The catalytic alkenylation of the unactivated distal γC(sp³)–H bonds of aliphatic acids with simple acrylates and vinyl iodides is described. This method allows for the introduction of an alkene group into aliphatic acid derivatives in the form of activated olefins and vinyl iodides. Notably, olefination with vinyl iodides provides access to a wide range of challenging γ-vinyl acid derivatives with aliphatic olefin functionality introduced in a diastereoselective manner.

中文翻译：

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钯与烯烃和烯基碘化物催化的直接脂肪族γC（sp ³）–H烯基化反应

描述了脂肪酸的未活化的远端γC（sp ³）–H键与简单的丙烯酸酯和乙烯基碘的催化烯基化反应。该方法允许将烯烃基团以活化的烯烃和乙烯基碘的形式引入到脂肪酸衍生物中。值得注意的是，用乙烯基碘进行的烯烃化反应提供了多种具有挑战性的，以非对映选择性方式引入的具有脂族烯烃官能团的具有挑战性的γ-乙烯基酸衍生物。