We thank Alexander Radbruch and colleagues for their comments regarding our and more recent publications. They highlight an experiment comparing gadolinium retention in the rat brain after high doses of linear or macrocyclic gadolinium-based contrast agents (GBCAs),¹ demonstrating retention of tiny amounts of soluble gadolinium in brain tissue for all agents, but higher concentrations of the insoluble fraction for linear than for macrocyclic agents. Of note, another paper² by the same group reported that brain tissue of rats with proven gadolinium deposition showed no histopathological changes with either linear or macrocyclic agents.

中文翻译：

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g沉积或螯合沉积-作者的回复

我们感谢Alexander Radbruch及其同事对我们的出版物和最新出版物的评论。他们着重进行了一项实验，比较了大剂量线性或基于大环contrast的造影剂（GBCA）后大鼠脑中retention的保留情况，[ ^1]表明所有试剂在脑组织中都保留有少量可溶性g ，但是不溶部分的浓度较高对于线性试剂，对于大环化合物而言。值得注意的是，同一小组的另一篇论文²报道，已证实proven沉积的大鼠的脑组织在使用线性或大环药物后均未显示出组织病理学变化。