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Iron-catalyzed peroxidation–carbamoylation of alkenes with hydroperoxides and formamides via formyl C(sp2)–H functionalization
Chemical Communications ( IF 4.9 ) Pub Date : 2017-11-01 00:00:00 , DOI: 10.1039/c7cc08074c
Jun-Kee Cheng 1, 2, 3, 4 , Liang Shen 1, 2, 3, 4 , Liu-Hai Wu 1, 2, 3, 4 , Xu-Hong Hu 5, 6, 7, 8, 9 , Teck-Peng Loh 5, 6, 7, 8, 9
Affiliation  

A reaction protocol in which FeCl3 and tert-butyl hydroperoxide facilitated a selective radical coupling reaction of aryl alkenes or 1,3-enynes with tert-butyl hydroperoxide and formamides to prepare an array of β-peroxy amides has been achieved. The β-peroxy amide could serve as a synthetic precursor which was facilely converted to β-hydroxy amide, β-keto amide and β-lactam following subsequent chemical transformation.

中文翻译:

通过甲酰基C(sp 2)-H官能团与氢过氧化物和甲酰胺的铁催化过氧化-氨基甲酰基化

已经实现了其中FeCl 3丁基过氧化氢促进芳基烯烃或1,3-烯炔与丁基过氧化氢和甲酰胺的选择性自由基偶联反应以制备一系列β-过氧酰胺的反应方案。β-过氧酰胺可以用作合成的前体,其在随后的化学转化后容易地转化为β-羟基酰胺,β-酮酰胺和β-内酰胺。
更新日期:2017-11-16
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