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Unexpected Synthesis of 2,3,5,6-Tetrahydro-1H -pyrrolo[3,4-c ]pyridine-1,3,6-triones by a Double Michael Addition/CS2 Extrusion/Double Cyclization Sequence
European Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2017-11-15 , DOI: 10.1002/ejoc.201701097
Giacomo Mari 1 , Lucia De Crescentini 1 , Gianfranco Favi 1 , Stefania Santeusanio 1 , Samuele Lillini 2 , Fabio Mantellini 1
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Bis adducts derived from a double Michael addition of rhodanine to an azo-ene system of two molecules of 1,2-diaza-1,3-dienes (DDs) have furnished the corresponding 2,3,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyridine-1,3,6-triones by means of a CS2 extrusion/double cyclization sequence. The incorporation of two units (4 and 2 atoms) of DDs into the fused bicyclic heterocycles represents a new application of this versatile class of molecules in heterocyclic synthesis.

中文翻译:

通过双迈克尔加成/CS2 挤出/双环化序列意外合成 2,3,5,6-四氢-1H-吡咯并[3,4-c]吡啶-1,3,6-三酮

由罗丹宁双迈克尔加成到两分子 1,2-二氮杂-1,3-二烯 (DDs) 的偶氮烯系统产生的双加合物提供了相应的 2,3,5,6-四氢-1H- pyrrolo[3,4-c]pyridine-1,3,6-triones 通过 CS2 挤出/双环化序列。将 DD 的两个单元(4 个和 2 个原子)掺入稠合的双环杂环代表了这种多功能分子在杂环合成中的新应用。
更新日期:2017-11-15
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