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A novel trityl/acridine derivatization agent for analysis of thiols by (matrix-assisted)(nanowire-assisted)laser desorption/ionization and electrospray ionization mass spectrometry
Analytical Methods ( IF 3.1 ) Pub Date : 2017-10-30 00:00:00 , DOI: 10.1039/c7ay01965c
Artyom P. Topolyan 1, 2, 3 , Maria A. Belyaeva 1, 2, 3 , Mariya S. Slyundina 3, 4, 5 , Valentina V. Ilyushenkova 3, 4, 5 , Andrey A. Formanovsky 1, 2, 3 , Vladimir A. Korshun 1, 2, 3, 6, 7 , Roman S. Borisov 3, 4, 5, 8, 9
Affiliation  

The derivatization reagent was prepared in situ by the reaction of tris(2,6-dimethoxyphenyl)methylium hexafluorophosphate with N-(2-aminoethyl)maleimide and used for the modification of a number of low molecular weight thiols. The adducts were analyzed by (MA)(NA)LDI MS and ESI MS. All registered mass spectra ((MA)(NA)LDI, ESI) revealed intense peaks of the cations of the derivatization products. The increment of the derivatization agent (499 Da) shifts the ion peaks of analytes from noisy low mass regions, thus allowing the detection of low molecular weight thiols. LDI analysis of the natural-gas condensate sample showed the presence of saturated alkylthiols (up to C22H45SH).

中文翻译:

新型三苯甲基/ ac啶化剂,用于(基质辅助)(纳米线辅助)激光解吸/电离和电喷雾电离质谱分析硫醇

通过六氟磷酸三(2,6-二甲氧基苯基)甲基鎓与N-(2-氨基乙基)马来酰亚胺的反应原位制备衍生试剂,并将其用于许多低分子量硫醇的改性。用(MA)(NA)LDI MS和ESI MS分析加合物。所有已记录的质谱图((MA)(NA)LDI,ESI)均显示了衍生化产物阳离子的强烈峰。衍生化剂的增量(499 Da)将分析物的离子峰从嘈杂的低质量区域移开,从而允许检测低分子量硫醇。天然气冷凝液样品的LDI分析表明存在饱和烷基硫醇(最高C 22 H 45 SH)。
更新日期:2017-11-15
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