High-throughput screening and activity-guided purification identified nicoyamycin A, a natural product comprised of an uncommon 3-methyl-1,4-dioxane ring incorporated into a desferrioxamine-like backbone via a spiroaminal linkage. Nicoyamycin A potently inhibits uropathogenic Escherichia coli growth in low iron medium, a promising step toward developing novel antibiotics to treat recalcitrant bacterial infections.

中文翻译：

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发现低铁环境中尿毒症性大肠杆菌生长抑制剂烟碱霉素A

高通量筛选和活性指导纯化可鉴定烟碱霉素A，这是一种天然产物，它由一个不常见的3-甲基-1,4-二恶烷环组成，它们通过螺氨基键合到去铁胺样骨架中。尼古丁霉素A在低铁培养基中有效抑制尿毒症性大肠杆菌的生长，这是开发新型抗生素来治疗顽固性细菌感染的有希望的一步。