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Induced cortical responses require developmental sensory experience
Brain ( IF 14.5 ) Pub Date : 2017-11-16 , DOI: 10.1093/brain/awx286
Prasandhya Astagiri Yusuf 1 , Peter Hubka 1 , Jochen Tillein 1, 2 , Andrej Kral 1, 3
Affiliation  

Sensory areas of the cerebral cortex integrate the sensory inputs with the ongoing activity. We studied how complete absence of auditory experience affects this process in a higher mammal model of complete sensory deprivation, the congenitally deaf cat. Cortical responses were elicited by intracochlear electric stimulation using cochlear implants in adult hearing controls and deaf cats. Additionally, in hearing controls, acoustic stimuli were used to assess the effect of stimulus mode (electric versus acoustic) on the cortical responses. We evaluated time-frequency representations of local field potential recorded simultaneously in the primary auditory cortex and a higher-order area, the posterior auditory field, known to be differentially involved in cross-modal (visual) reorganization in deaf cats. The results showed the appearance of evoked (phase-locked) responses at early latencies (<100 ms post-stimulus) and more abundant induced (non-phase-locked) responses at later latencies (>150 ms post-stimulus). In deaf cats, substantially reduced induced responses were observed in overall power as well as duration in both investigated fields. Additionally, a reduction of ongoing alpha band activity was found in the posterior auditory field (but not in primary auditory cortex) of deaf cats. The present study demonstrates that induced activity requires developmental experience and suggests that higher-order areas involved in the cross-modal reorganization show more auditory deficits than primary areas.

中文翻译:

诱导皮层反应需要发展感官经验

大脑皮层的感觉区域将感觉输入与正在进行的活动整合在一起。我们研究了完全缺乏听觉经验如何在完全感觉剥夺的高等哺乳动物模型(先天性聋猫)中影响这一过程。皮质反应是通过在成人听力对照和聋猫中使用耳蜗植入物进行耳蜗内电刺激而引起的。另外,在听觉对照中,听觉刺激被用于评估刺激模式(电对听觉)对皮层反应的影响。我们评估了同时记录在主要听觉皮层和较高级区域(后听觉区域)中的局部场电位的时频表示,已知该区域以不同的方式参与聋猫的交叉模态(视觉)重组。结果显示在早期潜伏期(刺激后<100 ms)出现诱发(锁相)响应,在后期潜伏期(刺激后> 150 ms)出现更丰富的诱导(非锁相)响应。在聋猫中,在两个研究领域的总功率和持续时间中均观察到诱导反应大大降低。此外,在聋猫的后听觉区域(但在原发听觉皮层中)未发现正在进行的α带活动减少。本研究表明,诱导活动需要发展经验,并表明参与交叉模式重组的高阶区域比主要区域表现出更多的听觉缺陷。刺激后100毫秒)和更晚的延迟(刺激后> 150毫秒)更丰富的诱导(非锁相)响应。在聋猫中,在两个研究领域的总功率和持续时间中均观察到诱导反应大大降低。此外,在聋猫的后听觉区域(但在原发听觉皮层中)未发现正在进行的α带活动减少。本研究表明,诱导活动需要发展经验,并表明参与交叉模式重组的高阶区域比主要区域表现出更多的听觉缺陷。刺激后100毫秒)和更晚的延迟(刺激后> 150毫秒)更丰富的诱导(非锁相)响应。在聋猫中,在两个研究领域的总功率和持续时间中均观察到诱导反应大大降低。另外,在聋猫的后听觉区域(但在原发听觉皮层中)未发现正在进行的α带活动减少。本研究表明,诱导活动需要发展经验,并表明参与交叉模式重组的高阶区域比主要区域表现出更多的听觉缺陷。聋猫的后听觉区域(而不是原发听觉皮层)发现正在进行的α带活动减少。本研究表明,诱导活动需要发展经验,并表明参与交叉模式重组的高阶区域比主要区域表现出更多的听觉缺陷。聋猫的后听觉区域(而不是原发听觉皮层)发现正在进行的α带活动减少。本研究表明诱导的活动需要发展经验,并建议参与交叉模式重组的高阶区域比主要区域表现出更多的听觉缺陷。
更新日期:2017-11-16
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