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Iodonium-Induced Cyclization of N-Allenylindoles and N-Allenylpyrroles: An Access to Iododihydropyrido[1,2-a]indoles and Dihydroindolizines
Synlett ( IF 2 ) Pub Date : 2017-11-14 , DOI: 10.1055/s-0036-1591506
Patrick Toullec 1, 2 , Charlotte Grandclaudon 1 , Veronique Michelet 1
Affiliation  

The formation of iodinated dihydropyrido[1,2-a]indoles and dihydroindolizines was achieved by an iodocarbocyclization reaction of N-allenylindoles and N-allenylpyrroles. This transformation proceeded under very mild conditions using N-iodosuccinimide as the electrophilic iodine source to deliver the products via a 6-endo cyclization process. Careful choice of the solvent and concentration were mandatory to obtain the cyclization in good yields.

中文翻译:

N-Allenylindoles 和 N-Allenylpyrroles 的碘诱导环化:获得 Iododihydropyrido[1,2-a]indoles 和 Dihydroindolizines

碘化二氢吡啶并[1,2-a]吲哚和二氢吲哚嗪的形成是通过N-烯丙基吲哚和N-烯丙基吡咯的碘碳环化反应实现的。这种转化在非常温和的条件下进行,使用 N-碘代琥珀酰亚胺作为亲电子碘源,通过 6-内环化过程传递产物。必须仔细选择溶剂和浓度才能以良好的收率获得环化。
更新日期:2017-11-14
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