Half-sandwich ruthenium(II) complexes containing N^N-chelated imino-pyridyl ligands that are selectively toxic to cancer cells,Chemical Communications

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Half-sandwich ruthenium(II) complexes containing N^N-chelated imino-pyridyl ligands that are selectively toxic to cancer cells
Chemical Communications ( IF 4.9 ) Pub Date : 2017-11-07 00:00:00 , DOI: 10.1039/c7cc08270c
Meng Tian _{1,

2,

3,

4,

5} , Juanjuan Li _{1,

2,

3,

4,

5} , Shumiao Zhang _{1,

2,

3,

4,

5} , Lihua Guo _{1,

2,

3,

4,

5} , Xiangdong He _{1,

2,

3,

4,

5} , Deliang Kong _{1,

2,

3,

4,

5} , Hairong Zhang _{1,

2,

3,

4,

5} , Zhe Liu _{1,

2,

3,

4,

5}

Affiliation

Chemotherapy is limited by its poor selectivity towards cancer cells over normal cells. Herein, we designed half-sandwich ruthenium imino-pyridyl complexes [(η⁶-bz)Ru(N^N)Cl]PF₆ to achieve selective cytotoxicity to cancer cells. This kind of ruthenium complex has unique characteristics and is worthy of further exploration in the design of new anticancer drugs.

中文翻译：

含有对癌细胞具有选择性毒性的N ^ N螯合的亚氨基吡啶基配体的半三明治钌（II）配合物

化学疗法由于其对癌细胞的选择性不及正常细胞而受到限制。在本文中，我们设计了半夹心钌亚氨基吡啶基配合物[（η ⁶ -BZ）的Ru（N ^ N）CL] PF ₆，以实现选择性细胞毒性至癌细胞。这种钌配合物具有独特的特性，值得在新的抗癌药物的设计中进行进一步的探索。

更新日期：2017-11-16

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