Hybrid nanoparticles with a large bridging organic group were prepared by mechanochemical-assisted sol–gel reaction. Planetary ball mill (PBM) was used for the first time to access the bis-silylated precursors, containing complex functionalities (such as hydantoins or a symmetrical urea obtained from α-amino esters). The process is based on a sequential reaction pathway involving liquid-assisted grinding (LAG) and 1,1′-carbonyldimidazole (CDI)-mediated one-pot/two-step reactions. Then hydantoins and the symmetric urea were used for the one-pot preparation of the corresponding bis-silylated compounds in a vibrational ball mill (VBM), followed by the mechanochemical sol–gel preparation of biohybrid bridged silsesquioxane nanospheres of uniform size.

中文翻译：

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球磨从分子到硅基生物杂化材料

通过机械化学辅助的溶胶-凝胶反应制备了具有较大桥接有机基团的杂化纳米颗粒。首次使用行星式球磨机（PBM）来访问含有复杂功能（例如乙内酰脲或由α-氨基酯制得的对称尿素）的双甲硅烷基化前体。该过程基于顺序反应路径，涉及液体辅助研磨（LAG）和1,1'-羰基二咪唑（CDI）介导的一锅/两步反应。然后，乙内酰脲和对称尿素在振动球磨机（VBM）中一锅法制备相应的双甲硅烷基化化合物，然后用机械化学溶胶-凝胶法制备大小均一的生物混合桥连倍半硅氧烷纳米球。