kg of body weight/day) administrated orally with adult Wistar male rats for five weeks. Neurobehavioral tests were chosen to assess a variety of behavioral domains. Particle diameters in test suspensions were determined through dynamic light scattering and showed an average hydrodynamic diameter of approximately 38.92 nm. No statistically significant behavioral effects were observed in all tests performed (p > 0.05). In the elevated plus maze, PS-NPs-exposed rats showed greater number of entries into open arms compared to controls. Also, PS-NPs had no significant influence on body weight of animals. Taking into account the subtle and transient nature of neurobehavioral consequences, however, these results underline the possibility of even pristine plastic nanoparticles to induce behavioral alteration in the rest of the food web, including for marine biota and humans. Indeed even though studied neurobehavioral effects in our study was not statistically significant, the observed subtle effects may be clinically considerable.



中文翻译:

口服暴露于原始聚苯乙烯纳米塑料的大鼠的神经行为评估

塑料的日益使用引起了人们对这些聚合材料对淡水的污染的担忧。关于它们对环境和公共卫生的潜在影响的知识是有限的。最近的出版物表明,塑料的降解将导致纳米级塑料颗粒释放到环境中。因此,获得有关纳米塑料是否以及如何影响生物的知识至关重要。本研究旨在分析长期暴露于大鼠后的聚苯乙烯纳米颗粒(PS-NP)的潜在神经行为作用。使用成年Wistar雄性大鼠口服五周的四种测试剂量(1、3、6和10 mg PS-NPs / kg体重/天)研究了PS-NP的潜在作用。选择神经行为测试来评估各种行为领域。通过动态光散射确定测试悬浮液中的粒径,并显示出约38.92 nm的平均流体动力学直径。在所有执行的测试中均未观察到统计学上显着的行为影响(p> 0.05)。在高架迷宫中,与对照组相比,暴露于PS-NPs的大鼠的张开双臂的进入数量更多。另外,PS-NP对动物的体重也没有显着影响。然而,考虑到神经行为后果的微妙和短暂的性质,这些结果强调了即使是原始的塑料纳米颗粒也可能在其余食物网(包括海洋生物区系和人类)中诱发行为改变的可能性。

更新日期:2017-11-16
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